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S2

Schedule 2 (S2) medicines in South Africa

A pharmacist can sell it directly, without a prescription.

About S2 Drugs

Where S2 sits on the scale

A pharmacist can sell it directly, without a prescription.

Schedule 2 medicines sit behind the pharmacy counter. A pharmacist can decide to sell one of these directly, using their own professional judgement, without a doctor's prescription. It can also be dispensed against a prescription like the higher tiers, in which case the usual repeat limits apply. A child under 12 may only be sold a Schedule 2 substance on a prescription, or on a written order that names the purpose and carries a signature the seller recognises. Even though it cannot be advertised to the public in the ordinary sense, its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Cited: Act s22A(6)(e)

Who may supply

Only a pharmacist, pharmacist intern or supervised pharmacist's assistant may sell it without a prescription. It may otherwise be dispensed by a pharmacist against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Cited: Act s22A(5)(a), s22A(5)(d), s22A(5)(e), s22A(6)(r)

Repeats: If dispensed on prescription, it can be repeated only if the prescriber indicated a number of repeats, and never for more than six months in total; the prescription must also be presented for dispensing within 30 days of issue.

Cited: reg 33(3)(i) (General Regulations, 2017)

Cited: Act s22A(6)(d), s22A(6)(f)

Advertising: May be advertised only to health professionals, not the public.

Cited: reg 42(2), reg 42(3) (General Regulations, 2017)

Labelling: Must show the letter S and the number 2 in a square border, immediately before the product's brand name.

Cited: reg 10(1)(a) (General Regulations, 2017)

What is a Schedule 2 medicine in South Africa?

A pharmacist can sell it directly, without a prescription. Schedule 2 medicines sit behind the pharmacy counter. A pharmacist can decide to sell one of these directly, using their own professional judgement, without a doctor's prescription. It can also be dispensed against a prescription like the higher tiers, in which case the usual repeat limits apply. A child under 12 may only be sold a Schedule 2 substance on a prescription, or on a written order that names the purpose and carries a signature the seller recognises. Even though it cannot be advertised to the public in the ordinary sense, its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Can a pharmacist sell a Schedule 2 medicine without a prescription?

No prescription is needed. Only a pharmacist, pharmacist intern or supervised pharmacist's assistant may sell it without a prescription. It may otherwise be dispensed by a pharmacist against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction. If dispensed on prescription, it can be repeated only if the prescriber indicated a number of repeats, and never for more than six months in total; the prescription must also be presented for dispensing within 30 days of issue.

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

Substances listed under S2

282 listed in the Consolidated Schedules, 154 with a registered medicine.

Registered medicines in S2

Showing 108 of 108 chemicals in schedule S2
Registered products
NameBrandsDosagesApplicantsRegistrationsSchedule
AbirateroneAlernova0,5 mgTrinity Pharma (Pty) Ltd550310.309S2
AcetylcysteineParvolex200mg / 10mlPharmacare limited û woodmeadNX0156S2
Acetylsalicylic acidCardasa100 mgViatris Healthcare (Pty) Ltd540456S2
AlbendazoleZentel, Albendazole cospharm1 mg, 20 mg/ml, 400 mg2 applicants3 registrationsS2
AmeprazoleTumsigon otc20 mgDezzo Trading 392 (Pty) Ltd560847S2
Ammonium chlorideExpectalin with codeine, Diphal expectorant, Benylin forte, +3 more5 mL, 12.5 mg, 10 mg, 125 mg, 12,5 mg/10 mg/10 mg/125 mg/50 mg per 5 ml, 16, 667 / 1,667 / 6,667 mg / 120 mg / 50 mg6 applicants6 registrationsS2
AntazolineGemini1 mlAdcock ingram limitedH1254S2
Ascorbic acidCorenza c, Famucaps2 mg, 2,5 mg and 200 mg2 applicants2 registrationsS2
AtovaquoneMalanil100mg, 250mgAcino Pharma (Pty) Ltd370075S2
AtropineColstat300 mgLebasi Pharmaceuticals (Pty) LtdC0955S2
AzelastineRhinolast nasal, Optilast, Arzep nasal, +3 morespray, 0,14 mg, 1,0 mg and 0,365 mg4 applicants6 registrationsS2
Bamipine CancelledSoventolNot statedHolpro Pharmaceuticals (Pty) LtdC0735S2
Bevonium methylsulphate CancelledAcabelNot statedNatterman S.A. (Pty) Ltd *C0926S2
BilastineIlaxten, Ilaxten odt, Basmedene, +1 more2,5 mg/ml, 10 mg, 20 mg2 applicants5 registrationsS2
Bismuth oxideDe-nol, Ulcerone, D f chewsolution, 1023 applicants3 registrationsS2
BromhexineBronahex, Adco-linctopent, Dur-elix mucolytic, +3 moresolution, 0,2 %, 2.41 mg/5 ml, 5 ml5 applicants7 registrationsS2
Buclizine CancelledLongifenesyrupPharmacare limited û woodmeadC0947S2
CaffeineB-dol, Nomopain, Sinucon, +2 more10 mg, 10 mg/5 mg/400 mg/50 mg, 200 mg/6 mg/ 20 mg/2 mg, 450 mg, 5 mg, 30 mg, 10 mg5 applicants5 registrationsS2
CarbocisteineAcuphlem, Mucoflem, Merck-carbocisteine, +28 morecapsules, syrup, 5 ml, 375 mg19 applicants35 registrationsS2
CetirizineAllermine, Atrizin, AURO cetirizine, +1 more5 mg, 10 mg4 applicants5 registrationsS2
ChlorpheniramineHistabate, Flusin s, Sinumax allergy sinus, +13 more1,25 mg and 2,5 mg,, 2 mg, 10 mg, 500 mg, 4 mg, 5 ml, +7 more9 applicants19 registrationsS2
ChlorzoxazoneParaflexNot statedJanssen Pharmaceutica (Pty) LtdB1018S2
Cholestyramine resinTyracholpowderAscend Laboratories (Pty) Ltd561213S2
CimetidineMexiena200 mgBiotech Laboratories (Pty) Ltd560740S2
CinnarizineTranzet, Stugeron, Stugeron forte, +2 more25 mg, 75 mg4 applicants6 registrationsS2
Clemastine CancelledDegoran allergytabletGlaxosmithkline Consumer Healthcare SA (Pty) LtdC0552S2
ClonidineMenograine25 μgPharmacare limited û woodmeadM0041S2
CodeineTrifen expect paediatric, Trifen expect adult, Mybulen, +9 more5 mg/5 ml, 5 ml, 9 mg/7,2 mg/3,6 mg per 5 ml, 10 mg/200 mg/350 mg, +6 more7 applicants15 registrationsS5
ColchicineAspen colchicine ds, Kolcrys, Gouteze otc, +4 more0,5 mg, 0.5 mg, 1.0mg5 applicants7 registrationsS2
ColestyramineQuestran lite4g/sachetEquity Pharmaceutical (Pty) LtdD0039S2
Cyclandelate CancelledCyclospasmol200 MGRiker Laboratory SA (Pty) LtdH0579S2
CyclizineMedazine s5 mlMedpro Pharmaceutica (Pty) Ltd270204S2
CyproheptadineZyactin, Actincypro4 mg2 applicants2 registrationsS2
DesloratadineDeselex, Neoclarityne, Neoloridin, +25 moretablets, syrup, 2,5 mg, 2.5 mg, +3 more17 applicants35 registrationsS2
DextromethorphanCoryx cough and cold, Dilinct dry cough, Benydex, +2 more5 mL/10 mg/30 mg/1.25 mg, 15 mg3 applicants5 registrationsS2
DiclofenacPanamor, Motifine, Diclofenac unicorn, +1 more1,292 g/100 g, 12,5, patch, 25 mg, +3 more3 applicants11 registrationsS2
DicyclomineMeddev, Merbentyl, Microgel, +5 more10 ml, tablets, syrup, 5 mg/400 mg/200 mg per 5 ml5 applicants10 registrationsS2
Dimethindene CancelledFenostilNot statedCiba-geigy (Pty) LtdC0785S2
DiphenhydramineBennet's diphenhydramine, Benylin four flu liquid, Benylin four flu, +12 moreelixir, 12.5 mg/22.5 mg/500.0 mg, 20 mL, capsule, +4 more9 applicants16 registrationsS2
Diphtheria toxoidAdacel, Cihexa0,5 ml, ≥ 30 IU, ≥ 40 IU, ≥ 4 IU, 15 mcg, 40 DU, 8 DU, 32 DU, 10 mcg2 applicants2 registrationsS2
Diphtheria toxoid nltBoostrix0,5 mlGlaxosmithkline South Africa (Pty) Limited491042S2
DoxylamineRepose, Somnil, Doxynite, +2 moredrops, 25 mg4 applicants6 registrationsS2
EbastineKestine, Noribas, Ebastine adco, +1 more10 MG3 applicants4 registrationsS2
EpinastineRelestat0.5mgAbbvie (Pty) Ltd370691S2
ErgotamineErgate, Medihaler ergotamine, GynergenNot stated3 applicants3 registrationsS2
EsomeprazoleNexipraz otc, Nexilok, Nextell otc0,6 mg, 20mg, 20 mg, 30 mg3 applicants4 registrationsS2
EtilefrineEffortil10 mg/1 mlPharmaco Distribution (Pty) LtdF0197S2
ExalamideHyperanointment, solution2 applicants2 registrationsS2
FlavoxateUrispas, Flospasm, Bladuril200mg, 200 mg2 applicants3 registrationsS2
Flunarizine CancelledSibelium t, Sibelium5 mg, 10 mgJanssen Pharmaceutica (Pty) Ltd2 registrationsS2
FosfomycinUticide3 gUnicorn Pharmaceuticals (Pty) Ltd530574S2
Human papillomavirus typeCervarix1 dose (0,5 mL)Glaxosmithkline South Africa (Pty) Limited410366S2
IbuprofenMypaid, Lotem, Panado plus, +8 more200mg / 250mg, suspension, 5 ml, 30 mg, 200 mg, +9 more7 applicants12 registrationsS2
Influenza virus vaccineInfluvac tetra0,5 mLAbbott Laboratories S.A. (Pty) Ltd520094S2
Influenza virus vaccine a a b bVaxigrip tetraNot statedSanofi-aventis South Africa (Pty) Ltd510838S2
Isothipendyl CancelledAndantol jellyNot statedAdcock ingram limitedG2335S2
KetotifenParke-med ketotifen, Zetofen, Adco-ketotifen alcohol and sugar free, +3 moredrops, 0,25 mg3 applicants6 registrationsS2
Lactobacillus acidophilus 1 10 cfu estriolGynoflor1x108 CFU, 0,03 mgAdcock ingram limited550343S2
LevocabastineSinumax allergy nasal, Livostin edsprayJohnson & Johnson (Pty) Ltd û Cape Town2 registrationsS2
LevocetirizineXyzal, Cetaway, Levoway5mg & 0,5 mg/mL, oral solution, 0.5mg/ml, solution, +1 more4 applicants5 registrationsS2
LevonorgestrelLevonorgestrel unicorn, Lornestin1,5 mg, 1,50 mg2 applicants2 registrationsS2
Live attenuated measles virusPriorix0,5 mlGlaxosmithkline South Africa (Pty) Limited330346S2
Lodoxamide CancelledAlomideNot statedNovartis South Africa (Pty) LtdX0026S2
LoperamideAdco loperamide, Dischem anti-diarrhoeal, Lenide s, +14 more2 mg, tablets, 1 mg per 5 ml, syrup7 applicants20 registrationsS2
LoratadineRhineton non drowsy, Lorfast10 mgRanbaxy (SA) (Pty) Ltd2 registrationsS2
Measles virus vaccine live attenuatedMeasbio0,5 mlThe biovac institute430541S2
MebeverineBevispas, Sandoz-mebeverine HCL, Mylan mebeverine, +1 more135 mg4 applicants4 registrationsS2
Mebhydrolin napadisylateFabahistinsuspension, 50 MGBayer (Pty) Ltd (Animal Health Division)2 registrationsS2
Mefenamic acidFenamin, Adco-mefenamic acid, Ponac, +1 more5 ml, 50 mg/5 ml, 50 mg per 5 ml, 250 mg, +1 more2 applicants8 registrationsS3
MephenesinSpasmend150 mg, 500 mgAdcock ingram limitedB1490S2
MepyramineAntihist, Mepyraderm, Mepyramine maleate B.P., +15 moreampoules, cream, 50 MG, 100 MG, +4 more12 applicants24 registrationsS2
MethocarbamolMylospas, Methocarbamol shanur, Robaxin750 mg, tablets4 applicants4 registrationsS2
MupirocinMuprican, Piban, Bactroban topical, +1 more2 g, 20 mg, 20mg3 applicants4 registrationsS2
Mycobacterium bovisVesiculture30 mgKahma Biotech (Pty) Ltd320745S2
Non-typeable haemophilus influenzae nthi proteinSynflorix0,5 mLGlaxosmithkline South Africa (Pty) Limited430401S2
NoscapineNitepaxsuspension2 applicants2 registrationsS2
NystatinCandacide100 000 iu per mlRanbaxy Pharmaceutical (Pty) Ltd310288S2
OestriolSynapause vaginal1 mg/gPharmacare limited û woodmeadV0201S2
OlopatadineOftapat1,0 mgAustell Pharmaceuticals (Pty) Ltd530401S2
OmeprazoleGazigon otc20 mgDezzo Trading 392 (Pty) Ltd560848.847 - RS2
OtiloniumSpasmomen40 mgMenarini South Africa (Pty) Ltd510623S2
PantoprazolePeptazol, Prazoloc otc, Ulcevan, +3 more20 mg, 20mg, 40 mg5 applicants8 registrationsS4
ParacetamolAdco flupain, Sinugesic, Sinutab sinus pain non drowsy, +5 more1,5 g, 30 mg/ 500 mg, 30 mg, 60 mg, 500 mg, +4 more6 applicants10 registrationsS2
PhenazoneAuroneNot statedPharmacare limited û woodmeadH1389S2
PhenazopyridinePyridium, Azodine, Cystogesic10 mg/200 mg/350 mg2 applicants3 registrationsS2
Pipoxolan CancelledRowapraxinNot statedAdcock ingram limitedB0178S2
PiroxicamRheugesic20 mg, gelCipla Medpro (Pty) Ltd2 registrationsS2
Pneumococcal polysaccharide conjugate vaccinePrevenar20 mgPfizer Laboratories (Pty) Ltd590853S2
Potassium chloridePlenish-k sr600 mgPharmacare limited û woodmead520441S2
Povidone-iodineBetadine vaginal10 % w/w2 applicants2 registrationsS2
Prifinium CancelledRiabalinjectionThe Premier Pharmaceutical Co Ltd2 registrationsS2
Proglumide CancelledMilidNot statedScp Pharmaceuticals (Pty) LtdB0143S2
PropanthelinePro-banthine, ProlinergicNot stated3 applicants3 registrationsS2
PseudoephedrineBetafed5 mlRanbaxy Pharmaceutical (Pty) Ltd310249S2
RupatadineRupanase, Rupallerg, Rutarn, +8 more10 mg, 10mg8 applicants11 registrationsS2
SalbutamolAsthavent ecohaler, Ventimax cfc free, Azmaler, +2 more2 mg,4 mg, 100 µg, 100 μg, injection, +2 more5 applicants9 registrationsS2
Sars-cov-2rs recombinant spike proteinCovovax5,0 μgCipla Medpro (Pty) Ltd561236S2
Sodium cromoglycateStop-allerg eye1 mlAdcock ingram limitedW0430S2
SulfacetamideLennon sulphacetamide eye3,5 gPharmacare limited û woodmeadH1169S2
SumatriptanMigrex50 mgSandoz South Africa (Pty) LtdA380508S2
Tetanus toxoidTetanus vaccine cipla, Tetanus toxoid biovacNot stated2 applicants2 registrationsS2
Tetanus toxoid purified CancelledTetavaxNot statedSanofi-aventis South Africa (Pty) Ltd290637S2
TheophyllineSolphyllin15 mlAdcock ingram limitedG0701S2
TriprolidineActidil, Triprolidine hydrochloride2 mg/ 5 ml2 applicants3 registrationsS2
TrospiumUricon20mgViatris South Africa (Pty) Ltd350406S2
UlipristalElla30 mgCipla Medpro (Pty) Ltd460280S2
Vi capsular polysaccharide typhoid fever vaccineTyphim vi0,5 mLSanofi-aventis South Africa (Pty) Ltd290091S2
XylometazolineOtrivin plus0.5 mg/ml + 0.6 mg/mGlaxosmithkline Consumer Healthcare SA (Pty) Ltd460819S2