Schedule 2 (S2) medicines in South Africa
A pharmacist can sell it directly, without a prescription.
About S2 Drugs
Where S2 sits on the scale
A pharmacist can sell it directly, without a prescription.
Schedule 2 medicines sit behind the pharmacy counter. A pharmacist can decide to sell one of these directly, using their own professional judgement, without a doctor's prescription. It can also be dispensed against a prescription like the higher tiers, in which case the usual repeat limits apply. A child under 12 may only be sold a Schedule 2 substance on a prescription, or on a written order that names the purpose and carries a signature the seller recognises. Even though it cannot be advertised to the public in the ordinary sense, its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Cited: Act s22A(6)(e)
Who may supply
Only a pharmacist, pharmacist intern or supervised pharmacist's assistant may sell it without a prescription. It may otherwise be dispensed by a pharmacist against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Cited: Act s22A(5)(a), s22A(5)(d), s22A(5)(e), s22A(6)(r)
Repeats: If dispensed on prescription, it can be repeated only if the prescriber indicated a number of repeats, and never for more than six months in total; the prescription must also be presented for dispensing within 30 days of issue.
Cited: reg 33(3)(i) (General Regulations, 2017)
Cited: Act s22A(6)(d), s22A(6)(f)
Advertising: May be advertised only to health professionals, not the public.
Cited: reg 42(2), reg 42(3) (General Regulations, 2017)
Labelling: Must show the letter S and the number 2 in a square border, immediately before the product's brand name.
Cited: reg 10(1)(a) (General Regulations, 2017)
What is a Schedule 2 medicine in South Africa?
A pharmacist can sell it directly, without a prescription. Schedule 2 medicines sit behind the pharmacy counter. A pharmacist can decide to sell one of these directly, using their own professional judgement, without a doctor's prescription. It can also be dispensed against a prescription like the higher tiers, in which case the usual repeat limits apply. A child under 12 may only be sold a Schedule 2 substance on a prescription, or on a written order that names the purpose and carries a signature the seller recognises. Even though it cannot be advertised to the public in the ordinary sense, its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Can a pharmacist sell a Schedule 2 medicine without a prescription?
No prescription is needed. Only a pharmacist, pharmacist intern or supervised pharmacist's assistant may sell it without a prescription. It may otherwise be dispensed by a pharmacist against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction. If dispensed on prescription, it can be repeated only if the prescriber indicated a number of repeats, and never for more than six months in total; the prescription must also be presented for dispensing within 30 days of issue.
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
Substances listed under S2
282 listed in the Consolidated Schedules, 154 with a registered medicine.
- (+)-norpseudoephedrine, see Cathine
- Aconite alkaloids
- Acrivastine1
- Adrenaline7
- Albendazole1
- Alcaftadine
- Alkaloids and glycosides
- Alverin
- Amethocaine, see Tetracaine
- Aminopentamide
- Amyl nitrite
- Antazoline3
- Antihistamines
- Antimicrobial substances
- Apomorphine1
- Aptocaine
- Arecoline
- Arsenic1
- Aspirin19
- Atovaquone2
- Atropine5
- Azatadine
- Azelastine3
- Bambuterol
- Bamipine1
- BCG vaccine, see Mycobacterium bovis
- Beclomethasone dipropionate2
- Belladonna alkaloids1
- Benproperine
- Benzydamine2
- Bevonium methylsulphate1
- Bilastine1
- Bismuth1
- Bromhexine3
- Bromides
- Brompheniramine3
- Buclizine2
- Budesonide4
- Butinoline
- Calabar bean alkaloids
- Camphorated Opium Tincture
- Camylofin
- Cantharidin
- Canthaxanthin
- Carbinoxamine2
- Carbocisteine1
- Carbuterol
- Carisoprodol
- Chlormezanone1
- Chlorodyne
- Chlorpheniramine30
- Chlorprenaline
- Chlorzoxazone2
- Cholestyramine1
- Cimetidine1
- Cinnarizine1
- Clemastine1
- Clemizole
- Clidinium bromide1
- Clonidine1
- Codeine34
- Colchicine1
- Cyclandelate1
- Cyclizine4
- Cyclopentolate2
- Cyproheptadine2
- D-norpseudoephedrine, see Cathine
- Dequalinium3
- Desloratadine2
- Dexchlorpheniramine2
- Dextromethorphan15
- Diclofenac2
- Dicyclomine2
- Dihydrocodeine1
- Dimethindene2
- Dimethothiazine
- Dimetindene
- Diphenhydramine13
- Diphenoxin
- Diphenoxylate preparations containing not more than 2,5 milligrams of diphenoxylate
- Diphenylpyraline1
- Diphtheria toxoid vaccine
- Doxycycline1
- Doxylamine6
- Ebastine1
- Emedastine
- Emepronium
- Emetine
- Ephedra alkaloids
- Ephedrine11
- Epinastine1
- Ergot alkaloids
- Ergotamine4
- Esomeprazole2
- Estradiol6
- Estriol2
- Ethylmorphine
- Etilefrine1
- Etodroxizine1
- Exalamide1
- Famotidine1
- Fedrilate
- Fenoprofen1
- Fenoterol2
- Flavoxate1
- Fluconazole1
- Flunarizine1
- Flunisolide
- Flurbiprofen1
- Fluticasone furoate3
- Fluticasone propionate6
- Fusafungine
- Fusidic acid3
- Gadopentetic acid
- Gamma benzene hexachloride
- Gelsemium alkaloids
- Griseofulvin1
- Haemophilus influenzae vaccine
- Halogenated hydroxyquinolines
- Hepatitis B vaccine1
- Hexametazine
- Hexoprenaline1
- Homatropine1
- Hormones
- Human pappillomavirus vaccine
- Hyaluronic acid
- Hydrocortisone10
- Hydroquinone
- Hyoscine butylbromide1
- Ibuprofen7
- Indometacin
- Influenza virus vaccine2
- Ipratropium6
- Isoaminile
- Isoprenaline1
- Isopropamide
- Isothipendyl1
- Ketoprofen3
- Ketotifen1
- Lansoprazole1
- Levocabastine1
- Levodropropizine
- Levonorgestrel1
- Lithium salts
- Lobelia alkaloids
- Local anaesthetics
- Lodoxamide1
- Loperamide1
- Measles vaccine
- Mebeverine1
- Mebhydrolin1
- Meclozine
- Mefenamic acid1
- Melatonin1
- Mepenzolate bromide
- Mephenesin1
- Mepyramine15
- Mequitazine
- Mercuric ammonium chloride
- Mercuric chloride
- Mercuric iodide
- Mercuric oxides
- Mercury organic compounds
- Mesna
- Metaproterenol2
- Methixene
- Methocarbamol1
- Metholilazine
- Methoxyphenamine
- Metronidazole2
- Miconazole2
- Minoxidil1
- Mizolastine
- Mometasone furoate7
- Monoethanolamine
- Morphine4
- Mumps vaccine
- Mupirocin1
- Mycobacterium bovis vaccine
- Nabumetone1
- Naphazoline6
- Naproxen2
- Natamycin1
- Nedocromil
- Nicergoline
- Nicotine1
- Nizatidine
- Noscapine1
- Nux vomica1
- Nystatin2
- Octatropine
- Oleoresin of aspidium
- Olopatidine
- Omeprazole1
- Opium
- Orlistat1
- Orphenadrine2
- Otilonium bromide1
- Oxatomide
- Oxybuprocaine1
- Oxymetazoline2
- Oxyphencyclimine
- Oxyphenonium
- p-Synephrine
- Pantoprazole2
- Papaverine2
- Paracetamol78
- Pentoxyfylline
- Perfluorooctane
- Pertussis toxoid vaccine
- Phenazone4
- Phenazopyridine1
- Phenindamine
- Pheniramine3
- Phenylpropanolamine13
- Phenyltoloxamine3
- Pholedrine
- Pimethixene
- Pinaverium
- Pipenzolate
- Pipoxolan1
- Pirbuterol
- Piroxicam1
- Pizotifen
- Pneumococcal vaccine
- Podophyllum resin
- Poldine methylsulphate
- Polio vaccine
- Potassium11
- Povidone iodine1
- Prifinium bromide1
- Procaterol
- Procyclidine
- Proglumide1
- Proguanil1
- Promethazine6
- Propantheline bromide1
- Propyphenazone
- Proxymetacaine
- Pseudoephedrine29
- Pyrobutamine
- Quinine2
- Rabeprazole1
- Ranitidine1
- Reproterol
- Rimiterol
- Rizatriptan1
- Rotavirus
- Rubella vaccine
- Rupatadine1
- Sabadilla alkaloids
- Salbutamol3
- Salmefamol
- Siccanin
- Sodium cromoglycate1
- Strychnine
- Sulfadiazine silver
- Sulphonamides
- Sumatriptan1
- Terbutaline
- Tetanus toxoid2
- Tetanus vaccine
- Tetracaine1
- Tetrahydrozoline4
- Thenalidine
- Thenyldiamine
- Theophylline2
- Thiethylperazine
- Tiaprofenic acid
- Timepidium
- Triamcinolone2
- Trimebutine
- Trimeprazine
- Tripelennamine
- Triprolidine6
- Trospium1
- Tulobuterol1
- Typhoid vaccine
- Ulipristal1
- Vitamin A6
- Vitamin E1
- Xylometazoline2
Registered medicines in S2
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Abiraterone | Alernova | 0,5 mg | Trinity Pharma (Pty) Ltd | 550310.309 | S2 |
| Acetylcysteine | Parvolex | 200mg / 10ml | Pharmacare limited û woodmead | NX0156 | S2 |
| Acetylsalicylic acid | Cardasa | 100 mg | Viatris Healthcare (Pty) Ltd | 540456 | S2 |
| Albendazole | Zentel, Albendazole cospharm | 1 mg, 20 mg/ml, 400 mg | 2 applicants | 3 registrations | S2 |
| Ameprazole | Tumsigon otc | 20 mg | Dezzo Trading 392 (Pty) Ltd | 560847 | S2 |
| Ammonium chloride | Expectalin with codeine, Diphal expectorant, Benylin forte, +3 more | 5 mL, 12.5 mg, 10 mg, 125 mg, 12,5 mg/10 mg/10 mg/125 mg/50 mg per 5 ml, 16, 667 / 1,667 / 6,667 mg / 120 mg / 50 mg | 6 applicants | 6 registrations | S2 |
| Antazoline | Gemini | 1 ml | Adcock ingram limited | H1254 | S2 |
| Ascorbic acid | Corenza c, Famucaps | 2 mg, 2,5 mg and 200 mg | 2 applicants | 2 registrations | S2 |
| Atovaquone | Malanil | 100mg, 250mg | Acino Pharma (Pty) Ltd | 370075 | S2 |
| Atropine | Colstat | 300 mg | Lebasi Pharmaceuticals (Pty) Ltd | C0955 | S2 |
| Azelastine | Rhinolast nasal, Optilast, Arzep nasal, +3 more | spray, 0,14 mg, 1,0 mg and 0,365 mg | 4 applicants | 6 registrations | S2 |
| Bamipine Cancelled | Soventol | Not stated | Holpro Pharmaceuticals (Pty) Ltd | C0735 | S2 |
| Bevonium methylsulphate Cancelled | Acabel | Not stated | Natterman S.A. (Pty) Ltd * | C0926 | S2 |
| Bilastine | Ilaxten, Ilaxten odt, Basmedene, +1 more | 2,5 mg/ml, 10 mg, 20 mg | 2 applicants | 5 registrations | S2 |
| Bismuth oxide | De-nol, Ulcerone, D f chew | solution, 102 | 3 applicants | 3 registrations | S2 |
| Bromhexine | Bronahex, Adco-linctopent, Dur-elix mucolytic, +3 more | solution, 0,2 %, 2.41 mg/5 ml, 5 ml | 5 applicants | 7 registrations | S2 |
| Buclizine Cancelled | Longifene | syrup | Pharmacare limited û woodmead | C0947 | S2 |
| Caffeine | B-dol, Nomopain, Sinucon, +2 more | 10 mg, 10 mg/5 mg/400 mg/50 mg, 200 mg/6 mg/ 20 mg/2 mg, 450 mg, 5 mg, 30 mg, 10 mg | 5 applicants | 5 registrations | S2 |
| Carbocisteine | Acuphlem, Mucoflem, Merck-carbocisteine, +28 more | capsules, syrup, 5 ml, 375 mg | 19 applicants | 35 registrations | S2 |
| Cetirizine | Allermine, Atrizin, AURO cetirizine, +1 more | 5 mg, 10 mg | 4 applicants | 5 registrations | S2 |
| Chlorpheniramine | Histabate, Flusin s, Sinumax allergy sinus, +13 more | 1,25 mg and 2,5 mg,, 2 mg, 10 mg, 500 mg, 4 mg, 5 ml, +7 more | 9 applicants | 19 registrations | S2 |
| Chlorzoxazone | Paraflex | Not stated | Janssen Pharmaceutica (Pty) Ltd | B1018 | S2 |
| Cholestyramine resin | Tyrachol | powder | Ascend Laboratories (Pty) Ltd | 561213 | S2 |
| Cimetidine | Mexiena | 200 mg | Biotech Laboratories (Pty) Ltd | 560740 | S2 |
| Cinnarizine | Tranzet, Stugeron, Stugeron forte, +2 more | 25 mg, 75 mg | 4 applicants | 6 registrations | S2 |
| Clemastine Cancelled | Degoran allergy | tablet | Glaxosmithkline Consumer Healthcare SA (Pty) Ltd | C0552 | S2 |
| Clonidine | Menograine | 25 μg | Pharmacare limited û woodmead | M0041 | S2 |
| Codeine | Trifen expect paediatric, Trifen expect adult, Mybulen, +9 more | 5 mg/5 ml, 5 ml, 9 mg/7,2 mg/3,6 mg per 5 ml, 10 mg/200 mg/350 mg, +6 more | 7 applicants | 15 registrations | S5 |
| Colchicine | Aspen colchicine ds, Kolcrys, Gouteze otc, +4 more | 0,5 mg, 0.5 mg, 1.0mg | 5 applicants | 7 registrations | S2 |
| Colestyramine | Questran lite | 4g/sachet | Equity Pharmaceutical (Pty) Ltd | D0039 | S2 |
| Cyclandelate Cancelled | Cyclospasmol | 200 MG | Riker Laboratory SA (Pty) Ltd | H0579 | S2 |
| Cyclizine | Medazine s | 5 ml | Medpro Pharmaceutica (Pty) Ltd | 270204 | S2 |
| Cyproheptadine | Zyactin, Actincypro | 4 mg | 2 applicants | 2 registrations | S2 |
| Desloratadine | Deselex, Neoclarityne, Neoloridin, +25 more | tablets, syrup, 2,5 mg, 2.5 mg, +3 more | 17 applicants | 35 registrations | S2 |
| Dextromethorphan | Coryx cough and cold, Dilinct dry cough, Benydex, +2 more | 5 mL/10 mg/30 mg/1.25 mg, 15 mg | 3 applicants | 5 registrations | S2 |
| Diclofenac | Panamor, Motifine, Diclofenac unicorn, +1 more | 1,292 g/100 g, 12,5, patch, 25 mg, +3 more | 3 applicants | 11 registrations | S2 |
| Dicyclomine | Meddev, Merbentyl, Microgel, +5 more | 10 ml, tablets, syrup, 5 mg/400 mg/200 mg per 5 ml | 5 applicants | 10 registrations | S2 |
| Dimethindene Cancelled | Fenostil | Not stated | Ciba-geigy (Pty) Ltd | C0785 | S2 |
| Diphenhydramine | Bennet's diphenhydramine, Benylin four flu liquid, Benylin four flu, +12 more | elixir, 12.5 mg/22.5 mg/500.0 mg, 20 mL, capsule, +4 more | 9 applicants | 16 registrations | S2 |
| Diphtheria toxoid | Adacel, Cihexa | 0,5 ml, ≥ 30 IU, ≥ 40 IU, ≥ 4 IU, 15 mcg, 40 DU, 8 DU, 32 DU, 10 mcg | 2 applicants | 2 registrations | S2 |
| Diphtheria toxoid nlt | Boostrix | 0,5 ml | Glaxosmithkline South Africa (Pty) Limited | 491042 | S2 |
| Doxylamine | Repose, Somnil, Doxynite, +2 more | drops, 25 mg | 4 applicants | 6 registrations | S2 |
| Ebastine | Kestine, Noribas, Ebastine adco, +1 more | 10 MG | 3 applicants | 4 registrations | S2 |
| Epinastine | Relestat | 0.5mg | Abbvie (Pty) Ltd | 370691 | S2 |
| Ergotamine | Ergate, Medihaler ergotamine, Gynergen | Not stated | 3 applicants | 3 registrations | S2 |
| Esomeprazole | Nexipraz otc, Nexilok, Nextell otc | 0,6 mg, 20mg, 20 mg, 30 mg | 3 applicants | 4 registrations | S2 |
| Etilefrine | Effortil | 10 mg/1 ml | Pharmaco Distribution (Pty) Ltd | F0197 | S2 |
| Exalamide | Hyperan | ointment, solution | 2 applicants | 2 registrations | S2 |
| Flavoxate | Urispas, Flospasm, Bladuril | 200mg, 200 mg | 2 applicants | 3 registrations | S2 |
| Flunarizine Cancelled | Sibelium t, Sibelium | 5 mg, 10 mg | Janssen Pharmaceutica (Pty) Ltd | 2 registrations | S2 |
| Fosfomycin | Uticide | 3 g | Unicorn Pharmaceuticals (Pty) Ltd | 530574 | S2 |
| Human papillomavirus type | Cervarix | 1 dose (0,5 mL) | Glaxosmithkline South Africa (Pty) Limited | 410366 | S2 |
| Ibuprofen | Mypaid, Lotem, Panado plus, +8 more | 200mg / 250mg, suspension, 5 ml, 30 mg, 200 mg, +9 more | 7 applicants | 12 registrations | S2 |
| Influenza virus vaccine | Influvac tetra | 0,5 mL | Abbott Laboratories S.A. (Pty) Ltd | 520094 | S2 |
| Influenza virus vaccine a a b b | Vaxigrip tetra | Not stated | Sanofi-aventis South Africa (Pty) Ltd | 510838 | S2 |
| Isothipendyl Cancelled | Andantol jelly | Not stated | Adcock ingram limited | G2335 | S2 |
| Ketotifen | Parke-med ketotifen, Zetofen, Adco-ketotifen alcohol and sugar free, +3 more | drops, 0,25 mg | 3 applicants | 6 registrations | S2 |
| Lactobacillus acidophilus 1 10 cfu estriol | Gynoflor | 1x108 CFU, 0,03 mg | Adcock ingram limited | 550343 | S2 |
| Levocabastine | Sinumax allergy nasal, Livostin ed | spray | Johnson & Johnson (Pty) Ltd û Cape Town | 2 registrations | S2 |
| Levocetirizine | Xyzal, Cetaway, Levoway | 5mg & 0,5 mg/mL, oral solution, 0.5mg/ml, solution, +1 more | 4 applicants | 5 registrations | S2 |
| Levonorgestrel | Levonorgestrel unicorn, Lornestin | 1,5 mg, 1,50 mg | 2 applicants | 2 registrations | S2 |
| Live attenuated measles virus | Priorix | 0,5 ml | Glaxosmithkline South Africa (Pty) Limited | 330346 | S2 |
| Lodoxamide Cancelled | Alomide | Not stated | Novartis South Africa (Pty) Ltd | X0026 | S2 |
| Loperamide | Adco loperamide, Dischem anti-diarrhoeal, Lenide s, +14 more | 2 mg, tablets, 1 mg per 5 ml, syrup | 7 applicants | 20 registrations | S2 |
| Loratadine | Rhineton non drowsy, Lorfast | 10 mg | Ranbaxy (SA) (Pty) Ltd | 2 registrations | S2 |
| Measles virus vaccine live attenuated | Measbio | 0,5 ml | The biovac institute | 430541 | S2 |
| Mebeverine | Bevispas, Sandoz-mebeverine HCL, Mylan mebeverine, +1 more | 135 mg | 4 applicants | 4 registrations | S2 |
| Mebhydrolin napadisylate | Fabahistin | suspension, 50 MG | Bayer (Pty) Ltd (Animal Health Division) | 2 registrations | S2 |
| Mefenamic acid | Fenamin, Adco-mefenamic acid, Ponac, +1 more | 5 ml, 50 mg/5 ml, 50 mg per 5 ml, 250 mg, +1 more | 2 applicants | 8 registrations | S3 |
| Mephenesin | Spasmend | 150 mg, 500 mg | Adcock ingram limited | B1490 | S2 |
| Mepyramine | Antihist, Mepyraderm, Mepyramine maleate B.P., +15 more | ampoules, cream, 50 MG, 100 MG, +4 more | 12 applicants | 24 registrations | S2 |
| Methocarbamol | Mylospas, Methocarbamol shanur, Robaxin | 750 mg, tablets | 4 applicants | 4 registrations | S2 |
| Mupirocin | Muprican, Piban, Bactroban topical, +1 more | 2 g, 20 mg, 20mg | 3 applicants | 4 registrations | S2 |
| Mycobacterium bovis | Vesiculture | 30 mg | Kahma Biotech (Pty) Ltd | 320745 | S2 |
| Non-typeable haemophilus influenzae nthi protein | Synflorix | 0,5 mL | Glaxosmithkline South Africa (Pty) Limited | 430401 | S2 |
| Noscapine | Nitepax | suspension | 2 applicants | 2 registrations | S2 |
| Nystatin | Candacide | 100 000 iu per ml | Ranbaxy Pharmaceutical (Pty) Ltd | 310288 | S2 |
| Oestriol | Synapause vaginal | 1 mg/g | Pharmacare limited û woodmead | V0201 | S2 |
| Olopatadine | Oftapat | 1,0 mg | Austell Pharmaceuticals (Pty) Ltd | 530401 | S2 |
| Omeprazole | Gazigon otc | 20 mg | Dezzo Trading 392 (Pty) Ltd | 560848.847 - R | S2 |
| Otilonium | Spasmomen | 40 mg | Menarini South Africa (Pty) Ltd | 510623 | S2 |
| Pantoprazole | Peptazol, Prazoloc otc, Ulcevan, +3 more | 20 mg, 20mg, 40 mg | 5 applicants | 8 registrations | S4 |
| Paracetamol | Adco flupain, Sinugesic, Sinutab sinus pain non drowsy, +5 more | 1,5 g, 30 mg/ 500 mg, 30 mg, 60 mg, 500 mg, +4 more | 6 applicants | 10 registrations | S2 |
| Phenazone | Aurone | Not stated | Pharmacare limited û woodmead | H1389 | S2 |
| Phenazopyridine | Pyridium, Azodine, Cystogesic | 10 mg/200 mg/350 mg | 2 applicants | 3 registrations | S2 |
| Pipoxolan Cancelled | Rowapraxin | Not stated | Adcock ingram limited | B0178 | S2 |
| Piroxicam | Rheugesic | 20 mg, gel | Cipla Medpro (Pty) Ltd | 2 registrations | S2 |
| Pneumococcal polysaccharide conjugate vaccine | Prevenar | 20 mg | Pfizer Laboratories (Pty) Ltd | 590853 | S2 |
| Potassium chloride | Plenish-k sr | 600 mg | Pharmacare limited û woodmead | 520441 | S2 |
| Povidone-iodine | Betadine vaginal | 10 % w/w | 2 applicants | 2 registrations | S2 |
| Prifinium Cancelled | Riabal | injection | The Premier Pharmaceutical Co Ltd | 2 registrations | S2 |
| Proglumide Cancelled | Milid | Not stated | Scp Pharmaceuticals (Pty) Ltd | B0143 | S2 |
| Propantheline | Pro-banthine, Prolinergic | Not stated | 3 applicants | 3 registrations | S2 |
| Pseudoephedrine | Betafed | 5 ml | Ranbaxy Pharmaceutical (Pty) Ltd | 310249 | S2 |
| Rupatadine | Rupanase, Rupallerg, Rutarn, +8 more | 10 mg, 10mg | 8 applicants | 11 registrations | S2 |
| Salbutamol | Asthavent ecohaler, Ventimax cfc free, Azmaler, +2 more | 2 mg,4 mg, 100 µg, 100 μg, injection, +2 more | 5 applicants | 9 registrations | S2 |
| Sars-cov-2rs recombinant spike protein | Covovax | 5,0 μg | Cipla Medpro (Pty) Ltd | 561236 | S2 |
| Sodium cromoglycate | Stop-allerg eye | 1 ml | Adcock ingram limited | W0430 | S2 |
| Sulfacetamide | Lennon sulphacetamide eye | 3,5 g | Pharmacare limited û woodmead | H1169 | S2 |
| Sumatriptan | Migrex | 50 mg | Sandoz South Africa (Pty) Ltd | A380508 | S2 |
| Tetanus toxoid | Tetanus vaccine cipla, Tetanus toxoid biovac | Not stated | 2 applicants | 2 registrations | S2 |
| Tetanus toxoid purified Cancelled | Tetavax | Not stated | Sanofi-aventis South Africa (Pty) Ltd | 290637 | S2 |
| Theophylline | Solphyllin | 15 ml | Adcock ingram limited | G0701 | S2 |
| Triprolidine | Actidil, Triprolidine hydrochloride | 2 mg/ 5 ml | 2 applicants | 3 registrations | S2 |
| Trospium | Uricon | 20mg | Viatris South Africa (Pty) Ltd | 350406 | S2 |
| Ulipristal | Ella | 30 mg | Cipla Medpro (Pty) Ltd | 460280 | S2 |
| Vi capsular polysaccharide typhoid fever vaccine | Typhim vi | 0,5 mL | Sanofi-aventis South Africa (Pty) Ltd | 290091 | S2 |
| Xylometazoline | Otrivin plus | 0.5 mg/ml + 0.6 mg/m | Glaxosmithkline Consumer Healthcare SA (Pty) Ltd | 460819 | S2 |