Mepyramine
Sold as Antihist, Mepyraderm, Mepyramine maleate B.P., Pymal, Mepyramine B.P., E.A.H. Green, Mepyrimal, Mepyramine maleate fresenius, Pyriped elixer, Mepyralen, Anthisan, Norstan-mepyramine maleate, Mepelix, Mepyramine maleate, Allergex mepyrimal, Demazin itch relief, Pyramine, Triohist
N'-[(4-Methoxyphenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
Drag to rotate. Structure from PubChem CID 4992.
Background
Registration
- Applicants
- 12
- Registrations
- 24
- Schedule source
- Consolidated Schedules 06 July 2026
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Unimed Healthcare (Pty) Ltd | Antihist, Mepyraderm | ampoules, cream | 290026, 340471 | S2 | None |
| The Premier Pharmaceutical Co LtdCancelled | Mepyramine maleate B.P., Pymal, Mepyramine B.P., Pyriped elixer, Pyramine | 50 MG, 100 MG, injection, cream | C0632, C0633, C0672, C0673, C0690, C0800, G2298 | S2 | None |
| Propan Pharmaceuticals (Pty) Ltd *Cancelled | E.A.H. Green | Not stated | C0699 | S2 | None |
| Adcock ingram limited1 of 2 cancelled | Mepyrimal, Allergex mepyrimal | syrup, cream | C0790, G1540 | S2 | None |
| Fresenius Medical Care South Africa (Pty) Ltd | Mepyramine maleate fresenius | 50 mg | C0791 | S2 | None |
| Pharmacare limited û woodmeadCancelled | Mepyralen | elixir | C0826 | S2 | None |
| Sanofi-aventis South Africa (Pty) Ltd | Anthisan | 50, injection, elixir, 100 | C0830, C0849, C0850, C0852 | S2 | None |
| Quatromed limited | Norstan-mepyramine maleate | elixir | C0867 | S2 | None |
| Pharmakon manufacturing laboratoriesCancelled | Mepelix, Mepyramine maleate | 50 MG | C0950, C0952 | S2 | None |
| Zentiva South Africa (Pty) Ltd | Anthisan | cream | G1340 | S2 | None |
| Inova Pharmaceuticals (Pty) Ltd | Demazin itch relief | Not stated | G1881 | S2 | None |
| Resmed healthcare | Triohist | 25 mg | Q0097 | S2 | PIPIL |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Antihist ampoules EACH 2,0 ml AMPOULE CONTAINS MEPYRAMINE MALEATE 50,0 mg | Ampoules | 29002629/5.7.1/0026 | Registered | S2 | None |
| Mepyraderm cream EACH 10,0 g CREAM CONTAINS MEPYRAMINE MALEATE 200,0 mg | Cream | 34047134/13.4/0471 | Registered | S2 | None |
| Mepyramine maleate 50 MG B.P. EACH TABLET CONTAINS: MEPYRAMINE MALEATE A 50 MG | 50 MG | C0632 | Cancelled | S2 | None |
| Mepyramine maleate 100 MG B.P. EACH TABLET CONTAINS:MEPYRAMINE MALEATE A 100 MG | 100 MG | C0633 | Cancelled | S2 | None |
| Pymal tablets 100 MG TABLET MEPYRAMINE MALEATE A 100 MG | 100 MGTablets | C0672 | Cancelled | S2 | None |
| Pymal tablets 50 MG TABLET MEPYRAMINE MALEATE A 50 MG | 50 MGTablets | C0673 | Cancelled | S2 | None |
| Mepyramine injection B.P. 2 ML MEPYRAMINE MALEATE A 50 MG | Injection | C0690 | Cancelled | S2 | None |
| E.A.H. Green 5 ML MEPYRAMINE MALEATE A 25 MG | Not listed | C0699 | Cancelled | S2 | None |
| Mepyrimal syrup EACH 5 ml CONTAINS MEPYRAMINE MALEATE A 25 mg | Syrup | C0790 | Cancelled | S2 | None |
| Mepyramine maleate fresenius 50 MG EACH 2,0 ml SOLUTION CONTAINS MEPYRAMINE MALEATE A 50,0 mg | 50 mg | C0791 | Old Medicine | S2 | None |
| Pyriped elixer 5 ML MEPYRAMINE MALEATE A 25 MG | Not listed | C0800 | Cancelled | S2 | None |
| Mepyralen elixir EACH 5 ml ELIXIR CONTAINS MEPYRAMINE MALEATE A 25 mg | Elixir | C0826 | Cancelled | S2 | None |
| Anthisan 50 EACH TABLET CONTAINS MEPYRAMINE MALEATE A 50 mg | 50 | C0830 | Old Medicine | S2 | None |
| Anthisan injection 2 ML MEPYRAMINE MALEATE A 50 MG | Injection | C0849 | Old Medicine | S2 | None |
| Anthisan elixir EACH 5 ml CONTAINS MEPYRAMINE MALEATE A 25 mg | Elixir | C0850 | Old Medicine | S2 | None |
| Anthisan 100 TABLET MEPYRAMINE MALEATE A 100 MG | 100 | C0852 | Old Medicine | S2 | None |
| Norstan-mepyramine maleate elixir EACH 5 ml ELIXIR CONTAINS MEPYRAMINE MALEATE A 25 mg | Elixir | C0867 | Old Medicine | S2 | None |
| Mepelix 5 ML MEPYRAMINE MALEATE A 0,025 G | Not listed | C0950 | Cancelled | S2 | None |
| Mepyramine maleate tablets 50 MG TABLET MEPYRAMINE MALEATE A 50 MG | 50 MGTablets | C0952 | Cancelled | S2 | None |
| Anthisan cream EACH 100,0 g CONTAINS MEPYRAMINE MALEATE A 2,0 g | Cream | G1340 | Old Medicine | S2 | None |
| Allergex mepyrimal cream EACH 100,0 g CREAM CONTAINS MEPYRAMINE MALEATE A 2,0 g | Cream | G1540 | Old Medicine | S2 | None |
| Demazin itch relief EACH 10 g CONTAINS MEPYRAMINE MALEATE A 200 mg | Not listed | G1881 | Old Medicine | S2 | None |
| Pyramine cream 10 G MEPYRAMINE MALEATE A 200 MG | Cream | G2298 | Cancelled | S2 | None |
| Triohist EACH 5,0 ml SOLUTION CONTAINS MEPYRAMINE MALEATE 25,0 mg | 25 mgSolution | Q0097Q/5.7.1/0097Approved 20 September 1982 | Registered | S2 | PIPIL |
Regulatory status
Where S2 sits on the scale
A pharmacist can sell it directly, without a prescription.
Schedule 2 medicines sit behind the pharmacy counter. A pharmacist can decide to sell one of these directly, using their own professional judgement, without a doctor's prescription. It can also be dispensed against a prescription like the higher tiers, in which case the usual repeat limits apply. A child under 12 may only be sold a Schedule 2 substance on a prescription, or on a written order that names the purpose and carries a signature the seller recognises. Even though it cannot be advertised to the public in the ordinary sense, its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S2, matched to the Consolidated Schedules by ingredient, confidence high.
Who may supply: Only a pharmacist, pharmacist intern or supervised pharmacist's assistant may sell it without a prescription. It may otherwise be dispensed by a pharmacist against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Mepyramine maleate
S2: Mepyramine
Consolidated Schedules 06 July 2026, line 2298
Pharmacological class: Antihistaminics. (class 5.7.1)
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.