Diphenhydramine
2-Benzhydryloxy-N,N-dimethylethanamine
Drag to rotate. Structure from PubChem CID 3100.
Background
Listing
- Schedules
- Schedule 2
- Source
- Consolidated Schedules 06 July 2026
Registered medicines
14 registered products listed
Counted through the register's ingredient index, which does not reach every record.
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Diphenhydramine | Bennet's diphenhydramine, Benadryl, Benadryl elixer, +9 more | elixir, capsule, mixture, cream, +2 more | 8 applicants | 13 registrations | S2 |
| Diphenhydramine, paracetamol Cancelled | Tylenol pm, Mypaid night pain | Not stated | 2 applicants | 2 registrations | S1 to S3conditions apply |
| Diphenhydramine, paracetamol, pseudoephedrine | Benylin four flu liquid | 20 mL | Johnson & Johnson (Pty) Ltd û East London | 330345 | S2 |
| Diphenhydramine, pseudoephedrine | Benylin four flu | 12.5 mg/22.5 mg/500.0 mg | Johnson & Johnson (Pty) Ltd û East London | 330509 | S2 |
| Ascorbic acid, diphenhydramine, paracetamol, phenylephrine Cancelled | Cold stop | Not stated | Adcock ingram limited | B0085 | S1 to S4conditions apply |
| Codeine, diphenhydramine, mepyramine, paracetamol, phenylephrine Cancelled | Antiflu | tablets | The Premier Pharmaceutical Co Ltd | C0834 | S1 to S6conditions apply |
| Diphenhydramine, paracetamol, phenylephrine, vitamin c | Fluend | Not stated | Ascendis Pharma (Pty) Ltd | C1009 | S1 to S4conditions apply |
| Dextromethorphan, diphenhydramine, paracetamol, pseudoephedrine, vitamin c Cancelled | Flu-med | syrup | Adcock ingram limited | D0053 | S1 to S6conditions apply |
| Dextromethorphan, diphenhydramine, phenylephrine Cancelled | Benyphed | Not stated | Johnson & Johnson (Pty) Ltd û East London | E0198 | S1 to S4conditions apply |
| Caffeine, codeine, diphenhydramine, paracetamol | Propain, Diphagesic, Forte pain, +2 more | powders, 10 mg/5 mg/400 mg/50 mg, tablets | 3 applicants | 5 registrations | S2 |
| Codeine, diphenhydramine, paracetamol | Antiflu, Betapyn, Dipardod | syrup | 2 applicants | 3 registrations | S1 to S6conditions apply |
| Diphenhydramine, mepyramine | Histodor | cream | Pharmacare limited û woodmead | G1756 | S2 |
Show the other 2 registered products
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Dextromethorphan, diphenhydramine Cancelled | Benydex | Not stated | Johnson & Johnson (Pty) Ltd û East London | H0319 | S2 |
| Dextromethorphan, diphenhydramine, ephedrine, paracetamol Cancelled | Colcaps nite med | Not stated | Adcock ingram limited | S0155 | S1 to S6conditions apply |
2 more registered products name Diphenhydramine in their active ingredient
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Ammonium chloride, codeine, diphenhydramine | Expectalin with codeine, Benylin forte, Flutex co, +2 more | 5 mL, 12.5 mg, 10 mg, 125 mg, linctus | 4 applicants | 5 registrations | S2 |
| Diphenhydramine, guaifenesin, pholcodine Cancelled | Folcofen, Procof | Not stated | 2 applicants | 2 registrations |
Regulatory status
Where S2 sits on the scale
A pharmacist can sell it directly, without a prescription.
Schedule 2 medicines sit behind the pharmacy counter. A pharmacist can decide to sell one of these directly, using their own professional judgement, without a doctor's prescription. It can also be dispensed against a prescription like the higher tiers, in which case the usual repeat limits apply. A child under 12 may only be sold a Schedule 2 substance on a prescription, or on a written order that names the purpose and carries a signature the seller recognises. Even though it cannot be advertised to the public in the ordinary sense, its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S2, as the Consolidated Schedules list it.
Who may supply: Only a pharmacist, pharmacist intern or supervised pharmacist's assistant may sell it without a prescription. It may otherwise be dispensed by a pharmacist against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Diphenhydramine
S2: Diphenhydramine
Consolidated Schedules 06 July 2026, line 1865
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.