Codeine
Also known as: methylmorphine
(4R,4AR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
Drag to rotate; arrow keys step through the atoms. Structure from PubChem CID 5284371.
Listing
- Schedules
- Schedule 2 to 6, conditions apply
- Source
- Consolidated Schedules 06 July 2026
Registered medicines
34 registered products listed
Counted through the register's ingredient index, which does not reach every record.
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Codeine | Amstil, Astrapain, Vacudol, +128 more | tablets, 1 g, 1ml, 1 mg, +42 more | 49 applicants | 250 registrations | S6 |
6 more registered products name Codeine in their active ingredient
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Colzor Adult | Colzor adult | Not stated | Adcock ingram limited | 270436 | |
| Adco-neofed Paediatric Cancelled | Adco-neofed paediatric | Not stated | Adcock ingram limited | 270485 | |
| Neofed Adult | Neofed adult | Not stated | Adcock ingram limited | 270486 | |
| Colzor Paediatric Cancelled | Colzor paediatric | Not stated | Adcock ingram limited | 270487 | |
| Dinexol Paediatric Cough Cancelled | Dinexol paediatric cough | syrup | Pharmacare limited û woodmead | 270530 | |
| Trifen Expect Paediatric | Trifen expect paediatric | 5 mg/5 ml | Ranbaxy (SA) (Pty) Ltd | 270536 | S2 |
| Trifen Expect Adult | Trifen expect adult | 5 ml | Ranbaxy (SA) (Pty) Ltd | 270537 | S2 |
| Flusin Junior Cough | Flusin junior cough | 1 g, 5 mg | Pharmacare limited û woodmead | 280433 | |
| Flutex Antitussive | Flutex antitussive | Not stated | Pharmacare limited û woodmead | 280434 | |
| Zurituss Adult Cancelled | Zurituss adult | Not stated | Adcock ingram limited | 280537 | |
| Zurituss Paediatric Cancelled | Zurituss paediatric | Not stated | Adcock ingram limited | 280538 | |
| Tripofed Paediatric | Tripofed paediatric | Not stated | Viatris South Africa (Pty) Ltd | 280681 |
Show the other 12 registered products
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Tripofed Adult | Tripofed adult | Not stated | Viatris South Africa (Pty) Ltd | 290447 | |
| Endcol Paediatric Expectorant Cancelled | Endcol paediatric expectorant | Not stated | Pharmacare limited û woodmead | T0255 | |
| Endcol Expectorant | Endcol expectorant | Not stated | Pharmacare limited û woodmead | U0011 | |
| Acutussive Adult Expect Cancelled | Acutussive adult expect | Not stated | Teva Pharmaceuticals (Pty) Ltd | X0010 | |
| Acutussive Paed Expect Cancelled | Acutussive paed expect | Not stated | Teva Pharmaceuticals (Pty) Ltd | X0011 | |
| Innospect Adult | Innospect adult | Not stated | Innovata pharmaceuticals | Y0139 | |
| Innospect Paed | Innospect paed | Not stated | Innovata pharmaceuticals | Y0140 | |
| Expyn Cancelled | Expyn | Not stated | The Premier Pharmaceutical Co Ltd | B0807 | |
| Cetacod Cancelled | Cetacod | capsules | The Premier Pharmaceutical Co Ltd | B1456 | |
| Docsed Cancelled | Docsed | Not stated | Pharmacare limited û woodmead | G0616 | |
| Pyracod Cancelled | Pyracod | syrup | The Premier Pharmaceutical Co Ltd | G0893 | |
| Codef | Codef | syrup | Unimed Healthcare (Pty) Ltd | G1236 |
Regulatory status
Where S2 to S6 sits on the scale
Depends on which listing applies
At the least restrictive, Schedule 2: a pharmacist can sell it directly, without a prescription. At the most restrictive, Schedule 6: prescription-only, no repeats without a new prescription. The listings below say which applies to which form, strength or pack size.
Schedule S2 to S6, as the Consolidated Schedules list it.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it.
Consolidated Schedules listings for Codeine
S6: Codeine (methylmorphine)
- single component codeine preparations;
- oral solid preparations, in combination with one or more therapeutically active substances, in preparations not registered in terms of the Act, or when intended for export; (S2, S3)
- liquid oral preparations and mixtures, in combination with one or more therapeutically active substances, in preparations not registered in terms of the Act, or when intended for export. (S2, S3)
Consolidated Schedules 06 July 2026, lines 10128 to 10136
S3: Codeine (methylmorphine)
- oral solid preparations, in combination with one or more therapeutically active substances, containing more than 10 milligrams of codeine (calculated as base) per dosage unit, when contained in products registered in terms of the Act, and not intended for export;
- liquid oral preparations and mixtures, in combination with one or more therapeutically active substances, containing more than 10 milligrams of codeine (calculated as base) per 5 millilitre dosage unit, when contained in products registered in terms of the Act, and not intended for export;
- except oral solid preparations, in combination with one or more therapeutically active substances, containing not more than 10 milligrams of codeine (calculated as base) per dosage unit, with a maximum daily dose not exceeding 80 milligrams, and in packs containing sufficient dosage units for a maximum treatment period of 5 days and limited to one pack per customer, when contained in products registered in terms of the Act, and not intended for export; (S2)
- except liquid oral preparations and mixtures, in combination with one or more therapeutically active substances, containing not more than 10 milligrams of codeine (calculated as base) per 5 millilitre dosage unit, with a maximum daily dose not exceeding 80 milligrams, and with a pack size not exceeding 100 millilitres and limited to one pack per customer, when contained in products registered in terms of the Act, and not intended for export; (S2)
- except single component codeine preparations. (S6)
Consolidated Schedules 06 July 2026, lines 3350 to 3372
S2: Codeine (methylmorphine)
- oral solid preparations, in combination with one or more therapeutically active substances, containing not more than 10 milligrams of codeine (calculated as base) per dosage unit, with a maximum daily dose not exceeding 80 milligrams, and in packs containing sufficient dosage units for a maximum treatment period of 5 days, and limited to one pack per customer, when contained in products registered in terms of the Act, and not intended for export;
- liquid oral preparations and mixtures, in combination with one or more therapeutically active substances, containing not more than 10 milligrams of codeine (calculated as base) per 5 millilitre dosage unit, with a maximum daily dose not exceeding 80 milligrams, and with a pack size not exceeding 100 millilitres, when contained in products registered in terms of the Act, and not intended for export;
- except oral solid preparations, in combination with one or more therapeutically active substances, containing more than 10 milligrams of codeine (calculated as base) per dosage unit; (S3)
- except liquid oral preparations and mixtures, in combination with one or more therapeutically active substances, containing more than 10 milligrams of codeine (calculated as base) per 5 millilitre dosage unit; (S3)
- except single component codeine preparations. (S6)
Consolidated Schedules 06 July 2026, lines 1758 to 1778
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.