Promethazine
N,N-Dimethyl-1-phenothiazin-10-ylpropan-2-amine
Drag to rotate. Structure from PubChem CID 4927.
Background
Listing
- Schedules
- Schedule 2, conditions apply
- Cross-referenced to
- Schedule 5
- Source
- Consolidated Schedules 06 July 2026
Registered medicines
6 registered products listed
Counted through the register's ingredient index, which does not reach every record.
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Codeine, paracetamol, promethazine | Astrapain, Vacudol, Goldgesic, +20 more | 120 mg, syrup, 5 ml, 10 mg/200 mg/350 mg, +1 more | 10 applicants | 23 registrations | S2 |
| Paracetamol, promethazine Cancelled | Propain | syrup | The Premier Pharmaceutical Co Ltd | B1234 | S1 to S3conditions apply |
| Promethazine | Promethazine hcl-fresenius, Promethazine elixer, Promahist elixer, +8 more | 5 mg/5 ml, 10, 25 mg, 25 mg / ml, +3 more | 9 applicants | 15 registrations | S2conditions apply |
| Codeine, paracetamol, promethazine, pseudoephedrine Cancelled | Colcaps children's | 5 ml | Adcock ingram limited | D0054 | S2 |
| Caffeine, mepyramine, promethazine | Histodor | Not stated | Pharmacare limited û woodmead | E0125 | S2 to S3conditions apply |
| Codeine, ephedrine, promethazine | Lenazine forte cough, Antituss cough, Sedlinct, +2 more | 9 mg/7,2 mg/3,6 mg per 5 ml, linctus, mixture, syrup | 3 applicants | 5 registrations | S2 |
1 more registered product name Promethazine in their active ingredient
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Promethazine theoclate | Avomine | Not stated | Pharmacare limited û woodmead | C0851 |
Regulatory status
Where S2 sits on the scale
A pharmacist can sell it directly, without a prescription.
Schedule 2 medicines sit behind the pharmacy counter. A pharmacist can decide to sell one of these directly, using their own professional judgement, without a doctor's prescription. It can also be dispensed against a prescription like the higher tiers, in which case the usual repeat limits apply. A child under 12 may only be sold a Schedule 2 substance on a prescription, or on a written order that names the purpose and carries a signature the seller recognises. Even though it cannot be advertised to the public in the ordinary sense, its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S2, as the Consolidated Schedules list it.
Who may supply: Only a pharmacist, pharmacist intern or supervised pharmacist's assistant may sell it without a prescription. It may otherwise be dispensed by a pharmacist against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Promethazine
S2: Promethazine
- when intended for use as an antihistamine, and
- when intended for application to the skin, and
- when intended specifically for the treatment of travel sickness. (S5)
Consolidated Schedules 06 July 2026, lines 2586 to 2592
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.