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Doxycycline

Schedule 2 to 4, conditions apply
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C22H24N2O8444.40 g/mol

(4S,4AR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

Drag to rotate. Structure from PubChem CID 54671203.

Background

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Listing

Schedules
Schedule 2 to 4, conditions apply
Source
Consolidated Schedules 06 July 2026

Registered medicines

1 registered product listed

Counted through the register's ingredient index, which does not reach every record.

Registered products
NameBrandsDosagesApplicantsRegistrationsSchedule
DoxycyclineDoxycyl, Dumoxin, Cyclidox ec, +15 morecapsules, 50 mg, 100 mg, 200 mg12 applicants25 registrationsS2 to S4conditions apply

1 more registered product name Doxycycline in their active ingredient

Registered products
NameBrandsDosagesApplicantsRegistrationsSchedule
Doxycycline hydrochloride eauivalent to doxycycline CancelledBsp doxycycline100Brovar S & P (Pty) LtdY0042

Regulatory status

Where S2 to S4 sits on the scale

Depends on which listing applies

At the least restrictive, Schedule 2: a pharmacist can sell it directly, without a prescription. At the most restrictive, Schedule 4: prescription-only medicine. The listings below say which applies to which form, strength or pack size.

Schedule S2 to S4, as the Consolidated Schedules list it.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Doxycycline

  • S4: Doxycycline

    • except when intended and labelled for the chemoprophylaxis of malaria in those aged 8 years and older. (S2)
    • except in preparations thereof for the treatment of animals and registered in terms of the provisions of the Fertilizers, Farm Feeds, Agricultural Remedies and Stock Remedies Act, 1947 (Act 36 of 1947).

    Consolidated Schedules 06 July 2026, lines 6118 to 6123

  • S2: Doxycycline

    • when intended and labelled for the chemoprophylaxis of malaria in those aged 8 years and older. (S4)

    Consolidated Schedules 06 July 2026, lines 1873 to 1875

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

Research articles

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