Estradiol
(8R,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Drag to rotate; arrow keys step through the atoms. Structure from PubChem CID 5757.
Listing
- Schedules
- Schedule 2 to 4, conditions apply
- Source
- Consolidated Schedules 06 July 2026
Registered medicines
6 registered products listed
Counted through the register's ingredient index, which does not reach every record.
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Estradiol | Femigel, Climara, Estring, +12 more | 0,5 mg/ 2,5 mg, 1 mg, 1 mg & 2 mg, 1 mg/100 mg, +10 more | 10 applicants | 22 registrations | S4 |
3 more registered products name Estradiol in their active ingredient
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Evorel Sequi | Evorel sequi | 3,1 mg/ 3,2 mg | Adcock ingram limited | 310538 | S4 |
| Bijuva | Bijuva | 1 mg/100 mg | Adcock ingram limited | 570075 | S4 |
| Mixogen Cancelled | Mixogen | injection | Donmed Pharmaceuticals (Pty) Ltd | G3190 |
Regulatory status
Where S2 to S4 sits on the scale
Depends on which listing applies
At the least restrictive, Schedule 2: a pharmacist can sell it directly, without a prescription. At the most restrictive, Schedule 4: prescription-only medicine. The listings below say which applies to which form, strength or pack size.
Schedule S2 to S4, as the Consolidated Schedules list it.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Estradiol
S4: Estradiol
- when intended for hormone replacement therapy;
- except when intended for human vaginal use; (S2)
- except when intended for oral contraception. (S3)
Consolidated Schedules 06 July 2026, lines 6246 to 6251
S3: Estradiol
- when intended for oral contraception;
- except when intended for human vaginal use; (S2)
- except when intended for hormone replacement therapy. (S4)
Consolidated Schedules 06 July 2026, lines 3514 to 3524
S2: Estradiol
- when intended for human vaginal use;
- except when intended for oral contraception; (S3)
- except when intended for hormone replacement therapy. (S4)
Consolidated Schedules 06 July 2026, lines 1927 to 1933
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.