Rupatadine

Sold as Rupanase, Rupallerg, Rutarn, Rupagex, Rupaxine, Zealargy, Raztrol, Raputeze, Histanaze, Rupastral, Rupahist

C₂₆H₂₆ClN₃416.00 g/mol

13-Chloro-2-[1-[(5-methyl-3-pyridinyl)methyl]piperidin-4-ylidene]-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene

Drag to rotate. Structure from PubChem CID 133017.

Loading Wikipedia summary

Registration

Applicants: 8
Registrations: 11
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Inova Pharmaceuticals (Pty) Ltd	Rupanase, Rupallerg	10	460119, 510694	S2	None
Austell Pharmaceuticals (Pty) Ltd	Rutarn	10	520184	S2	None
Adcock ingram limited	Rupagex, Rupaxine	10 mg	530724, 530725.724	S2	PI PIL
Pharma-q Holdings (Pty) LtdCertificate held by Pharma-q (Pty) Ltd	Zealargy	10 mg	540789	S2	PI PIL
Ranbaxy (SA) (Pty) LtdCertificate held by Ranbaxy Pharmaceuticals (Pty) Ltd	Raztrol	10mg	550293	S2	PI PIL
Abex Pharmaceutica (Pty) Ltd	Raputeze, Histanaze	10 mg	570071, 570072.071	S2	PI PIL
Astral Pharma (Pty) Ltd	Rupastral	10 mg	570199	S2	PI PIL
Unimed Healthcare (Pty) Ltd	Rupahist	Not stated	580062	S2	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Rupanase 10 EACH TABLET CONTAINS: RUPATADINE FUMARATE EQUIVALENT TO RUPATADINE 10,0 mg	10	46011946/5.7.1/0119	Registered	S2	None
Rupallerg 10 EACH TABLET CONTAINS: RUPATADINE FUMARATE EQUIVALENT TO RUPATADINE 10,0 mg	10	51069452/5.7.1/0694	Registered	S2	None
Rutarn 10 Each tablet contains RUPATADINE FUMARATE EQUIVALENT TO RUPATADINE 10,0 mg	10	52018452/5.7.1/0184	Registered	S2	None
Rupagex EACH TABLET CONTAINS RUPATADINE FUMARATE EQUIVALENT TO RUPATADINE 10,0 mg	10 mgTablet	53072453/5.7.1/0724Approved 30 July 2024	Registered	S2	PI PIL
Rupaxine EACH TABLET CONTAINS RUPATADINE FUMARATE EQUIVALENT TO RUPATADINE 10,0 mg	10 mgTablet.	530725.72453/5.7.1/0725.724Approved 30 July 2024	Registered	S2	PI PIL
Zealargy EACH TABLET CONTAINS RUPATADINE 10,0 mg	10 mgTablet	54078954/5.7.1/0789Approved 22 June 2021	Registered	S2	PI PIL
Raztrol EACH TABLET CONTAINS RUPATADINE 10,0 mg	10mgTablet	55029355/5.7.1/0293Approved 7 December 2021	Registered	S2	PI PIL
Raputeze EACH TABLET CONTAINS :RUPATADINE FUMARATE EQUIVALENT TO RUPATADINE 10,0 mg	10 mgTablets	57007157/5.7.1/0071Approved 26 November 2024	Registered	S2	PI PIL
Histanaze EACH TABLET CONTAINS :RUPATADINE FUMARATE EQUIVALENT TO RUPATADINE 10,0 mg	10 mgTablets	570072.07157/5.7.1/0072.071Approved 26 November 2024	Registered	S2	PI PIL
Rupastral Each Tablet contains: Rupatadine fumarate equivalent to rupatadine 10,0 mg	10 mgTablet	57019957/5.7.1/0199Approved 27 May 2025	Registered	S2	PI PIL
Rupahist EACH TABLET CONTAINS: RUPATADINE FUMARATE EQUIVALENT TO RUPATAINE 10,0 mg	Not listed	58006258/5.7.1/0062	Registered	S2	None

Regulatory status

Where S2 sits on the scale

S0S1S2S3S4S5S6S7S8

A pharmacist can sell it directly, without a prescription.

Schedule 2 medicines sit behind the pharmacy counter. A pharmacist can decide to sell one of these directly, using their own professional judgement, without a doctor's prescription. It can also be dispensed against a prescription like the higher tiers, in which case the usual repeat limits apply. A child under 12 may only be sold a Schedule 2 substance on a prescription, or on a written order that names the purpose and carries a signature the seller recognises. Even though it cannot be advertised to the public in the ordinary sense, its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S2, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: Only a pharmacist, pharmacist intern or supervised pharmacist's assistant may sell it without a prescription. It may otherwise be dispensed by a pharmacist against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Rupatadine fumarate equivalent to rupatadine

S2: Rupatadine
Consolidated Schedules 06 July 2026, line 2650

Pharmacological class: Antihistaminics. (class 5.7.1)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

Rupagex, Adcock ingram limited is scheduled S2 in its official SAHPRA documents, read with 90% confidence.

Professional information (PI)For healthcare professionalsRupagex, Adcock ingram limited Patient information leaflet (PIL)For patients and carersRupagex, Adcock ingram limited

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

Loading PubMed articles

Background