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zameds

Oestriol

Sold as Incurin, Synapause vaginal

S2Read from the PI-PIL document and verified
Loading the molecular structure
C18H24O3288.40 g/mol

(8R,9S,13S,14S,16R,17R)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

Drag to rotate. Structure from PubChem CID 5756.

Background

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Registration

Applicants
2
Registrations
2
Schedule source
SAHPRA documentation

Applicants and registrations

ApplicantBrandsDosagesRegistrationsScheduleLeaflets
Intervet South Africa (Pty) LtdIncurinNot stated98/10Not determinedNone
Pharmacare limited û woodmeadCertificate held by PharmacareSynapause vaginal1 mg/gV0201S2PIPIL

Variants

ProductStrength and formRegistrationStatusScheduleLeaflets
Incurin

EACH TABLET CONTAINS OESTRIOL 1.0 mg

Not listed98/1098/22.6.1/10RegisteredNot determinedNone
Synapause vaginal cream

EACH 1 g CREAM CONTAINS OESTRIOL 1 mg

1 mg/gCreamV0201V/18.6/201Approved 12 March 2026RegisteredS2PIPIL

Regulatory status

Where S2 sits on the scale

A pharmacist can sell it directly, without a prescription.

Schedule 2 medicines sit behind the pharmacy counter. A pharmacist can decide to sell one of these directly, using their own professional judgement, without a doctor's prescription. It can also be dispensed against a prescription like the higher tiers, in which case the usual repeat limits apply. A child under 12 may only be sold a Schedule 2 substance on a prescription, or on a written order that names the purpose and carries a signature the seller recognises. Even though it cannot be advertised to the public in the ordinary sense, its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S2, read from the product's PI-PIL leaflet.

Who may supply: Only a pharmacist, pharmacist intern or supervised pharmacist's assistant may sell it without a prescription. It may otherwise be dispensed by a pharmacist against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

Synapause vaginal cream, Pharmacare limited û woodmead is scheduled S2 in its official SAHPRA documents, read with 90% confidence.

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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