Loperamide

Sold as Adco loperamide, Dischem anti-diarrhoeal, Lenide s, Loperastat, Imodium melt, Gartromide, Loperim, Dilorax, Lopidium, Cipla loperamide, Imodium, Imodium caps, Gastron, Adco prodium, Adco-loperamide, Diarrostop, Norimode, Betaperamide

C₂₉H₃₃ClN₂O₂477.00 g/mol

4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide

Drag to rotate. Structure from PubChem CID 3955.

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Registration

Applicants: 7
Registrations: 20
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Adcock ingram limited1 of 6 cancelled	Adco loperamide, Gartromide, Adco prodium, Adco-loperamide, Diarrostop, Betaperamide	2 mg, tablets	280003, 590536, X0303, Y0005, Y0045, Z0113	S2	PI PIL
Pharmacare limited û woodmead2 of 5 cancelled	Dischem anti-diarrhoeal, Lenide s, Gastron, Norimode	tablets, syrup	280140, 280141, V0213, V0214, Y0073	S2	None
Ranbaxy (SA) (Pty) LtdCertificate held by Ranbaxy Pharmaceuticals (Pty) Ltd	Loperastat	1 mg per 5 ml	280649	S2	PI PIL
Johnson & Johnson (Pty) Ltd û East LondonCertificate held by Johnson &Amp; Johnson (Pty) Ltd1 of 3 cancelled	Imodium melt, Imodium	2 mg	290213, H0152, J0166	S2	PI PIL
Mothopo pharma chem	Loperim, Dilorax	Not stated	A390075, A390104	S2	None
Cipla Medpro (Pty) Ltd1 of 2 cancelled	Lopidium, Cipla loperamide	Not stated	A390406, A390407	S2	None
Johnson & Johnson (Pty) Ltd û Cape Town	Imodium caps	Not stated	U0213	S2	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Adco loperamide EACH 5 ml SYRUP CONTAINS LOPERAMIDE HYDROCHLORIDE 1 mg	2 mgTablets	28000328/11.9/0003Approved 22 May 2026	Registered	S2	PI PIL
Dischem anti-diarrhoeal tablets EACH TABLET CONTAINS LOPERAMIDE HYDROCHLORIDE 2 mg	Tablets	28014028/11.9/0140	Registered	S2	None
Lenide - s EACH 5 ml SYRUP CONTAINS LOPERAMIDE HYDROCHLORIDE 1 mg	-	28014128/11.9/141	Cancelled	S2	None
Loperastat syrup* EACH 10 ml SYRUP CONTAINS LOPERAMIDE HYDROCHLORIDE 2 mg	1 mg per 5 mlSyrup	28064928/11.9/0649Approved 14 March 2023	Registered	S2	PI PIL
Imodium melt tablets TABLET LOPERAMIDE HYDROCHLORIDE 2 MG	2 mgOrodispersible tablets	29021329/11.9/0213Approved 28 November 2023	Registered	S2	PI PIL
Gartromide EACH 5,0 ml SYRUP CONTAINS: LOPERAMIDE HYDROCHLORIDE 1,0 mg	Not listed	59053659/11.9/0536	Registered	S2	None
Loperim EACH 1,0 ml SOLUTION CONTAINS LOPERAMIDE HYDROCHLORIDE 2,0 mg	Not listed	A390075A39/11.9/0075	Registered	S2	None
Dilorax EACH 1,0 ml DROPS CONTAINS LOPERAMIDE HYDROCHLORIDE 0,001 g	Not listed	A390104A39/11.9/0104	Registered	S2	None
Lopidium EACH TABLET CONTAINS LOPERAMIDE HYDROCHLORIDE 2,0 mg	Not listed	A390406A39/11.9/0406	Cancelled	S2	None
Cipla loperamide EACH TABLET CONTAINS LOPERAMIDE HYDROCHLORIDE 2,0 mg	Not listed	A390407A39/11.9/0407	Registered	S2	None
Imodium 2 MG EACH TABLET CONTAINS LOPERAMIDE HYDROCHLORIDE 2,0 mg	2 mg	H0152H/11.9/152	Registered	S2	None
Imodium EACH 1 ml SYRUP CONTAINS LOPERAMIDE HYDROCHLORIDE 0,2 mg	Not listed	J0166J/11.9/166	Cancelled	S2	None
Imodium caps EACH CAPSULE CONTAINS LOPERAMIDE HYDROCHLORIDE 2 mg	Not listed	U0213U/11.9/213	Registered	S2	None
Gastron tablets EACH TABLET CONTAINS LOPERAMIDE HYDROCHLORIDE 2 MG	Tablets	V0213V/11.9/213	Registered	S2	None
Gastron syrup EACH 5 ML CONTAINS LOPERAMIDE HYDROCHLORIDE 1 MG	Syrup	V0214V/11.9/214	Registered	S2	None
Adco prodium EACH TABLET CONTAINS LOPERAMIDE HYDROCHLORIDE 2 mg	Not listed	X0303X/11.9/303	Registered	S2	None
Adco-loperamide EACH TABLET CONTAINS :LOPERAMIDE HYDROCHLORIDE 2 mg	2 mgTablets	Y0005Y/11.9/5Approved 22 May 2026	Registered	S2	PI PIL
Diarrostop tablets EACH TABLET CONTAINS LOPERAMIDE HYDROCHLORIDE 2 mg	Tablets	Y0045Y/11.9/45	Cancelled	S2	None
Norimode tablets EACH TABLET CONTAINS LOPERAMIDE HYDROCHLORIDE 2 mg	Tablets	Y0073Y/11.9/73	Cancelled	S2	None
Betaperamide EACH TABLET CONTAINS LOPERAMIDE HYDROCHLORIDE 2 mg	Not listed	Z0113Z/11.9/113	Registered	S2	None

Regulatory status

Where S2 sits on the scale

S0S1S2S3S4S5S6S7S8

A pharmacist can sell it directly, without a prescription.

Schedule 2 medicines sit behind the pharmacy counter. A pharmacist can decide to sell one of these directly, using their own professional judgement, without a doctor's prescription. It can also be dispensed against a prescription like the higher tiers, in which case the usual repeat limits apply. A child under 12 may only be sold a Schedule 2 substance on a prescription, or on a written order that names the purpose and carries a signature the seller recognises. Even though it cannot be advertised to the public in the ordinary sense, its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S2, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: Only a pharmacist, pharmacist intern or supervised pharmacist's assistant may sell it without a prescription. It may otherwise be dispensed by a pharmacist against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Loperamide hydrochloride

S2: Loperamide
Consolidated Schedules 06 July 2026, line 2255

Pharmacological class: Antidiarrhoeals. (class 11.9)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsAdco loperamide, Adcock ingram limited Patient information leaflet (PIL)For patients and carersAdco loperamide, Adcock ingram limited

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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