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Orphenadrine

Schedule 2 to 4, conditions apply
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C18H23NO269.40 g/mol

N,N-Dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine

Drag to rotate. Structure from PubChem CID 4601.

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Listing

Schedules
Schedule 2 to 4, conditions apply
Source
Consolidated Schedules 06 July 2026

Registered medicines

2 registered products listed

Counted through the register's ingredient index, which does not reach every record.

Registered products
NameBrandsDosagesApplicantsRegistrationsSchedule
Orphenadrine, paracetamolBesemax, Uniflex, Betaflex nc, +1 more35 mg and 450 mg, 450mg, 450 mg2 applicants4 registrationsS1 to S4conditions apply
OrphenadrineOrpadrex, Disipal, Norflex, +1 more50 mg4 applicants4 registrationsS4

Regulatory status

Where S2 to S4 sits on the scale

Depends on which listing applies

At the least restrictive, Schedule 2: a pharmacist can sell it directly, without a prescription. At the most restrictive, Schedule 4: prescription-only medicine. The listings below say which applies to which form, strength or pack size.

Schedule S2 to S4, as the Consolidated Schedules list it.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Orphenadrine

  • S4: Orphenadrine

    • except when contained in preparations intended for use as a muscle relaxant.

    Consolidated Schedules 06 July 2026, line 7407

  • S2: Orphenadrine

    • when contained in preparations intended for use as a muscle relaxant.

    Consolidated Schedules 06 July 2026, line 2468

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

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