Schedule 3 (S3) medicines in South Africa
Needs a doctor's prescription, dispensed by a pharmacist.
About S3 Drugs
Where S3 sits on the scale
Needs a doctor's prescription, dispensed by a pharmacist.
Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Who may supply
A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Cited: Act s22A(5)(b), s22A(5)(c), s22A(5)(d), s22A(5)(e), s22A(6)(r)
Prescription: Requires a prescription from an authorised prescriber.
Repeats: Can be repeated only if the prescriber indicated a number of repeats on the prescription, and never for more than six months in total; the prescription must also be presented for dispensing within 30 days of issue.
Cited: reg 33(3)(i) (General Regulations, 2017)
Cited: Act s22A(6)(d), s22A(6)(f)
Advertising: May be advertised only to health professionals, not the public.
Cited: reg 42(2), reg 42(3) (General Regulations, 2017)
Labelling: Must show the letter S and the number 3 in a square border, immediately before the product's brand name.
Cited: reg 10(1)(a) (General Regulations, 2017)
What is a Schedule 3 medicine in South Africa?
Needs a doctor's prescription, dispensed by a pharmacist. Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Can a pharmacist sell a Schedule 3 medicine without a prescription?
A prescription is required. A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction. Can be repeated only if the prescriber indicated a number of repeats on the prescription, and never for more than six months in total; the prescription must also be presented for dispensing within 30 days of issue.
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
Substances listed under S3
439 listed in the Consolidated Schedules, 234 with a registered medicine.
- (-)-6 epigallocatechin gallate
- Acamprosate
- Acebutolol1
- Aceclofenac
- Acetazolamide1
- Acetohexamide1
- Acetylcholine1
- Acetylcysteine1
- Acipimox1
- Aclidinium
- Adapalene1
- Adrenaline7
- Alclofenac
- Alendronic acid3
- Aliskiren
- Allopurinol1
- Alogliptin
- Alprenolol
- Amiloride2
- Amlodipine10
- Ancrod
- Anthiolimine
- Arsanilic acid
- Ascorbic Acid, see Vitamin C
- Atenolol2
- Atropine5
- Azapropazone1
- Balsalazide
- Barnidipine
- Beclamide
- Beclomethasone dipropionate2
- Benazepril2
- Bendazac
- Benfluorex
- Benoxaprofen
- Benzbromarone
- Benzydamine2
- Bepridil
- Beta-benzalbutyramide
- Beta-galactosidase
- Betahistine1
- Betaxolol1
- Bethanidine1
- Bevantolol
- Bezafibrate1
- Bisoprolol3
- Bopindolol
- Bowel cleansers
- Brimonidine2
- Brinzolamide10
- Budesonide4
- Bufexamac1
- Buflomedil
- Buformin
- Bumetanide1
- Butecosone
- Cadralazine
- Caffeine36
- Calcipotriol2
- Calcium19
- Calcium carbimide
- Calcium disodium edetate
- Calcium dobesilate
- Candesartan
- Captopril2
- Carazolol1
- Carbachol
- Carbamazepine1
- Carbenoxolone
- Carbimazole1
- Carbuterol
- Carprofen1
- Carteolol1
- Carvedilol1
- Celecoxib1
- Celiprolol
- Chenodeoxycholic acid
- Chlorazanil
- Chlorexolone
- Chlorothiazide and other derivatives of benzo-1,2,4-thiadiazine-7-sulphonamide-1,1-dioxide
- Chlorpropamide1
- Chlorthalidone
- Cholecalciferol, see Vitamin D
- Chromonar1
- Ciclesonide1
- Cilazapril
- Cilomilast
- Cimetidine1
- Clevidipine1
- Clofibrate
- Clonidine1
- Clopidogrel2
- Codeine34
- Colchicine1
- Colestipol
- Copper1
- Corticosteroids
- Cyanocobalamin, see Vitamin B12
- Cyclandalate
- Cyclopentolate2
- Cyphenothrin
- Darifenacin1
- Debrisoquine
- Delapril
- Dexketoprofen trometamol
- Dialysate preparations
- Dichlorphenamide
- Diclofenac2
- Dienogest2
- Diflunisal
- Diftalone
- Digitalis
- Dihydrocodeine1
- Dihydroergocristine
- Dilevalol
- Diltiazem1
- Dimercaprol1
- Dipivefrin
- Dipyridamole1
- Dipyrocetyl
- Disulfiram1
- Dithranol
- Dornase alfa
- Dorzolamide10
- Doxazosin1
- Drospirenone2
- Eltenac
- Enalapril3
- Endralazine
- Eprosartan2
- Ergocalciferol, see Vitamin D
- Escin
- Esculin
- Esmolol
- Estradiol6
- Estriol2
- Ethacrynic acid
- Ethosuximide1
- Etisazol
- Etodolac1
- Etodolic acid
- Etofenamate
- Etofenprox
- Etoricoxib1
- Exenatide1
- Felbamate
- Felbinac1
- Felodipine2
- Fenbufen
- Fenclofenac
- Fendiline
- Fenofibrate3
- Fenoprofen1
- Fenoterol2
- Fentiazac
- Fenticonazole1
- Firocoxib1
- Floctafenine
- Flufenamic acid
- Flunisolide
- Flunixin2
- Fluorescein2
- Flurbiprofen1
- Fluticasone furoate3
- Fluticasone propionate6
- Folinic acid2
- Frusemide1
- Gabapentin1
- Gadoxetic acid1
- Gelatine succinylated
- Gemfibrozil1
- Gestodene
- Glafenine
- Glibenclamide2
- Glibornuride
- Gliclazide1
- Glimepiride2
- Glimidine
- Glipizide1
- Gliquidone
- Glucosamine
- Glutathione
- Glycopyrronium8
- Guanabenz
- Guanethidine1
- Guanfacine
- Guanoxan
- Hexoprenaline1
- Homatropine1
- Hormones
- Hydralazine1
- Hydrochlorothiazide21
- Hydroquinone
- Hydroxypropyl methylcellulose1
- Hyoscine butylbromide1
- Ibuprofen7
- Imepitoin1
- Imidapril
- Indacaterol4
- Indapamide7
- Indometacin
- Indoprofen
- Indoramin1
- Injections
- Insulin3
- Insulin aspart2
- Insulin degludec3
- Insulin glargine2
- Insulin lispro1
- Ipratropium6
- Irbesartan7
- Iron1
- Isoprenaline1
- Isosorbide2
- Isoxicam
- Isradipine
- Ivabradine1
- Ivermectin1
- Ketanserin
- Ketoprofen3
- Ketorolac1
- Labetalol1
- Lacidipine
- Lacosamide1
- Lamotrigine1
- Lercanidipine2
- Levalbuterol1
- Levetiracetam1
- Levobunolol
- Levonorgestrel1
- Levosemindan
- Levothyroxine1
- Lidoflazine1
- Linagliptin1
- Liothyronine sodium1
- Lisinopril2
- Lonazolac
- Lornoxicam1
- Losartan3
- Lumiracoxib
- Macrogol2
- Meclofenamic acid1
- Mefenamic acid1
- Meloxicam2
- Mepindolol
- Mesalazine1
- Mesulphene
- Metaproterenol2
- Metformin6
- Methazolamide
- Methimazole
- Methsuximide
- Methyldopa3
- Metipranolol
- Metolazone
- Metoprolol1
- Mibefradil
- Mirabegron1
- Moexipril1
- Mometasone furoate7
- Montelukast2
- Moxonidine1
- Nabumetone1
- Nadolol
- Naftidrofuryl
- Naproxen2
- Nateglinide
- Nebivolol1
- Nepafenac1
- Nicardipine1
- Nicotine1
- Nifedipine1
- Niflumic acid
- Nimodipine1
- Nisoldipine1
- Nitrendipine
- Nitroglycerine
- Noradrenaline theophylline, see Theodrenaline
- Norelgestromin
- Norethisterone2
- Norgestrel
- Normal Saline
- Olmesartan
- Olsalazine1
- Orlistat1
- Oxaprozin1
- Oxcarbazepine1
- Oxitracetam
- Oxovinca
- Oxybutynin1
- Oxyprenolol
- Pantothenic Acid, see Vitamin B5
- Para-aminosalicylic acid
- Paracetamol78
- Parecoxib1
- Parenteral Nutrition formulations
- Penbutolol
- Penicillinase
- Pentaerythritol tetranitrate
- Pentolinium
- Pentosan polysulfate sodium
- Perindopril2
- Phenformin
- Phenobarbital
- Phenoxymethylpenicillin2
- Phentolamine
- Phenytoin1
- Physostigmine
- Pilocarpine1
- Pindolol
- Pioglitazone1
- Piracetam1
- Pirbuterol
- Piretanide
- Piroxicam1
- Pirprofen
- Potassium11
- Potassium canrenoate
- Practolol
- Prazosin1
- Primidone1
- Probenecid1
- Probucol
- Procaterol
- Proctofene
- Propacetamol
- Propiverine1
- Propranolol1
- Proquazone
- Proscillaridine
- Protamine1
- Prothionamide
- Pygeum africanum
- Pyrazinamide3
- Pyridoxine, see Vitamin B6
- Pyrimethamine3
- Pyrithioxin
- Quinapril2
- Racecadotril1
- Raloxifene1
- Ramipril2
- Ranitidine1
- Raubasine1
- Rauwolfia alkaloids
- Repaglinide1
- Reproterol
- Reserpine1
- Riboflavin, see Vitamin B2
- Rimiterol
- Risedronate1
- Rofecoxib
- Rosiglitazone
- Roxarzone
- Sacubitril2
- Salbutamol3
- Salmefamol
- Saxagliptin1
- Silimarin, see Silymarin
- Silymarin1
- Sitagliptin phosphate2
- Sodium phosphate7
- Sodium picosulphate
- Solcoseryl
- Solifenacin2
- Sotalol1
- Spirapril
- Spironolactone2
- Strontium1
- Strophanthus
- Sulindac1
- Suloctidil
- Sulphinpyrazone
- Sulthiame1
- Suprofen
- Tasosartan
- Tazarotene
- Telmisartan10
- Tenidap
- Tenoxicam1
- Tepoxalin
- Terazosin1
- Terbutaline
- Terizidone1
- Terodiline
- Theodrenaline, see Noradrenaline theophylline
- Thiacetazone1
- Thiamine, see Vitamin B1
- Thiocolchicoside
- Thyroid gland
- Tiagabine
- Tiaprofenic acid
- Ticagrelor1
- Ticlopidine
- Timolol10
- Tiotropium1
- Tolamolol
- Tolazamide
- Tolbutamide1
- Tolfenamic acid1
- Tolmetin
- Tolterodine1
- Topiramate1
- Torasemide1
- Trandolapril2
- Tretinoin1
- Triamterene1
- Tricaine
- Trifarotene1
- Trimethadione
- Tropicamide1
- Tulobuterol1
- Umeclidinium1
- Ursodeoxycholic acid1
- V. cholera
- Valdecoxib1
- Valproic acid1
- Valsartan6
- Vedaprofen
- Verapamil2
- Veratrum alkaloids
- Vigabatrin1
- Vildagliptin2
- Vincamine
- Vinpocetine
- Vitamin B111
- Vitamin B123
- Vitamin B25
- Vitamin B3, see Niacin
- Vitamin B51
- Vitamin B69
- Vitamin C37
- Vitamin D7
- Vitamin K
- Water for Injection
- Xamoterol
- Xipamide1
- Zafirlukast
- Zinc salts
- Zomepirac
Registered medicines in S3
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Acebutolol | Butobloc, Merck acebutolol | 400 mg | 2 applicants | 2 registrations | S3 |
| Acetazolamide | Diamox sodium parenteral | 500 mg | Acino Pharma (Pty) Ltd | H1929 | S3 |
| Acetohexamide | Dimelor | Not stated | Quatromed limited | G3034 | S3 |
| Acetylcholine | Miochol-e, Miochol intraocular, Covochol | 20 mg | 3 applicants | 3 registrations | S3 |
| Acetylcysteine | Aloribex | 300 | Ipharma (Pty) Ltd | 340178 | S3 |
| Acipimox Cancelled | Olbetam | Not stated | Pfizer Laboratories (Pty) Ltd | W0365 | S3 |
| Adapalene | Differin, Deriva, Dapta | 1 mg/g, 1mg, gel, cream | 3 applicants | 5 registrations | S3 |
| Alendronic acid | Boniran, Ran-alendronate, Femax, +18 more | 10 mg, 70 mg, 5600 IU | 17 applicants | 26 registrations | S3 |
| Allopurinol | Be-uric, Urinol, Adco allopurinol, +29 more | 100 mg, 100/300 mg, 100 mg, 300 mg, 300 mg | 19 applicants | 51 registrations | S3 |
| Amiloride | Gsa-retic, Aquadrex, Dezretic, +7 more | 5/50, tablets, 5 mg/50 mg | 7 applicants | 10 registrations | S3 |
| Amlodipine | Exforge, Co exforge, Twynsta, +30 more | 5/160 mg, 5/320 mg, 5 mg/160 mg/12,5 mg, 5 mg/160 mg/25 mg, +38 more | 17 applicants | 113 registrations | S3 |
| Aspirin | Clopiwin plus | 75 mg | Sanofi-aventis South Africa (Pty) Ltd | 440657 | S3 |
| Atenolol | Tenormin, Aspen atenolol, Hexa-blok, +14 more | 25 mg, 50 mg, 100 mg | 13 applicants | 31 registrations | S3 |
| Atenolol o | Atenolol arya | 50 | Arya Pharma (Pty) Ltd | 300026 | S3 |
| Atropine | Atropine eye | 10 mg/ml | Adcock ingram limited | J0312 | S3 |
| Azapropazone Cancelled | Rheumox | Not stated | Pharmacare limited û woodmead | E0221 | S3 |
| Benazepril | Brexace, Cardalis, Fortekor | 2,5 mg/20 mg, 5, 10 mg/80 mg, 20 | 3 applicants | 6 registrations | S3 |
| Betahistine | Vertin, Serc, Hidrist, +9 more | 8 mg, 16 mg, 24 mg, 24mg, +1 more | 10 applicants | 24 registrations | S3 |
| Betaxolol | Betoptic s single dose, Loxoptic, Comutax, +3 more | 0,25% | 3 applicants | 6 registrations | S3 |
| Bethanidine Cancelled | Esbatal | Not stated | Wellcome (Pty) Ltd | C0970 | S3 |
| Bezafibrate | Sandoz bezafibrate, Bezachole sr, Bezalip, +1 more | 200 mg, 400 | 3 applicants | 4 registrations | S3 |
| Bisoprolol | Ziak, Cardicor, Cordicor, +31 more | 1/10, 2,5/6,25 mg, 2,5 mg, 2,5/6,25, +12 more | 16 applicants | 79 registrations | S3 |
| Brimonidine | Brimoct eye, Simbrinza, Agobrim w/v eye, +1 more | drops, 0.15% w/v, 1,5 mg/ml,, 10 mg/mL + 2 mg/mL | 4 applicants | 4 registrations | S3 |
| Brinzolamide | Azoptic | 10 mg/ml | Novartis South Africa (Pty) Ltd | 340382 | S3 |
| Bumetanide | Burinex | 1 mg | Adcock ingram limited | G0094 | S3 |
| Caffeine | Cafcit | 5 mg | Equity Pharmaceutical (Pty) Ltd | 560312 | S3 |
| Calcium chloride | Ringer-lactate fresenius, Calcium chloride fresenius | 1 000 ml, 10 ml | Fresenius Kabi Manufacturing SA (Pty) Ltd | 2 registrations | S3 |
| Candesartan cilexetil Cancelled | Canuretic | 16/12,5 mg, | Austell Pharmaceuticals (Pty) Ltd | 490054 | S3 |
| Captopril | Capace, Adco-captopril, Zapto-co, +11 more | 12,5 mg/ 25 mg / 50 mg, 12,5 mg, 25 mg, 50 mg, +1 more | 11 applicants | 25 registrations | S3 |
| Carazolol Cancelled | Suacron | Not stated | Pfizer Laboratories (Pty) Ltd | 84/3 | S3 |
| Carbamazepine | Bio-carbamazepine, Carbamazepine austell, Pinomaz cr, +2 more | 100 mg, 200 mg, 400 mg | 5 applicants | 7 registrations | S3 |
| Carbimazole | Vidalta, Thybimak, Carbithoid, +3 more | 5 mg, 10 mg, 15 mg, 20 mg | 4 applicants | 15 registrations | S3 |
| Carprofen | Norocarp for dogs, Rimadyl, Norocarp, +4 more | injection, 20 mg, 25 mg, 50 mg, +2 more | 4 applicants | 16 registrations | S3 |
| Carteolol Cancelled | Teoptic, Mikelan | 2% | 2 applicants | 2 registrations | S3 |
| Carvedilol | Dilatrend, Carloc, Carvetrend, +9 more | 6,25 mg, 12,5 mg, tablet, 1,25 mg, +2 more | 12 applicants | 34 registrations | S3 |
| Celecoxib | Celebrex, Cecoxela, Celecoxib unicorn, +18 more | 100 mg, 200 mg | 15 applicants | 40 registrations | S3 |
| Chlorpropamide | Hypomide, Diabitex, Diabinese, +1 more | 100 mg, 250 mg | 3 applicants | 5 registrations | S3 |
| Chromium chloride hexahydrate 5 33 g | Addaven | 10 mL | Fresenius Kabi South Africa (Pty) Ltd | 490996 | S3 |
| Chromonar Cancelled | Intensain | 75 | Boehringer Mannheim (SA) (Pty) Ltd | 2 registrations | S3 |
| Ciclesonide | Alvesco, Omnair | 50 µg, 80, 160 | 2 applicants | 3 registrations | S3 |
| Cimetidine | Bio-cimetidine | 200, 400 | Biotech Laboratories (Pty) Ltd | 2 registrations | S3 |
| Citric acid | Picolax | 60 mg | Ferring (Pty) Ltd | A390058 | S3 |
| Clevidipine | Cleviprex | Not stated | Safeline Pharmaceuticals (Pty) Ltd | 570265 | S3 |
| Clopidogrel | Clopidogrel PD, Clopidogrel biotech, Deplatt, +5 more | 75 mg, 75/75 mg, 75mg, 75mg, 75 mg/75 mg | 5 applicants | 8 registrations | S3 |
| Codeine | Adco napacod, Myprodol | 10 mg, 500 mg, 10 mg/200 mg/250 mg | Adcock ingram limited | 3 registrations | S3 |
| Cyclopentolate | Minims cyclopentolate hydrochloride | 0,5 ml | Soflens (Pty) Ltd | C0049 | S3 |
| Darifenacin | Enablex | 7,5 mg, 15 mg | Pharmacare limited û woodmead | 2 registrations | S3 |
| Desogestrel | Desimar | 0,15 mg | Cipla Medpro (Pty) Ltd | 481041 | S3 |
| Dexketoprofen trometamol | Ketesse | 25 mg, 50 mg/2 ml | 2 applicants | 3 registrations | S3 |
| Dextrose | Dextrose fresenius, Sodium chloride with dextrose fresenius, Maintenance fresenius, +1 more | 1 000 ml, 5%, 10%, 20%, +4 more | 2 applicants | 9 registrations | S3 |
| Diclofenac | Flenodic, Flenodic im, Panamor eye, +2 more | 1 mg/ml, 25 mg, 25 mg/ml, 50, +3 more | 4 applicants | 11 registrations | S3 |
| Dienogest | Visanne, Endoact, Metrinelle, +7 more | 2mg, 2 mg, 300 mg | 7 applicants | 10 registrations | S3 |
| Digoxin | Lanoxin paediatric/geriatric | 0,25 mg/ 0,0625 mg | Pharmacare limited û woodmead | G2847 | S3 |
| Diltiazem | Adco-zildem sr, Zildem, Adco zildem, +2 more | 30 mg, 60 mg, 90, 180, +1 more | 3 applicants | 8 registrations | S3 |
| Dimercaprol | B.A.L | injection | Abbott Laboratories S.A. (Pty) Ltd | H2795 | S3 |
| Dipyridamole | Persantin, Plato | 25, 100 | 2 applicants | 3 registrations | S3 |
| Disulfiram | Antabuse | Not stated | Teva Pharmaceuticals (Pty) Ltd | G2932 | S3 |
| Dorzolamide | Trusopt, Cosopt, Dorzopt forte, +8 more | 20mg, 20/5 mg, 20 mg, 5 mg, 20 mg | 4 applicants | 11 registrations | S3 |
| Doxazosin | Cardura xl, Cardugen, Adco-doxazosin, +4 more | 1 mg, 2 mg, 4 mg, 8 mg | 5 applicants | 21 registrations | S3 |
| Drospirenone | Yasmin, Ruby, Jarina | 3mg, 3 mg/0,03 mg | 2 applicants | 3 registrations | S3 |
| Elementary iron | Cosmofer | 50 mg | Acino Pharma (Pty) Ltd | 370434 | S3 |
| Enalapril | Hypace, Pharmapress, Tenezil, +33 more | 2.5 mg, 2,5 mg, 5 mg, 10 mg, +9 more | 21 applicants | 79 registrations | S3 |
| Eprosartan | Teveten, Teveten plus | 600 | Abbott Laboratories S.A. (Pty) Ltd | 2 registrations | S3 |
| Ergocalciferol | A-lennon calciferol | 1,25 mg | Pharmacare limited û woodmead | H2053 | S3 |
| Ethinylestradiol | Melodene, Evra, Lexilev, +2 more | 0.02 mg/0.075 mg, 0,03 mg/0,075 mg, 0,15 mg/0.03 mg, 6 mg, +1 more | 4 applicants | 5 registrations | S3 |
| Ethosuximide | Ethosuximide equity, Ethosuximide mc pharma, Zarontin, +1 more | syrup | 3 applicants | 5 registrations | S3 |
| Etodolac | Lodine | 200 mg, 300 mg | Akromed Products (Pty) Ltd | 3 registrations | S3 |
| Etoricoxib | Arcoxia, Exinef, Azcura, +29 more | 30 mg, 60 mg, 60/ 90/ 120 mg, 60 mg / 90 mg / 120 mg, +2 more | 21 applicants | 107 registrations | S3 |
| Exenatide Cancelled | Byetta, Bydureon bcise | 5 ug, 10 ug | Astrazeneca Pharmaceuticals (Pty) Ltd | 3 registrations | S3 |
| Felodipine | Plendil, Tri-plen, Tri-plen forte, +3 more | 2,5 mg, 5 mg, 10 mg | 4 applicants | 11 registrations | S3 |
| Fenofibrate | Lipanthyl, Tricor, Lipfeno, +2 more | 145 mg, 160 mg, 200 mg | 3 applicants | 7 registrations | S3 |
| Fenoterol | Adco-nebrafen | 4 ml | Adcock Ingram Critical Care (Pty) Ltd | 350004 | S3 |
| Firocoxib | Previcox | 57 mg, 227 mg | Boehringer Ingelheim Animal Health South Africa (Pty) Ltd | 2 registrations | S3 |
| Fish oil | Smoflipid | 1 000 ml | Fresenius Kabi South Africa (Pty) Ltd | 410060 | S3 |
| Folinic acid | Vorina, Rescuvolin | 15 mg, 1000 mg | 2 applicants | 2 registrations | S3 |
| Furosemide | Dino-retic, Furosemide unimed, Litha furosemide, +27 more | 2 ml, 10 mg/ml, 10 ml 100, 20 mg/2 ml, +15 more | 21 applicants | 46 registrations | S3 |
| Gabapentin | Neurontin, Negsez, Gabapentin MSQ, +12 more | 100 mg, 300 mg, 400 mg, 600, +1 more | 15 applicants | 48 registrations | S3 |
| Gadoxetic acid | Primovist | 5 ml, 7,5 ml, 10 ml | Bayer (Pty) Ltd û Isando | 3 registrations | S3 |
| Gemfibrozil | Lopid | 600 | Pfizer Laboratories (Pty) Ltd | Y0245 | S3 |
| Glibenclamide | Diacare, Glucovance, Daonil, +4 more | 2,5, 3,5, 5, 500 mg/2,5 mg, +1 more | 7 applicants | 10 registrations | S3 |
| Gliclazide | Glycron, Diaglucide, Ziclin, +22 more | 30 mg, 40 mg, 60 mg, 80 mg | 16 applicants | 33 registrations | S3 |
| Glimepiride | Glamaryl, Mylan glimepiride, Glimepiride zydus, +9 more | 1 mg, 2 mg, 2/500, 3 mg, +1 more | 12 applicants | 36 registrations | S3 |
| Glipizide Cancelled | Minidiab | 5 mg | Pfizer Laboratories (Pty) Ltd | L0248 | S3 |
| Glycerol | Intralipid | 1 000 mL | Fresenius Kabi South Africa (Pty) Ltd | K0316 | S3 |
| Glycopyrronium | Ultibro breezhaler | 110/ 50 μg | Novartis South Africa (Pty) Ltd | 471183 | S3 |
| Guanethidine Cancelled | Guanethidine sulphate, Ismelin, Normoten | 10 mg, 25 mg | 3 applicants | 5 registrations | S3 |
| Hydralazine | Hypimak, Hyperex, Hyperphen, +1 more | 10 mg, 25 mg, 50 mg | 4 applicants | 9 registrations | S3 |
| Hydrochlorothiazide | Accuretic, Zestoretic, Loretic, +62 more | 10/12,5, 10, 12.5 mg, 12,5 mg, +33 more | 31 applicants | 120 registrations | S3 |
| Ibuprofen | Inflamax paediatric, Parafengen iv, Nocomypro, +2 more | 5 ml, 200 mg, 400 mg/ 325 mg, 1000 mg, 300 mg | 5 applicants | 5 registrations | S3 |
| Imepitoin | Pexion | 100 mg, 400 mg | Boehringer Ingelheim Animal Health South Africa (Pty) Ltd | 2 registrations | S3 |
| Indapamide | Hydro-less, Mylan indapamide, Adco-dapamax, +16 more | 1.5 mg, 1.5mg, 2, 2,5 mg, +6 more | 12 applicants | 23 registrations | S3 |
| Indomethacin | Amdocin, Arthrexin, Indomethacin biotech, +1 more | 25 mg, 50, 100 mg | 4 applicants | 6 registrations | S3 |
| Indoramin | Baratol | 25 mg | Akromed Products (Pty) Ltd | K0176 | S3 |
| Insulin | Apidra, Actrapid hm (ge) | 1 mL, 100 units | 2 applicants | 2 registrations | S3 |
| Insulin aspart | Novorapid, Novomix, Ryzodeg, +2 more | 100 U/mL | 2 applicants | 5 registrations | S3 |
| Insulin degludec | Tresiba | 100 U/ml, 200 U/ml | Novo Nordisk (Pty) Ltd û (Rivonia) | 2 registrations | S3 |
| Insulin glargine | Lantus, Optisulin, Basaglar, +5 more | 000 IU/10 ml 1, 3.64mg / 1ml, 100 IU/mL, 500 IU/5 ml | 4 applicants | 10 registrations | S3 |
| Insulin human | Insuman rapid ( ), Insuman basal ( ), Insuman comb ( ) | 300 IU/3 ML, 300 IU/3 ml 30/70, 1000 IU/10 ML, 1000 IU/10 ML 30/70 | Sanofi-aventis South Africa (Pty) Ltd | 6 registrations | S3 |
| Insulin lispro | Humalog, Humalog mix, Humalog kwikpen, +8 more | 25, 50, 100 units/ml, 200 units/ml | 2 applicants | 12 registrations | S3 |
| Insulin zinc Cancelled | Isophane insulin, Insulin (lente) | Not stated | The Boots Company (SA) (Pty) Ltd | 2 registrations | S3 |
| Ipratropium | Combivent U.D.V, Duolin respules, Adco-combineb | 0,5 mg/2,5 mg in 2,5 mL, 0.5mg, 2,5 ml, 2.5mg | 3 applicants | 3 registrations | S3 |
| Irbesartan | Aprovel, Irbelo, Ran-irbesartan, +15 more | 75 mg, 150 mg, 300 mg | 13 applicants | 47 registrations | S3 |
| Iron | Ferinject | 50 mg/ 500 mg | Takeda (Pty) Ltd | 450948 | S3 |
| Isosorbide dinitrate | Aspen isosorbide dinitrate, Apo-isosorbide dinitrate, Dinospray, +8 more | 1 mg/1 mL, 5 mg, 10 mg, 30 mg, +2 more | 6 applicants | 13 registrations | S3 |
| Isosorbide mononitrate | Imotrate sr, Monicor sr, Ismo, +1 more | 20 mg, 60 mg | 4 applicants | 4 registrations | S3 |
| Ivabradine | Tardacon, Pulsidon, Ratecon, +3 more | 5 mg, 5mg, 5 mg /7,5 mg, 5,0 mg, +2 more | 3 applicants | 12 registrations | S3 |
| Ivermectin | Soolantra, Iladek | 3 mg, 10 mg | 2 applicants | 2 registrations | S3 |
| Ketoconazole | Kez | 20 mg | Pharma Dynamics (Pty) Ltd | 330472 | S3 |
| Ketoprofen | Ketink | 100 mg | Afrivet Business Management (Pty) Ltd | 17/03 | S3 |
| Ketorolac | Acular, Ketorolac pharma-q | 0,4 %, 5 mg/ml, 5 mg/ mL | 2 applicants | 3 registrations | S3 |
| L-alanine | Dipeptiven | 100 mL | Fresenius Kabi South Africa (Pty) Ltd | 330210 | S3 |
| Labetalol | Aspen labetalol, Adco labetalol, Labetalol RBC, +1 more | 5 mg/ml, 5 mg, 100 mg | 3 applicants | 5 registrations | S3 |
| Lacosamide | Lacopat, Vimcosa | 50, 100, 150, 200 | Macleods Pharmaceuticals SA (Pty) Ltd | 7 registrations | S3 |
| Lactose | Rovulum | 2 mg | Pharmacare limited û woodmead | 520336 | S3 |
| Lamotrigine | Lamictin p5, Lamictin p25, Lamictin, +25 more | 2 mg, 5 mg, 25 mg, 50 mg, +2 more | 18 applicants | 101 registrations | S3 |
| Lercanidipine | Zanidip, Lercanidipine teva, Lercanidipine ivax, +8 more | 10 mg, 20 mg | 8 applicants | 20 registrations | S3 |
| Leucovorin | Leucovorin abic, Leucovorin faulding | 3mg/ml -, 100 MG/10 ml, 200 mg/20 ml, 300 mg/30 ml | 2 applicants | 4 registrations | S3 |
| Levalbuterol | Levalbuterol cipla, Silea | 0,31 mg/3 ml, 0,31 mg/3ml, 0,63 mg/3 ml, 1,25 mg/3 ml, +1 more | Cipla Medpro (Pty) Ltd | 6 registrations | S3 |
| Levetiracetam | Keppra, Redilev, Keplev, +14 more | 1 000, 250 mg, 250 mg / 750 mg / 1 000 mg, 500 mg, +4 more | 17 applicants | 58 registrations | S3 |
| Levonorgestrel | Microval | 0,03 mg | Pharmacare limited û woodmead | E0058 | S3 |
| Levothyroxine | Leventa for dogs, Synthroid, Eltroxin new formulation, +5 more | 1 mg/ml, 25 mcg, 25 ug, 25 µg, +25 more | 8 applicants | 45 registrations | S3 |
| Lidoflazine | Clinium | Not stated | Janssen Pharmaceutica (Pty) Ltd | H0566 | S3 |
| Liothyronine | Tertroxin | 5, 20 ug | 2 applicants | 2 registrations | S3 |
| Lisinopril | Liso | 2,5/ 5/ 10/ 20 mg | Unicorn Pharmaceuticals (Pty) Ltd | 4 registrations | S3 |
| Lornoxicam | Xefo, Xefo iv/im, Xefo rapid, +5 more | 4 mg, 8 mg | 3 applicants | 13 registrations | S3 |
| Losartan | Cozaar, Zartan, Austell losartan, +19 more | 12,5 mg, 25 mg, 50 mg, 100 mg | 19 applicants | 55 registrations | S3 |
| Macrogol | Klean-prep | 68.96 g | Pharmacare limited û woodmead | Z0340 | S3 |
| Magnesium sulphate | Adco magnesium sulphate | 2 mL | Adcock Ingram Critical Care (Pty) Ltd | V0253 | S3 |
| Mannitol | Mannitol fresenius | 50 ml | Fresenius Kabi Manufacturing SA (Pty) Ltd | W0190 | S3 |
| Meclofenamic acid Cancelled | Meclomen | Not stated | Adcock ingram limited | N0055 | S3 |
| Mefenamic acid | Ponac | 50 mg per 5 ml, 250 mg | Pharmacorp (Pty) Ltd | 2 registrations | S3 |
| Meloxicam | Metacam, Metacam for horses, Equicam, +26 more | 0,5 %, 1 mg, 1,5 mg/ml, 2%, +10 more | 20 applicants | 54 registrations | S3 |
| Mesalazine | Pentasa, Asacol, Salofalk, +5 more | 1 g, 1 200, 1,5 g, 2 g, +11 more | 7 applicants | 23 registrations | S3 |
| Metformin | Metformin HCL fc kiara, Mylan metformin, Metforal, +49 more | 000 mg 1, 0mg 100, 1 000, 50 mg/500 mg, +13 more | 30 applicants | 115 registrations | S3 |
| Methyldopa | Methyldopa unimed, A-lennon methyldopa, Aldomet, +9 more | 50 MG/ML, 250 mg, 250mg, 500 mg | 8 applicants | 16 registrations | S3 |
| Metoprolol Cancelled | Lopresor | 100 | Novartis South Africa (Pty) Ltd | H0072 | S3 |
| Mirabegron | Betmiga, Urton, Vesirel | 25 mg, 50 mg | 3 applicants | 6 registrations | S3 |
| Moexipril Cancelled | Perdix | 7,5, 15 | Ucb SA (Pty) Ltd | 2 registrations | S3 |
| Montelukast | Singulair, Topraz, Monte-air, +39 more | 4 mg, 4.15 mg, 5 mg, 10 mg, +3 more | 24 applicants | 101 registrations | S3 |
| Moxonidine | Cynt, Physiotens, Moxonidine oethmaan | 0,2, 0,3, 0,4 | 2 applicants | 9 registrations | S3 |
| Nebivolol | Nebilet, Nebicard, Lovispes, +2 more | 5 mg | 4 applicants | 5 registrations | S3 |
| Nepafenac | Nevanac | 1mg | Novartis South Africa (Pty) Ltd | 421006 | S3 |
| Nicardipine | Nicardipine equity, Nagavene | 10 mg | Equity Pharmaceutical (Pty) Ltd | 2 registrations | S3 |
| Nifedipine | Nifedalat, Nifedalat sr, Anginor cr, +20 more | 5 mg, 10 mg, 20 mg, 30 mg, +2 more | 10 applicants | 41 registrations | S3 |
| Nimodipine | Aspen nimodipine iv, Nimotop, Nimotop iv | 30 mg | 3 applicants | 3 registrations | S3 |
| Nisoldipine Cancelled | Syscor-cc | 30 | Pharmacare limited û woodmead | 300350 | S3 |
| Olmesartan medoxomil | Olmetec | 10, 20, 40 | Menarini South Africa (Pty) Ltd | 3 registrations | S3 |
| Olsalazine Cancelled | Dipentum | 250 | Pharmaco Distribution (Pty) Ltd | V0301 | S3 |
| Oxaprozin Cancelled | Deflam | 600 mg | Pharmacare limited û woodmead | R0129 | S3 |
| Oxcarbazepine | Oxcarbazepine viatris, Eizurex, Ruzecin, +2 more | 150, 300, 600 | 3 applicants | 11 registrations | S3 |
| Oxybutynin | Mylan oxybutynin, Oxybutynin oethmaan, Lenditro, +5 more | 5 mg, 5mg, 10 mg | 8 applicants | 9 registrations | S3 |
| Paracetamol | Paracetamol paediatric b. Braun, Pypataran iv | 10 mg, 100 mg, 500 MG | 2 applicants | 3 registrations | S3 |
| Parecoxib | Rayzon iv/im, Perodyn, Pericob, +6 more | 5 ml, 40 mg | 5 applicants | 9 registrations | S3 |
| Perindopril | Vectoryl, Prexum, Perdotor, +6 more | 2 mg, 4 mg, 5 mg and 10 mg, 5 mg, +2 more | 4 applicants | 20 registrations | S3 |
| Phenytoin | Phlexy, Phenytoin sodium ascendis, Phenpatin, +7 more | 5 ml, 50 mg/ml, 50 MG, 100 mg, +1 more | 7 applicants | 12 registrations | S3 |
| Pioglitazone | Pioglitazone hydrochloride macleods, Cipla pioglitazone hydrochloride, Cipla-pioglitazone, +1 more | 15 mg, 15 mg/30 mg, 30 mg | 2 applicants | 6 registrations | S3 |
| Piracetam | Nootropil | ampoule | Glaxosmithkline South Africa (Pty) Limited | H0596 | S3 |
| Piroxicam | Xycam, Pixicam, Pirofen | suppositories, 20 mg, dispersible tablets | 3 applicants | 5 registrations | S3 |
| Poly ethylene glycol | Moviprep | 112 g | Norgine (Pty) Ltd | 420407 | S3 |
| Potassium chloride | Cardioplegic induction fresenius | 3.757 g/500 m AND 1.375 g/500 ml | Fresenius Kabi Manufacturing SA (Pty) Ltd | 300133 | S3 |
| Prazosin | Pratsiol, Prazapress | 1 mg, 2 mg, 5 mg | Pharmacare limited û woodmead | 5 registrations | S3 |
| Primidone | Mysoline | Not stated | Pharmaplan (Pty) Ltd | B0572 | S3 |
| Probenecid | Colchicine houde, Proben | Not stated | 2 applicants | 2 registrations | S3 |
| Propiverine | Detrunorm, Detrunorm« paed, Detrunorm xl | 15mg | 2 applicants | 3 registrations | S3 |
| Propranolol | Dynablok, Cardiblok, Indoblok, +10 more | 10mg, 10 mg, 40mg, 40 mg, +3 more | 12 applicants | 25 registrations | S3 |
| Protamine | Protamine sulphate bp | injection | Pharmacare limited û woodmead | H0813 | S3 |
| Raloxifene | Evista, Evenne, Raltivis, +3 more | Not stated | 4 applicants | 6 registrations | S3 |
| Ramipril | Ramipril-hexal, Retace, Vanicon, +15 more | 1,25 mg, 2,5 mg, 5 mg, 10 mg | 13 applicants | 51 registrations | S3 |
| Raubasine Cancelled | Melanex | Not stated | Boehringer Mannheim (SA) (Pty) Ltd | H0641 | S3 |
| Repaglinide Cancelled | Novonorm, Normidab | 0,5 mg, 1,0 mg, 1 mg, 2,0 mg, +1 more | 2 applicants | 6 registrations | S3 |
| Reserpine | Lennon-reserpine | Not stated | Pharmacare limited û woodmead | B0886 | S3 |
| Risedronate | Actamax, Dronex, Osteonel once-a-week, +5 more | 35 mg | 7 applicants | 8 registrations | S3 |
| Sacubitril | Arnizyd, Valsartan sacubitril zydus, Sacubitril valsartan cipla, +6 more | 24/26 mg, 24/26, 24 mg/ 26 mg, 24 mg/26 mg, +10 more | 4 applicants | 24 registrations | S3 |
| Sacubitril valsartan sodium | Entresto, Vymada | 50 mg, 100 mg, 200 mg | Novartis South Africa (Pty) Ltd | 6 registrations | S3 |
| Saxagliptin | Onglyza | 2,5, 5 | Astrazeneca Pharmaceuticals (Pty) Ltd | 2 registrations | S3 |
| Sitagliptin | Januvia, Sitagliptin teva, Sitagliptin zydus, +15 more | 25 mg, 50 mg, 50/1 000, 100 mg | 13 applicants | 52 registrations | S3 |
| Sodium chloride | Sodium chloride fresenius | 0,45 g, 200 ml | Fresenius Kabi Manufacturing SA (Pty) Ltd | 3 registrations | S3 |
| Sodium valproate | Eprolep cr, Navalpro liquid, Navalpro, +1 more | 200mg, 200 mg/5 ml, 300, 400 mg/4 ml, +1 more | 3 applicants | 6 registrations | S3 |
| Solifenacin | Trunace, Bulapt, Enirlad, +13 more | 5 mg, 10 mg | 10 applicants | 30 registrations | S3 |
| Sotalol | Sotahexal | 80, 160 | Sandoz South Africa (Pty) Ltd | 2 registrations | S3 |
| Spironolactone | Spironolactone accord, Spironolactone unicorn, Jubactone fc, +5 more | 25 mg, 100mg, 100 mg | 7 applicants | 15 registrations | S3 |
| Sulindac | Sulindac biotech, Garec-sulindac, Apotex-sulindac, +2 more | 150 mg, 200 mg, tablets | 4 applicants | 6 registrations | S3 |
| Sulthiame | Ospolot | Not stated | Bayer (Pty) Ltd (Animal Health Division) | B0868 | S3 |
| Telmisartan | Semintra, Semintra for cats, Micardis, +16 more | 10mg/ml, 20 mg, 40 mg, 80 mg | 12 applicants | 38 registrations | S3 |
| Telmisartan usp Cancelled | Lesirta co | 40/12,5, 80/12,5 | Aurogen South Africa (Pty) Ltd | 2 registrations | S3 |
| Tenoxicam | Tobitil | tablets | Innovata pharmaceuticals | 310608 | S3 |
| Terazosin | Hytrin, Apex-terazosin, Terapress | 1 mg, 2 mg, 5 mg, 10 mg | 2 applicants | 12 registrations | S3 |
| Ticagrelor | Brilinta, Mybrinta, Ticakem, +4 more | 90 mg | 5 applicants | 7 registrations | S3 |
| Timolol | Timoptol-xe, Oglasan xe, Timoptol | 0,5%, 2.5 mg/ 5.0 mg, 2.5mg / 5mg | 2 applicants | 4 registrations | S3 |
| Tiotropium | Spiriva, Forvent, Spiriva respimat, +5 more | 10, 16 micrograms, 18 | 4 applicants | 8 registrations | S3 |
| Tolbutamide Cancelled | Artosin, Tydadex | Not stated | 2 applicants | 2 registrations | S3 |
| Tolfenamic acid | Tolfedine injectable, Tolfedine | 20 mg, 60 mg | Vetpharma (Pty) Ltd | 3 registrations | S3 |
| Tolterodine l-tartrate | Detrusitol sr | 2 mg, 4 mg | Viatris Healthcare (Pty) Ltd | 2 registrations | S3 |
| Topiramate | Topamax, Topamax sc, Adco topiramate, +15 more | 15 mg, 25 mg, 25/50/100/200 mg, 25 mg / 50 mg /100 mg, +4 more | 11 applicants | 59 registrations | S3 |
| Torasemide | Unat, Auro-torasemide, Risat, +3 more | 2,5 mg, 5 mg, 5 mg / 10 mg / 20 mg, 10 mg, +1 more | 5 applicants | 16 registrations | S3 |
| Trandolapril | Mavik, Tarka, Trandopress, +4 more | 0,5 mg, 1 mg, 2 mg, 4 mg, +2 more | 4 applicants | 24 registrations | S3 |
| Trifarotene | Aklief | 50 μg | Galderma Laboratories S.A. (Pty) Ltd | 561007 | S3 |
| Tropicamide | Mydriacyl, Mydriaticum, Minims tropicamide | 0,5 mℓ, 1 % | 3 applicants | 3 registrations | S3 |
| Ug ethinyl estradiol and | Triphasil | 50 μg/30 μg ; 75 μg /40 μg ; 125 μg /30 μg | Pharmacare limited û woodmead | N0040 | S3 |
| Ursodeoxycholic acid | Ursofalk, Ursotan | Not stated | 2 applicants | 2 registrations | S3 |