Topiramate

Sold as Topamax, Topamax sc, Adco topiramate, Topiramate MSQ, Sencresus, Topalex, Epitoz, Topiran, Topiramate unicorn, Zydus topiramate sprinkles, Covan-toprax, Restan topiramate, Pamiram, Epimate, Topiramate unimed, Sandoz topiramate, Toplep, Piramax

C₁₂H₂₁NO₈S339.36 g/mol

[(1R,2S,6S,9R)-4,4,11,11-Tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-6-yl]methyl sulfamate

Drag to rotate. Structure from PubChem CID 5284627.

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Registration

Applicants: 11
Registrations: 59
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Janssen Pharmaceutica (Pty) Ltd	Topamax, Topamax sc, Topalex	15 mg, 25 mg, 50 mg, 100 mg, 200 mg	300236, 300237, 300238, 300239, 320662, 320663, 320664, 410622, 410623, 410624	S3	None
Adcock ingram limited11 of 12 cancelled	Adco topiramate, Covan-toprax, Restan topiramate	25 mg, 50 mg, 100 mg, 200 mg	410149, 410150, 410151, 410152, 420806, 420807, 420808, 420809, 420810, 420811, 420812, 420813	S3	None
LHC Pharmaceuticals (Pty) Ltd	Topiramate MSQ	25, 50, 100	410443, 410444, 431142	S3	None
Trinity Pharma (Pty) Ltd	Sencresus, Epimate	25/50/100/200 mg, 25, 50, 100, 200	410473, 410474, 410475, 410476, 430823, 430824, 430825, 430826	S3	PI PIL
Zydus Healthcare (Pty) LtdCertificate held by Zydus Healthcare SA (Pty) Ltd	Epitoz, Topiramate unicorn, Zydus topiramate sprinkles	25 mg / 50 mg /100 mg, 25	410711, 410712, 410713, 420277, 420278, 420279, 420453	S3	PI PIL
Pharmacare limited û woodmead	Topiran	25 mg, 50 mg, 100 mg, 200 mg	410846, 410847, 410858, 410859	S3	None
Ascendis Pharma (Pty) Ltd	Pamiram	25, 50, 100, 200	420827, 420828, 420829, 420830	S3	None
Unimed Healthcare (Pty) Ltd	Topiramate unimed	25, 50, 100	A400118, A400119, A400120	S3	None
Sandoz South Africa (Pty) Ltd	Sandoz topiramate	200	A400121	S3	None
Ranbaxy (SA) (Pty) LtdCertificate held by Ranbaxy Pharmaceuticals {Pty) Ltd	Toplep	25mg/50mg/100mg/200mg	A400348, A400349, A400350, A400351	S3	PI PIL
Cipla Medpro (Pty) LtdCancelled	Piramax	25, 100, 200	A400471, A400472, A400473	S3	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Topamax 25 MG EACH TABLET CONTAINS TOPIRAMATE 25 mg	25 mg	30023630/2.5/0236	Registered	S3	None
Topamax 50 MG EACH TABLET CONTAINS TOPIRAMATE 50 mg	50 mg	30023730/2.5/0237	Registered	S3	None
Topamax 100 MG EACH TABLET CONTAINS TOPIRAMATE 100 mg	100 mg	30023830/2.5/0238	Registered	S3	None
Topamax 200 MG EACH TABLET CONTAINS TOPIRAMATE 200 mg	200 mg	30023930/2.5/0239	Registered	S3	None
Topamax sc 15 MG EACH CAPSULE CONTAINS TOPIRAMATE 15,0 mg	15 mg	32066232/2.5/0662	Registered	S3	None
Topamax sc 25 MG EACH CAPSULE CONTAINS TOPIRAMATE 25,0 mg	25 mg	32066332/2.5/0663	Registered	S3	None
Topamax sc 50 MG EACH CAPSULE CONTAINS TOPIRAMATE 50,0 mg	50 mg	32066432/2.5/0664	Registered	S3	None
Adco topiramate tablets 25 MG EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25 mgTablets	41014941/2.5/0149	Cancelled	S3	None
Adco topiramate tablets 50 MG EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	50 mgTablets	41015041/2.5/0150	Cancelled	S3	None
Adco topiramate tablets 100 MG EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	100 mgTablets	41015141/2.5/0151	Cancelled	S3	None
Adco topiramate tablets 200 MG EACH TABLET CONTAINS TOPIRAMATE 200,0 mg	200 mgTablets	41015241/2.5/0152	Cancelled	S3	None
Topiramate 25 MSQ EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25	41044341/2.5/0443	Registered	S3	None
Topiramate 100 MSQ EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	100	41044441/2.5/0444	Registered	S3	None
Sencresus 25 EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25/50/100/200 mgFilm-coated tablets.	41047341/2.5/0473Approved 24 March 2025	Registered	S3	PI PIL
Sencresus 500 EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	25/50/100/200 mgFilm-coated tablets.	41047441/2.5/0474Approved 24 March 2025	Registered	S3	PI PIL
Sencresus 100 EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	25/50/100/200 mgFilm-coated tablets.	41047541/2.5/0475Approved 24 March 2025	Registered	S3	PI PIL
Sencresus 200 EACH TABLET CONTAINS TOPIRAMATE 200,0 mg	25/50/100/200 mgFilm-coated tablets.	41047641/2.5/0476Approved 24 March 2025	Registered	S3	PI PIL
Topalex 25 MG EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25 mg	41062241/2.5/0622	Registered	S3	None
Topalex 50 MG EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	50 mg	41062341/2.5/0623	Registered	S3	None
Topalex 100 MG EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	100 mg	41062441/2.5/0624	Registered	S3	None
Epitoz 25 EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25 mg / 50 mg /100 mgFilm-coated tablets.	41071141/2.5/0711Approved 8 September 2022	Registered	S3	PI PIL
Epitoz 50 EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	25 mg / 50 mg /100 mgFilm-coated tablets.	41071241/2.5/0712Approved 8 September 2022	Registered	S3	PI PIL
Epitoz 100 EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	25 mg / 50 mg /100 mgFilm-coated tablets.	41071341/2.5/0713Approved 8 September 2022	Registered	S3	PI PIL
Topiran 50 MG EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	50 mg	41084641/2.5/0846	Registered	S3	None
Topiran 100 MG EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	100 mg	41084741/2.5/0847	Registered	S3	None
Topiran 25 MG EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25 mg	41085841/2.5/0858	Registered	S3	None
Topiran 200 MG EACH TABLET CONTAINS TOPIRAMATE 200,0 mg	200 mg	41085941/2.5/0859	Registered	S3	None
Topiramate 25 unicorn EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25 mg / 50 mg /100 mgFilm-coated tablets	42027742/2.5/0277Approved 8 September 2022	Registered	S3	PI PIL
Topiramate 50 unicorn EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	25 mg / 50 mg /100 mgFilm-coated tablets	42027842/2.5/0278Approved 8 September 2022	Registered	S3	PI PIL
Topiramate 100 unicorn EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	25 mg / 50 mg /100 mgFilm-coated tablets	42027942/2.5/0279Approved 8 September 2022	Registered	S3	PI PIL
Zydus topiramate sprinkles 25 EACH SPRINKLE CAPSULE CONTAINS TOPIRAMATE 25,0 mg	25	42045342/2.5/0453	Registered	S3	None
Covan-toprax 25 MG EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25 mg	42080642/2.5/0806	Cancelled	S3	None
Covan-toprax 50 MG EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	50 mg	42080742/2.5/0807	Cancelled	S3	None
Covan-toprax 100 MG EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	100 mg	42080842/2.5/0808	Registered	S3	None
Covan-toprax 200 MG EACH TABLET CONTAINS TOPIRAMATE 200,0 mg	200 mg	42080942/2.5/0809	Cancelled	S3	None
Restan topiramate 25 MG EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25 mg	42081042/2.5/0810	Cancelled	S3	None
Restan topiramate 50 MG EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	50 mg	42081142/2.5/0811	Cancelled	S3	None
Restan topiramate 100 MG EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	100 mg	42081242/2.5/0812	Cancelled	S3	None
Restan topiramate 200 MG EACH TABLET CONTAINS TOPIRAMATE 200,0 mg	200 mg	42081342/2.5/0813	Cancelled	S3	None
Pamiram 25 EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25	42082742/2.5/0827	Registered	S3	None
Pamiram 50 EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	50	42082842/2.5/0828	Registered	S3	None
Pamiram 100 EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	100	42082942/2.5/0829	Registered	S3	None
Pamiram 200 EACH TABLET CONTAINS TOPIRAMATE 200,0 mg	200	42083042/2.5/0830	Registered	S3	None
Epimate 25 EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25	43082343/2.5/0823	Registered	S3	None
Epimate 50 EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	50	43082443/2.5/0824	Registered	S3	None
Epimate 100 EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	100	43082543/2.5/0825	Registered	S3	None
Epimate 200 EACH TABLET CONTAINS TOPIRAMATE 200,0 mg	200	43082643/2.5/0826	Registered	S3	None
Topiramate 50 MSQ EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	50	43114243/2.5/1142	Registered	S3	None
Topiramate 25 unimed EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25	A400118A40/2.5/0118	Registered	S3	None
Topiramate 50 unimed EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	50	A400119A40/2.5/0119	Registered	S3	None
Topiramate 100 unimed EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	100	A400120A40/2.5/0120	Registered	S3	None
Sandoz topiramate 200 EACH TABLET CONTAINS TOPIRAMATE 200,0 mg	200	A400121A40/2.5/0121	Registered	S3	None
Toplep 25 EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25mg/50mg/100mg/200mgTablet. Oral solution	A400348A40/2.5/0348Approved 16 May 2022	Registered	S3	PI PIL
Toplep 50 EACH TABLET CONTAINS TOPIRAMATE 50,0 mg	25mg/50mg/100mg/200mgTablet. Oral solution	A400349A40/2.5/0349Approved 16 May 2022	Registered	S3	PI PIL
Toplep 100 EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	25mg/50mg/100mg/200mgTablet. Oral solution	A400350A40/2.5/0350Approved 16 May 2022	Registered	S3	PI PIL
Toplep 200 EACH TABLET CONTAINS TOPIRAMATE 200,0 mg	25mg/50mg/100mg/200mgTablet. Oral solution	A400351A40/2.5/0351Approved 16 May 2022	Registered	S3	PI PIL
Piramax 25 EACH TABLET CONTAINS TOPIRAMATE 25,0 mg	25	A400471A40/2.5/0471	Cancelled	S3	None
Piramax 100 EACH TABLET CONTAINS TOPIRAMATE 100,0 mg	100	A400472A40/2.5/0472	Cancelled	S3	None
Piramax 200 EACH TABLET CONTAINS TOPIRAMATE 200,0 mg	200	A400473A40/2.5/0473	Cancelled	S3	None

Regulatory status

Where S3 sits on the scale

S0S1S2S3S4S5S6S7S8

Needs a doctor's prescription, dispensed by a pharmacist.

Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S3, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Topiramate

S3: Topiramate
Consolidated Schedules 06 July 2026, line 4341

Pharmacological class: Anticonvulsants, including anti-epileptics. (class 2.5)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

Sencresus 25, Trinity Pharma (Pty) Ltd is scheduled S3 in its official SAHPRA documents, read with 90% confidence.

Professional information (PI)For healthcare professionalsSencresus 25, Trinity Pharma (Pty) Ltd Patient information leaflet (PIL)For patients and carersSencresus 25, Trinity Pharma (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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