Captopril

Sold as Capace, Adco-captopril, Mylan captopril, Zapto, Captohexal, Parke-med captopril, Bio captopril, Bio-captopril, Captopril biotech, Captopril ascendis, Cardiace, Merck-captopril, Tensiomin-cor

C₉H₁₅NO₃S217.29 g/mol

(2S)-1-[(2S)-2-Methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid

Drag to rotate. Structure from PubChem CID 44093.

Loading Wikipedia summary

Registration

Applicants: 11
Registrations: 23
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Pharmacare limited û woodmead	Capace	25 mg	270398	S3	None
Adcock ingram limitedCancelled	Adco-captopril, Parke-med captopril	25 mg, 50 mg, 50 mg -	270593, 270594, 310645	S3	None
Viatris Healthcare (Pty) Ltd	Mylan captopril	12,5 mg/ 25 mg / 50 mg	290228, 320528	S3	PI PIL
Acino Pharma (Pty) LtdCancelled	Zapto	25, 50	290396, 290416	S3	None
Hexal Pharma (SA) (Pty) Ltd1 of 2 cancelled	Captohexal	12,5, 50	310039, 310041	S3	None
Biotech Laboratories (Pty) Ltd	Bio captopril, Bio-captopril	12,5 mg, 25, 50 mg	310657, 310658, 310659	S3	None
Arya Pharma (Pty) Ltd	Captopril biotech	25 mg, 50 mg	320006, 320007	S3	None
Ascendis Pharma (Pty) Ltd	Captopril ascendis	25, 50	320107, 320108	S3	None
Triomed (Pty) LtdCancelled	Cardiace	12,5, 25,0, 50,0	320346, 320347, 320348	S3	None
Viatris South Africa (Pty) Ltd	Merck-captopril	12,5	320545	S3	None
Elttab Pharmaceuticals CCCancelled	Tensiomin-cor	25 mg, 50 mg	330278, 330279	S3	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Capace 25 MG EACH TABLET CONTAINS CAPTOPRIL 25 mg	25 mg	27039827/7.1/0398	Registered	S3	None
Adco-captopril 25 MG EACH TABLET CONTAINS CAPTOPRIL 25 mg	25 mg	27059327/7.1/0593	Cancelled	S3	None
Adco-captopril 50 MG EACH TABLET CONTAINS CAPTOPRIL 50 mg	50 mg	27059427/7.1/0594	Cancelled	S3	None
Mylan captopril 25 EACH TABLET CONTAINS CAPTOPRIL 25 mg	12,5 mg/ 25 mg / 50 mgWhite capsule-shaped tablet	29022829/7.1/0228Approved 18 October 2024	Registered	S3	PI PIL
Zapto-50 EACH TABLET CONTAINS CAPTOPRIL 50 mg	50	29039629/7.1/0396	Cancelled	S3	None
Zapto-25 EACH TABLET CONTAINS CAPTOPRIL 25 mg	25	29041629/7.1/0416	Cancelled	S3	None
Captohexal 12,5 EACH TABLET CONTAINS CAPTOPRIL 12,5 mg	12,5	31003931/7.1/0039	Registered	S3	None
Captohexal 50 EACH TABLET CONTAINS CAPTOPRIL 50 mg	50	31004131/7.1/0041	Cancelled	S3	None
Parke-med - captopril 50 MG EACH TABLET CONTAINS CAPTOPRIL A 50,0 mg	50 mg -	31064531/7.1/0645	Cancelled	S3	None
Bio captopril 12,5 MG each tablet CONTAINS CAPTOPRIL 12,5 mg	12,5 mg	31065731/7.1/0657	Registered	S3	None
Bio-captopril 25 EACH TABLET CONTAINS CAPTOPRIL 25,0 mg	25	31065831/7.1/0658	Registered	S3	None
Bio captopril 50 MG EACH TABLET CONTAINS CAPTOPRIL 50,0 mg	50 mg	31065931/7.1/0659	Registered	S3	None
Captopril 25 MG biotech EACH TABLET CONTAINS CAPTOPRIL 25,0 mg	25 mg	32000632/7.1/0006	Registered	S3	None
Captopril 50 MG biotech EACH TABLET CONTAINS CAPTOPRIL 50,0 mg	50 mg	32000732/7.1/0007	Registered	S3	None
Captopril 25 ascendis EACH TABLET CONTAINS CAPTOPRIL 25,0 mg	25	32010732/7.1/0107	Registered	S3	None
Captopril 50 ascendis EACH TABLET CONTAINS CAPTOPRIL 50,0 mg	50	32010832/7.1/0108	Registered	S3	None
Cardiace 12,5 EACH TABLET CONTAINS CAPTOPRIL 12,50 mg	12,5	32034632/7.1/0346	Cancelled	S3	None
Cardiace 25,0 EACH TABLET CONTAINS CAPTOPRIL 25,0 mg	25,0	32034732/7.1/0347	Cancelled	S3	None
Cardiace 50,0 EACH TABLET CONTAINS CAPTOPRIL 50,0 mg	50,0	32034832/7.1/0348	Cancelled	S3	None
Mylan captopril 50 EACH TABLET CONTAINS CAPTOPRIL 50,0 mg	12,5 mg/ 25 mg / 50 mgWhite capsule-shaped tablet	32052832/7.1/0528Approved 18 October 2024	Registered	S3	PI PIL
Merck-captopril 12,5 EACH TABLET CONTAINS CAPTOPRIL 12,5 mg	12,5	32054532/7.1/0545	Registered	S3	None
Tensiomin-cor 25 MG EACH TABLET CONTAINS CAPTOPRIL 25,0 mg	25 mg	33027833/7.1/0278	Cancelled	S3	None
Tensiomin-cor 50 MG EACH TABLET CONTAINS CAPTOPRIL 50,0 mg	50 mg	33027933/7.1/0279	Cancelled	S3	None

Regulatory status

Where S3 sits on the scale

S0S1S2S3S4S5S6S7S8

Needs a doctor's prescription, dispensed by a pharmacist.

Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S3, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Captopril

S3: Captopril
Consolidated Schedules 06 July 2026, line 3280

Pharmacological class: Vasodilators, hypotensive, antihypertensive medicines include other antihypertensive medicines e.g. ACE-inhibitors, ARBs, RAAS, etc] (class 7.1)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsMylan captopril 25, Viatris Healthcare (Pty) Ltd Patient information leaflet (PIL)For patients and carersMylan captopril 25, Viatris Healthcare (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

Loading PubMed articles

Background