Lamotrigine

Sold as Lamictin p5, Lamictin p25, Lamictin, Lamictin p50, Lametec, Lamictin p2, Lamitor, Trinity lamotrigine, Girotec, AURO lamotrigine, Girotec-d, Zesiton, Lamidus odt, Lamotrigine kiara, Serinem, Rigadel, Lamotrigine accord, Epitec, Aspen lamotrigine, Lamotrigine unimed, Merck-lamotrigine, Lamotrigine MSQ, Toclon, Lamilepsy, Adco-mictrin, Lamotrigine austell, Lamidus, Zydus lamotrigine, Zydus-lamotrigine

C₉H₇Cl₂N₅256.09 g/mol

6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine

Drag to rotate. Structure from PubChem CID 3878.

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Registration

Applicants: 18
Registrations: 101
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Glaxosmithkline South Africa (Pty) Limited2 of 8 cancelled	Lamictin p5, Lamictin p25, Lamictin, Lamictin p50, Lamictin p2	25, 50, 100, 200	290303, 290304, 290472, 320459, 360407, Z0280, Z0281, Z0282	S3	None
Cipla Medpro (Pty) Ltd1 of 5 cancelled	Lametec, Epitec	25, 50, 100, 200	350143, A380571, A380572, A380573, A380574	S3	None
Dr Reddyæs Laboratories (Pty) LtdCertificate held by Dr. Reddy’s Laboratories (Pty) Ltd.	Lamitor	25, 50, 100, 200	370051, 370052, 370053, 410375	S3	PI
Trinity Pharma (Pty) Ltd	Trinity lamotrigine	25, 50, 100, 200	410705, 410706, 410707, 410708	S3	None
Aurogen South Africa (Pty) Ltd	Girotec, AURO lamotrigine, Girotec-d, Zesiton, Lamidus odt	5 mg, 25 mg, 50 mg, 100 mg, 200 mg	430047, 430048, 430049, 430050, 430051, 430053, 430054, 450627, 450628, 450629, 450630, 450631, 450632, 450633, 450634, 450635, 450636, 450637, 450638, 450639, 450640, 450641	S3	None
Unichem SA (Pty) Ltd	Lamotrigine kiara	25 mg, 50 mg, 100 mg, 200 mg	460408, 460409, 460410, 460411	S3	None
Unicorn Pharmaceuticals (Pty) Ltd	Serinem	25, 50, 100, 200	460412, 460413, 460414, 460415	S3	None
Dezzo Trading 392 (Pty) Ltd	Rigadel	25, 50, 100, 200	570029, 570030, 570031, 570032	S3	PI PIL
Accord Healthcare (Pty) Ltd	Lamotrigine accord	5 mg, 25 mg, 100 mg	570710, 570711, 570712	S3	None
Pharmacare limited û woodmead	Aspen lamotrigine	25 mg, 50 mg, 100 mg, 200 mg	A380585, A380586, A380587, A380588	S3	None
Unimed Healthcare (Pty) Ltd	Lamotrigine unimed	25, 50, 100, 200	A390473, A390474, A390475, A390476	S3	None
Merck Generics Rsa (Pty) Ltd	Merck-lamotrigine	2 mg, 5 mg, 25 mg, 50 mg, 100 mg, 200 mg	A390492, A390493, A390494, A390495, A400010, A400011, A400012, A400013, A400014, A400015	S3	None
LHC Pharmaceuticals (Pty) Ltd	Lamotrigine MSQ	25, 50, 100, 200	A400036, A400037, A400038, A400039	S3	None
Ranbaxy (SA) (Pty) LtdCancelled	Toclon	25, 50, 100, 200	A400040, A400041, A400042, A400043	S3	None
Pharma Dynamics (Pty) Ltd	Lamilepsy	25 mg, 50 mg, 100 mg, 200 mg	A400166, A400167, A400169, A400173	S3	None
Adcock ingram limitedCancelled	Adco-mictrin	50, 100, 200	A400183, A400185, A400186	S3	None
Austell Pharmaceuticals (Pty) Ltd	Lamotrigine austell	25 mg, 50 mg, 100 mg, 200 mg	A400273, A400274, A400275, A400276	S3	None
Zydus Healthcare (Pty) LtdCancelled	Lamidus, Zydus lamotrigine, Zydus-lamotrigine	50 mg, 100 mg, 200 mg	A400763, A400764, A400765, A400768, A400769, A400770	S3	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Lamictin p5 EACH TABLET CONTAINS LAMOTRIGINE 5 mg	Not listed	29030329/2.5/0303	Registered	S3	None
Lamictin p25 EACH TABLET CONTAINS LAMOTRIGINE 25 mg	Not listed	29030429/2.5/0304	Registered	S3	None
Lamictin 200 EACH TABLET CONTAINS LAMOTRIGINE 200 mg	200	29047229/2.5/0472	Registered	S3	None
Lamictin p50 EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	Not listed	32045932/2.5/0459	Cancelled	S3	None
Lametec EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	Not listed	35014335/2.5/0143	Cancelled	S3	None
Lamictin p2 EACH TABLET CONTAINS LAMOTRIGINE 2,0 mg	Not listed	36040736/2.5/0407	Cancelled	S3	None
Lamitor-25 EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25Tablets	37005137/2.5/0051Approved 31 December 2008	Registered	S3	PI
Lamitor-50 EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50Tablets	37005237/2.5/0052Approved 31 December 2008	Registered	S3	PI
Lamitor-100 EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100Tablets	37005337/2.5/0053Approved 31 December 2008	Registered	S3	PI
Lamitor-200 EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200Tablets	41037541/2.5/0375Approved 31 December 2008	Registered	S3	PI
Trinity lamotrigine 25 EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25	41070541/2.5/0705	Registered	S3	None
Trinity lamotrigine 50 EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50	41070641/2.5/0706	Registered	S3	None
Trinity lamotrigine 100 EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100	41070741/2.5/0707	Registered	S3	None
Trinity lamotrigine 200 EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200	41070841/2.5/0708	Registered	S3	None
Girotec 25 MG EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25 mg	43004743/2.5/0047	Registered	S3	None
Girotec 50 MG EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50 mg	43004843/2.5/0048	Registered	S3	None
Girotec 100 MG EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100 mg	43004943/2.5/0049	Registered	S3	None
Girotec 200 MG EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200 mg	43005043/2.5/0050	Registered	S3	None
AURO lamotrigine tablets 25 MG EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25 mgTablets	43005143/2.5/0051	Registered	S3	None
AURO lamotrigine tablets 100 MG EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100 mgTablets	43005343/2.5/0053	Registered	S3	None
AURO lamotrigine tablets 200 MG EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200 mgTablets	43005443/2.5/0054	Registered	S3	None
Girotec-d 5 MG EACH TABLET CONTAINS LAMOTRIGINE 5,0 mg	5 mg	45062745/2.5/0627	Registered	S3	None
Girotec-d 25 MG EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25 mg	45062845/2.5/0628	Registered	S3	None
Girotec-d 50 MG EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50 mg	45062945/2.5/0629	Registered	S3	None
Girotec-d 100 MG tablet EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100 mgTablet	45063045/2.5/0630	Registered	S3	None
Girotec-d 200 MG tablet EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200 mgTablet	45063145/2.5/0631	Registered	S3	None
Zesiton 5 MG tablet EACH TABLET CONTAINS LAMOTRIGINE 5,0 mg	5 mgTablet	45063245/2.5/0632	Registered	S3	None
Zesiton 25 MG tablet EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25 mgTablet	45063345/2.5/0633	Registered	S3	None
Zesiton 50 MG tablet EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50 mgTablet	45063445/2.5/0634	Registered	S3	None
Zesiton 100 MG tablet EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100 mgTablet	45063545/2.5/0635	Registered	S3	None
Zesiton 200 MG tablet EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200 mgTablet	45063645/2.5/0636	Registered	S3	None
Lamidus 5 MG odt EACH TABLET CONTAINS LAMOTRIGINE 5,0 mg	5 mg	45063745/2.5/0637	Registered	S3	None
Lamidus 25 MG odt EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25 mg	45063845/2.5/0638	Registered	S3	None
Lamidus 50 MG odt EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50 mg	45063945/2.5/0639	Registered	S3	None
Lamidus 100 MG odt EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100 mg	45064045/2.5/0640	Registered	S3	None
Lamidus 200 MG odt EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200 mg	45064145/2.5/0641	Registered	S3	None
Lamotrigine 25 MG kiara EACH TABLET CONTAINS :LAMOTRIGINE 25,0 mg	25 mg	46040846/2.5/0408	Registered	S3	None
Lamotrigine 50 MG kiara EACH TABLET CONTAINS :LAMOTRIGINE 50,0 mg	50 mg	46040946/2.5/0409	Registered	S3	None
Lamotrigine 100 MG kiara EACH TABLET CONTAINS :LAMOTRIGINE 100,0 mg	100 mg	46041046/2.5/0410	Registered	S3	None
Lamotrigine 200 MG kiara EACH TABLET CONTAINS :LAMOTRIGINE 200,0 mg	200 mg	46041146/2.5/0411	Registered	S3	None
Serinem 25 EACH TABLET CONTAINS :LAMOTRIGINE 25,0 mg	25	46041246/2.5/0412	Registered	S3	None
Serinem 50 EACH TABLET CONTAINS :LAMOTRIGINE 50,0 mg	50	46041346/2.5/0413	Registered	S3	None
Serinem 100 EACH TABLET CONTAINS :LAMOTRIGINE 100,0 mg	100	46041446/2.5/0414	Registered	S3	None
Serinem 200 EACH TABLET CONTAINS :LAMOTRIGINE 200,0 mg	200	46041546/2.5/0415	Registered	S3	None
Rigadel 25 EACH TABLET LAMOTRIGINE 25,0 mg	25Tablet	57002957/2.5/0029Approved 27 September 2022	Registered	S3	PI PIL
Rigadel 50 EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50Tablet	57003057/2.5/0030Approved 27 September 2022	Registered	S3	PI PIL
Rigadel 100 EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100Tablet	57003157/2.5/0031Approved 27 September 2022	Registered	S3	PI PIL
Rigadel 200 EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200Tablet	57003257/2.5/0032Approved 27 September 2022	Registered	S3	PI PIL
Lamotrigine 5 MG accord EACH TABLET CONTAINS: LAMOTRIGINE 5,0 mg	5 mg	57071057/2.5/0710	Registered	S3	None
Lamotrigine 25 MG accord EACH TABLET CONTAINS: LAMOTRIGINE 25,0 mg	25 mg	57071157/2.5/0711	Registered	S3	None
Lamotrigine 100 MG accord EACH TABLET CONTAINS: LAMOTRIGINE 100,0 mg	100 mg	57071257/2.5/0712	Registered	S3	None
Epitec 25 EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25	A380571A38/2.5/0571	Registered	S3	None
Epitec 50 EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50	A380572A38/2.5/0572	Registered	S3	None
Epitec 100 EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100	A380573A38/2.5/0573	Registered	S3	None
Epitec 200 EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200	A380574A38/2.5/0574	Registered	S3	None
Aspen lamotrigine 25 MG EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25 mg	A380585A38/2.5/0585	Registered	S3	None
Aspen lamotrigine 50 MG EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50 mg	A380586A38/2.5/0586	Registered	S3	None
Aspen lamotrigine 100 MG EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100 mg	A380587A38/2.5/0587	Registered	S3	None
Aspen lamotrigine 200 MG EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200 mg	A380588A38/2.5/0588	Registered	S3	None
Lamotrigine 25 unimed EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25	A390473A39/2.5/0473	Registered	S3	None
Lamotrigine 50 unimed EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50	A390474A39/2.5/0474	Registered	S3	None
Lamotrigine 100 unimed EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100	A390475A39/2.5/0475	Registered	S3	None
Lamotrigine 200 unimed EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200	A390476A39/2.5/0476	Registered	S3	None
Merck-lamotrigine 25 MG EACH TABLET CONTAINS :LAMOTRIGINE 25,0 mg	25 mg	A390492A39/2.5/0492	Registered	S3	None
Merck-lamotrigine 50 MG EACH TABLET CONTAINS: LAMOTRIGINE 50,0 mg	50 mg	A390493A39/2.5/0493	Registered	S3	None
Merck-lamotrigine 100 MG EACH TABLET CONTAINS: LAMOTRIGINE 100,0 mg	100 mg	A390494A39/2.5/0494	Registered	S3	None
Merck-lamotrigine 200 MG EACH TABLET CONTAINS :LAMOTRIGINE 200,0 mg	200 mg	A390495A39/2.5/0495	Registered	S3	None
Merck-lamotrigine dispersible 2 MG EACH TABLET CONTAINS LAMOTRIGINE 2,0 mg	2 mgDispersible	A400010A40/2.5/0010	Registered	S3	None
Merck-lamotrigine dispersible 5 MG EACH TABLET CONTAINS LAMOTRIGINE 5,0 mg	5 mgDispersible	A400011A40/2.5/0011	Registered	S3	None
Merck-lamotrigine dispersible 25 MG EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25 mgDispersible	A400012A40/2.5/0012	Registered	S3	None
Merck-lamotrigine dispersible 50 MG EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50 mgDispersible	A400013A40/2.5/0013	Registered	S3	None
Merck-lamotrigine dispersible 100 MG EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100 mgDispersible	A400014A40/2.5/0014	Registered	S3	None
Merck-lamotrigine dispersible 200 MG EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200 mgDispersible	A400015A40/2.5/0015	Registered	S3	None
Lamotrigine 25 MSQ EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25	A400036A40/2.5/0036	Registered	S3	None
Lamotrigine 50 MSQ EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50	A400037A40/2.5/0037	Registered	S3	None
Lamotrigine 100 MSQ EACH TABLET CONTAINS: LAMOTRIGINE 100,0 mg	100	A400038A40/2.5/0038	Registered	S3	None
Lamotrigine 200 MSQ EACH TABLET CONTAINS:LAMOTRIGINE 200,0 mg	200	A400039A40/2.5/0039	Registered	S3	None
Toclon 25 EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25	A400040A40/2.5/0040	Cancelled	S3	None
Toclon 50 EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50	A400041A40/2.5/0041	Cancelled	S3	None
Toclon 100 EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100	A400042A40/2.5/0042	Cancelled	S3	None
Toclon 200 EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200	A400043A40/2.5/0043	Cancelled	S3	None
Lamilepsy 100 MG EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100 mg	A400166A40/2.5/0166	Registered	S3	None
Lamilepsy 200 MG EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200 mg	A400167A40/2.5/0167	Registered	S3	None
Lamilepsy 50 MG EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50 mg	A400169A40/2.5/0169	Registered	S3	None
Lamilepsy 25 MG EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25 mg	A400173A40/2.5/0173	Registered	S3	None
Adco-mictrin 200 EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200	A400183A40/2.5/0183	Cancelled	S3	None
Adco-mictrin 50 EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50	A400185A40/2.5/0185	Cancelled	S3	None
Adco-mictrin 100 EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100	A400186A40/2.5/0186	Cancelled	S3	None
Lamotrigine 25 MG austell EACH TABLET CONTAINS LAMOTRIGINE 25,0 mg	25 mg	A400273A40/2.5/0273	Registered	S3	None
Lamotrigine 50 MG austell EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50 mg	A400274A40/2.5/0274	Registered	S3	None
Lamotrigine 100 MG austell EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100 mg	A400275A40/2.5/0275	Registered	S3	None
Lamotrigine 200 MG austell EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200 mg	A400276A40/2.5/0276	Registered	S3	None
Lamidus 50 EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50	A400763A40/2.5/0763	Cancelled	S3	None
Lamidus 100 EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100	A400764A40/2.5/0764	Cancelled	S3	None
Lamidus 200 EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200	A400765A40/2.5/0765	Cancelled	S3	None
Zydus lamotrigine 50 MG tablets EACH TABLET CONTAINS LAMOTRIGINE 50,0 mg	50 mgTablets	A400768A40/2.5/0768	Cancelled	S3	None
Zydus-lamotrigine 100 MG tablets EACH TABLET CONTAINS LAMOTRIGINE 100,0 mg	100 mgTablets	A400769A40/2.5/0769	Cancelled	S3	None
Zydus-lamotrigine 200 MG tablets EACH TABLET CONTAINS LAMOTRIGINE 200,0 mg	200 mgTablets	A400770A40/2.5/0770	Cancelled	S3	None
Lamictin 25 EACH TABLET CONTAINS LAMOTRIGINE 25 mg	25	Z0280Z/2.5/280	Registered	S3	None
Lamictin 50 EACH TABLET CONTAINS LAMOTRIGINE 50 mg	50	Z0281Z/2.5/281	Registered	S3	None
Lamictin 100 EACH TABLET CONTAINS LAMOTRIGINE 100 mg	100	Z0282Z/2.5/282	Registered	S3	None

Regulatory status

Where S3 sits on the scale

S0S1S2S3S4S5S6S7S8

Needs a doctor's prescription, dispensed by a pharmacist.

Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S3, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Lamotrigine

S3: Lamotrigine
Consolidated Schedules 06 July 2026, line 3874

Pharmacological class: Anticonvulsants, including anti-epileptics. (class 2.5)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsLamitor-25, Dr Reddyæs Laboratories (Pty) Ltd Patient information leaflet (PIL)For patients and carersRigadel 25, Dezzo Trading 392 (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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