Alendronic acid

Sold as Boniran, Ran-alendronate, Femax, Osteonate, Aldren, Zydus alendronate, Fosadron, Accord-alendronate, Ostena, DYNA alendronate, Densate, Ossadura, Gensof, Natrebon once weekly, Osteobon, Fosagen, Merck-alendronate, Alendronate oethmaan, Densalen

C₄H₁₃NO₇P₂249.10 g/mol

(4-Amino-1-hydroxy-1-phosphonobutyl)phosphonic acid

Drag to rotate. Structure from PubChem CID 2088.

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Registration

Applicants: 15
Registrations: 24
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
MSQ Pharma (Pty) Ltd	Boniran, Ran-alendronate	10, 70	410431, 410432, 410433, 410434	S3	None
Elle pharmCertificate held by Astral Pharma (Pty) Ltd	Femax	70 mg	420221	S3	PI PIL
Pharma Dynamics (Pty) Ltd	Osteonate	70 mg	420235	S3	PI PIL
Zydus Healthcare (Pty) LtdCancelled	Aldren, Zydus alendronate	70	420236, 420276	S3	None
Innovata pharmaceuticals	Fosadron	Not stated	420410	S3	None
Accord Healthcare (Pty) Ltd	Accord-alendronate, Ostena	10, 70	421014, 421015, 421016	S3	None
Unicorn Pharmaceuticals (Pty) Ltd	DYNA alendronate	70 mg	430266	S3	None
Novagen Pharma (Pty) Ltd	Densate	70 mg	450581	S3	None
Aurogen South Africa (Pty) Ltd	Ossadura, Gensof	10 mg, 70 mg	450582, 450583, 450584, 450585	S3	None
Austell Pharmaceuticals (Pty) LtdCancelled	Natrebon once weekly	70 mg	510129	S3	None
Cipla Medpro (Pty) Ltd	Osteobon	70	A390396	S3	None
Viatris Healthcare (Pty) Ltd	Fosagen	70 mg	A390597	S3	None
Merck Generics Rsa (Pty) Ltd	Merck-alendronate	70 mg	A390598	S3	None
Oethmaan Biosims (Pty) Ltd	Alendronate oethmaan	70	A400514	S3	None
Trinity Pharma (Pty) Ltd	Densalen	70	A400515	S3	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Boniran 10 EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 10,0 mg	10	41043141/3.2/0431	Registered	S3	None
Boniran 70 EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70	41043241/3.2/0432	Registered	S3	None
Ran-alendronate 10 EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 10,0 mg	10	41043341/3.2/0433	Registered	S3	None
Ran-alendronate 70 EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70	41043441/3.2/0434	Registered	S3	None
Femax 70 EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70 mgTablets	42022142/3.2/0221Approved 21 November 2022	Registered	S3	PI PIL
Osteonate 70 MG EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70 mgTablets	42023542/3.2/0235Approved 20 July 2025	Registered	S3	PI PIL
Aldren 70 tablets EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70Tablets	42023642/3.2/0236	Cancelled	S3	None
Zydus alendronate 70 tablets EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70Tablets	42027642/3.2/0276	Cancelled	S3	None
Fosadron EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	Not listed	42041042/3.2/0410	Registered	S3	None
Accord-alendronate 70 EACH TABLET CONTAINBS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70	42101442/3.2/1014	Registered	S3	None
Ostena 10 EACH TABLET CONTAIN : ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 10,0 mg	10	42101542/3.2/1015	Registered	S3	None
Ostena 70 EACH TABLET CONTAINBS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70	42101642/3.2/1016	Registered	S3	None
DYNA alendronate 70 MG EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70 mg	43026643/3.2/0266	Registered	S3	None
Densate 70 MG EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70 mg	45058145/3.2/0581	Registered	S3	None
Ossadura 10 MG EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 10,0 mg	10 mg	45058245/3.2/0582	Registered	S3	None
Ossadura 70 MG EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70 mg	45058345/3.2/0583	Registered	S3	None
Gensof 10 MG EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 10,0 mg	10 mg	45058445/3.2/0584	Registered	S3	None
Gensof 70 MG EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70 mg	45058545/3.2/0585	Registered	S3	None
Natrebon once weekly 70 MG EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70 mg	51012951/3.2/0129	Cancelled	S3	None
Osteobon 70 EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70	A390396A39/3.2/0396	Registered	S3	None
Fosagen 70 MG EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70 mg	A390597A39/3.2/0597	Registered	S3	None
Merck-alendronate 70 MG EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70 mg	A390598A39/3.2/0598	Registered	S3	None
Alendronate 70 oethmaan EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70	A400514A40/3.2/0514	Registered	S3	None
Densalen 70 EACH TABLET CONTAINS ALENDRONATE SODIUM EQUIVALENT TO ALENDRONIC ACID 70,0 mg	70	A400515A40/3.2/0515	Registered	S3	None

Regulatory status

Where S3 sits on the scale

S0S1S2S3S4S5S6S7S8

Needs a doctor's prescription, dispensed by a pharmacist.

Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S3, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Alendronate sodium equivalent to alendronic acid

S3: Alendronic acid
Consolidated Schedules 06 July 2026, line 3126

Pharmacological class: Non-hormonal preparations. (class 3.2)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsFemax 70, Elle pharm Patient information leaflet (PIL)For patients and carersFemax 70, Elle pharm

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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