Caffeine
1,3,7-Trimethylpurine-2,6-dione
Drag to rotate. Structure from PubChem CID 2519.
Background
Listing
- Schedules
- Schedule 3, conditions apply
- Source
- Consolidated Schedules 06 July 2026
Registered medicines
36 registered products listed
Counted through the register's ingredient index, which does not reach every record.
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Caffeine, codeine, meprobamate, paracetamol | Acugesil, Astrapain forte, Vacudol forte, +27 more | 320 mg, tablets, 1 mg, capsules, +3 more | 16 applicants | 33 registrations | S5 |
| Caffeine, paracetamol, phenylephrine | Bsp cold and flu, Adco sinal ns | capsules | 2 applicants | 2 registrations | S1 to S4conditions apply |
| Caffeine, chlorpheniramine, paracetamol, phenylephrine, vitamin c | Sinustat flu, Flustat, Degoran c, +1 more | capsules, 5 mg | 4 applicants | 4 registrations | S1 to S4conditions apply |
| Caffeine, codeine, doxylamine, paracetamol | Paxidal, Tensodol, Zurich-paxidal, +20 more | 10 mg, 5 mg, 450 mg, 30 mg, effervescent, 2 mg, 5mg / 10mg / 45mg / 450mg, +3 more | 15 applicants | 24 registrations | S2 |
| Caffeine, paracetamol, vitamin c | Grippon hot relief honey lemon, Grippon hot relief ginger | Not stated | Adcock ingram limited | 2 registrations | S1 to S3conditions apply |
| Caffeine, chlorpheniramine, paracetamol, pseudoephedrine | Flusin | capsules | Pharmacare limited û woodmead | 280273 | S1 to S6conditions apply |
| Caffeine, chlorpheniramine, ephedrine, paracetamol | Sinuend, Flusin, Sinucon | 200 mg/6 mg/ 20 mg/2 mg | 2 applicants | 3 registrations | S2 |
| Aspirin, caffeine, paracetamol | Compral pain, Aspimol, Excedrin, +16 more | 324 mg, powders, tablets, 500 mg | 6 applicants | 22 registrations | S0 |
| Aspirin, caffeine | Paneze, Fams aspirin compound, Anadin, +12 more | tablets, 77, 400.0 mg, powders, +1 more | 11 applicants | 15 registrations | S2 to S3conditions apply |
| Ascorbic acid, aspirin, caffeine | Medi soothe with vitamin c lemon, Fluexprin c cold & flu lemon | Not stated | Pharmacare limited û woodmead | 2 registrations | S1 to S3conditions apply |
| Caffeine | Cayona, Cafcit, Antisom, +5 more | 5 mg, 20 mg/ml, tablets | 7 applicants | 8 registrations | S3 |
| Caffeine, paracetamol | Calpol extra, Mlungisi-verlig, Paracaff | tablets | 3 applicants | 3 registrations | S1 to S3conditions apply |
Show the other 24 registered products
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Aspirin, caffeine, vitamin c Cancelled | L.C.C. Ginger medicated cold and flu remedy, L.C.C. Honey lemon medicated cold and flu remedy | Not stated | Adcock ingram limited | 2 registrations | S1 to S3conditions apply |
| Caffeine, codeine, paracetamol, phenyltoloxamine Cancelled | Suncodin | tablets | Sanofi-aventis South Africa (Pty) Ltd | B0697 | S1 to S6conditions apply |
| Caffeine, dextropropoxyphene, paracetamol | Zomax | Not stated | Adcock ingram limited | B0882 | S1 to S6conditions apply |
| Caffeine, codeine, paracetamol | Biopyn, Antipyn, Docdol, +1 more | tablets | 3 applicants | 4 registrations | S1 to S6conditions apply |
| Aspirin, caffeine, codeine, paracetamol | Tenston, Propain co | tablets | Adcock ingram limited | 2 registrations | S1 to S6conditions apply |
| Aspirin, caffeine, phenacetin Cancelled | Aspirin compound bpc, A p c nitro brand | tablets | 2 applicants | 2 registrations | S2 to S4conditions apply |
| Aspirin, caffeine, chlorpheniramine, dextropropoxyphene, paracetamol Cancelled | Propoxan | Not stated | Keatings | B1542 | S1 to S6conditions apply |
| Caffeine, chlorpheniramine, paracetamol, phenylephrine | Degoran plus, Grippon cold and flu, Histacon | capsules | 2 applicants | 3 registrations | S1 to S4conditions apply |
| Caffeine, codeine, paracetamol, pheniramine, phenylephrine Cancelled | Flupac | Not stated | The Premier Pharmaceutical Co Ltd | C0685 | S1 to S6conditions apply |
| Aspirin, caffeine, chlorpheniramine, phenylephrine | Dristan | tablet | Pfizer Laboratories (Pty) Ltd | C0717 | S1 to S4conditions apply |
| Ascorbic acid, caffeine, chlorpheniramine, paracetamol, phenylephrine | Grippon, Dristan cold & flu | capsules | 2 applicants | 2 registrations | S1 to S4conditions apply |
| Atropine, caffeine, chlorpheniramine, paracetamol, phenylephrine, vitamin c | Colstat | 300 mg | Lebasi Pharmaceuticals (Pty) Ltd | C0955 | S2 |
| Caffeine, mepyramine, paracetamol, phenylephrine Cancelled | Cetamine | Not stated | The Premier Pharmaceutical Co Ltd | D0031 | S1 to S4conditions apply |
| Caffeine, mepyramine, promethazine | Histodor | Not stated | Pharmacare limited û woodmead | E0125 | S2 to S3conditions apply |
| Ascorbic acid, caffeine, ephedrine, thiamine, vitamin a Cancelled | Be-leane slimming | capsules | The Premier Pharmaceutical Co Ltd | E1251 | S1 to S6conditions apply |
| Caffeine, codeine, diphenhydramine, paracetamol | Propain, Diphagesic, Forte pain, +2 more | powders, 10 mg/5 mg/400 mg/50 mg, tablets | 3 applicants | 5 registrations | S2 |
| Ascorbic acid, atropine, caffeine, chlorpheniramine, paracetamol, phenylephrine | Famucaps | 2 mg | Brunel Laboratoria (Pty) Ltd | G1235 | S2 |
| Caffeine, nicotinic acid, nux vomica Cancelled | Force x | Not stated | Astley Laboratories S.A (Pty) Ltd | G2545 | S1 to S4conditions apply |
| Caffeine, nicotinic acid Cancelled | No hot blood & bangalala | 1 | J L Rosenberg (Pty) Ltd * | G2599 | S1 to S4conditions apply |
| Caffeine, ergotamine | Cafergot | Not stated | Pharmaco Distribution (Pty) Ltd | H0538 | S2 to S3conditions apply |
| Belladonna alkaloids, butalbital, caffeine, ergotamine Cancelled | Cafergot-pb | Not stated | Pharmaco Distribution (Pty) Ltd | H0582 | S1 to S6conditions apply |
| Aspirin, caffeine, chlorpheniramine, vitamin c | Nitroflu cold and flu, Ultraviro c | capsules | 2 applicants | 2 registrations | S1 to S3conditions apply |
| Anhydrous, caffeine, chlorpheniramine, paracetamol, phenylephrine, vitamin c Cancelled | Cepacol cold | capsules | Adcock ingram limited | R0247 | S1 to S4conditions apply |
| Anhydrous, caffeine, codeine, meprobamate, paracetamol Cancelled | Painagon | tablets | Ranbaxy (SA) (Pty) Ltd | R0270 | S1 to S6conditions apply |
24 more registered products name Caffeine in their active ingredient
Show the other 12 registered products
Regulatory status
Where S3 sits on the scale
Needs a doctor's prescription, dispensed by a pharmacist.
Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S3, as the Consolidated Schedules list it.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Caffeine
S3: Caffeine
- when intended for injection.
Consolidated Schedules 06 July 2026, line 3256
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.