Schedule 1 (S1) medicines in South Africa
Sold by a pharmacist, no doctor's prescription needed.
About S1 Drugs
Where S1 sits on the scale
Sold by a pharmacist, no doctor's prescription needed.
Schedule 1 medicines are normally sold by a pharmacist, or by a supervised pharmacist intern or assistant, without a doctor's visit; a veterinarian, or a licensed dispensing doctor, dentist or nurse prescriber, may also supply them. A nurse or other non-doctor prescriber may only prescribe the specific substances the Schedule names for that purpose, and may only dispense them if licensed to do so. A child under 12 may only be sold one of these medicines on a prescription, or on a written order that names the purpose and carries a signature the seller recognises.
Cited: Act s22A(4), s22A(4)(b)
Who may supply
A pharmacist, or a supervised pharmacist intern or assistant; manufacturers and wholesalers supplying people who may lawfully possess it; a veterinarian, who may prescribe, compound or dispense it; a medical practitioner or dentist, who may prescribe it, and may compound or dispense it only if licensed under section 22C(1)(a); a nurse or other registered non-doctor prescriber, who may prescribe only the Scheduled substances the Schedule identifies for that purpose, and dispense them if licensed to do so; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Cited: Act s22A(4)(a)(ii), s22A(4)(a)(iii), s22A(4)(a)(iv), s22A(4)(a)(v)(aa), s22A(6)(r)
Advertising: May be advertised to the public.
Cited: reg 42(1) (General Regulations, 2017)
Labelling: Must show the letter S and the number 1 in a square border, immediately before the product's brand name.
Cited: reg 10(1)(a) (General Regulations, 2017)
What is a Schedule 1 medicine in South Africa?
Sold by a pharmacist, no doctor's prescription needed. Schedule 1 medicines are normally sold by a pharmacist, or by a supervised pharmacist intern or assistant, without a doctor's visit; a veterinarian, or a licensed dispensing doctor, dentist or nurse prescriber, may also supply them. A nurse or other non-doctor prescriber may only prescribe the specific substances the Schedule names for that purpose, and may only dispense them if licensed to do so. A child under 12 may only be sold one of these medicines on a prescription, or on a written order that names the purpose and carries a signature the seller recognises.
Can a pharmacist sell a Schedule 1 medicine without a prescription?
No prescription is needed. A pharmacist, or a supervised pharmacist intern or assistant; manufacturers and wholesalers supplying people who may lawfully possess it; a veterinarian, who may prescribe, compound or dispense it; a medical practitioner or dentist, who may prescribe it, and may compound or dispense it only if licensed under section 22C(1)(a); a nurse or other registered non-doctor prescriber, who may prescribe only the Scheduled substances the Schedule identifies for that purpose, and dispense them if licensed to do so; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
Substances listed under S1
182 listed in the Consolidated Schedules, 80 with a registered medicine.
- 5-Hydroxy Tryptophan
- Acetanilide
- Acetarsol
- Acetylcysteine1
- Acyclovir1
- Ambroxol
- Amethocaine, see Tetracaine
- Amorolfine1
- Anethole trithione
- Anticoagulants
- Antimony potassium tartrate and antimony sodium tartrate
- Any compound structurally derived from either beta-aminopropylbenzene or beta-aminoisopropylbenzene by
- Arsenic1
- Ascorbic Acid, see Vitamin C
- Azelaic acid1
- Bacitracin1
- Bee venom
- Belladonna alkaloids1
- Benzethonium chloride
- Benzocaine8
- Benzydamine2
- Bifidobacterium adolescentis
- Bifidobacterium animalis subsp. Animalis
- Bifidobacterium animalis subsp. Lactis
- Bifidobacterium bifidum
- Bifidobacterium breve
- Bifidobacterium lactis
- Bifidobacterium longum subsp. Infantis
- Bifidobacterium longum subsp. Longum
- Bifonazole1
- Bioallethrin
- Bitolterol
- Boron
- Bufexamac1
- Bunamidine
- Butoconazole
- Calcium19
- Carbamoyl benzamide phenyl isoxazoline
- Cetirizine2
- Chlorhexidine8
- Chloroform2
- Chromium
- Ciclopirox
- Clotrimazole4
- Collagenase clotridiopeptidase
- Copper1
- Cyanocobalamin, see Vitamin B12
- Deanol
- Dequalinium3
- Diclofenac2
- Diosmine
- Dithiazanine
- Econazole1
- Enilconazole
- Ephedra alkaloids
- Ephedrine11
- Escin
- Ether
- Ethyl chloride1
- Ethylphenylephrine
- Etofenamate
- Felbinac1
- Fenbendazole
- Fenticonazole1
- Fexofenadine1
- Flubendazole
- Flufenamic acid
- Fluorescein2
- Fluorides
- Flurbiprofen1
- Folic Acid2
- Glycosaminoglycan polysulphate
- Gramicidin
- Hyaluronic acid
- Hyoscine butylbromide1
- Ibuprofen7
- Icodextrin1
- Idoxuridine2
- Indanazoline
- Indometacin
- Iodine8
- Iron1
- Irrigation fluids
- Isoconazole1
- Ketoconazole1
- Ketoprofen3
- L-Tryptophan
- Lactobacillus acidophilus1
- Lactobacillus brevis
- Lactobacillus casei
- Lactobacillus caucasicus
- Lactobacillus fermentum
- Lactobacillus gasseri
- Lactobacillus helveticus
- Lactobacillus johnsonii
- Lactobacillus paracasei
- Lactobacillus plantarum
- Lactobacillus reuteri
- Lactobacillus rhamnosus
- Lactobacillus salivarius
- Lactococcus lactis
- Levocetirizine2
- Lidocaine12
- Lignocaine, see Lidocaine
- Local anaesthetics
- Loratadine2
- Lufenuron
- Luxabendazole
- Lysozyme
- Magnesium22
- Malathion1
- Manganese
- Mebendazole1
- Methenamine
- Methionine
- Miconazole2
- Microfibrillar collagen hydrochloride
- Molybdenum
- Morantel
- N-acetyl-aspartyl-glutamic acid
- Naphazoline6
- Naproxen2
- Niacin4
- Nicotinamide8
- Nicotine1
- Nitrofurantoin1
- Nitrofurazone2
- Normal Saline
- Nystatin2
- O-(β-hydroxyethyl) rutosides
- Ornidazole
- Orthodichlorobenzene
- Oxetacaine1
- Oxibendazole1
- Oxymetazoline2
- p-Synephrine
- Pancreatin3
- Pantothenic Acid, see Vitamin B5
- Paracetamol78
- Paradichlorobenzene
- Penciclovir1
- Pentosan polysulfate sodium
- Phenylephrine38
- Phospholipids2
- Phosphorus
- Polymixin B
- Pramoxine1
- Prilocaine2
- Procaine1
- Propentofylline1
- Propylhexedrine
- Proteolytic enzymes
- Pyrantel pamoate
- Pyridoxilate
- Pyridoxine, see Vitamin B6
- Racecadotril1
- Riboflavin, see Vitamin B2
- Selenium1
- Sertaconazole
- Terbinafine2
- Tetracaine1
- Tetrahydrozoline4
- Thiabendazole
- Thiamine, see Vitamin B1
- Thiomersal1
- Thiram
- Ticlatone
- Tioconazole
- Tolmetin
- Tyrothricin
- Vanadium
- Vitamin B111
- Vitamin B123
- Vitamin B25
- Vitamin B51
- Vitamin B69
- Vitamin C37
- Vitamin H2
- Vitamin K
- Water for Injection
- Xylometazoline2
- Zinc2
Registered medicines in S1
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Acetycysteine | Acc for | 200 mg | Sandoz South Africa (Pty) Ltd | 550685 | S1 |
| Acetylcysteine | Pholtex mucus, Mucofizz, Tussmuco, +2 more | 200 mg, 600 mg | 4 applicants | 8 registrations | S1 |
| Amorolfine | Loceryl, Onyban, Amorolfine glenmark, +5 more | 5 %, 5 % w/v, 5%, 50 mg/1 ml, +1 more | 7 applicants | 8 registrations | S1 |
| Amylmetacresol | Strepsils numbing | 2.4 mg / 1.2 mg / 0.6 mg | Reckitt Benckinser Pharmaceuticals (Pty) Ltd | 280647 | S1 |
| Azelaic acid | Skinoren, Skinoren acne | gel, cream | Adcock ingram limited | 2 registrations | S1 |
| Benzocaine | Coryx throat | 100 mL | Cipla Medpro (Pty) Ltd | W0058 | S1 |
| Benzydamine | Gesoral, Septolete co | 15 ml, lozenge, 1.5mg/5mg/ml | 2 applicants | 3 registrations | S1 |
| Bile salts Cancelled | Entozyme | Not stated | A H Robins Co (SA) (Pty) Ltd* | E0926 | S1 |
| Cetirizine | Allecet, Acuzyrt, Seasoneze, +2 more | 1 mL, 10,0 mg, tablets, 10 mg, +1 more | 5 applicants | 8 registrations | S1 |
| Clotrimazole | Fungistop topical, Fungistop vaginal, Xeraspor t, +2 more | 1 g, 10 mg, 20mg / 1g | 3 applicants | 5 registrations | S1 |
| Ethyl | Adco-ethyl chloride | spray | Adcock ingram limited | G2750 | S1 |
| Fexofenadine | Telfast, Fexaway, Fastway, +16 more | 120 mg, 180 mg, suspension, 120mg/180mg | 16 applicants | 38 registrations | S1 |
| Fluorescein | Minims fluorescein sodium | 10 mg | Soflens (Pty) Ltd | T86 | S1 |
| Flurbiprofen | Strepsils intensive | 8.75mg | Reckitt Benckinser Pharmaceuticals (Pty) Ltd | 350015 | S1 |
| Hyoscine butylbromide | Juposci | 5 mg | Adcock Ingram Healthcare (Pty) Ltd - Clayville | 590174 | S1 |
| Hyoscine-n-butyl | Hyospasmol | 5 ml, injection | Pharmacare limited û woodmead | 2 registrations | S1 |
| Ibuprofen | Brufen, Nurofen express, Lenafen | granules, 200mg, 200 mg, 600 | 3 applicants | 5 registrations | S1 |
| Ketoprofen | Fastum | 2.5 g per 100 g | Menarini South Africa (Pty) Ltd | Z0165 | S1 |
| Levocetirizine | Texamer, Cetorin, Levocetirizine austell, +2 more | 0,5 mg/ml, 2 mg, 2,5 MG/ 5 ML, 5 mg | 3 applicants | 7 registrations | S1 |
| Lidocaine | Emla | 5%, 25 mg/ 25 mg | Pharmacare limited û woodmead | 2 registrations | S1 |
| Malathion | Lesoderm | lotion | Resmed healthcare | T0205 | S1 |
| Mebendazole | Rioworm, Adco-wormex, Wormgo, +9 more | tablets, suspension, 100 mg, 100mg/ 5ml, +2 more | 7 applicants | 22 registrations | S1 |
| Miconazole | Daktarin | cream, 20mg / 1g | 2 applicants | 2 registrations | S1 |
| Nicotine | Nicorette quickmist | 1 mg | Johnson & Johnson (Pty) Ltd û East London | 500547 | S1 |
| Ox bile | Nutrizym | Not stated | Merck (Pty) Ltd | E0509 | S1 |
| Oxibendazole | Seroh | Not stated | Logos Agvet (Pty) Ltd | 83/521 | S1 |
| Oxymetazoline | Sinarest, Iliadin aloe | 1 mL, 1,0 ml | 2 applicants | 3 registrations | S1 |
| Pancreatin | Creon, Pankreozym, Combizym | 10 000, 25 000, 40 000 | 2 applicants | 6 registrations | S1 |
| Paracetamol | Pacipayn | 500 mg | Austell Pharmaceuticals (Pty) Ltd | 561139 | S1 |
| Phenylephrine | Rusaine | 10 mg | Unimed Healthcare (Pty) Ltd | 560060 | S1 |
| Pramoxine | Anusol pain relief | ointment | Mdi Healthcare CC | T0065 | S1 |
| Procaine Cancelled | Gerovital, Procaine in saline, Pulperyl | 1 % | 3 applicants | 3 registrations | S1 |
| Sodium cromoglycate | Cromobex | 20 mg/ml | Ipharma (Pty) Ltd | 290382 | S1 |
| Terbinafine | Terbane nail | 10 % w/w | Sandoz South Africa (Pty) Ltd | 561092 | S1 |
| Thiomersal | Merthiolate tincture, Micro thiomersalate tincture | Not stated | 2 applicants | 2 registrations | S1 |
| Xylometazoline | Zylovin | 1 mg/mL | Lamar International (Pty) Ltd | 510735 | S1 |