Oxymetazoline

Sold as Drinasal paediatric, Vicks sinex decongestant nasal, Iliadin baby nose, Sinustop paediatric nasal metered, Sinarest, Oxinaze, Zadin nasal, Metaz moisturizing nasal, Oxyspray moisturizing, Oxymetazoline medirite, Oxymist, Iliadin aloe, Sinustop paediatric nasal, Nazene paediatric nasal metered, Nazene paediatric nasal, Nazene adult nasal metered, Nazene adult nasal, Iliadin preservative-free metered, Drixine, Iliadin eye, Ocuzol eye, Allergex eye, Iliadin nose, Advil decongestant, Iliadin, Nose-x nose, Ent-o-line nose, Oxylin liquifilm sterile ophthalmic, Iliadin kids- nose, Sinustop nasal

S1Read from the PI-PIL document and verified

C₁₆H₂₄N₂O260.37 g/mol

6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol

Drag to rotate. Structure from PubChem CID 4636.

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Registration

Applicants: 14
Registrations: 41
Schedule source: SAHPRA documentation

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Viatris South Africa (Pty) LtdCancelled	Drinasal paediatric	0,025%	270390	Not determined	None
Procter & Gamble South Africa Trading (Pty) Ltd4 of 7 cancelled	Vicks sinex decongestant nasal, Iliadin baby nose, Iliadin preservative-free metered, Iliadin nose, Iliadin, Iliadin kids- nose	spray, drops, 0,025 %, 0,05 %	330339, 340366, A390615, A390616, H1400, N0206, V0296	Not determined	None
Adcock ingram limited2 of 8 cancelled	Sinustop paediatric nasal metered, Sinustop paediatric nasal, Nazene paediatric nasal metered, Nazene paediatric nasal, Nazene adult nasal metered, Nazene adult nasal, Allergex eye, Sinustop nasal	1 ml, drops, spray	390199, A390198, A390200, A390201, A390211, A390225, H1274, Y0251	Not determined	PI PIL
Ipharma (Pty) Ltd	Sinarest	1 mL	440745, 440746	S1	PI PIL
Unimed Healthcare (Pty) Ltd	Oxinaze	0,025 %, 0,05 %	440747, 440748	Not determined	None
Sandoz South Africa (Pty) Ltd	Zadin nasal	0,025, 0,05 %	440749, 440750, 440751, 440752	Not determined	None
Zydus Healthcare (Pty) Ltd	Metaz moisturizing nasal, Oxyspray moisturizing	spray	450231, 450232	Not determined	None
Cipla Medpro (Pty) Ltd	Oxymetazoline medirite, Oxymist	0,025, 0,05	470790, 470791, 470792, 470793	Not determined	None
P&g South African Trading (Pty) LtdCertificate held by P&g South African Trading (Pty) Ltd	Iliadin aloe	1,0 ml	50335	S1	PI PIL
Bayer (Pty) Ltd û IsandoCancelled	Drixine	0,025%, 0,05 %	E0224, H1376	Not determined	None
Merck (Pty) Ltd	Iliadin eye	drops	H1172	Not determined	None
The Premier Pharmaceutical Co LtdCancelled	Ocuzol eye, Nose-x nose, Ent-o-line nose	drops, spray	H1273, V0015, V0016, V0017, V0018	Not determined	None
Glaxosmithkline Consumer Healthcare SA (Pty) Ltd	Advil decongestant	Not stated	J0397	Not determined	None
Abbvie (Pty) Ltd	Oxylin liquifilm sterile ophthalmic	solution	V0041	Not determined	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Drinasal paediatric 0,025% EACH 1 ml LIQUID CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,25 mg	0,025%	27039027/16.1/0390	Cancelled	Not determined	None
Vicks sinex decongestant nasal spray EACH 15,0 ml SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 7,5 mg	Spray	33033933/16.1/0339	Cancelled	Not determined	None
Iliadin baby nose drops EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,1 mg	Drops	34036634/16.1/0366	Registered	Not determined	None
Sinustop paediatric nasal metered spray	1 mlPaediatric nasal metered spray	390199A39/16.1/0199Approved 28 September 2021	Registered	Not determined	PI PIL
Sinarest 0,025 % EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE 0,25 mg	1 mLNasal spray, solution	44074544/16.1/0745Approved 24 October 2025	Registered	S1	PI PIL
Sinarest 0,05 % EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE 0,5 mg	1 mLNasal spray, solution	44074644/16.1/0746Approved 24 October 2025	Registered	S1	PI PIL
Oxinaze 0,025 % EACH 1,0 ml DROPS CONTAINS OXYMETAZOLINE 0,25 mg	0,025 %	44074744/16.1/0747	Registered	Not determined	None
Oxinaze 0,05 % EACH 1,0 ml DROPS CONTAINS OXYMETAZOLINE 0,5 mg	0,05 %	44074844/16.1/0748	Registered	Not determined	None
Zadin 0,025 nasal spray EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE 0,25 mg	0,025Spray	44074944/16.1/0749	Registered	Not determined	None
Zadin 0,05 % nasal spray EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE 0,5 mg	0,05 %Spray	44075044/16.1/0750	Registered	Not determined	None
Zadin 0,025 nasal drops EACH 1,0 ml DROPS CONTAINS OXYMETAZOLINE 0,25 mg	0,025Drops	44075144/16.1/0751	Registered	Not determined	None
Zadin 0,05 % nasal drops EACH 1,0 ml DROPS CONTAINS OXYMETAZOLINE 0,5 mg	0,05 %Drops	44075244/16.1/0752	Registered	Not determined	None
Metaz moisturizing nasal spray EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,5 mg	Spray	45023145/16.1/0231	Registered	Not determined	None
Oxyspray moisturizing EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,5 mg	Not listed	45023245/16.1/0232	Registered	Not determined	None
Oxymetazoline 0,025 medirite EACH 1,0 ml SOLUTION CONTAINS:OXYMETAZOLINE HYDROCHLORIDE 0,025 mg	0,025	47079047/16.1/0790	Registered	Not determined	None
Oxymetazoline 0,05 medirite EACH 1,0 ml SOLUTION CONTAINS:OXYMETAZOLINE HYDROCHLORIDE 0,05 mg	0,05	47079147/16.1/0791	Registered	Not determined	None
Oxymist 0,025 EACH 1,0 ml SOLUTION CONTAINS: OXYMETAZOLINE HYDROCHLORIDE 0,25 mg	0,025	47079247/16.1/0792	Registered	Not determined	None
Oxymist 0,05 EACH 1,0 ml SOLUTION CONTAINS: OXYMETAZOLINE HYDROCHLORIDE 0,5 mg	0,05	47079347/16.1/0793	Registered	Not determined	None
Iliadin aloe EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,5 mg	1,0 mlNasal spray, solution	5033550/16.1/0335Approved 20 September 2022	Registered	S1	PI PIL
Sinustop paediatric nasal drops EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,250 mg	Drops	A390198A39/16.1/0198	Registered	Not determined	None
Nazene paediatric nasal metered spray EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,250 mg	Spray	A390200A39/16.1/0200	Registered	Not determined	None
Nazene paediatric nasal drops EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,250 mg	Drops	A390201A39/16.1/0201	Cancelled	Not determined	None
Nazene adult nasal metered spray EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,50 mg	1 mlNasal metered spray	A390211A39/16.1/0211Approved 27 September 2021	Registered	Not determined	PI PIL
Nazene adult nasal drops EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,500 mg	Drops	A390225A39/16.1/0225	Cancelled	Not determined	None
Iliadin preservative-free 0,05 % metered spray EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE 0,5 mg	0,05 %Spray	A390615A39/16.1/0615	Cancelled	Not determined	None
Iliadin preservative-free 0,025 % metered spray EACH 1,0 ml SOLUTION CONTAINS OXYMETAZOLINE 0,25 mg	0,025 %Spray	A390616A39/16.1/0616	Cancelled	Not determined	None
Drixine 0,025% EACH 1 ML CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,25 mg	0,025%	E0224E/16.1/224	Cancelled	Not determined	None
Iliadin eye drops EACH 1 ML CONTAINS OXYMETAZOLINE HYDROCHLORIDE A 0,25 mg	Drops	H1172	Old Medicine	Not determined	None
Ocuzol eye drops EACH 1 ml CONTAINS OXYMETAZOLINE HYDROCHLORIDE A 0,5 mg	Drops	H1273	Cancelled	Not determined	None
Allergex eye drops EACH 1 ml CONTAINS :OXYMETAZOLINE HYDROCHLORIDE A 0,25 mg	Drops	H1274	Old Medicine	Not determined	None
Drixine 0,05 % EACH ml CONTAINS OXYMETAZOLINE HYDROCHLORIDE A 0,50 mg	0,05 %	H1376	Cancelled	Not determined	None
Iliadin nose drops EACH 1 ml CONTAINS OXYMETAZOLINE HYDROCHLORIDE A 0,50 mg	Drops	H1400	Old Medicine	Not determined	None
Advil decongestant EACH 1 g SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,5 mg	Not listed	J0397J/16.1/397	Registered	Not determined	None
Iliadin gel 0,05 % EACH 1,0 g GEL CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,05 mg	0,05 %Gel	N0206N/16.1/206	Cancelled	Not determined	None
Nose-x nose drops* EACH 5 ml CONTAINS OXYMETAZOLINE HYDROCHLORIDE 2,5 mg	Drops	V0015V/16.1/15	Cancelled	Not determined	None
Nose-x nose spray* EACH 5 ml CONTAINS OXYMETAZOLINE HYDROCHLORIDE 2,5 mg	Spray	V0016V/16.1/16	Cancelled	Not determined	None
Ent-o-line nose drops* EACH 5 ml CONTAINS OXYMETAZOLINE HYDROCHLORIDE 2,5 mg	Drops	V0017V/16.1/17	Cancelled	Not determined	None
Ent-o-line nose spray* EACH 5 ml CONTAINS OXYMETAZOLINE HYDROCHLORIDE 2,5 mg	Spray	V0018V/16.1/18	Cancelled	Not determined	None
Oxylin liquifilm sterile ophthalmic solution EACH 1 ml SOLUTION CONTAINS: OXYMETAZOLINE HYDROCHLORIDE 0,25 mg	Solution	V0041V/15.4/41	Registered	Not determined	None
Iliadin kids- nose drops EACH 1 ml DROPS OR METERED SPRAY CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0.025 mg	Drops	V0296V/16.1/296	Registered	Not determined	None
Sinustop nasal spray EACH 1 ml SOLUTION CONTAINS OXYMETAZOLINE HYDROCHLORIDE 0,5 mg	Spray	Y0251Y/16.1/251	Registered	Not determined	None

Regulatory status

Where S1 sits on the scale

S0S1S2S3S4S5S6S7S8

Sold by a pharmacist, no doctor's prescription needed.

Schedule 1 medicines are normally sold by a pharmacist, or by a supervised pharmacist intern or assistant, without a doctor's visit; a veterinarian, or a licensed dispensing doctor, dentist or nurse prescriber, may also supply them. A nurse or other non-doctor prescriber may only prescribe the specific substances the Schedule names for that purpose, and may only dispense them if licensed to do so. A child under 12 may only be sold one of these medicines on a prescription, or on a written order that names the purpose and carries a signature the seller recognises.

Schedule S1, read from the product's PI-PIL leaflet.

The Consolidated Schedules list this ingredient up to S2; the leaflet's S1 applies to this product.

Who may supply: A pharmacist, or a supervised pharmacist intern or assistant; manufacturers and wholesalers supplying people who may lawfully possess it; a veterinarian, who may prescribe, compound or dispense it; a medical practitioner or dentist, who may prescribe it, and may compound or dispense it only if licensed under section 22C(1)(a); a nurse or other registered non-doctor prescriber, who may prescribe only the Scheduled substances the Schedule identifies for that purpose, and dispense them if licensed to do so; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Oxymetazoline

S2: Oxymetazoline
- except when intended for nasal use
Consolidated Schedules 06 July 2026, line 2476
S1: Oxymetazoline
- when intended for nasal use.
Consolidated Schedules 06 July 2026, line 952

Pharmacological class: Nasal decongestants. (class 16.1)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsSinustop paediatric nasal metered spray, Adcock ingram limited Patient information leaflet (PIL)For patients and carersSinustop paediatric nasal metered spray, Adcock ingram limited

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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