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Lidocaine

Schedule 1 to 4, conditions apply
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C14H22N2O234.34 g/mol

2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide

Drag to rotate. Structure from PubChem CID 3676.

Background

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Listing

Schedules
Schedule 1 to 4, conditions apply
Also listed as
Lignocaine (Schedule 1 and 4), see Lidocaine
Source
Consolidated Schedules 06 July 2026

Registered medicines

14 registered products listed

Counted through the register's ingredient index, which does not reach every record.

Registered products
NameBrandsDosagesApplicantsRegistrationsSchedule
Lidocaine, prilocaineEmla, Topla5%, 25 mg/ 25 mg2 applicants3 registrationsS1
LidocaineMerck-ceftriaxone diluent, Lignocaine-hcl b braun, Versatis, +24 more0,5 %, 1 % 10 ML, 1 % 20 ML, 1 % 5 ML, +19 more12 applicants43 registrationsS1 to S4conditions apply
Chlorhexidine gluconate, lidocaineEndostil6 ml, 11 mlGen-eye (Pty) Ltd2 registrationsS1 to S4conditions apply
Bromhexine, lidocaine, oxytetracyclineBisolvomycin vetNot statedJanssen Pharmaceutica (Pty) Ltd83/329S1 to S4conditions apply
Dequalinium, lidocaineDequadin mouth paint, FlusinlozengesPharmacare limited û woodmead2 registrationsS1 to S4conditions apply
Betamethasone valerate, lidocaine, phenylephrineBetnovate compoundsuppositoriesGlaxosmithkline South Africa (Pty) LimitedE0538S1 to S4conditions apply
Lidocaine, methylprednisolone CancelledDepo-medrol with lidocaineNot statedPfizer Laboratories (Pty) LtdF0228S1 to S4conditions apply
Epinephrine bitartrate, lidocaineLignotox "a", Lignane a, Lidocaine a803 applicants3 registrationsS1 to S4conditions apply
Lidocaine, norepinephrine bitartrateLignane 'n' dental cartridges, Lidocaine n dental cart.802 applicants2 registrationsS1 to S4conditions apply
Lidocaine, norepinephrineXylotox lNot statedAdcock ingram limitedG2798S1 to S4conditions apply
Lidocaine, neomycin, prednisoloneOptacin ear /oordruppelsdrops/oordruppelsGenpharm Pharmaceuticals (1993) (Pty) LtdH1419S1 to S4conditions apply
Epinephrine, lidocaineLignospan2%The Dental Warehouse (Pty) LtdJ0208S1 to S4conditions apply
Show the other 2 registered products
Registered products
NameBrandsDosagesApplicantsRegistrationsSchedule
Fluorescein, lidocaine CancelledMinims lidocaine and fluoresceinNot statedSoflens (Pty) LtdL0369S1 to S4conditions apply
Adrenaline, lidocaineXylotox e80-a, Xylestesin-a, Locaine aNot stated2 applicants3 registrationsS1 to S4conditions apply

2 more registered products name Lidocaine in their active ingredient

Registered products
NameBrandsDosagesApplicantsRegistrationsSchedule
Lidocaine, lindane, neomycin, nystatin, triamcinolone acetonide CancelledOridermylNot statedBayer (Pty) Ltd (Animal Health Division)83/795
Cetrimide, lidocaineXylonorgelThe Dental Warehouse (Pty) LtdX0881

Regulatory status

Where S1 to S4 sits on the scale

Depends on which listing applies

At the least restrictive, Schedule 1: sold by a pharmacist, no doctor's prescription needed. At the most restrictive, Schedule 4: prescription-only medicine. The listings below say which applies to which form, strength or pack size.

Schedule S1 to S4, as the Consolidated Schedules list it.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Lidocaine

  • S4: Lidocaine

    • when intended for ophthalmic or parenteral use;
    • when intended for the treatment of neuropathic pain associated with previous herpes zoster infection;
    • except when intended for topical use; (S1)
    • except in oral preparations containing 2 percent or less of lidocaine per dosage form. (S1)

    Consolidated Schedules 06 July 2026, lines 6923 to 6935

  • S1: Lidocaine

    • when intended for topical use;
    • in oral preparations containing 2 percent or less of lidocaine, per dosage unit;
    • except when intended for ophthalmic or parenteral use; (S4)
    • except when intended for the treatment of neuropathic pain associated with previous herpes zoster infection. (S4)

    Consolidated Schedules 06 July 2026, lines 777 to 786

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

Research articles

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