Phenylephrine

Sold as Minims phenylephrine hydrochloride, Sudafed pe sinus decongestant, Phenylephrine cipla, Hypopress, Phenpressor, Rusaine, Phenylephrine ps equity, Phenylephrine RBC, Phenylcord, Paripres, Phenylephrine hetero, Phenylephrine fresenius, Phenylephrine covan, Phenylephrine hydrochloride, Ei-deel, Phenylephrine eye, Optimed, Naphensyl, Sine off sinus, Preferin liquifilm sterile eye, Phenylephrine hydrochloride nose, Eye-gene nf eye, Fenox nasal

S4Read from the PI-PIL document and verified

C₉H₁₃NO₂167.20 g/mol

3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol

Drag to rotate. Structure from PubChem CID 6041.

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Registration

Applicants: 19
Registrations: 28
Schedule source: SAHPRA documentation

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Soflens (Pty) Ltd1 of 2 cancelled	Minims phenylephrine hydrochloride	2,5 %, 10 %	310458, D0022	Not determined	None
Johnson & Johnson (Pty) Ltd û East LondonCancelled	Sudafed pe sinus decongestant	Not stated	420099	Not determined	None
Cipla Medpro (Pty) LtdCancelled	Phenylephrine cipla	Not stated	520466	Not determined	None
Umsebe healthcare	Hypopress	0,1 mg/ml, 0.1/ 10mg/ml	550352, 550353	S4	PI PIL
Juno Pharma SA (Pty) LtdCertificate held by Kahma Biotech (Pty) Ltd	Phenpressor	10 mg	550361	Not determined	PI PIL
Unimed Healthcare (Pty) LtdCertificate held by Lebasi Pharmaceuticals (Pty) Ltd	Rusaine	10 mg	560060	S1	PI PIL
Equity Pharmaceutical (Pty) Ltd	Phenylephrine ps equity	50 ug/ml	570540	Not determined	None
RBC Pharmaceuticals (Pty) Ltd	Phenylephrine RBC	10 mg/ml	580131	Not determined	None
Accord Healthcare (Pty) Ltd	Phenylcord	10 mg/ml	590062	Not determined	None
Ruby Pharmaceuticals (Pty) Ltd	Paripres	Not stated	590417	Not determined	None
Hetero Drugs South Africa (Pty) Ltd	Phenylephrine hetero	100 mg/10 ml	590460	Not determined	None
Fresenius Kabi Manufacturing SA (Pty) Ltd	Phenylephrine fresenius	10 mg/1 ml	590892	Not determined	None
Adcock ingram limitedCertificate held by Abbott Laboratories South Africa (Pty) Ltd1 of 2 cancelled	Phenylephrine covan, Phenylephrine hydrochloride	10 mg/mL	F0011, LX0113	S4	PI PIL
Abbott Laboratories S.A. (Pty) LtdCertificate held by Abbott Laboratories South Africa (Pty) Ltd	Phenylephrine hydrochloride	10 mg/mL	H0630	S4	PI PIL
Specpharm Holdings (Pty) Ltd	Ei-deel	Not stated	H1230	Not determined	None
The Premier Pharmaceutical Co LtdCancelled	Phenylephrine eye, Optimed, Naphensyl	drops, 0,25 %, 1 %	H1307, H1310, H1403, H1596	Not determined	None
Pharmacare limited û woodmead3 of 4 cancelled	Sine off sinus, Phenylephrine hydrochloride nose, Eye-gene nf eye	spray, drops, 1%	J0066, L0137, L0138, X0132	Not determined	None
Abbvie (Pty) LtdCancelled	Preferin liquifilm sterile eye	drops	J0084	Not determined	None
Boots Pharmaceuticals (Pty) LtdCancelled	Fenox nasal	spray	Z0254	Not determined	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Minims phenylephrine hydrochloride 2,5 % EACH 0,5 ml EYE DROPS CONTAINS PHENYLEPHRINE HYDROCHLORIDE 12,50 mg	2,5 %	31045831/15.4/0458	Cancelled	Not determined	None
Sudafed pe sinus decongestant EACH TABLET CONTAINS PHENYLEPHRINE HYDROCHLORIDE 10,0 mg	Not listed	42009942/5.8/0099	Cancelled	Not determined	None
Phenylephrine cipla Each injection contains: Phenylphrine	Not listed	52046652/7.2/0466	Cancelled	Not determined	None
Hypopress 0,1 mg/ml EACH 1,0 ml SOLUTION CONTAINS PHENYLEPHRINE HYDROCHLORIDE 0,1 mg	0,1 mg/mlSolution for injection or infusion	55035255/6.1/0352Approved 10 May 2024	Registered	S4	PI PIL
Hypopress 10 mg/ml EACH 1,0 ml SOLUTION CONTAINS PHENYLEPHRINE HYDROCHLORIDE 10,0 mg	0.1/ 10mg/mlSolution for injection or infusion	55035355/6.1/0353Approved 9 November 2021	Registered	Not determined	PI PIL
Phenpressor 10 mg/ml EACH 1,0 ml SOLUTION CONTAINS PHENYLEPHRINE HYDROCHLORIDE 10,0 mg	10 mgInjection	55036155/7.2/0361Approved 18 April 2023	Registered	Not determined	PI PIL
Rusaine 10 mg/ml EACH 1,0 ml SOLUTION CONTAINS PHENYLEPHRINE HYDROCHLORIDE 10, 0 mg	10 mgSolution for injection/infusion	56006056/7.2/0060Approved 6 June 2023	Registered	S1	PI PIL
Phenylephrine 50 ug/ml ps equity Each 1,0 ml solution contains: Phenylephrine Hydrochloride equivalent to phenylephrine 50,0 ug	50 ug/ml	57054057/6.1/0540	Registered	Not determined	None
Phenylephrine 10 mg/ml RBC EACH 1,0 ml SOLUTION CONTAINS: PHENYLEPHRINE HYDROCHLORIDE 10,0 mg	10 mg/ml	58013158/7.2/0131	Registered	Not determined	None
Phenylcord 10 mg/ml EACH VIAL CONTAINS: PHENYLEPHRINE HYDROCHLORIDE 10,0 mg	10 mg/ml	59006259/7.2/0062	Registered	Not determined	None
Paripres EACH 1,0 ml SOLUTION CONTAINS: PHENYLEPHRINE HYDROCHLORIDE 10,0 mg	Not listed	59041759/7.2/0417	Registered	Not determined	None
Phenylephrine 100 mg/10 ML hetero EACH 10,0 ml SOLUTION CONTAINS: PHENYLEPHRINE HYDROCHLORIDE 100,0 mg	100 mg/10 ml	59046059/7.2/0460	Registered	Not determined	None
Phenylephrine 10 mg/1 ML fresenius EACH 1,0 ml SOLUTION CONTAINS: PHENYLEPHRINE HYDROCHLORIDE 10,0 mg	10 mg/1 ml	59089259/7.2/0892	Registered	Not determined	None
Minims phenylephrine hydrochloride 10 % EACH 100 ml CONTAINS PHENYLEPHRINE HYDROCHLORIDE 10 g	10 %	D0022D/15.4/22	Registered	Not determined	None
Phenylephrine covan EACH 1 ml CONTAINS PHENYLEPHRINE 100 mg	Not listed	F0011F/15.4/11	Cancelled	Not determined	None
Phenylephrine hydrochloride injection EACH I ml CONTAINS: PHENYLEPHRINE HYDROCHLORIDE A 10 mg	10 mg/mLSolution for injection.	H0630Approved 5 October 2022	Old Medicine	S4	PI PIL
Ei-deel EACH 10 ml CONTAINS PHENYLEPHRINE HYDROCHLORIDE A 0,01 g	Not listed	H1230	Old Medicine	Not determined	None
Phenylephrine eye drops EACH 1 ml CONTAINS PHENYLEPHRINE HYDROCHLORIDE A 1,0 mg	Drops	H1307	Cancelled	Not determined	None
Optimed EACH 1 ml CONTAINS PHENYLEPHRINE HYDROCHLORIDE A 12,5 mg	Not listed	H1310	Cancelled	Not determined	None
Naphensyl 1 % EACH 10 ml CONTAINS :PHENYLEPHRINE HYDROCHLORIDE A 100 mg	1 %	H1403	Cancelled	Not determined	None
Naphensyl 0,25 % EACH 1 ml SOLUTION CONTAINS: PHENYLEPHRINE HYDROCHLORIDE A 2,5 mg	0,25 %	H1596	Cancelled	Not determined	None
Sine - off sinus spray EACH 100 ml CONTAINS PHENYLEPHRINE HYDROCHLORIDE 0,5 g	-Spray	J0066J/16.1/66	Cancelled	Not determined	None
Preferin liquifilm sterile eye drops EACH 1 ml SOLUTION CONTAINS PHENYLEPHRINE HYDROCHLORIDE 1,32 mg	Drops	J0084J/15.4/84	Cancelled	Not determined	None
Phenylephrine hydrochloride nose drops EACH 15 ml CONTAINS PHENYLEPHRINE HYDROCHLORIDE 37,5 mg	Drops	L0137L/16.1/137	Cancelled	Not determined	None
Phenylephrine hydrochloride 1% nose drops EACH 15 ml CONTAINS PHENYLEPHRINE HYDROCHLORIDE 150,0 mg	1%Drops	L0138L/16.1/138	Cancelled	Not determined	None
Phenylephrine hydrochloride injection EACH 1,0 ml SOLUTION CONTAINS PHENYLEPHRINE HYDROCHLORIDE 10,0 mg	10 mg/mLSolution for injection.	LX0113L/5.1/113Approved 5 October 2022	Registered	S4	PI PIL
Eye-gene nf eye drops EACH 1 ml SOLUTION CONTAINS PHENYLEPHRINE HYDROCHLORIDE 1 mg	Drops	X0132X/15.4/132	Registered	Not determined	None
Fenox nasal spray EACH 15 ml BOTTLE CONTAINS PHENYLEPHRINE 75,0 mg	Spray	Z0254Z/16.1/254	Cancelled	Not determined	None

Regulatory status

Where S4 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only medicine.

Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S4, read from the product's PI-PIL leaflet.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Phenylephrine hydrochloride

S4: Phenylephrine
- when intended for injection
- except ophthalmic preparations containing 0,2 percent or less. (S0)
- except for oral dosage forms, nasal dosage forms, or ophthalmic dosage forms containing more than 0,2 percent (S1)
Consolidated Schedules 06 July 2026, lines 7545 to 7552
S1: Phenylephrine
- when intended for oral dosage forms, nasal dosage forms, or ophthalmic dosage forms containing more than 0,2 percent; (S1)
- except ophthalmic preparations containing 0,2 percent or less; (S0)
- except when intended for injection. (S4)
Consolidated Schedules 06 July 2026, lines 1007 to 1014

Pharmacological class: Cardiac stimulants. (class 6.1)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

Hypopress 0,1 mg/ml, Umsebe healthcare is scheduled S4 in its official SAHPRA documents, read with 90% confidence.

Professional information (PI)For healthcare professionalsHypopress 0,1 mg/ml, Umsebe healthcare Patient information leaflet (PIL)For patients and carersHypopress 0,1 mg/ml, Umsebe healthcare

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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