S5 - Controlled Substance
Controlled substance
About S5 Drugs
Where S5 sits on the scale
Prescription-only, with tighter controls on repeats.
Schedule 5 medicines need a prescription, and repeat dispensing is capped at six months in total; the prescriber must state upfront how many times, and at what intervals, it may be repeated. Extra limits apply to some uses: if it is being used for its anxiolytic, antidepressant, tranquillising or analgesic properties, it cannot be prescribed for longer than six months without a further consultation. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Who may supply
A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it.
Cited: Act s22A(5)(b), s22A(5)(c), s22A(5)(d), s22A(5)(e)
Prescription: Requires a prescription from an authorised prescriber.
Repeats: Capped at six months in total, and only if the prescriber stated in advance the number of repeats and the interval between them; the same six-month cap applies to anxiolytic, antidepressant or tranquillising use unless a registered psychiatrist has been consulted, and to analgesic use unless another medical practitioner has been consulted. The prescription must also be presented for dispensing within 30 days of issue.
Cited: reg 33(3)(i) (General Regulations, 2017)
Cited: Act s22A(6)(d), s22A(6)(g), s22A(6)(h)
Advertising: May be advertised only to health professionals, not the public.
Cited: reg 42(2), reg 42(3) (General Regulations, 2017)
Labelling: Must show the letter S and the number 5 in a square border, immediately before the product's brand name.
Cited: reg 10(1)(a) (General Regulations, 2017)
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
S5 Scheduled Drugs
| Name | Variants | Applicant | Number | Schedule |
|---|---|---|---|---|
| Xylazine (Xylavet, Xylavet For Horses) | 2 %, 10 % | Intervet South Africa (Pty) Ltd | 2 registrations | S5 |
| Alfaxalone (Alfaxan-cd Rtu Anaesthetic) Cancelled | injection | Lebasi Pharmaceuticals (Pty) Ltd | 01/14 | S5 |
| Detomidine (Equidine) | Not stated | Virbac Rsa (Pty) Ltd | 13/06 | S5 |
| Dexmedetomidine (Dexdomitor) | Not stated | Zoetis South Africa (Pty) Ltd | 17-Aug | S5 |
| Midazolam (Sedolam) | 50 | Wildlife Pharmaceuticals (Pty) Ltd | 19/15 | S5 |
| Alfaxalone (Alfaxan Multidose) | 10mg | Zoetis South Africa (Pty) Ltd | 19/21 | S5 |
| Medetomidine (Domivet) | Not stated | Kyron Animal Health (Pty) Ltd | 22-Oct | S5 |
| Maprotiline (Luprodil) Cancelled | - 10, - 25, - 50, - 75 | Pharmacare limited û woodmead | 4 registrations | S5 |
| Midazolam (Dormicum) | 7,5 mg, 15 mg/3 ml, 15 mg, 5 mg/5 ml, 50 mg/10 ml | Pharmaco Distribution (Pty) Ltd | 5 registrations | S5 |
| Alprazolam (Xanor, Xanor Sr, Mylan Alprazolam) | 2,0 mg, 0,5 mg, 1,0 mg, 0,25 mg | Viatris Healthcare (Pty) Ltd | 9 registrations | S5 |
| Risperidone (Risperdal, Risperdal Consta, Risperlet) | 1 mg, 2 mg, 1 mg / ML, 0,5 mg, 25 mg, 37,5 mg, 50 mg, 3 mg, 4 mg | Janssen Pharmaceutica (Pty) Ltd | 12 registrations | S5 |
| Risperidone (Risperdal, Adco-risperidone, Propan-risperidone) | 3 mg, 0,5 mg, 1 mg, 2 mg, 4 mg, 6 mg | Adcock ingram limited | 13 registrations | S5 |
| Diazepam (Dynapam) | Not stated | Aquila Healthcare (Pty) Ltd | 270348 | S5 |
| Fluphenazine (Pheracarm Rapid ( )) Cancelled | 2,5 mg/ml 10 ml | Pharmacare limited û woodmead | 270354 | S5 |
| Chlorpromazine (Chlorpromazine Unimed) | 25, 50 | Unimed Healthcare (Pty) Ltd | 2 registrations | S5 |
| Alprazolam (Biozane, Alprazolam Biotech) | 0,5 mg, 1 mg, 10 mg/200 mg/350 mg, 0,5 | Biotech Laboratories (Pty) Ltd | 4 registrations | S5 |
| Buspirone (Astrid) Cancelled | 10 mg | Sanofi-aventis South Africa (Pty) Ltd | 280086 | S5 |
| Alprazolam (Anxirid, Azor) | 1,0 mg, 0,5 mg, - 0,25, 0,5, 1,0 | Pharmacare limited û woodmead | 5 registrations | S5 |
| Isoflurane (Isofor, Terrell) | Not stated | Safeline Pharmaceuticals (Pty) Ltd | 2 registrations | S5 |
| Bromazepam (Bromaze) Cancelled | 6 | Sandoz South Africa (Pty) Ltd | 280216 | S5 |
| Sulpiride (Prem-sulpiride) Cancelled | 200 | Adcock ingram limited | 280524 | S5 |
| Diazepam (Tranject) | ampoules | Unimed Healthcare (Pty) Ltd | 280578 | S5 |
| Hydroxyzine (Neurax) | Not stated | Unimed Healthcare (Pty) Ltd | 290003 | S5 |
| Citalopram (Cipramil, Adco-talomil, Adco Talomil) | 20 mg, 10mg/20mg/40 mg. | Adcock ingram limited | 4 registrations | S5 |
| Temazepam (Vernison) Cancelled | Not stated | The Premier Pharmaceutical Co Ltd | 290482 | S5 |
| Fluoxetine (Lilly-fluoxetine, Prozac) Cancelled | 20 | Eli Lilly (S.A.) (Pty) Ltd | 2 registrations | S5 |
| Paroxetine (Xixia Paroxetine) | 20 | Viatris South Africa (Pty) Ltd | 290556 | S5 |
| Diazepam (Diazepam Pharm C) | 10 mg/2 ml | Pharmacorp (Pty) Ltd | 290603 | S5 |
| Zolpidem hemitartrate (Stilnox) | 10 mg | Sanofi-aventis South Africa (Pty) Ltd | 290651 | S5 |
| Sevoflurane (Ultane) | breathed in (inhalation) Liquid | Abbvie (Pty) Ltd | 290748 | S5 |
| Fluoxetine (Lorien, Trio-fluoxetine) | 20 mg, tablets | Pharmacare limited û woodmead | 3 registrations | S5 |
| Buspirone (Pasrin) | 10 | Pharmacare limited û woodmead | 300168 | S5 |
| Alprazolam (Adco-alzam, Adco Alzam, Propan Alprazolam, +2 more) | 0,5 mg, 0,25 mg, 1,0 mg, 1 mg | Adcock ingram limited | 9 registrations | S5 |
| Alprazolam (Zopax) Cancelled | 0,25, 0,5, 1,0 | Cipla Medpro (Pty) Ltd | 3 registrations | S5 |
| Fluoxetine (Fluoxetine Biotech, Defiton) | 20 mg | Biotech Laboratories (Pty) Ltd | 2 registrations | S5 |
| Fluoxetine (Seronil) | 20 mg | Alliance Pharma (Pty) Ltd | 300397 | S5 |
| Sulpiride (* Sulpiride Biotech) | 200 | Biotech Laboratories (Pty) Ltd | 300511 | S5 |
| Alprazolam (Apotex-alprazolam) Cancelled | 0,25 mg | Apotex SA (Pty) Ltd | 310013 | S5 |
| Alprazolam (Xanolam) Cancelled | 0,5 mg | Garec (Pty) Ltd | 310015 | S5 |
| Tramadol (Nobligan, Tramal Sr, Tramal) | 100, 100 mg, 150 mg, 50 mg, 50 mg., 50mg | Janssen Pharmaceutica (Pty) Ltd | 6 registrations | S5 |
| Olanzapine (Zyprexa, Zyprexa Im, Zyprexa Velotab) | 5, 10, 2,5, 10.0 mg, 5 mg, 10 mg | Equity Pharmaceutical (Pty) Ltd | 6 registrations | S5 |
| Clomipramine (Apotex-clomipramine) Cancelled | 10 | Adcock ingram limited | 310063 | S5 |
| Clomipramine (Apotex-clomipramine) Cancelled | 25 | Zimbili Pharma CC | 310065 | S5 |
| Clomipramine (Apotex-clomipramine) Cancelled | 50 | Apotex SA (Pty) Ltd | 310067 | S5 |
| Hydroxyzine (Pharma-q Hydroxyzine) | 100 mg/2 ml | Pharma-q Holdings (Pty) Ltd | 310070 | S5 |
| Diazepam (Calmpose) | injection | Dezzo Trading 392 (Pty) Ltd | 310192 | S5 |
| Alprazolam (Coprax) | 0,25, 0,5, 1,0 | Pharma-q Holdings (Pty) Ltd | 3 registrations | S5 |
| Propofol (Diprivan Pfs, Diprivan) | 1 % 20 ml, 1 % 50 ml, 2 % 50 ml, 2 % 10 ML, 1% 20ml, 1 % 100 ml | Pharmacare limited û woodmead | 8 registrations | S5 |
| Desflurane (Suprane) | 240 ml | Baxter Healthcare South Africa (Pty) Ltd | 310417 | S5 |
| Diazepam (Calmpose) | tablets | Oethmaan Biosims (Pty) Ltd | 310515 | S5 |
| Fluoxetine (Modipran) | 20 mg, 20, 40 | Ipharma (Pty) Ltd | 3 registrations | S5 |
| Fluoxetine (Fluoxetine Oethmaan) | 20 | Oethmaan Biosims (Pty) Ltd | 320040 | S5 |
| Diazepam (Pharma-q Diazepam) | 10 mg/2 ml | Pharma-q Holdings (Pty) Ltd | 320197 | S5 |
| Donepezil (Aricept) | 5 mg, 10 mg | Pfizer Laboratories (Pty) Ltd | 2 registrations | S5 |
| Venlafaxine (Efexor Xr) | 75 mg, 150 mg | Viatris Healthcare (Pty) Ltd | 2 registrations | S5 |
| Sertraline (Zoloft) | 50 mg | Viatris Healthcare (Pty) Ltd | 320381 | S5 |
| Fluoxetine (Nuzak, Fluoxetine Actor, Cipla-fluoxetine) | 20 mg, 20, oral solution | Cipla Medpro (Pty) Ltd | 4 registrations | S5 |
| Mirtazapine (Remeron) Cancelled | 15 mg, 30 mg | Organon South Africa (Pty) Ltd | 2 registrations | S5 |
| Zopiclone (Sandoz Zopiclone) | 7,5 mg | Sandoz South Africa (Pty) Ltd | 320487 | S5 |
| Ziprasidone (Geodon, Geodon Im) | 20 mg, 40 mg, 60 mg, 80 mg, 20 mg/ml | Viatris Healthcare (Pty) Ltd | 5 registrations | S5 |
| Quetiapine (Seroquel, Seroquel Xr, Truvalin, +1 more) | 25, 100, 200, 300, 50, 400, 150 | Imperial Market Access Healthcare SA (Pty) Ltd | 18 registrations | S5 |
| Tramadol (Tramahexal, Tramahexal Sr) | capsules, 100 mg/2 ml, 150 | Sandoz South Africa (Pty) Ltd | 3 registrations | S5 |
| Zopiclone (Alchera) | Not stated | Pharmacare limited û woodmead | 330029 | S5 |
| Propofol (Propofol Fresenius, Propofol Fresenius ( ), Propofol Mct/lct ( ) Fresenius, +1 more) | 1 %, 2 % 20 ML, 2 % 50 ML, 2 % 100 ML, 1% 20 ml, 1% 50 ml, 1% 100 ml, 20 mg | Fresenius Kabi South Africa (Pty) Ltd | 8 registrations | S5 |
| Reboxetine (Edronax) Cancelled | 4 mg | Pfizer Laboratories (Pty) Ltd | 330246 | S5 |
| Clomipramine (Companil) | 25, 50, 75 | Afripharm South Africa (Pty) Ltd | 3 registrations | S5 |
| Fluvoxamine (Faverin, Luvox) | 100 mg., 50 | Abbott Laboratories S.A. (Pty) Ltd | 3 registrations | S5 |
| Ketamine (Pharma-q Ketamine) | 10 mg/ml, 50 mg/ml, 100 mg/ml | Pharma-q Holdings (Pty) Ltd | 3 registrations | S5 |
| Zopiclone (Adco Zopimed, Propan Zopiclone) | Not stated | Adcock ingram limited | 2 registrations | S5 |
| Clomipramine (Pharma-q Clomipramine Hcl) | 25 mg/2 ml | Pharma-q Holdings (Pty) Ltd | 330473 | S5 |
| Fluoxetine (Deprozan) | Not stated | Elttab Pharmaceuticals CC | 330541 | S5 |
| Danazol (Danogen) | 100, 200 | Cipla Medpro (Pty) Ltd | 2 registrations | S5 |
| Droperidol (Pharma-q Droperidol) Cancelled | 5 mg/2 ml | Pharma-q Holdings (Pty) Ltd | 340126 | S5 |
| Fluoxetine (Ranflocs) Cancelled | 20 | Ranbaxy (SA) (Pty) Ltd | 340129 | S5 |
| Dexmedetomidine (Precedex, Eusedex) | 1 mL | Pfizer Laboratories (Pty) Ltd | 2 registrations | S5 |
| Fluoxetine (Rezak) Cancelled | Not stated | Dr Reddyæs Laboratories (Pty) Ltd | 340279 | S5 |
| Isotretinoin (Acnetane) | 10 mg, 20 mg | Adcock ingram limited | 2 registrations | S5 |
| Zopiclone (Z-dorm) | Not stated | Kiara Health (Pty) Ltd | 340421 | S5 |
| Paracetamol, tramadol (Tramacet, Ultracet) | 37.5 mg / 25 mg, 37,5 mg/325 mg | Janssen Pharmaceutica (Pty) Ltd | 2 registrations | S5 |
| Zopiclone (Zopivane) | 7,5 mg | Cipla Medpro (Pty) Ltd | 350021 | S5 |
| Sulpiride (Endepex, Sulpiride Oethmaan) | 50 | Oethmaan Biosims (Pty) Ltd | 2 registrations | S5 |
| Moclobemide (Adco-moclobemide) Cancelled | 150 mg, 300 mg | Adcock ingram limited | 2 registrations | S5 |
| Propofol (Recofol) | 1 % 20 ml, 1 % 50 ml, 1 % 100 ml | Viatris Healthcare (Pty) Ltd | 3 registrations | S5 |
| Clomipramine (Clomidep) | 25 mg | Ranbaxy Pharmaceutical (Pty) Ltd | 350253 | S5 |
| Midazolam (Midazolam Hexal Biotech, Mizam ( )) | 5 mg/1 ml, 15 mg/3 ml, 1 mg/ml 5 ml, 5 mg/ml 5 ml, 5 mg/ml 10 ml | Biotech Laboratories (Pty) Ltd | 5 registrations | S5 |
| Midazolam (Midacum) | 5 mg/ml, 15 mg/3 ml | Oethmaan Biosims (Pty) Ltd | 2 registrations | S5 |
| Clozapine (Cloment) | 25, 100, suspension | Acino Pharma (Pty) Ltd | 3 registrations | S5 |
| Isotretinoin (Oratane) | 10 mg, 20 mg, 40 mg, 5 mg | Acino Pharma (Pty) Ltd | 4 registrations | S5 |
| Fluvoxamine (Fluvoxamine Oethmaan) | 50, 100 | Oethmaan Biosims (Pty) Ltd | 2 registrations | S5 |
| Moclobemide (Depnil, Moclobix) | 300 | Sandoz South Africa (Pty) Ltd | 2 registrations | S5 |
| Zolpidem (Noxidem) | 10 | Sandoz South Africa (Pty) Ltd | 360087 | S5 |
| Citalopram (Cilift) | 20 mg | Pharmacare limited û woodmead | 360092 | S5 |
| Zolpidem (Zolpihexal) | 10 | Hexal Pharma (SA) (Pty) Ltd | 360095 | S5 |
| Paroxetine (Adco-paroxetine) | 20 mg | Adcock ingram limited | 360096 | S5 |
| Zolpidem hemitartrate (Adco-zolpidem Hemitartrate) | 5 mg, 10 mg | Adcock ingram limited | 2 registrations | S5 |
| Paroxetine (Paroxetine Oethmaan) | 20, 40 | Oethmaan Biosims (Pty) Ltd | 2 registrations | S5 |
| Sertraline (Serlife) | 50, 100 | Ranbaxy (SA) (Pty) Ltd | 2 registrations | S5 |
| Sertraline (Tralidep) | 50, 100 | Arya Pharma (Pty) Ltd | 2 registrations | S5 |
| Escitalopram (Cipralex) | 5 mg, 10 mg, 15 mg, 20 mg | H. Lundbeck (Pty) Ltd | 4 registrations | S5 |
| Zolpidem (Zolnoxs) | 10 mg | Pharmacare limited û woodmead | 360328 | S5 |
| Tramadol (Dolotram) | 50 mg/100 mg, 50 mg | Ranbaxy Pharmaceutical (Pty) Ltd | 3 registrations | S5 |
| Zopiclone (Zopigen) | Not stated | Viatris South Africa (Pty) Ltd | 360426 | S5 |
| Zopiclone (Z-dorm Hs) | Not stated | Oethmaan Biosims (Pty) Ltd | 360447 | S5 |
| Citalopram (Citalopram Oethmaan) | 20 mg, 40 | Oethmaan Biosims (Pty) Ltd | 2 registrations | S5 |
| Citalopram (Citalo Unimed) | 20 | Unimed Healthcare (Pty) Ltd | 360518 | S5 |
| Midazolam (Midanium, Miranost, Midazolam Nasal Cipla) | 5 mg/5 ML, 15 mg/3 ML, 50 mg/10 ml, 5 mg | Cipla Medpro (Pty) Ltd | 5 registrations | S5 |
| Modafinil (Provigil) | 100mg | Acino Pharma (Pty) Ltd | 370025 | S5 |
| Fluvoxamine (Fluvoxamine-hexal) | 100 | Biotech Laboratories (Pty) Ltd | 370102 | S5 |
| Clozapine (Clozapine Oethmaan, Clozapine-hexal) | 25 mg/50 mg/100 mg, 50, 100 | Oethmaan Biosims (Pty) Ltd | 3 registrations | S5 |
| Propofol (Sabax Propofol ( ), Adco Propofol ( )) | 1 % 20 ml, 1 % 50 ML, 2 % 20 ml, 2 % 50 ml, 2 % 100 ml | Adcock Ingram Critical Care (Pty) Ltd | 5 registrations | S5 |
| Propofol (Sabax Propofol ( )) | 1 % 100 ml | Adcock ingram limited | 370246 | S5 |
| Fluoxetine (Zydus-fluoxetine) | 20 mg | Zydus Healthcare (Pty) Ltd | 370265 | S5 |
| Duloxetine (Cymbalta) Cancelled | 30, 60 | Eli Lilly (S.A.) (Pty) Ltd | 2 registrations | S5 |
| Olanzapine (Olexar) | 2,5, 5, 10 | Cipla Medpro (Pty) Ltd | 3 registrations | S5 |
| Zopiclone (Zopisleep) | 7.5 mg | Ipharma (Pty) Ltd | 370375 | S5 |
| Trazodone (Aspen Trazodone) | 50 mg, 100 mg | Pharmacare limited û woodmead | 2 registrations | S5 |
| Venlafaxine (Venlor, Venlor Xr, Venlafaxine Cipla, +1 more) | 37,5, 225 mg, 300 mg, 37,5 mg, 75 mg, 150 mg, 225, 75, 150 | Cipla Medpro (Pty) Ltd | 17 registrations | S5 |
| Zolpidem (Ivedal, Ivedal Mr) | 10 mg, 12,5 | Sanofi-aventis South Africa (Pty) Ltd | 2 registrations | S5 |
| Paroxetine (Deparoc) Cancelled | 20 mg | Pharmacare limited û woodmead | 370595 | S5 |
| Tramadol (Domadol) | 50 mg, 100 mg | Unichem SA (Pty) Ltd | 3 registrations | S5 |
| Fluoxetine (Trizac) Cancelled | 20 mg | Unichem SA (Pty) Ltd | 370612 | S5 |
| Paroxetine (Sedarin) | Not stated | Biotech Laboratories (Pty) Ltd | 370665 | S5 |
| Sertraline (Serdep) | 50, 100 | Cipla Medpro (Pty) Ltd | 2 registrations | S5 |
| Citalopram (Ran-citalopram) | 10, 40, 20 | Ranbaxy (SA) (Pty) Ltd | 3 registrations | S5 |
| Citalopram (Simayla Citalopram, Seran) | 40, 10 | Ranbaxy Pharmaceutical (Pty) Ltd | 2 registrations | S5 |
| Citalopram (Simayla Citalopram, Tamomilt, Merck Citalopram, +1 more) | 20, 10, - 40 | Trinity Pharma (Pty) Ltd | 5 registrations | S5 |
| Paroxetine (Serrapress) | 20 mg | Pharma Dynamics (Pty) Ltd | 380069 | S5 |
| Paroxetine (Paroxetine Unicorn) | 20 mg | Unicorn Pharmaceuticals (Pty) Ltd | 380072 | S5 |
| Tramadol (Tramahexal Sr) | 100, 200 | Hexal Pharma (SA) (Pty) Ltd | 2 registrations | S5 |
| Clozapine (Aspen Clozapine) | 25 mg, 100 mg | Pharmacare limited û woodmead | 2 registrations | S5 |
| Midazolam (Midazolam PHARMC) | 50 mg/10 mL | Pharmacorp (Pty) Ltd | 380190 | S5 |
| Isotretinoin (Acnetret) | 20, 10 | Cipla Medpro (Pty) Ltd | 2 registrations | S5 |
| Tramadol (Tramgesic Flashtabs) | Not stated | Adcock ingram limited | 380274 | S5 |
| Sertraline (Adco-zertra) | 50, 100 | Adcock ingram limited | 2 registrations | S5 |
| Testosterone (Testogel, Androgel) | 50 mg/5 g | Medi Challenge (Pty) Ltd | 2 registrations | S5 |
| Midazolam (Miloz) Cancelled | 5, 15 | Gulf Drug Company (Pty) Ltd | 2 registrations | S5 |
| Sevoflurane (Sojourn) | Not stated | Safeline Pharmaceuticals (Pty) Ltd | 410098 | S5 |
| Mirtazapine (Aspen Mirtazapine) | 15 mg, 30 mg | Pharmacare limited û woodmead | 2 registrations | S5 |
| Sertraline (Sermax) Cancelled | 50, 100 | Be-tabs Pharmaceuticals (Pty) Ltd | 2 registrations | S5 |
| Risperidone (Rutra, Auro-risperidone, Auroperdal) | 1 mg, 2 mg, 3 mg, 4 mg, 0,5 mg, 1 mg/ml | Aurogen South Africa (Pty) Ltd | 12 registrations | S5 |
| Etomidate (B. Braun Etomidate) | 2 mg/ml | B Braun Medical (Pty) Ltd | 410294 | S5 |
| Citalopram (Acti-lift) | 20 mg | Activo Health (Pty) Ltd | 410297 | S5 |
| Risperidone (Aspen Risperidone) | 0,5 mg, 1 mg, 2 mg, 3 mg, 4 mg, oral solution | Pharmacare limited û woodmead | 6 registrations | S5 |
| Mirtazapine (Mirtazapine Viatris) | 15, 30 | Viatris South Africa (Pty) Ltd | 2 registrations | S5 |
| Bupropion (Wellbutrin Xl, Voxra Xl) | 150, 300 | Glaxosmithkline South Africa (Pty) Limited | 4 registrations | S5 |
| Escitalopram (Lexamil, Escitalopram Be-tabs) | 5 mg/ 10mg / 20mg, 5, 10, 20 | Cipla Medpro (Pty) Ltd | 6 registrations | S5 |
| Desvenlafaxine (Exsira) | 100 mg, 50 mg | Pfizer Laboratories (Pty) Ltd | 2 registrations | S5 |
| Venlafaxine (Odiven, Odiven Xr) | 37,5, 50, 75, 150 | Zydus Healthcare (Pty) Ltd | 6 registrations | S5 |
| Risperidone (Zoxadon, Zoxadon Odt) | 1 mg, 2 mg, 0,5 mg, 3 mg, 4 mg | Pharma Dynamics (Pty) Ltd | 8 registrations | S5 |
| Citalopram (DRL Citalopram) Cancelled | 40 | Dr Reddyæs Laboratories (Pty) Ltd | 410459 | S5 |
| Mirtazapine (Ramure) | 15 mg, 30 mg | Pharmacia South Africa (Pty) Ltd | 2 registrations | S5 |
| Citalopram (Recita, Auro-citalopram) | 20 mg, 10 mg, 40 mg | Aurogen South Africa (Pty) Ltd | 5 registrations | S5 |
| Escitalopram (Ficali, Xixia Escitalopram, Felitor) | 5, 10, 15, 20, 10 mg | Trinity Pharma (Pty) Ltd | 9 registrations | S5 |
| Varenicline (Champix) | 0,5 mg, 1 mg | Pfizer Laboratories Pfe (Pty) Ltd | 2 registrations | S5 |
| Sertraline (Sertraline Unimed) | 50, 100 mg | Unimed Healthcare (Pty) Ltd | 2 registrations | S5 |
| Isoflurane (Pe-isoflurane) | Not stated | Pharmaceutical Enterprises (Pty) Ltd | 410807 | S5 |
| Donepezil (Ariknow) | 5, 10 | Ranbaxy Pharmaceutical (Pty) Ltd | 2 registrations | S5 |
| Donepezil (Ran-donepezil, Arimer) | 5, 10 | MSQ Pharma (Pty) Ltd | 4 registrations | S5 |
| Escitalopram (Citraz) Cancelled | 5, 10, 20 | Dr Reddyæs Laboratories (Pty) Ltd | 3 registrations | S5 |
| Risperidone (Mylan Risperidone) Cancelled | 0,25 mg, 0,5 mg, 1 mg, 2mg, 3, 4mg, 6mg | Viatris Healthcare (Pty) Ltd | 7 registrations | S5 |
| Escitalopram (Espradep, Aspen Escitalopram) | 10 mg, 15 mg | Pharmacare limited û woodmead | 4 registrations | S5 |
| Risperidone (Risponz, Zydus Risperidone) | 1, 2, 3, 4 | Zydus Healthcare (Pty) Ltd | 8 registrations | S5 |
| Quetiapine (Quetiapine Viatris, Qlantris Xr) | 25, 100, 150, 200, 300, 50 mg, 150 mg, 200 mg, 300 mg, 400 mg | Viatris South Africa (Pty) Ltd | 10 registrations | S5 |
| Duloxetine (Cymgen) | 30, 60 | Pharmacare limited û woodmead | 2 registrations | S5 |
| Midazolam (Midazolam Safeline) Cancelled | 15 mg -, 50 mg - | Safeline Pharmaceuticals (Pty) Ltd | 2 registrations | S5 |
| Haloperidol (Haloperidol GDC) | 5 | Gulf Drug Company (Pty) Ltd | 420065 | S5 |
| Haloperidol (Haloject) Cancelled | 5 mg/ml | Viatris Healthcare (Pty) Ltd | 420075 | S5 |
| Risperidone (Risperidone Unimed, Pmi Risperidone) | 0,5, 1 mg/ml, 1, 2, 3, 4 | Unimed Healthcare (Pty) Ltd | 6 registrations | S5 |
| Risperidone (Sandoz Risperidone, Risperidone Hexal) Cancelled | 0,5, 1 mg/ml | Sandoz South Africa (Pty) Ltd | 2 registrations | S5 |
| Risperidone (Rispacor, Accord Risperidone) | 0,5, 1, 2, 3, 4 | Accord Healthcare (Pty) Ltd | 10 registrations | S5 |
| Paroxetine (Lenio) | 20 mg, 30 mg | Aurogen South Africa (Pty) Ltd | 2 registrations | S5 |
| Paroxetine (Texine) | 20 mg, 30 mg | Unimed Healthcare (Pty) Ltd | 2 registrations | S5 |
| Citalopram (Gulf Citalopram) | 20 | Gulf Drug Company (Pty) Ltd | 420214 | S5 |
| Venlafaxine (Litha Venlafaxine Sr, Mylan Venlafaxine) | 75, 150 | Viatris South Africa (Pty) Ltd | 3 registrations | S5 |
| Venlafaxine (Litha Venlafaxine Sr, Valexor Sr) Cancelled | 150, 75 | Acino Pharma (Pty) Ltd | 3 registrations | S5 |
| Paliperidone (Invega, Xeplion) | 3 mg, 6 mg, 9 mg, 12 mg, 25 mg/0,25 ml, 50 mg/0,50 ml, 75 mg/0,75 ml, 100 mg/1,0 ml, 150 mg/1,50 ml | Janssen Pharmaceutica (Pty) Ltd | 9 registrations | S5 |
| Risperidone (Schizorol) | 0,5, 1, 2, 3, 4, 6, 8 | Ascendis Pharma (Pty) Ltd | 7 registrations | S5 |
| Midazolam (Accord-midazolam, Midazolam Accord) | 15 mg/3 ml, 50 mg/10 ml, 5 mg/5 ml, 1,0 mg | Accord Healthcare (Pty) Ltd | 4 registrations | S5 |
| Venlafaxine (Efegen Xr, Venlafaxine Unicorn Xr) | 75, 150 | Ranbaxy (SA) (Pty) Ltd | 4 registrations | S5 |
| Donepezil (Donecept, Donecept Odt) | 5, 10 | Cipla Medpro (Pty) Ltd | 4 registrations | S5 |
| Zopiclone (Bio Zopiclone) | 7,5 mg | Biotech Laboratories (Pty) Ltd | 420537 | S5 |
| Citalopram (Arrow Citalopram) | 40, 20 | Astral Pharma (Pty) Ltd | 2 registrations | S5 |
| Zolpidem (Redinoct) Cancelled | 10 | Dr Reddyæs Laboratories (Pty) Ltd | 420721 | S5 |
| Atomoxetine (Strattera) Cancelled | 80 mg, 10 mg, 18 mg, 25 mg, 40 mg, 60 mg | Eli Lilly (S.A.) (Pty) Ltd | 6 registrations | S5 |
| Risperidone (Risnia) | 0,5 mg, 1 mg, 2 mg, 3 mg, 4 mg, 6 mg | Cipla Medpro (Pty) Ltd | 6 registrations | S5 |
| Olanzapine (Redilanz, Redilanz Odt, DRL Olanzapine Odt) | 2,5, 5, 10, 15 | Dr Reddyæs Laboratories (Pty) Ltd | 7 registrations | S5 |
| Escitalopram (Zytomil, DYNA Escitalopram) | 10 mg, 20 mg | Pharma Dynamics (Pty) Ltd | 3 registrations | S5 |
| Tramadol (Tramaspen) | 50 mg, 100 mg/2 ml | Pharmacare limited û woodmead | 2 registrations | S5 |
| Risperidone (Risplan) Cancelled | 0,5 mg | Pharmaplan (Pty) Ltd | 420968 | S5 |
| Risperidone (Risplan) Cancelled | 1,0 mg, 2,0 mg, 3,0 mg, 4,0 mg, 6,0 mg | Acino Pharma (Pty) Ltd | 5 registrations | S5 |
| Escitalopram (Escitalopram Unimed, *Escilex, Escilex) | 10, 5 mg, 10 mg, 20 mg | Unimed Healthcare (Pty) Ltd | 4 registrations | S5 |
| Citalopram (Bio Citalopram) | 10, 20, 30 | Biotech Laboratories (Pty) Ltd | 3 registrations | S5 |
| Risperidone (Rispevon) | 1, 2, 3, 4 | Trinity Pharma (Pty) Ltd | 4 registrations | S5 |
| Zopiclone (Sedastell, Austovane, Zopiclone Unicorn, +1 more) | 3,75 mg, 7,5 mg | Austell Pharmaceuticals (Pty) Ltd | 6 registrations | S5 |
| Olanzapine (Oleanz Rapitab, Oleanz) | 5, 10 | Ranbaxy (SA) (Pty) Ltd | 4 registrations | S5 |
| Venlafaxine (Accord Venlafaxine Xr) | 75 mg, 150 mg | Accord Healthcare (Pty) Ltd | 2 registrations | S5 |
| Midazolam (Midazolam B Braun) Cancelled | 1 mg/ml, 5 mg/ml | B Braun Medical (Pty) Ltd | 2 registrations | S5 |
| Zolpidem (Medploz) | 5 mg, 10 mg | Aurogen South Africa (Pty) Ltd | 2 registrations | S5 |
| Zolpidem (Nyxe) | 10 mg, 5 mg | Novagen Pharma (Pty) Ltd | 2 registrations | S5 |
| Modafinil (Modalert) Cancelled | 100, 200 | Ranbaxy (SA) (Pty) Ltd | 2 registrations | S5 |