Vortioxetine

Sold as Brintellix, Vorellix, Vortioxetine cipla, Vortioxetine unichem, Vortioxetine aspen, Brivor, Vortioxetine DYNA, Trintogen, Vortioxetine adco, Vortioxetine lundbeck, Netixev, Voxbrint, Elibrin, Vortioxetine zydus, Makollix, Brintomak

C₁₈H₂₂N₂S298.40 g/mol

1-[2-(2,4-Dimethylphenyl)sulfanylphenyl]piperazine

Drag to rotate. Structure from PubChem CID 9966051.

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Registration

Applicants: 10
Registrations: 50
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Adcock ingram limited	Brintellix, Trintogen, Vortioxetine adco	5 mg, 5 mg/ 10 mg/ 20 mg, 10 mg, 15 mg, 20 mg	480429, 480430, 480431, 480432, 550129, 550130, 550131, 550132.129, 550133.13, 550134.131	S5	PI PIL
Cipla Medpro (Pty) Ltd	Vorellix, Vortioxetine cipla	5, 10, 15, 20	530699, 530700, 530701, 530702, 530703.699, 530704.7, 530705.701, 530706.702	S5	PI PIL
Unichem SA (Pty) Ltd	Vortioxetine unichem	5 mg, 10 mg, 20 mg	540556, 540557, 540558	S5	None
Pharmacare limited û woodmeadCertificate held by Pharmacare limited	Vortioxetine aspen	2,4 mg	540702, 540703, 540704	S5	PI PIL
Pharma Dynamics (Pty) Ltd	Brivor, Vortioxetine DYNA	5 mg, 10 mg, 20 mg	550105, 550106, 550107, 550108.105, 550109.106, 550110.107	S5	None
H. Lundbeck (Pty) Ltd	Vortioxetine lundbeck	5,10,15,20 mg	550580, 550581, 550582, 550583	S5	PI PIL
Pps Pharmaceuticals (Pty) Ltd	Netixev	5, 10, 20	550597, 550598, 550599	S5	None
Dr Reddyæs Laboratories (Pty) Ltd	Voxbrint	5, 10, 20	550600.597, 550601.598, 550602.599	S5	None
Zydus Healthcare (Pty) Ltd	Elibrin, Vortioxetine zydus	10, 20	550792, 550793, 550795.792, 550796.793	S5	None
Macleods Pharmaceuticals SA (Pty) Ltd	Makollix, Brintomak	5, 10, 20	570578, 570579, 570580, 570581.578, 570582.579, 570583.580	S5	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Brintellix 5 MG EACH TABLET CONTAINS :VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5 mg	48042948/1.2/0429	Registered	S5	None
Brintellix 10 MG EACH TABLET CONTAINS :VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	10 mg	48043048/1.2/0430	Registered	S5	None
Brintellix 15 MG EACH TABLET CONTAINS :VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 15,0 mg	15 mg	48043148/1.2/0431	Registered	S5	None
Brintellix 20 MG EACH TABLET CONTAINS :VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20 mg	48043248/1.2/0432	Registered	S5	None
Vorellix 5 ECAH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5Tablets	53069953/1.2/0699Approved 27 July 2021	Registered	S5	PI PIL
Vorellix 10 ECAH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	10Tablets	53070053/1.2/0700Approved 27 July 2021	Registered	S5	PI PIL
Vorellix 15 ECAH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 15,0 mg	15Tablets	53070153/1.2/0701Approved 27 July 2021	Registered	S5	PI PIL
Vorellix 20 ECAH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20Tablets	53070253/1.2/0702Approved 27 July 2021	Registered	S5	PI PIL
Vortioxetine cipla 5 ECAH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5Tablets	530703.69953/1.2/0703.699Approved 27 July 2021	Registered	S5	PI PIL
Vortioxetine cipla 10 ECAH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	10Tablets	530704.753/1.2/0704.700Approved 27 July 2021	Registered	S5	PI PIL
Vortioxetine cipla 15 ECAH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 15,0 mg	15Tablets	530705.70153/1.2/0705.701Approved 27 July 2021	Registered	S5	PI PIL
Vortioxetine cipla 20 ECAH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20Tablets	530706.70253/1.2/0706.702Approved 27 July 2021	Registered	S5	PI PIL
Vortioxetine 5 MG unichem EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5 mg	54055654/1.2/0556	Registered	S5	None
Vortioxetine 10 MG unichem EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	10 mg	54055754/1.2/0557	Registered	S5	None
Vortioxetine 20 MG unichem EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20 mg	54055854/1.2/0558	Registered	S5	None
Vortioxetine 5mg aspen VORTIOXETINE HYDROBROMIDE	2,4 mgTablet	54070254/1.2/0702Approved 22 November 2022	Registered	S5	PI PIL
Vortioxetine 10 MG aspen VORTIOXETINE HYDROBROMIDE	2,4 mgTablet	54070354/1.2/0703Approved 22 November 2022	Registered	S5	PI PIL
Vortioxetine 20 MG aspen VORTIOXETINE HYDROBROMIDE	2,4 mgTablet	54070454/1.2/0704Approved 22 November 2022	Registered	S5	PI PIL
Brivor 5 MG EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5 mg	55010555/1.2/0105	Registered	S5	None
Brivor 10 MG EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	10 mg	55010655/1.2/0106	Registered	S5	None
Brivor 20 MG EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20 mg	55010755/1.2/0107	Registered	S5	None
Vortioxetine 5 MG DYNA EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5 mg	550108.10555/1.2/0108.105	Registered	S5	None
Vortioxetine 10 MG DYNA EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	10 mg	550109.10655/1.2/0109.106	Registered	S5	None
Vortioxetine 20 MG DYNA EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20 mg	550110.10755/1.2/0110.107	Registered	S5	None
Trintogen 5 EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5 mg/ 10 mg/ 20 mgTablet	55012955/1.2/0129Approved 12 July 2022	Registered	S5	PI PIL
Trintogen 10 EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	5 mg/ 10 mg/ 20 mgTablet	55013055/1.2/0130Approved 12 July 2022	Registered	S5	PI PIL
Trintogen 20 EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	5 mg/ 10 mg/ 20 mgTablet	55013155/1.2/0131Approved 12 July 2022	Registered	S5	PI PIL
Vortioxetine 5 adco EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5 mg/ 10 mg/ 20 mgTablet	550132.12955/1.2/0132.129Approved 12 July 2022	Registered	S5	PI PIL
Vortioxetine 10 adco EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	5 mg/ 10 mg/ 20 mgTablet	550133.1355/1.2/0133.130Approved 12 July 2022	Registered	S5	PI PIL
Vortioxetine 20 adco EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	5 mg/ 10 mg/ 20 mgTablet	550134.13155/1.2/0134.131Approved 12 July 2022	Registered	S5	PI PIL
Vortioxetine 5 MG lundbeck EACH TABLET CONTAINS : VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5,10,15,20 mgFilm-coated tablets	55058055/1.2/0580Approved 30 January 2024	Registered	S5	PI PIL
Vortioxetine 10 MG lundbeck EACH TABLET CONTAINS : VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	5,10,15,20 mgFilm-coated tablets	55058155/1.2/0581Approved 30 January 2024	Registered	S5	PI PIL
Vortioxetine 15 MG lundbeck EACH TABLET CONTAINS : VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 15,0 mg	5,10,15,20 mgFilm-coated tablets	55058255/1.2/0582Approved 30 January 2024	Registered	S5	PI PIL
Vortioxetine 20 MG lundbeck EACH TABLET CONTAINS : VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	5,10,15,20 mgFilm-coated tablets	55058355/1.2/0583Approved 30 January 2024	Registered	S5	PI PIL
Netixev 5 EACH TABLET CONTAINS: VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5	55059755/1.2/0597	Registered	S5	None
Netixev 10 EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	10	55059855/1.2/0598	Registered	S5	None
Netixev 20 EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20	55059955/1.2/0599	Registered	S5	None
Voxbrint 5 EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5	550600.59755/1.2/0600.597	Registered	S5	None
Voxbrint 10 EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	10	550601.59855/1.2/0601.598	Registered	S5	None
Voxbrint 20 EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20	550602.59955/1.2/0602.599	Registered	S5	None
Elibrin 10 EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	10	55079255/1.2/0792	Registered	S5	None
Elibrin 20 EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20	55079355/1.2/0793	Registered	S5	None
Vortioxetine 10 zydus EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE 10,0 mg	10	550795.79255/1.2/0795.792	Registered	S5	None
Vortioxetine 20 zydus EACH TABLET CONTAINS VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20	550796.79355/1.2/0796.793	Registered	S5	None
Makollix 5 EACH TABLET CONTAINS: VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5	57057857/1.2/0578	Registered	S5	None
Makollix 10 EACH TABLET CONTAINS: VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	10	57057957/1.2/0579	Registered	S5	None
Makollix 20 EACH TABLET CONTAINS: VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20	57058057/1.2/0580	Registered	S5	None
Brintomak 5 EACH TABLET CONTAINS: VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 5,0 mg	5	570581.57857/1.2/0581.578	Registered	S5	None
Brintomak 10 EACH TABLET CONTAINS: VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 10,0 mg	10	570582.57957/1.2/0582.579	Registered	S5	None
Brintomak 20 EACH TABLET CONTAINS: VORTIOXETINE HYDROBROMIDE EQUIVALENT TO VORTIOXETINE 20,0 mg	20	570583.58057/1.2/0583.580	Registered	S5	None

Regulatory status

Where S5 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only, with tighter controls on repeats.

Schedule 5 medicines need a prescription, and repeat dispensing is capped at six months in total; the prescriber must state upfront how many times, and at what intervals, it may be repeated. Extra limits apply to some uses: if it is being used for its anxiolytic, antidepressant, tranquillising or analgesic properties, it cannot be prescribed for longer than six months without a further consultation. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S5, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it.

Consolidated Schedules listings for Vortioxetine hydrobromide equivalent to vortioxetine

S5: Vortioxetine
Consolidated Schedules 06 July 2026, line 9765

Pharmacological class: Psychoanaleptics (antidepressants). (class 1.2)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsVorellix 5, Cipla Medpro (Pty) Ltd Patient information leaflet (PIL)For patients and carersVorellix 5, Cipla Medpro (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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