Paroxetine

Sold as Xixia paroxetine, Adco-paroxetine, Paroxetine oethmaan, Deparoc, Sedarin, Serrapress, Paroxetine unicorn, Lenio, Texine, Apex paroxetine, Aropax cr, Paxotene, Paxil, Xet, Austell paroxetine, Aryaxel

C₁₉H₂₀FNO₃329.40 g/mol

(3S,4R)-3-(1,3-Benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine

Drag to rotate. Structure from PubChem CID 43815.

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Registration

Applicants: 13
Registrations: 21
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Viatris South Africa (Pty) Ltd	Xixia paroxetine	20	290556	S5	None
Adcock ingram limited	Adco-paroxetine	20 mg	360096	S5	PI PIL
Oethmaan Biosims (Pty) Ltd	Paroxetine oethmaan	20, 40	360160, 360161	S5	None
Pharmacare limited û woodmeadCancelled	Deparoc	20 mg	370595	S5	None
Biotech Laboratories (Pty) Ltd	Sedarin	Not stated	370665	S5	None
Pharma Dynamics (Pty) Ltd	Serrapress	20 mg	380069	S5	PI PIL
Unicorn Pharmaceuticals (Pty) Ltd	Paroxetine unicorn	20 mg	380072	S5	PI PIL
Aurogen South Africa (Pty) Ltd	Lenio	20 mg, 30 mg	420208, 420209	S5	None
Unimed Healthcare (Pty) Ltd	Texine	20 mg, 30 mg	420210, 420211	S5	None
Camox Pharmaceuticals (Pty) LtdCancelled	Apex paroxetine, Paxotene	20 mg -, 20 mg	A380474, A380706	S5	None
Glaxosmithkline South Africa (Pty) Limited	Aropax cr, Paxil	12,5, 20, 25	A380612, A380613, A390078	S5	PI PIL
Zydus Healthcare (Pty) Ltd	Xet, Aryaxel	20	A390216, A400712	S5	None
Austell Pharmaceuticals (Pty) Ltd	Austell paroxetine	20 mg, 30 mg	A390640, A390641	S5	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Xixia paroxetine 20 EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 20,0 mg	20	29055629/1.2/0556	Registered	S5	None
Adco-paroxetine 20 MG EACH TABLET CONTAINS PAROXETINE 20,0 mg	20 mgFilm-coated tablets.	36009636/1.2/0096Approved 21 February 2021	Registered	S5	PI PIL
Paroxetine 20 oethmaan EACH TABLET CONTAINS PAROXETINE 20,0 mg	20	36016036/1.2/0160	Registered	S5	None
Paroxetine 40 oethmaan EACH TABLET CONTAINS PAROXETINE 40,0 mg	40	36016136/1.2/0161	Registered	S5	None
Deparoc 20 MG EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 20,0 mg	20 mg	37059537/1.2/0595	Cancelled	S5	None
Sedarin EACH TABLET CONTAINS: PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 20,0 mg	Not listed	37066537/1.2/0665	Registered	S5	None
Serrapress 20 EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 20,0 mg	20 mgFilm coated tablets	38006938/1.2/0069Approved 10 October 2023	Registered	S5	PI PIL
Paroxetine unicorn 20 EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 20,0 mg	20 mgTablets.	38007238/1.2/0072	Registered	S5	PI PIL
Lenio 20 MG EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE 20,0 mg	20 mg	42020842/1.2/0208	Registered	S5	None
Lenio 30 MG EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE 30,0 mg	30 mg	42020942/1.2/0209	Registered	S5	None
Texine 20 MG EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE 20,0 mg	20 mg	42021042/1.2/0210	Registered	S5	None
Texine 30 MG EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE 30,0 mg	30 mg	42021142/1.2/0211	Registered	S5	None
Apex - paroxetine 20 MG tablets EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 20,0 mg	20 mg -Tablets	A380474A38/1.2/0474	Cancelled	S5	None
Aropax cr 12,5 each tablet CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 12,5 mg	12,5Controlled release tablet	A380612A38/1.2/0612Approved 19 December 2023	Registered	S5	PI PIL
Aropax cr 25 EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 25,0 mg	25Controlled release tablet	A380613A38/1.2/0613Approved 19 December 2023	Registered	S5	PI PIL
Paxotene 20 MG tablets EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 20,0 mg	20 mgTablets	A380706A38/1.2/0706	Cancelled	S5	None
Paxil 20 EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 20,0 mg	20	A390078A39/1.2/0078	Registered	S5	None
Xet 20 EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 20,0 mg	20	A390216A39/1.2/0216	Registered	S5	None
Austell paroxetine 20 MG EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 20,0 mg	20 mg	A390640A39/1.2/0640	Registered	S5	None
Austell paroxetine 30 MG EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 30,0 mg	30 mg	A390641A39/1.2/0641	Registered	S5	None
Aryaxel 20 EACH TABLET CONTAINS PAROXETINE HYDROCHLORIDE EQUIVALENT TO PAROXETINE 20,0 mg	20	A400712A40/1.2/0712	Registered	S5	None

Regulatory status

Where S5 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only, with tighter controls on repeats.

Schedule 5 medicines need a prescription, and repeat dispensing is capped at six months in total; the prescriber must state upfront how many times, and at what intervals, it may be repeated. Extra limits apply to some uses: if it is being used for its anxiolytic, antidepressant, tranquillising or analgesic properties, it cannot be prescribed for longer than six months without a further consultation. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S5, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it.

Consolidated Schedules listings for Paroxetine hydrochloride equivalent to paroxetine

S5: Paroxetine
Consolidated Schedules 06 July 2026, line 9618

Pharmacological class: Psychoanaleptics (antidepressants). (class 1.2)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsAdco-paroxetine 20 MG, Adcock ingram limited Patient information leaflet (PIL)For patients and carersAdco-paroxetine 20 MG, Adcock ingram limited

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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