Imipramine
Sold as Ethipramine, Imipramine HCL, Imipramine bp, Medipramine, Imipramine, Panpramine, Tofranil, Mipralin
3-(5,6-Dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Drag to rotate. Structure from PubChem CID 3696.
Background
Registration
- Applicants
- 4
- Registrations
- 14
- Schedule source
- Consolidated Schedules 06 July 2026
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Pharmacare limited û woodmead2 of 4 cancelled | Ethipramine, Mipralin | 10 mg, 25 mg | B0694, B0695, M0017, M0018 | S5 | None |
| The Premier Pharmaceutical Co LtdCancelled | Imipramine HCL, Imipramine bp, Medipramine, Imipramine, Panpramine | 10 MG, 25 MG, 25MG | B0750, B0757, B0822, B0823, B1215, B1257, B1258 | S5 | None |
| Ciba-geigy (Pty) LtdCancelled | Tofranil | Not stated | B1535 | S5 | None |
| Pharmaco Distribution (Pty) Ltd | Tofranil | 10, 25 | B1536, B1537 | S5 | None |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Ethipramine 25 MG EACH TABLET CONTAINS IMIPRAMINE HYDROCHLORIDE A 25 mg | 25 mg | B0694 | Old Medicine | S5 | None |
| Ethipramine 10 MG tablets EACH TABELT CONTAINS IMIPRAMINE HYDROCHLORIDE A 10 mg | 10 mgTablets | B0695 | Old Medicine | S5 | None |
| Imipramine HCL 10 MG TABLET IMIPRAMINE HYDROCHLORIDE A 10 MG | 10 MG | B0750 | Cancelled | S5 | None |
| Imipramine bp 1968 25 MG TABLET IMIPRAMINE HYDROCHLORIDE A 25 MG + 3% OVERAGE | 25 MG | B0757 | Cancelled | S5 | None |
| Medipramine 10 MG TABLET IMIPRAMINE HYDROCHLORIDE A 10 MG | 10 MG | B0822 | Cancelled | S5 | None |
| Medipramine 25mg TABLET IMIPRAMINE HYDROCHLORIDE A 25 MG | 25MG | B0823 | Cancelled | S5 | None |
| Imipramine TABLET IMIPRAMINE HYDROCHLORIDE A 25,75 MG | Not listed | B1215 | Cancelled | S5 | None |
| Panpramine 10 MG EACH TABLET CONTAINS: IMIPRAMINE HYDROCHLORIDE A 10 MG | 10 MG | B1257 | Cancelled | S5 | None |
| Panpramine 25 MG TABLET IMIPRAMINE HYDROCHLORIDE A 25 MG | 25 MG | B1258 | Cancelled | S5 | None |
| Tofranil 100 ML IMIPRAMINE HYDROCHLORIDE A 1,25 G | Not listed | B1535 | Cancelled | S5 | None |
| Tofranil 10 EACH TABLET CONTAINS IMIPRAMINE HYDROCHLORIDE A 10,0 mg | 10 | B1536 | Old Medicine | S5 | None |
| Tofranil 25 EACH TABLET CONTAINS IMIPRAMINE HYDROCHLORIDE A 25,0 mg | 25 | B1537 | Old Medicine | S5 | None |
| Mipralin 10 MG EACH TABLET CONTAINS IMIPRAMINE HYDROCHLORIDE 10 mg | 10 mg | M0017M/1.2/17 | Cancelled | S5 | None |
| Mipralin 25 MG EACH TABLET CONTAINS IMIPRAMINE HYDROCHLORIDE 25 MG | 25 mg | M0018M/1.2/18 | Cancelled | S5 | None |
Regulatory status
Where S5 sits on the scale
Prescription-only, with tighter controls on repeats.
Schedule 5 medicines need a prescription, and repeat dispensing is capped at six months in total; the prescriber must state upfront how many times, and at what intervals, it may be repeated. Extra limits apply to some uses: if it is being used for its anxiolytic, antidepressant, tranquillising or analgesic properties, it cannot be prescribed for longer than six months without a further consultation. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S5, matched to the Consolidated Schedules by ingredient, confidence high.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it.
Consolidated Schedules listings for Imipramine hydrochloride
S5: Imipramine
- unless listed elsewhere in the Schedules.
Consolidated Schedules 06 July 2026, line 9495
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
SAHPRA has not published a professional information or patient information leaflet for this product.