Clomipramine
Sold as Apotex-clomipramine, Companil, Pharma-q clomipramine HCL, Clomidep, Clomicalm, Anafranil, Anafranil sr, Equinorm, Merck-clomipramine HCL
3-(2-Chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Drag to rotate. Structure from PubChem CID 2801.
Background
Registration
- Applicants
- 11
- Registrations
- 18
- Schedule source
- Consolidated Schedules 06 July 2026
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Adcock ingram limitedCancelled | Apotex-clomipramine | 10 | 310063 | S5 | None |
| Zimbili Pharma CCCancelled | Apotex-clomipramine | 25 | 310065 | S5 | None |
| Apotex SA (Pty) LtdCancelled | Apotex-clomipramine | 50 | 310067 | S5 | None |
| Afripharm South Africa (Pty) Ltd | Companil | 25, 50, 75 | 330336, 330337, 330338 | S5 | None |
| Pharma-q Holdings (Pty) Ltd | Pharma-q clomipramine HCL | 25 mg/2 ml | 330473 | S5 | None |
| Ranbaxy Pharmaceutical (Pty) LtdCertificate held by Ranbaxy Pharmaceuticals (Pty) Ltd | Clomidep | 25 mg | 350253 | S5 | PIPIL |
| Virbac Rsa (Pty) Ltd | Clomicalm | 5 mg, 20 mg, 80 mg | 98/7, 98/8, 98/9 | S5 | None |
| Novartis South Africa (Pty) LtdCancelled | Anafranil | 25 | B1531 | S5 | None |
| Equity Pharmaceutical (Pty) LtdCertificate held by Equity Pharmaceuticals (Pty) Ltd. | Anafranil, Anafranil sr | 10, 75 | C0182, W0140 | S5 | PIPIL |
| Pharmacare limited û woodmead | Equinorm | 10 mg, 25 mg | Y0268, Y0269 | S5 | None |
| Merck Generics Rsa (Pty) Ltd1 of 2 cancelled | Merck-clomipramine HCL | 10 mg | Z0109, Z0110 | S5 | None |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Apotex-clomipramine 10 EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 10,0 mg | 10 | 31006331/1.2/0063 | Cancelled | S5 | None |
| Apotex-clomipramine 25 EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 25,0 mg | 25 | 31006531/1.2/0065 | Cancelled | S5 | None |
| Apotex-clomipramine 50 EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 50,0 mg | 50 | 31006731/1.2/0067 | Cancelled | S5 | None |
| Companil 25 EACH CAPSULE CONTAINS CLOMIPRAMINE HYDROCHLORIDE 25,0 mg | 25 | 33033633/1.2/0336 | Registered | S5 | None |
| Companil 50 EACH CAPSULE CONTAINS CLOMIPRAMINE HYDROCHLORIDE 50,0 mg | 50 | 33033733/1.2/0337 | Registered | S5 | None |
| Companil 75 EACH CAPSULE CONTAINS CLOMIPRAMINE HYDROCHLORIDE 75,0 mg | 75 | 33033833/1.2/0338 | Registered | S5 | None |
| Pharma-q clomipramine HCL injection 25 mg/2 ML EACH 2,0 ml SOLUTION CONTAINS CLOMIPRAMINE HYDROCHLORIDE 25,0 mg | 25 mg/2 mlInjection | 33047333/1.2/0473 | Registered | S5 | None |
| Clomidep EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 25,0 mg | 25 mgFilm-coated tablets | 35025335/1.2/0253Approved 11 June 2026 | Registered | S5 | PIPIL |
| Clomicalm 5 MG EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 5,0 mg | 5 mg | 98/798/2.4/7 | Registered | S5 | None |
| Clomicalm 20 MG EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 20,0 mg | 20 mg | 98/898/2.4/8 | Registered | S5 | None |
| Clomicalm 80 MG EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 80,0 mg | 80 mg | 98/998/2.4/9 | Registered | S5 | None |
| Anafranil 25 ampoules EACH 2 ml SOLUTION CONTAINS CLOMIPRAMINE HYDROCHLORIDE A 25 mg | 25Ampoules | B1531 | Cancelled | S5 | None |
| Anafranil 10 EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 10 mg | 10Tablet. divitabs | C0182C/1.2/182Approved 24 May 2022 | Registered | S5 | PIPIL |
| Anafranil sr 75 EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 75 mg | 75 | W0140W/1.2/140 | Registered | S5 | None |
| Equinorm 10 MG tablets EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 10 mg | 10 mgTablets | Y0268Y/1.2/268 | Registered | S5 | None |
| Equinorm 25 MG tablets EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 25 mg | 25 mgTablets | Y0269Y/1.2/269 | Registered | S5 | None |
| Merck-clomipramine HCL 10 MG EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE A 10,0 mg | 10 mg | Z0109 | Old Medicine | S5 | None |
| Merck-clomipramine HCL EACH TABLET CONTAINS CLOMIPRAMINE HYDROCHLORIDE 25,0 MG | Not listed | Z0110Z/1.2/110 | Cancelled | S5 | None |
Regulatory status
Where S5 sits on the scale
Prescription-only, with tighter controls on repeats.
Schedule 5 medicines need a prescription, and repeat dispensing is capped at six months in total; the prescriber must state upfront how many times, and at what intervals, it may be repeated. Extra limits apply to some uses: if it is being used for its anxiolytic, antidepressant, tranquillising or analgesic properties, it cannot be prescribed for longer than six months without a further consultation. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S5, matched to the Consolidated Schedules by ingredient, confidence high.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it.
Consolidated Schedules listings for Clomipramine hydrochloride
S5: Clomipramine
Consolidated Schedules 06 July 2026, line 9331
Pharmacological class: Psychoanaleptics (antidepressants). (class 1.2)
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
Schedule Verification
Clomidep, Ranbaxy Pharmaceutical (Pty) Ltd is scheduled S5 in its official SAHPRA documents, read with 90% confidence.
These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.