Venlafaxine

Sold as Efexor xr, Venlor, Odiven, Litha venlafaxine sr, Valexor sr, Efegen xr, Venlafaxine unicorn xr, Mylan venlafaxine, Accord venlafaxine xr, Venlafaxine xr adco, Letizia, Mebolex, Galinex, Cymlafax xr, Illovex xr, Odiven xr, Venlor xr, Venlafaxine cipla, Venlafaxine be-tabs mr, Venlafaxine xl austell, Faxedepor xl, Faxdepor xl, Venexor xr

C₁₇H₂₇NO₂277.40 g/mol

1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol

Drag to rotate. Structure from PubChem CID 5656.

Loading Wikipedia summary

Registration

Applicants: 13
Registrations: 56
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Viatris Healthcare (Pty) Ltd	Efexor xr	75 mg, 150 mg	320318, 320319	S5	None
Cipla Medpro (Pty) LtdCertificate held by Cipla Medpro (Pty) Ltd.3 of 17 cancelled	Venlor, Venlor xr, Venlafaxine cipla, Venlafaxine be-tabs mr	37,5 mg, 75 mg, 150 mg, 225 mg, 300 mg	370533, 560035, 560036, 560037, 560038, 560039, 590212, 590213.212, 590384, 590385, 590386, A400029, A400030, A400031, A400032, A400033, A400034	S5	PI PIL
Zydus Healthcare (Pty) LtdCertificate held by Zydus Healthcare SA (Pty) Ltd	Odiven, Odiven xr	37,5, 50, 75, 150	410440, 410441, 410442, 540072, 540073, 540074	S5	PI PIL
Viatris South Africa (Pty) Ltd1 of 3 cancelled	Litha venlafaxine sr, Mylan venlafaxine	75, 150	420254, 430097, 430098	S5	None
Acino Pharma (Pty) LtdCancelled	Litha venlafaxine sr, Valexor sr	75, 150	420255, 420257, 420258	S5	None
Ranbaxy (SA) (Pty) Ltd2 of 4 cancelled	Efegen xr, Venlafaxine unicorn xr	75, 150	420423, 420424, 420425, 420426	S5	None
Accord Healthcare (Pty) Ltd	Accord venlafaxine xr	75 mg, 150 mg	430138, 430139	S5	None
Adcock ingram limited	Venlafaxine xr adco, Cymlafax xr	37,5, 75, 150, 225 mg	430577, 430578, 430579, 520438, 520439	S5	PI PIL
Aurogen South Africa (Pty) LtdCancelled	Letizia, Mebolex, Galinex	37,5 mg, 75 mg	450650, 450651, 450652, 450653, 450654, 450655	S5	None
Pharma Dynamics (Pty) Ltd	Illovex xr	300 mg	530467	S5	None
Austell Pharmaceuticals (Pty) Ltd	Venlafaxine xl austell	75 mg, 150 mg	A400491, A400493	S5	None
Trinity Pharma (Pty) Ltd	Faxedepor xl, Faxdepor xl	75, 150	A400492, A400494	S5	None
Pharmacare limited û woodmead	Venexor xr	37,5 mg, 75 mg, 150 mg	A400606, A400607, A400608	S5	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Efexor xr 75 MG EACH CAPSULE CONTAINS VENLAFAXINE 75,0 mg	75 mg	32031832/1.2/0318	Registered	S5	None
Efexor xr 150 MG EACH CAPSULE CONTAINS VENLAFAXINE 150,0 mg	150 mg	32031932/1.2/0319	Registered	S5	None
Venlor 37,5 EACH TABLET CONTAINS VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO VENLAFAXINE 37,5 mg	37,5	37053337/1.2/0533	Registered	S5	None
Odiven 37,5 EACH TABLET CONTAINS VENLAFAXINE 37,5 mg	37,5	41044041/1.2/0440	Registered	S5	None
Odiven 50 EACH TABLET CONTAINS VENLAFAXINE 50,0 mg	50	41044141/1.2/0441	Registered	S5	None
Odiven 75 EACH TABLET CONTAINS VENLAFAXINE 75,0 mg	75	41044241/1.2/0442	Registered	S5	None
Litha venlafaxine sr 75 EACH CAPSULE CONTAINS: VENLAFAXINE 75,0 mg	75	42025442/1.2/0254	Cancelled	S5	None
Litha venlafaxine sr 150 EACH CAPSULE CONTAINS: VENLAFAXINE 150,0 mg	150	42025542/1.2/0255	Cancelled	S5	None
Valexor sr 75 EACH CAPSULE CONTAINS: VENLAFAXINE 75,0 mg	75	42025742/1.2/0257	Cancelled	S5	None
Valexor sr 150 EACH CAPSULE CONTAINS: VENLAFAXINE 150,0 mg	150	42025842/1.2/0258	Cancelled	S5	None
Efegen xr 75 EACH CAPSULE CONTAINS VENLAFAXINE 75,0 mg	75	42042342/1.2/0423	Registered	S5	None
Efegen xr 150 EACH CAPSULE CONTAINS VENLAFAXINE 150,0 mg	150	42042442/1.2/0424	Registered	S5	None
Venlafaxine unicorn xr 75 EACH CAPSULE CONTAINS VENLAFAXINE 75,0 mg	75	42042542/1.2/0425	Cancelled	S5	None
Venlafaxine unicorn xr 150 EACH CAPSULE CONTAINS VENLAFAXINE 150,0 mg	150	42042642/1.2/0426	Cancelled	S5	None
Mylan venlafaxine 75 EACH CAPSULE CONTAINS VENLAFAXINE 75,0 mg	75	43009743/1.2/0097	Registered	S5	None
Mylan venlafaxine 150 EACH CAPSULE CONTAINS VENLAFAXINE 150,0 mg	150	43009843/1.2/0098	Registered	S5	None
Accord venlafaxine 75 MG xr EACH CAPSULE CONTAINS VENLAFAXINE 75,0 mg	75 mg	43013843/1.2/0138	Registered	S5	None
Accord venlafaxine 150 MG xr EACH CAPSULE CONTAINS VENLAFAXINE 150,0 mg	150 mg	43013943/1.2/0139	Registered	S5	None
Venlafaxine xr 37,5 adco EACH CAPSULE CONTAINS :VENLAFAXINE 37,5 mg	37,5Extended release capsules	43057743/1.2/0577Approved 30 November 2021	Registered	S5	PI PIL
Venlafaxine xr 75 adco EACH CAPSULE CONTAINS VENLAFAXINE 75,0 mg	75Extended release capsules	43057843/1.2/0578Approved 30 November 2021	Registered	S5	PI PIL
Venlafaxine xr 150 adco EACH CAPSULE CONTAINS :VENLAFAXINE 150,0 mg	150Extended release capsules	43057943/1.2/0579Approved 30 November 2021	Registered	S5	PI PIL
Letizia 37,5 MG EACH TABLET CONTAINS :VENLAFAXINE 37,5 mg	37,5 mg	45065045/1.2/0650	Cancelled	S5	None
Letizia 75 MG EACH TABLET CONTAINS: VENLAFAXINE 75,0 mg	75 mg	45065145/1.2/0651	Cancelled	S5	None
Mebolex 37,5 MG tablets EACH TABLET CONTAINS: VENLAFAXINE 37,5 mg	37,5 mgTablets	45065245/1.2/0652	Cancelled	S5	None
Mebolex 75 MG tablets EACH TABLET CONTAINS :VENLAFAXINE 75,0 mg	75 mgTablets	45065345/1.2/0653	Cancelled	S5	None
Galinex 37,5 MG tablets EACH TABLET CONTAINS :VENLAFAXINE 37,5 mg	37,5 mgTablets	45065445/1.2/0654	Cancelled	S5	None
Galinex 75 MG tablets EACH TABLET CONTAINS: VENLAFAXINE 75,0 mg	75 mgTablets	45065545/1.2/0655	Cancelled	S5	None
Venlafaxine xr 225 adco	225Extended release capsules	52043852/1.2/0438Approved 30 November 2021	Registered	S5	PI PIL
Cymlafax xr 225	225 mgExtended release capsules.	52043952/1.2/0439.438Approved 30 November 2021	Registered	S5	PI PIL
Illovex xr 300 MG EACH TABLET CONTAINS VENLAFAXINE 300,0 mg	300 mg	53046753/1.2/0467	Registered	S5	None
Odiven xr 37,5 EACH CAPSULE CONTAINS VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO VENLAFAXINE 37,5 mg	37,5Extended-release capsule	54007254/1.2/0072Approved 10 September 2024	Registered	S5	PI PIL
Odiven xr 75 EACH CAPSULE CONTAINS VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO VENLAFAXINE 75,0 mg	75Extended-release capsule	54007354/1.2/0073Approved 10 September 2024	Registered	S5	PI PIL
Odiven xr 150 EACH CAPSULE CONTAINS VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO VENLAFAXINE 150,0 mg	150Extended-release capsule	54007454/1.2/0074Approved 10 September 2024	Registered	S5	PI PIL
Venlor xr 225 MG tablet EACH TABLET CONTAINS VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO VENLAFAXINE 225,0 mg	225 mgTablet	56003556/1.2/0035	Registrered	S5	None
Venlor xr 300 MG tablet EACH TABLET CONTAINS VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO VENLAFAXINE 300,0 mg	300 mgTablet	56003656/1.2/0036	Registrered	S5	None
Venlor xr 37,5 MG tablet EACH TABLET CONTAINS VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO VENLAFAXINE 37,5 mg	37,5 mgTablet	56003756/1.2/0037	Registered	S5	None
Venlor xr 75 MG tablet EACH TABLET CONTAINS VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO VENLAFAXINE 75,0 mg	75 mgTablet	56003856/1.2/0038	Registered	S5	None
Venlor xr 150 MG tablet EACH TABLET CONTAINS VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO VENLAFAXINE 150,0 mg	150 mgTablet	56003956/1.2/0039	Registered	S5	None
Venlor xr 225 EACH CAPSULE CONTAINS: VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO: VENLAFAXINE 225,0 mg	225Extended-release capsules	59021259/1.2/0212Approved 7 November 2024	Registered	S5	PI PIL
Venlafaxine 225 cipla EACH CAPSULE CONTAINS: VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO: VENLAFAXINE 225,0 mg	225	590213.21259/1.2/0213.212	Registered	S5	None
Venlafaxine 37,5 cipla EACH CAPSULE CONTAINS: VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO VENLAFAXINE 37,5 mg	37,5	59038459/1.2/0384	Registered	S5	None
Venlafaxine 75 cipla EACH CAPSULE CONTAINS: VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO: VENLAFAXINE 75,0 mg	75	59038559/1.2/0385	Registered	S5	None
Venlafaxine 150 cipla EACH CAPSULE CONTAINS: VENLAFAXINE HYDROCHLORIDE EQUIVALENT TO: VENLAFAXINE 150,0 mg	150	59038659/1.2/0386	Registered	S5	None
Venlafaxine be-tabs mr 37,5 EACH CAPSULE CONTAINS VENLAFAXINE 37,5 mg	37,5	A400029A40/1.2/0029	Cancelled	S5	None
Venlafaxine be-tabs mr 75 EACH CAPSULE CONTAINS VENLAFAXINE 75,0 mg	75	A400030A40/1.2/0030	Cancelled	S5	None
Venlafaxine be-tabs mr 150 EACH CAPSULE CONTAINS VENLAFAXINE 150,0 mg	150	A400031A40/1.2/0031	Cancelled	S5	None
Venlor xr 37,5 EACH CAPSULE CONTAINS VENLAFAXINE 37,5 mg	37,5Extended-release capsules.	A400032A40/1.2/0032Approved 7 November 2024	Registered	S5	PI PIL
Venlor xr 75 EACH CAPSULE CONTAINS VENLAFAXINE 75,0 mg	75Extended-release capsules	A400033A40/1.2/0033Approved 7 November 2024	Registered	S5	PI PIL
Venlor xr 150 EACH CAPSULE CONTAINS VENLAFAXINE 150,0 mg	150Extended-release capsules	A400034A40/1.2/0034Approved 7 November 2024	Registered	S5	PI PIL
Venlafaxine 150 MG xl austell EACH CAPSULE CONTAINS VENLAFAXINE 150,0 mg	150 mg	A400491A40/1.2/0491	Registered	S5	None
Faxedepor xl 150 EACH Capsule contains: Venlafaxine hydrochloride equivalent to venlafaxine 150,0 mg	150	A400492A40/1.2/0492	Registered	S5	None
Venlafaxine 75 MG xl austell EACH CAPSULE CONTAINS VENLAFAXINE 75,0 mg	75 mg	A400493A40/1.2/0493	Registered	S5	None
Faxdepor xl 75 EACH Capsule contains: Venlafaxine Hydrochloride equivalent to venlafaxine 75,0 mg	75	A400494A40/1.2/0494	Registered	S5	None
Venexor xr 37,5 MG EACH CAPSULE CONTAINS VENLAFAXINE 37,5 mg	37,5 mg	A400606A40/1.2/0606	Registered	S5	None
Venexor xr 75 MG EACH CAPSULE CONTAINS VENLAFAXINE 75,0 mg	75 mg	A400607A40/1.2/0607	Registered	S5	None
Venexor xr 150 MG EACH CAPSULE CONTAINS VENLAFAXINE 150,0 mg	150 mg	A400608A40/1.2/0608	Registered	S5	None

Regulatory status

Where S5 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only, with tighter controls on repeats.

Schedule 5 medicines need a prescription, and repeat dispensing is capped at six months in total; the prescriber must state upfront how many times, and at what intervals, it may be repeated. Extra limits apply to some uses: if it is being used for its anxiolytic, antidepressant, tranquillising or analgesic properties, it cannot be prescribed for longer than six months without a further consultation. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S5, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it.

Consolidated Schedules listings for Venlafaxine

S5: Venlafaxine
Consolidated Schedules 06 July 2026, line 9761

Pharmacological class: Psychoanaleptics (antidepressants). (class 1.2)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsVenlafaxine xr 37,5 adco, Adcock ingram limited Patient information leaflet (PIL)For patients and carersVenlafaxine xr 37,5 adco, Adcock ingram limited

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

Loading PubMed articles

Background