Propofol
Sold as Diprivan pfs, Propofol fresenius, Recofol, Diprivan, Sabax propofol ( ), Adco propofol ( ), Propofol fresenius ( ), Propofol mct/lct ( ) fresenius, Propofol mct/lct fresenius, Milsia, Propofol ( ) b.braun, Quifol w/v, B. Braun propofol ( ), Provive, Plofed, Cipla-propofol
Background
Registration
- Applicants
- 11
- Registrations
- 36
- Schedule source
- Consolidated Schedules 06 July 2026
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Pharmacare limited û woodmead | Diprivan pfs, Diprivan | 1 % 20 ml, 1 % 50 ml, 1% 20ml, 1 % 100 ml, 2 % 50 ml, 2 % 10 ML | 310375, 310376, 360084, 360085, 360086, T0226, X0030, X0031 | S5 | None |
| Fresenius Kabi South Africa (Pty) Ltd3 of 8 cancelled | Propofol fresenius, Propofol fresenius ( ), Propofol mct/lct ( ) fresenius, Propofol mct/lct fresenius | 1 %, 1% 20 ml, 1% 50 ml, 1% 100 ml, 2 % 20 ML, 2 % 50 ML, 2 % 100 ML, 20 mg | 330077, 370553, 370554, 370555, 411121, 411122, 411123, 411124 | S5 | PIPIL |
| Viatris Healthcare (Pty) Ltd | Recofol | 1 % 20 ml, 1 % 50 ml, 1 % 100 ml | 350228, 350229, 350230 | S5 | None |
| Adcock Ingram Critical Care (Pty) Ltd | Sabax propofol ( ), Adco propofol ( ) | 1 % 20 ml, 1 % 50 ML, 2 % 20 ml, 2 % 50 ml, 2 % 100 ml | 370244, 370245, 370247, 370248, 370249 | S5 | None |
| Adcock ingram limited | Sabax propofol ( ) | 1 % 100 ml | 370246 | S5 | None |
| Biotech Laboratories (Pty) Ltd | Milsia | 1 % 20 ml, 1 % 50 ml, 1 % 100 ml, 2 % | 450701, 450702, 450703, 450704 | S5 | PIPIL |
| B. Braun integrated pharmaceutical plantCertificate held by B. Braun Medical (Pty) Ltd | Propofol ( ) b.braun | 5 mg, 20 mg/ml) | 471219, 471220 | S5 | PIPIL |
| Qhayisa 2014 Trading & Projects (Pty) Ltd | Quifol w/v | 1 % | 561074 | S5 | None |
| B Braun Medical (Pty) LtdCertificate held by B. Braun Medical (Pty) Ltd | B. Braun propofol ( ) | 10 mg/ml | A390077 | S5 | PIPIL |
| Dezzo Trading 392 (Pty) Ltd | Provive | 1 % | A390447 | S5 | None |
| Cipla Medpro (Pty) LtdCancelled | Plofed, Cipla-propofol | 1 % 20 ml, 1 % | A400671, A400672 | S5 | None |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Diprivan 1 % pfs 20 ML EACH 1 ml INFUSION CONTAINS PROPOFOL 10,0 mg | 1 % 20 ml | 31037531/2.1/0375 | Registered | S5 | None |
| Diprivan 1 % pfs 50 ML EACH 1 ml INFUSION CONTAINS PROPOFOL 10,0 mg | 1 % 50 ml | 31037631/2.1/0376 | Registered | S5 | None |
| Propofol 1 % fresenius EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1 % | 33007733/2.1/0077 | Registered | S5 | None |
| Recofol 1 % 20 ML ampoule EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1 % 20 mlAmpoule | 35022835/2.1/0228 | Registered | S5 | None |
| Recofol 1 % 50 ML vial EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1 % 50 mlVial | 35022935/2.1/0229 | Registered | S5 | None |
| Recofol 1 % 100 ML vial EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1 % 100 mlVial | 35023035/2.1/0230 | Registered | S5 | None |
| Diprivan 2 % 50 ML EACH 1,0 ml EMULSION CONTAINS PROPOFOL 20,0 mg | 2 % 50 ml | 36008436/2.1/0084 | Registered | S5 | None |
| Diprivan 2 % pfs 10 ML EACH 1,0 ml EMULSION CONTAINS PROPOFOL 20,0 mg | 2 % 10 ML | 36008536/2.1/0085 | Registered | S5 | None |
| Diprivan 2 % pfs 50 ML EACH 1,0 ml EMULSION CONTAINS PROPOFOL 20,0 mg | 2 % 50 ML | 36008636/2.1/0086 | Registered | S5 | None |
| Sabax propofol 1 % (20 ml) EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1 % 20 ml | 37024437/2.1/0244 | Registered | S5 | None |
| Adco propofol 1 % (50 ml) EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1 % 50 ML | 37024537/2.1/0245 | Registered | S5 | None |
| Sabax propofol 1 % (100 ml) EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1 % 100 ml | 37024637/2.1/0246 | Registered | S5 | None |
| Sabax propofol 2 % (20 ml) EACH 1,0 ml EMULSION CONTAINS PROPOFOL 20,0 mg | 2 % 20 ml | 37024737/2.1/0247 | Registered | S5 | None |
| Sabax propofol 2 % (50 ml) EACH 1,0 ml EMULSION CONTAINS PROPOFOL 20,0 mg | 2 % 50 ml | 37024837/2.1/0248 | Registered | S5 | None |
| Adco propofol 2 % (100 ml) EACH 1,0 ml EMULSION CONTAINS PROPOFOL 20,0 mg | 2 % 100 ml | 37024937/2.1/0249 | Registered | S5 | None |
| Propofol 2 % fresenius (20 ML ampoule) EACH 1,0 ml EMULSION CONTAINS PROPOFOL 20,0 mg | 2 % 20 MLAmpoule) | 37055337/2.1/0553 | Cancelled | S5 | None |
| Propofol 2 % fresenius (50 ML vial) EACH 1,0 ml EMUSLION CONTAINS PROPOFOL 20,0 mg | 2 % 50 MLVial) | 37055437/2.1/0554 | Cancelled | S5 | None |
| Propofol 2 % fresenius (100 ML vial) EACH 1,0 ml EMULSION CONTAINS PROPOFOL 20,0 mg | 2 % 100 MLVial) | 37055537/2.1/0555 | Cancelled | S5 | None |
| Propofol mct/lct 1% (20 ml) fresenius EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1% 20 ml | 41112141/2.1/1121 | Registered | S5 | None |
| Propofol mct/lct 1% (50 ml) fresenius EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1% 50 ml | 41112241/2.1/1122 | Registered | S5 | None |
| Propofol mct/lct 1% (100 ml) fresenius EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1% 100 ml | 41112341/2.1/1123 | Registered | S5 | None |
| Propofol mct/lct 2% fresenius | 20 mgEmulsion for injection or infusion | 41112441/2.1/1124Approved 30 January 2025 | Registered | S5 | PIPIL |
| Milsia 1 % 20 ML EACH 1,0 ml SOLUTION CONTAINS PROPOFOL 10,0 mg | 1 % 20 ml | 45070145/2.1/0701 | Registered | S5 | None |
| Milsia 1 % 50 ML EACH 1,0 ml SOLUTION CONTAINS PROPOFOL 10,0 mg | 1 % 50 ml | 45070245/2.1/0702 | Registered | S5 | None |
| Milsia 1 % 100 ML EACH 1,0 ml SOLUTION CONTAINS PROPOFOL 10,0 mg | 1 % 100 ml | 45070345/2.1/0703 | Registered | S5 | None |
| Milsia 2 % EACH 1,0 ml SOLUTION CONTAINS PROPOFOL 20,0 mg | 2 %Emulsion for injection/infusion. | 45070445/2.1/0704Approved 6 April 2021 | Registered | S5 | PIPIL |
| Propofol 0.5 % (5 mg/ ml) b.braun Each 20 ml ampoule contains PROPOFOL 100,0 mg | 5 mgEmulsion for injection or infusion. | 47121947/2.1/1219Approved 12 July 2022 | Registered | S5 | PIPIL |
| Propofol 2 % (20 mg/ ml) b.braun Each 50 ml ampoule contains PROPOFOL 1000,0 mg | 20 mg/ml)Emulsion for injection or infusion. | 47122047/2.1/1220 | Registered | S5 | PIPIL |
| Quifol 1 % w/v injection EACH VIAL CONTAINS: PROPOFOL 1,0 %w/v | 1 %Injection | 56107456/2.1/1074 | Registered | S5 | None |
| B. Braun propofol 1 % (10 mg/ml) EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 10 mg/mlEmulsion for intravenous injection or infusion | A390077A39/2.1/0077Approved 30 August 2023 | Registered | S5 | PIPIL |
| Provive 1 % EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1 % | A390447A39/2.1/0447 | Registered | S5 | None |
| Plofed 1 % 20 ML EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1 % 20 ml | A400671A40/2.1/0671 | Cancelled | S5 | None |
| Cipla-propofol 1 % EACH 1,0 ml EMULSION CONTAINS PROPOFOL 10,0 mg | 1 % | A400672A40/2.1/0672 | Cancelled | S5 | None |
| Diprivan 1% 20ml EACH ml CONTAINS PROPOFOL 10,0 mg | 1% 20ml | T0226T/2.1/226 | Registered | S5 | None |
| Diprivan 1 % 50 ML EACH 50 ml VIAL CONTAINS PROPOFOL 500 mg | 1 % 50 ml | X0030X/2.1/30 | Registered | S5 | None |
| Diprivan 1 % 100 ML EACH 100 ml VIAL CONTAINS PROPOFOL 1 g | 1 % 100 ml | X0031X/2.1/31 | Registered | S5 | None |
Regulatory status
Where S5 sits on the scale
Prescription-only, with tighter controls on repeats.
Schedule 5 medicines need a prescription, and repeat dispensing is capped at six months in total; the prescriber must state upfront how many times, and at what intervals, it may be repeated. Extra limits apply to some uses: if it is being used for its anxiolytic, antidepressant, tranquillising or analgesic properties, it cannot be prescribed for longer than six months without a further consultation. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S5, matched to the Consolidated Schedules by ingredient, confidence high.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it.
Consolidated Schedules listings for Propofol
S5: Propofol
Consolidated Schedules 06 July 2026, line 9662
Pharmacological class: Anaesthetics. (class 2.1)
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
Schedule Verification
Propofol mct/lct 2% fresenius, Fresenius Kabi South Africa (Pty) Ltd is scheduled S5 in its official SAHPRA documents, read with 90% confidence.
These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.