Schedule 6 (S6) medicines in South Africa
Prescription-only, no repeats without a new prescription.
About S6 Drugs
Where S6 sits on the scale
Prescription-only, no repeats without a new prescription.
Schedule 6 covers the most tightly controlled ordinary prescription medicines. Every dispensing needs its own new prescription; nothing can be repeated on the same script. When prescribed, the quantity must be written out in both figures and words. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Cited: reg 33(3)(f)(i) (General Regulations, 2017)
Who may supply
A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it.
Cited: Act s22A(5)(b), s22A(5)(c), s22A(5)(d), s22A(5)(e)
Prescription: Requires a prescription from an authorised prescriber.
Repeats: None. A new prescription is required every time; it cannot be repeated on the same script. The prescription must also be presented for dispensing within 30 days of issue, and the whole course of treatment may not exceed 30 consecutive days.
Cited: Act s22A(6)(d), s22A(6)(i), s22A(6)(o)
Advertising: May be advertised only to health professionals, not the public.
Cited: reg 42(2), reg 42(3) (General Regulations, 2017)
Labelling: Must show the letter S and the number 6 in a square border, immediately before the product's brand name.
Cited: reg 10(1)(a) (General Regulations, 2017)
What is a Schedule 6 medicine in South Africa?
Prescription-only, no repeats without a new prescription. Schedule 6 covers the most tightly controlled ordinary prescription medicines. Every dispensing needs its own new prescription; nothing can be repeated on the same script. When prescribed, the quantity must be written out in both figures and words. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Can a pharmacist sell a Schedule 6 medicine without a prescription?
A prescription is required. A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it. None. A new prescription is required every time; it cannot be repeated on the same script. The prescription must also be presented for dispensing within 30 days of issue, and the whole course of treatment may not exceed 30 consecutive days.
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
Substances listed under S6
141 listed in the Consolidated Schedules, 32 with a registered medicine.
- (+)-norpseudoephedrine, see D-norpseudoephedrine / cathine
- Acetorphine
- Acetyldihydrocodeine
- Acetylmethadol
- Alfentanil1
- Allylprodine
- Alphacetylmethadol
- Alphameprodine
- Alphamethadol
- Alphaprodine
- Amineptine
- Amobarbital
- Anileridine
- Benzethidine
- Benzphetamine
- Benzylmorphine
- Beta-aminopropylbenzene and beta-aminoisopropylbenzene derivatives
- Betacetylmethadol
- Betameprodine
- Betamethadol
- Betaprodine
- Bezitramide
- Buprenorphine3
- Butalbital1
- Butorphanol1
- Carfentanil
- Cathine2
- Chlorodyne
- Chlorphentermine
- Clonitazene
- Coca leaf
- Codeine34
- Codoxime
- Colistin1
- Cyclobarbital
- D-norpseudoephedrine, see Cathine
- Desomorphine
- Dexamfetamine
- Dextromoramide
- Dextropropoxyphene4
- Dextrorphan
- Diampromide
- Diethylpropion1
- Diethylthiambutene
- Dihydrocodeine1
- Dihydroetorphine
- Dihydromorphine
- Dimenoxadol
- Dimepheptanol
- Dimethylthiambutene
- Dioxaphethyl butyrate
- Diphenoxin
- Diphenoxylate1
- Dipipanone1
- Drotebanol
- Ecgonine
- Ephedra alkaloids
- Ephedrine11
- Ethylmethylthiambutene
- Ethylmorphine
- Etonitazene
- Etorphine1
- Etoxeridine
- Fenproporex
- Fentanyl1
- Flunitrazepam1
- Furethidine
- Glutethimide
- Hydrocodone
- Hydromorphinol
- Hydromorphone1
- Hydroxypethidine
- Ibogaine
- Isomethadone
- Ketobemidone
- Levomoramide
- Levophenacylmorphan
- Levorphanol
- Lisdexamfetamine1
- Mecloqualone
- Mefenorex
- Meptazinol
- Metazocine
- Methadone1
- Methadone-intermediate
- Methorphan
- Methyldesorphine
- Methyldihydromorphine
- Methylphenidate1
- Metopon
- Moramide-intermediate
- Morpheridine
- Morphine4
- Morphine methobromide and other pentavalent nitrogen morphine derivatives
- Morphine-N-oxide
- Myrophine
- Nefopam
- Nicocodine
- Nicodicodine
- Nicomorphine
- Noracymethadol
- Norcodeine
- Norlevorphanol
- Normethadone
- Normorphine
- Norpipanone
- Opium and opiates
- Opium-poppy and poppy straw
- Oxycodone3
- Oxymorphone1
- p-Synephrine
- Pentazocine1
- Pentobarbital
- Pethidine1
- Phenadoxone
- Phenampromide
- Phenazocine
- Phendimetrazine1
- Phenomorphan
- Phenoperidine
- Phenylbutazone1
- Phenylpropanolamine13
- Piminodine
- Piritramide
- Proheptazine
- Properidine
- Propiram
- Pseudoephedrine29
- Racemoramide
- Racemorphan
- Remifentanil1
- Secobarbital
- Sufentanil1
- Tapentadol1
- Tetrahydrocannabinol
- Thebacon
- Thebaine
- Thiafentanyl
- Tilidine
- Trimeperidine
- Zipeprol
Registered medicines in S6
| Name | Brands | Dosages | Applicants | Registrations | Schedule |
|---|---|---|---|---|---|
| Alfentanil | Rapifen | 2 ml, 10 ML | 2 applicants | 2 registrations | S6 |
| Buprenorphine | Subutex sublingual, Sovenor, Butrans, +7 more | 0,4 mg, 1 ml, 2,0 mg, 2 mg, +7 more | 4 applicants | 26 registrations | S6 |
| Butorphanol | Torbugesic, Dolorex | 10mg | 2 applicants | 2 registrations | S6 |
| Cathine | Leanor, Lodenor, Thinz, +4 more | drops, capsules | 4 applicants | 7 registrations | S6 |
| Codeine | Omnopon-fresenius | 1ml | 2 applicants | 2 registrations | S6 |
| Cyclizine a 39 01 morphine | Cyclimorph | 10, 15 | Pharmacare limited û woodmead | 2 registrations | S6 |
| D-norpseudoephedrine | Relislim, Eetless | 20 mg, capsules | 2 applicants | 2 registrations | S6 |
| Diethylpropion Cancelled | Tenuate dospan | tablets | Adcock ingram limited | C0965 | S6 |
| Etorphine | M99, Captivon | 4,9 mg/ml, 9,8 mg/ml, 49, 98 | 3 applicants | 4 registrations | S6 |
| Fentanyl | Sublimaze | 2ml/10 ml | Piramal Critical Care South Africa (Pty) Ltd | 2 registrations | S6 |
| Flunitrazepam | Flunitrazepam biotech | 1 | Arya Pharma (Pty) Ltd | 350160 | S6 |
| Hydromorphone Cancelled | Jurnista | 4 mg, 8 mg, 16 mg, 32 mg, +1 more | Janssen Pharmaceutica (Pty) Ltd | 5 registrations | S6 |
| Methadone | Equity-methadone, Methadone adco, Rutrex, +4 more | 0,4 mg/mL, 2 mg / 1 ml, 10mg, 10 mg, +3 more | 6 applicants | 8 registrations | S6 |
| Methylphenidate | Ralitin, Adaphen, Ritalin la, +19 more | 5, 10 mg, 10mg, 10mg, 18 mg, +10 more | 16 applicants | 68 registrations | S6 |
| Morphine | Oramorph | 20 mg | Eurolab (Pty) Ltd | 550422 | S6 |
| Oxycodone | Oxycontin prolonged release, Oxynorm, Oxycorrel, +1 more | 5 mg, 10 mg, 20 mg, 40 mg, +1 more | 2 applicants | 17 registrations | S6 |
| Oxymorphone | Numorphan | Not stated | Boots Pharmaceuticals (Pty) Ltd | B1560 | S6 |
| Pentazocine | Pharma-q pentazocine, Sosenol, Pentazocine fresenius | 30 mg/1 ml, 30 mg, 45 mg | 3 applicants | 4 registrations | S6 |
| Phendimetrazine | Obex la, Obesan x | Not stated | 2 applicants | 2 registrations | S6 |
| Phenylbutazone | Fenylbutazone phenix, Arthridine nf, Oralject p butazone, +2 more | 20% | 5 applicants | 5 registrations | S6 |
| Remifentanil | Ultiva, Fortiva, Remifentanil teva, +5 more | 1 mg, 2 mg, 5 mg | 6 applicants | 19 registrations | S6 |
| Sufentanil | Pharma-q sufentanil, Pharma-q sufentanil forte, Mylan sufentanil, +2 more | 2 ml, 5 ug/ml 2 ml, 5ug/ml 10 ml, 10 ug/2 ml, +4 more | 3 applicants | 8 registrations | S6 |
| Tapentadol | Palexia, Palexia sr | 50 mg, 75 mg, 100 mg, 150 mg, +2 more | Adcock ingram limited | 8 registrations | S6 |