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S6

Schedule 6 (S6) medicines in South Africa

Prescription-only, no repeats without a new prescription.

About S6 Drugs

Where S6 sits on the scale

Prescription-only, no repeats without a new prescription.

Schedule 6 covers the most tightly controlled ordinary prescription medicines. Every dispensing needs its own new prescription; nothing can be repeated on the same script. When prescribed, the quantity must be written out in both figures and words. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Cited: reg 33(3)(f)(i) (General Regulations, 2017)

Who may supply

A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it.

Cited: Act s22A(5)(b), s22A(5)(c), s22A(5)(d), s22A(5)(e)

Prescription: Requires a prescription from an authorised prescriber.

Repeats: None. A new prescription is required every time; it cannot be repeated on the same script. The prescription must also be presented for dispensing within 30 days of issue, and the whole course of treatment may not exceed 30 consecutive days.

Cited: Act s22A(6)(d), s22A(6)(i), s22A(6)(o)

Advertising: May be advertised only to health professionals, not the public.

Cited: reg 42(2), reg 42(3) (General Regulations, 2017)

Labelling: Must show the letter S and the number 6 in a square border, immediately before the product's brand name.

Cited: reg 10(1)(a) (General Regulations, 2017)

What is a Schedule 6 medicine in South Africa?

Prescription-only, no repeats without a new prescription. Schedule 6 covers the most tightly controlled ordinary prescription medicines. Every dispensing needs its own new prescription; nothing can be repeated on the same script. When prescribed, the quantity must be written out in both figures and words. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Can a pharmacist sell a Schedule 6 medicine without a prescription?

A prescription is required. A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it. None. A new prescription is required every time; it cannot be repeated on the same script. The prescription must also be presented for dispensing within 30 days of issue, and the whole course of treatment may not exceed 30 consecutive days.

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

Substances listed under S6

141 listed in the Consolidated Schedules, 32 with a registered medicine.

Registered medicines in S6

Showing 23 of 23 chemicals in schedule S6
Registered products
NameBrandsDosagesApplicantsRegistrationsSchedule
AlfentanilRapifen2 ml, 10 ML2 applicants2 registrationsS6
BuprenorphineSubutex sublingual, Sovenor, Butrans, +7 more0,4 mg, 1 ml, 2,0 mg, 2 mg, +7 more4 applicants26 registrationsS6
ButorphanolTorbugesic, Dolorex10mg2 applicants2 registrationsS6
CathineLeanor, Lodenor, Thinz, +4 moredrops, capsules4 applicants7 registrationsS6
CodeineOmnopon-fresenius1ml2 applicants2 registrationsS6
Cyclizine a 39 01 morphineCyclimorph10, 15Pharmacare limited û woodmead2 registrationsS6
D-norpseudoephedrineRelislim, Eetless20 mg, capsules2 applicants2 registrationsS6
Diethylpropion CancelledTenuate dospantabletsAdcock ingram limitedC0965S6
EtorphineM99, Captivon4,9 mg/ml, 9,8 mg/ml, 49, 983 applicants4 registrationsS6
FentanylSublimaze2ml/10 mlPiramal Critical Care South Africa (Pty) Ltd2 registrationsS6
FlunitrazepamFlunitrazepam biotech1Arya Pharma (Pty) Ltd350160S6
Hydromorphone CancelledJurnista4 mg, 8 mg, 16 mg, 32 mg, +1 moreJanssen Pharmaceutica (Pty) Ltd5 registrationsS6
MethadoneEquity-methadone, Methadone adco, Rutrex, +4 more0,4 mg/mL, 2 mg / 1 ml, 10mg, 10 mg, +3 more6 applicants8 registrationsS6
MethylphenidateRalitin, Adaphen, Ritalin la, +19 more5, 10 mg, 10mg, 10mg, 18 mg, +10 more16 applicants68 registrationsS6
MorphineOramorph20 mgEurolab (Pty) Ltd550422S6
OxycodoneOxycontin prolonged release, Oxynorm, Oxycorrel, +1 more5 mg, 10 mg, 20 mg, 40 mg, +1 more2 applicants17 registrationsS6
OxymorphoneNumorphanNot statedBoots Pharmaceuticals (Pty) LtdB1560S6
PentazocinePharma-q pentazocine, Sosenol, Pentazocine fresenius30 mg/1 ml, 30 mg, 45 mg3 applicants4 registrationsS6
PhendimetrazineObex la, Obesan xNot stated2 applicants2 registrationsS6
PhenylbutazoneFenylbutazone phenix, Arthridine nf, Oralject p butazone, +2 more20%5 applicants5 registrationsS6
RemifentanilUltiva, Fortiva, Remifentanil teva, +5 more1 mg, 2 mg, 5 mg6 applicants19 registrationsS6
SufentanilPharma-q sufentanil, Pharma-q sufentanil forte, Mylan sufentanil, +2 more2 ml, 5 ug/ml 2 ml, 5ug/ml 10 ml, 10 ug/2 ml, +4 more3 applicants8 registrationsS6
TapentadolPalexia, Palexia sr50 mg, 75 mg, 100 mg, 150 mg, +2 moreAdcock ingram limited8 registrationsS6