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Buprenorphine

Sold as Subutex sublingual, Sovenor, Butrans, Sovetrin, Bupremed, Norbutrin, Sobrixa, Temgesic, Temgesic sublingual

S6
Loading the molecular structure
C29H41NO4467.60 g/mol

(1S,2S,6R,14R,15R,16R)-5-(Cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol

Drag to rotate. Structure from PubChem CID 644073.

Background

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Registration

Applicants
4
Registrations
24
Schedule source
Consolidated Schedules 06 July 2026

Applicants and registrations

ApplicantBrandsDosagesRegistrationsScheduleLeaflets
Adcock Ingram Critical Care (Pty) Ltd3 of 8 cancelledSubutex sublingual, Sobrixa, Temgesic, Temgesic sublingual0,4 mg, 1 ml, 2,0 mg, 8,0 mg, tablets330377, 330378, 330379, 600351, 600352, 600353, L0157, S0327S6None
Mundipharma (Pty) LtdSovenor, Butrans5, 10, 20410589, 410590, 410591, 480461, 480462, 480463S6None
Trinity Pharma (Pty) LtdSovetrin, Bupremed, Norbutrin5, 10, 20540224, 540225, 540226, 540227.224, 540228.225, 540229.226, 540230.224, 540231.225, 540232.226S6PIPIL
Reckitt Benckinser Pharmaceuticals (Pty) LtdTemgesic2 mlL0158S6None

Variants

ProductStrength and formRegistrationStatusScheduleLeaflets
Subutex sublingual 0,4 MG

EACH TABLET CONTAINS BUPRENORPHINE HYDROCHLORIDE EQUIVALENT TO BUPRENORPHINE 0,4 mg

0,4 mg33037733/34/0377CancelledS6None
Subutex sublingual 2,0 MG

EACH TABLET CONTAINS BUPRENORPHINE HYDROCHLORIDE EQUIVALENT TO BUPRENORPHINE 2,0 mg

2,0 mg33037833/34/0378CancelledS6None
Subutex sublingual 8,0 MG

EACH TABLET CONTAINS BUPRENORPHINE HYDROCHLORIDE EQUIVALENT TO BUPRENORPHINE 8,0 mg

8,0 mg33037933/34/0379CancelledS6None
Sovenor 5 patch

EACH PATCH CONTAINS BUPRENORPHINE 5,0 mg

5Patch41058941/2.7/0589RegisteredS6None
Sovenor 10 patch

EACH PATCH CONTAINS BUPRENORPHINE 10,0 mg

10Patch41059041/2.7/0590RegisteredS6None
Sovenor 20 patch

EACH PATCH CONTAINS BUPRENORPHINE 20,0 mg

20Patch41059141/2.7/0591RegisteredS6None
Butrans 5

EACH PATCH CONTAINS: BUPRENORPHINE 5,0 mg

548046148/2.7/0461RegisteredS6None
Butrans 10

EACH PATCH CONTAINS: BUPRENORPHINE 10,0 mg

1048046248/2.7/0462RegisteredS6None
Butrans 20

EACH PATCH CONTAINS: BUPRENORPHINE 20,0 mg

2048046348/2.7/0463RegisteredS6None
Sovetrin 5

EACH PATCH CONTAINS BUPRENORPHINE 5,0 mg

5Transdermal patch54022454/2.7/0224Approved 8 October 2024RegisteredS6PIPIL
Sovetrin 10

EACH PATCH CONTAINS BUPRENORPHINE 10,0 mg

10Transdermal patch54022554/2.7/0225Approved 8 October 2024RegisteredS6PIPIL
Sovetrin 20

EACH PATCH CONTAINS BUPRENORPHINE 20,0 mg

20Transdermal patch54022654/2.7/0226Approved 8 October 2024RegisteredS6PIPIL
Bupremed 5

EACH PATCH CONTAINS BUPRENORPHINE 5,0 mg

5Transdermal patch540227.22454/2.7/0227.224Approved 8 October 2024Old MedicineS6PIPIL
Bupremed 10

EACH PATCH CONTAINS BUPRENORPHINE 10,0 mg

10Transdermal patch540228.22554/2.7/0228.225Approved 8 October 2024RegisteredS6PIPIL
Bupremed 20

EACH PATCH CONTAINS BUPRENORPHINE 20,0 mg

20Transdermal patch540229.22654/2.7/0229.226Approved 8 October 2024RegisteredS6PIPIL
Norbutrin 5

EACH PATCH CONTAINS BUPRENORPHINE 5,0 mg

5Transdermal patch540230.22454/2.7/0230.224Approved 8 October 2024RegisteredS6PIPIL
Norbutrin 10

EACH PATCH CONTAINS BUPRENORPHINE 10,0 mg

10Transdermal patch540231.22554/2.7/0231.225Approved 8 October 2024RegisteredS6PIPIL
Norbutrin 20

EACH PATCH CONTAINS BUPRENORPHINE 20,0 mg

20Transdermal patch540232.22654/2.7/0232.226Approved 8 October 2024RegisteredS6PIPIL
Sobrixa 0,4 MG

EACH TABLET CONTAINS BUPRENORPHINE HYDROCHLORIDE EQUIVALENT TO BUPRENORPHINE 0,4 mg

0,4 mg60035160/34/0351RegisteredS6None
Sobrixa 2,0 MG

EACH TABLET CONTAINS BUPRENORPHINE HYDROCHLORIDE EQUIVALENT TO BUPRENORPHINE 2,0 mg

2,0 mg600352600/34/0352RegisteredS6None
Sobrixa 8,0 MG

EACH TABLET CONTAINS BUPRENORPHINE HYDROCHLORIDE EQUIVALENT TO BUPRENORPHINE 8,0 mg

8,0 mg60035360/34/0353RegisteredS6None
Temgesic 1 ML

EACH 1,0 ml SOLUTION CONTAINS BUPRENORPHINE HYDROCHLORIDE EQUIVALENT TO BUPRENORPHINE 0,3 mg

1 mlL0157L/2.9/157RegisteredS6None
Temgesic 2 ML

EACH 1,0 ml SOLUTION CONTAINS BUPRENORPHINE HYDROCHLORIDE EQUIVALENT TO BUPRENORPHINE 0,3 mg

2 mlL0158L/2.9/0158RegisteredS6None
Temgesic sublingual tablets

EACH TABLET CONTAINS BUPRENORPHINE HYDROCHLORIDE EQUIVALENT TO BUPRENORPHINE 0,2 mg

TabletsS0327S/2.7/327RegisteredS6None

Regulatory status

Where S6 sits on the scale

Prescription-only, no repeats without a new prescription.

Schedule 6 covers the most tightly controlled ordinary prescription medicines. Every dispensing needs its own new prescription; nothing can be repeated on the same script. When prescribed, the quantity must be written out in both figures and words. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S6, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it.

Consolidated Schedules listings for Buprenorphine hydrochloride equivalent to buprenorphine

  • S6: Buprenorphine

    Consolidated Schedules 06 July 2026, line 10099

Pharmacological class: Complementary Medicines: Health Supplements (class 34)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

Sovetrin 5, Trinity Pharma (Pty) Ltd is scheduled S6 in its official SAHPRA documents, read with 90% confidence.

Professional information (PI)For healthcare professionalsSovetrin 5, Trinity Pharma (Pty) LtdPatient information leaflet (PIL)For patients and carersSovetrin 5, Trinity Pharma (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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