Pemetrexed

Sold as Alimta, Lilly pemetrexed, Key pemetrexed, SPEC pemetrexed, Pemetrexed accord, Terexta, Pemetrexed cipla, Pemalimta, Pexali, Aliloma, Maligta, Natpem, Genpetrex, Luprexta, Peminjo inj, Malihet, Pesodin

C₂₀H₂₁N₅O₆427.40 g/mol

(2S)-2-[[4-[2-(2-Amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid

Drag to rotate. Structure from PubChem CID 135410875.

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Registration

Applicants: 12
Registrations: 37
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Eli Lilly (S.A.) (Pty) Ltd1 of 4 cancelled	Alimta, Lilly pemetrexed	100 mg, 500 mg	420448, 450038, 450039, A390028	S4	None
Key Oncologics (Pty) LtdCancelled	Key pemetrexed	500 mg	470587	S4	None
Specpharm (Pty) Ltd	SPEC pemetrexed	1 000, 100, 500	490729, 490730, 490731	S4	None
Accord Healthcare (Pty) Ltd1 of 4 cancelled	Pemetrexed accord, Terexta	100, 500	490888, 490889, 521002, 521003	S4	None
Cipla Medpro (Pty) LtdCancelled	Pemetrexed cipla, Pemalimta	100, 500	510242, 510243, 510244.242, 510245.243	S4	None
Macleods Pharmaceuticals SA (Pty) LtdCertificate held by Abex Pharmaceutica (Pty) Ltd	Pexali	100, 500	510518.516, 510519.517	S4	PI PIL
Kcp Products CCCertificate held by Kahma Biotech (Pty) Ltd	Aliloma	100mg/ 500mg	530564	S4	PI PIL
Juno Pharma SA (Pty) LtdCertificate held by Kahma Biotech (Pty) Ltd	Aliloma	100mg/ 500mg	530565	S4	PI PIL
Innovata pharmaceuticals	Maligta	100, 500	550904, 550905	S4	None
Adcock ingram limited	Natpem	1 000, 100, 500	560053, 560054, 560055	S4	None
Aurogen South Africa (Pty) Ltd	Genpetrex, Luprexta	000 mg 1, 100 mg, 500 mg	560197, 560198, 560199, 560200.197, 560201.198, 560202.199	S4	None
Hetero Drugs South Africa (Pty) Ltd	Peminjo inj, Malihet, Pesodin	100, 500	560434, 560435, 560436.434, 560437.435, 560438.434, 560439.435	S4	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Alimta 100 MG EACH VIAL CONTAINS PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 100,0 mg	100 mg	42044842/26/0448	Cancelled	S4	None
Lilly pemetrexed 100 MG EACH VIAL CONTAINS PEMETREXED SODIUM 100,0 mg	100 mg	45003845/26/0038	Registered	S4	None
Lilly pemetrexed 500 EACH VIAL CONTAINS PEMETREXED SODIUM 500,0 mg	500	45003945/26/0039	Registered	S4	None
Key pemetrexed 500 MG Each Vial contains: Pemetrexed Disodium Hemipentahydrate equivalent to Pemetrexed 500,0 mg	500 mg	47058747/26/0587	Cancelled	S4	None
SPEC pemetrexed 100 EACH VIAL CONTAINS : PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 100,0 mg	100	49072949/26/0729	Registered	S4	None
SPEC pemetrexed 500 EACH VIAL CONTAINS : PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 500,0 mg	500	49073049/26/0730	Registered	S4	None
SPEC pemetrexed 1 000 EACH VIAL CONTAINS : PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 1 000,0 mg	1 000	49073149/26/0731	Registered	S4	None
Pemetrexed accord 500 EACH VIAL CONTAINS PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 500,0 mg	500	49088849/26/0888	Registered	S4	None
Terexta 500 EACH VIAL CONTAINS PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 500,0 mg	500	49088949/26/0889	Registered	S4	None
Pemetrexed cipla 100 EACH VIAL CONTAINS PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 100,0 mg	100	51024251/26/0242	Cancelled	S4	None
Pemetrexed cipla 500 EACH VIAL CONTAINS PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 500,0 mg	500	51024351/26/0243	Cancelled	S4	None
Pemalimta 100 EACH VIAL CONTAINS PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 100,0 mg	100	510244.24251/26/0244.242	Cancelled	S4	None
Pemalimta 500 EACH VIAL CONTAINS PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 500,0 mg	500	510245.24351/26/0245.243	Cancelled	S4	None
Pexali 100	100Powder for concentrate for solution for infusion.	510518.51651/26/0518.516Approved 30 May 2023	Registered	S4	PI PIL
Pexali 500	500Powder for concentrate for solution for infusion.	510519.51751/26/0519.517Approved 30 May 2023	Registered	S4	PI PIL
Pemetrexed accord 100 EACH VIAL CONTAINS PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 100,0 mg	100	52100252/26/1002	Registered	S4	None
Terexta 100 Each Vial contains: Pemetrexed Disodium equivalent to Pemetrexed 100,0 mg	100	52100352/26/1003	Cancelled	S4	None
Aliloma 100 EACH VIAL CONTAINS PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 100,0 mg	100mg/ 500mgPowder for solution for infusion	53056453/26/0564Approved 19 October 2021	Registered	S4	PI PIL
Aliloma 500 EACH VIAL CONTAINS PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 500,0 mg	100mg/ 500mgPowder for solution for infusion	53056553/26/0565Approved 19 October 2021	Registered	S4	PI PIL
Maligta 100 EACH VIAL CONTAINS PEMETREXED 100,0 mg	100	55090455/26/0904	Registered	S4	None
Maligta 500 EACH VIAL CONTAINS PEMETREXED 500,0 mg	500	55090555/26/0905	Registered	S4	None
Natpem 100 EACH VIAL CONTAINS PEMETREXED 100,0 mg	100	56005356/26/0053	Registered	S4	None
Natpem 500 EACH VIAL CONTAINS PEMETREXED 500,0 mg	500	56005456/26/0054	Registered	S4	None
Natpem 1 000 EACH VIAL CONTAINS PEMETREXED 1 000,0 mg	1 000	56005556/26/0055	Registered	S4	None
Genpetrex 100 mg/vial EACH VIAL CONTAINS PEMETREXED DISODIUM HEMIPENTAHYDRATE EQUIVALENT TO PEMETREXED 100,0 mg	100 mg/Vial	56019756/26/0196	Registered	S4	None
Genpetrex 500 mg/vial EACH VIAL CONTAINS PEMETREXED DISODIUM HEMIPENTAHYDRATE EQUIVALENT TO PEMETREXED 500,0 mg	500 mg/Vial	56019856/26/0198	Registered	S4	None
Genpetrex 1 000 mg/vial EACH VIAL CONTAINS PEMETREXED DISODIUM HEMIPENTAHYDRATE EQUIVALENT TO PEMETREXED 1 000,0 mg	000 mg 1/Vial	56019956/26/0199	Registered	S4	None
Luprexta 100 mg/vial EACH VIAL CONTAINS PEMETREXED DISODIUM HEMIPENTAHYDRATE EQUIVALENT TO PEMETREXED 100,0 mg	100 mg/Vial	560200.19756/26/0200.197	Registered	S4	None
Luprexta 500 mg/vial EACH VIAL CONTAINS PEMETREXED DISODIUM HEMIPENTAHYDRATE EQUIVALENT TO PEMETREXED 500,0 mg	500 mg/Vial	560201.19856/26/0201.198	Registered	S4	None
Luprexta 1 000 mg/vial EACH VIAL CONTAINS PEMETREXED DISODIUM HEMIPENTAHYDRATE EQUIVALENT TO PEMETREXED 1 000,0 mg	000 mg 1/Vial	560202.19956/26/0202.199	Registered	S4	None
Peminjo 100 inj EACH VIAL CONTAINS PEMETREXED DISODIUM EQUIVALENT TO PEMETREXED 100,0 mg	100	56043456/26/0434	Registered	S4	None
Peminjo 500 inj EACH VIAL CONTAINS PEMETREXED DISODIUM EQUIVALENT TO PEMETREXED 500,0 mg	500	56043556/26/0435	Registered	S4	None
Malihet 100 injection EACH VIAL CONTAINS PEMETREXED DISODIUM EQUIVALENT TO PEMETREXED 100,0 mg	100Injection	560436.43456/26/0436.434	Registered	S4	None
Malihet 500 injection EACH VIAL CONTAINS PEMETREXED DISODIUM EQUIVALENT TO PEMETREXED 500,0 mg	500Injection	560437.43556/26/0437.435	Registered	S4	None
Pesodin 100 injection EACH VIAL CONTAINS PEMETREXED DISODIUM EQUIVALENT TO PEMETREXED 100,0 mg	100Injection	560438.43456/26/0438.434	Registered	S4	None
Pesodin 500 injection EACH VIAL CONTAINS PEMETREXED DISODIUM EQUIVALENT TO PEMETREXED 500,0 mg	500Injection	560439.43556/26/0439.435	Registered	S4	None
Alimta 500 MG EACH VIAL CONTAINS PEMETREXED SODIUM EQUIVALENT TO PEMETREXED 500,0 mg	500 mg	A390028A39/26/0028	Registered	S4	None

Regulatory status

Where S4 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only medicine.

Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S4, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Pemetrexed sodium equivalent to pemetrexed

S4: Pemetrexed
Consolidated Schedules 06 July 2026, line 7500

Pharmacological class: Cytostatic agents (class 26)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

Pexali 100, Macleods Pharmaceuticals SA (Pty) Ltd is scheduled S4 in its official SAHPRA documents, read with 90% confidence.

Professional information (PI)For healthcare professionalsPexali 100, Macleods Pharmaceuticals SA (Pty) Ltd Patient information leaflet (PIL)For patients and carersPexali 100, Macleods Pharmaceuticals SA (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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