Hydrochlorothiazide, lisinopril

Sold as Zestoretic, Adco zetomax co, Zetomax co, Lisoretic, Lisinopril co unicorn, Hexal-lisinopril co, Zydus-lisinopril/hydrochlorothiazide, Diace co, AURO lisinopril co, Sinopren co, Lisinozide, Zestozide, Lisozide ( )

C₂₁H₃₁N₃O₅405.50 g/mol

(2S)-1-[(2S)-6-Amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid

Drag to rotate. Structure from PubChem CID 5362119.

Loading Wikipedia summary

Registration

Applicants: 11
Registrations: 23
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Astrazeneca Pharmaceuticals (Pty) Ltd1 of 2 cancelled	Zestoretic	10, 20	270366, 290652	S3	None
Adcock ingram limited	Adco zetomax co, Zetomax co	10/12,5, 20/25, 20/12,5	370160, 370161, 370162	S3	PI PIL
Pharma Dynamics (Pty) Ltd	Lisoretic	10/12,5, 20/12,5	370475, 370476	S3	PI PIL
Unicorn Pharmaceuticals (Pty) Ltd	Lisinopril co unicorn	10/12,5, 20/12,5	370477, 370478	S3	None
Sandoz South Africa (Pty) LtdCancelled	Hexal-lisinopril co	10, 20	370631, 370632	S3	None
Zydus Healthcare (Pty) LtdCancelled	Zydus-lisinopril/hydrochlorothiazide, Diace co	20/12,5	410041, 410042	S3	None
Actor Pharma (Pty) Ltd - ApplicantCancelled	AURO lisinopril co	10 mg, 20 mg	410110, 410111	Not determined	None
Aurogen South Africa (Pty) Ltd	Sinopren co	10, 20	410187, 410188	Not determined	None
Novagen Pharma (Pty) LtdCancelled	Lisinozide	10 mg, 20 mg	411050, 411051	Not determined	None
Viatris South Africa (Pty) Ltd	Zestozide	10, 20	A390066, A390067	S3	None
Austell Pharmaceuticals (Pty) Ltd	Lisozide ( )	10, 20	A390108, A390109	S3	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Zestoretic 20 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL DIHYDRATE EQUIVALENT TO LISINOPRIL ANHYDROUS 20 mg	20	27036627/7.1.3/0366	Registered	Not determined	None
Zestoretic 10 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 10,0 mg	10	29065229/7.1.3/0652	Cancelled	S3	None
Adco zetomax co 10/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 10,0 mg	10/12,5Tablets.	37016037/7.1.3/0160Approved 21 December 2022	Registered	S3	PI PIL
Zetomax co 20/25 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 25,0 mg LISINOPRIL 20,0 mg	20/25	37016137/7.1.3/0161	Registered	S3	None
Zetomax co 20/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 20,0 mg	20/12,5	37016237/7.1.3/0162	Registered	S3	None
Lisoretic 10/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 10,0 mg	10/12,5Tablets..	37047537/7.1.3/0475Approved 3 March 2025	Registered	S3	PI PIL
Lisoretic 20/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 20,0 mg	20/12,5Tablets..	37047637/7.1.3/0476Approved 3 March 2025	Registered	S3	PI PIL
Lisinopril co unicorn 10/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 10,0 mg	10/12,5	37047737/7.1.3/0477	Registered	S3	None
Lisinopril co unicorn 20/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 20,0 mg	20/12,5	37047837/7.1.3/0478	Registered	S3	None
Hexal-lisinopril co 10 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,50 mg LISINOPRIL 10,0 mg	10	37063137/7.1.3/0631	Cancelled	S3	None
Hexal-lisinopril co 20 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 20,0 mg	20	37063237/7.1.3/0632	Cancelled	S3	None
Zydus-lisinopril/hydrochlorothiazide 20/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,50 mg LISINOPRIL 20,0 mg	20/12,5	41004141/7.1.3/0041	Cancelled	S3	None
Diace co 20/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,50 mg LISINOPRIL 20,0 mg	20/12,5	41004241/7.1.3/0042	Cancelled	S3	None
AURO lisinopril co 10 MG EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL DIHYDRATE EQUIVALENT TO LISINOPRIL 10,0 mg	10 mg	41011041/7.1.3/0110	Cancelled	Not determined	None
AURO lisinopril co 20 MG EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL DIHYDRATE EQUIVALENT TO LISINOPRIL 20,0 mg	20 mg	41011141/7.1.3/0111	Cancelled	Not determined	None
Sinopren co 10 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL DIHYDRATE EQUIVALENT TO LISINOPRIL 10,0 mg	10	41018741/7.1.3/0187	Registered	Not determined	None
Sinopren co 20 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL DIHYDRATE EQUIVALENT TO LISINOPRIL 20,0 mg	20	41018841/7.1.3/0188	Registered	Not determined	None
Lisinozide 10 MG EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg, LISINOPRIL DIHYDRATE EQUIVALENT TO LISINOPRIL 10,0 mg	10 mg	41105041/7.1.3/1050	Cancelled	Not determined	None
Lisinozide 20 MG EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL DIHYDRATE EQUIVALENT TO LISINOPRIL 20,0 mg	20 mg	41105141/7.1.3/1051	Cancelled	Not determined	None
Zestozide 10 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 10,0 mg	10	A390066A39/7.1.3/0066	Registered	S3	None
Zestozide 20 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 20,0 mg	20	A390067A39/7.1.3/0067	Registered	S3	None
Lisozide 10 (tablets) EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 10,0 mg	10(Tablets)	A390108A39/7.1.3/0108	Registered	S3	None
Lisozide 20 (tablets) EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg LISINOPRIL 20,0 mg	20(Tablets)	A390109A39/7.1.3/0109	Registered	S3	None

Regulatory status

Where S3 sits on the scale

S0S1S2S3S4S5S6S7S8

Needs a doctor's prescription, dispensed by a pharmacist.

Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S3, matched to the Consolidated Schedules by ingredient, confidence medium.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Hydrochlorothiazide, lisinopril

S3: Hydrochlorothiazide
Consolidated Schedules 06 July 2026, line 3721
S3: Lisinopril
Consolidated Schedules 06 July 2026, line 3902

Pharmacological class: Other hypotensives. (class 7.1.3)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsAdco zetomax co 10/12,5, Adcock ingram limited Patient information leaflet (PIL)For patients and carersAdco zetomax co 10/12,5, Adcock ingram limited

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

Loading PubMed articles

Background