Hydrochlorothiazide, irbesartan
Sold as Coaprovel, Isart co, Irbesartan hydrochlorothiazide zydus, Ran irbesartan co, Irbelo co, Co-irbecard, Jubitan co, Co-irbewin
Combination product
This product contains more than one active ingredient, so it has no single molecular structure.
Background
Registration
- Applicants
- 6
- Registrations
- 14
- Schedule source
- Consolidated Schedules 06 July 2026
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Sanofi Industries South Africa (Pty) LtdCancelled | Coaprovel | 150/12,5, 300/12,5 | 330324, 330325 | S3 | None |
| Zydus Healthcare (Pty) LtdCancelled | Isart co, Irbesartan hydrochlorothiazide zydus | 150, 150/12,5 mg, 300, 300/12,5 mg | 450073, 450074, 450075, 450076 | S3 | None |
| Ranbaxy Pharmaceutical (Pty) Ltd | Ran irbesartan co, Irbelo co | 300/12,5 | 450967, 450968 | S3 | None |
| Smart Pharmaceuticals (Pty) Ltd | Co-irbecard | 300/25 mg | 470737 | S3 | None |
| Jubilant Pharma SA (Pty) LtdCancelled | Jubitan co | 150/12,5, 300/12,5, 300/25 | 490964, 490965, 490966 | S3 | None |
| Sanofi-aventis South Africa (Pty) Ltd | Co-irbewin | 150/12,5, 300/12,5 | A400287, A400290 | S3 | None |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Coaprovel 150/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg IRBESARTAN 150,0 mg | 150/12,5 | 33032433/7.1.3/0324 | Cancelled | S3 | None |
| Coaprovel 300/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg IRBESARTAN 300,0 mg | 300/12,5 | 33032533/7.1.3/0325 | Cancelled | S3 | None |
| Isart co 150 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg IRBESARTAN 150,0 mg | 150 | 45007345/7.1.3/0073 | Cancelled | S3 | None |
| Isart co 300 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg IRBESARTAN 300,0 mg | 300 | 45007445/7.1.3/0074 | Cancelled | S3 | None |
| Irbesartan hydrochlorothiazide zydus 150/12,5 MG EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg IRBESARTAN 150,0 mg | 150/12,5 mg | 45007545/7.1.3/0075 | Cancelled | S3 | None |
| Irbesartan hydrochlorothiazide zydus 300/12,5 MG EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg IRBESARTAN 300,0 mg | 300/12,5 mg | 45007645/7.1.3/0076 | Cancelled | S3 | None |
| Ran irbesartan co 300/12,5 EACH TABLET CONTAINS: HYDROCHLOROTHIAZIDE 12,5 mg, IRBESARTAN 300,0 mg | 300/12,5 | 45096745/7.1.3/0967 | Registered | S3 | None |
| Irbelo co 300/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,5 mg IRBESARTAN 300,0 mg | 300/12,5 | 45096845/7.1.3/0968 | Registered | S3 | None |
| Co-irbecard 300/25 MG Each Tablet contains: Irbesartan 300,0 mg ; Hydrochlorothiazide 25,0 mg | 300/25 mg | 47073747/7.1.3/0737 | Registered | S3 | None |
| Jubitan co 150/12,5 EACH TABLET CONTAINS: IRBESARTAN 150,0 mg HYDROCHLOROTHIAZIDE 12,5 mg | 150/12,5 | 49096449/7.1.3/0964 | Cancelled | S3 | None |
| Jubitan co 300/12,5 EACH TABLET CONTAINS: IRBESARTAN 300,0 mg HYDROCHLOROTHIAZIDE 12,5 mg | 300/12,5 | 49096549/7.1.3/0965 | Cancelled | S3 | None |
| Jubitan co 300/25 EACH TABLET CONTAINS: IRBESARTAN 300,0 mg HYDROCHLOROTHIAZIDE 25,0 mg | 300/25 | 49096649/7.1.3/0966 | Cancelled | S3 | None |
| Co-irbewin 300/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,50 mg IRBESARTAN 300,0 mg | 300/12,5 | A400287A40/7.1.3/0287 | Registered | S3 | None |
| Co-irbewin 150/12,5 EACH TABLET CONTAINS HYDROCHLOROTHIAZIDE 12,50 mg IRBESARTAN 150,0 mg | 150/12,5 | A400290A40/7.1.3/0290 | Registered | S3 | None |
Regulatory status
Where S3 sits on the scale
Needs a doctor's prescription, dispensed by a pharmacist.
Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S3, matched to the Consolidated Schedules by ingredient, confidence medium.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Hydrochlorothiazide, irbesartan
S3: Hydrochlorothiazide
Consolidated Schedules 06 July 2026, line 3721
S3: Irbesartan
Consolidated Schedules 06 July 2026, line 3806
Pharmacological class: Other hypotensives. (class 7.1.3)
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
SAHPRA has not published a professional information or patient information leaflet for this product.