Dextromethorphan, pseudoephedrine, triprolidine
Sold as Coryx cough and cold, Tuscodin cm, Sinuclear cough, Acugest dm adult, Endcol d paediatric cough, Endcol d cough
Combination product
This product contains more than one active ingredient, so it has no single molecular structure.
Background
Registration
- Applicants
- 4
- Registrations
- 6
- Schedule source
- SAHPRA documentation
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Cipla Medpro (Pty) LtdCertificate held by Cipla Medpro (Pty) Ltd. | Coryx cough and cold | 5 mL/10 mg/30 mg/1.25 mg | 270490 | S2 | PIPIL |
| The Premier Pharmaceutical Co LtdCancelled | Tuscodin cm | Not stated | 280143 | Not determined | None |
| Pharmacare limited û woodmead2 of 3 cancelled | Sinuclear cough, Endcol d paediatric cough, Endcol d cough | syrup, linctus | 300065, Z0121, Z0122 | Not determined | None |
| Teva Pharmaceuticals (Pty) LtdCancelled | Acugest dm adult | Not stated | X0004 | Not determined | None |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Coryx cough and cold EACH 5 ml CONTAINS DEXTROMETHORPHAN 10 mg PSEUDOEPHEDRINE HYDROCHLORIDE 30 mg TRIPROLIDINE HYDROCHLORIDE 1,25 mg | 5 mL/10 mg/30 mg/1.25 mgSolution | 27049027/10.1/0490Approved 26 April 2022 | Registered | S2 | PIPIL |
| Tuscodin cm* EACH 5 ml SOLUTION CONTAINS DEXTROMETHORPHAN HYDROBROMIDE 10 mg PSEUDOEPHEDRINE HYDROCHLORIDE 30 mg TRIPROLIDINE HYDROCHLORIDE 1,25 mg | Not listed | 28014328/10.1/0143 | Cancelled | Not determined | None |
| Sinuclear cough syrup EACH 5 ml SOLUTION CONTAINS DEXTROMETHORPHAN HYDROBROMIDE 10 mg PSEUDOEPHEDRINE HYDROCHLORIDE 30 mg TRIPROLIDINE HYDROCHLORIDE 1,25 mg | Syrup | 30006530/10.1/0065 | Registered | Not determined | None |
| Acugest dm adult EACH 5 ml SOLUTION CONTAINS DEXTROMETHORPHAN HYDROBROMIDE 10 mgPSEUDOEPHEDRINE HYDROCHLORIDE 30 mgTRIPROLIDINE HYDROCHLORIDE 1,25 mg | Not listed | X0004X/10.1/4 | Cancelled | Not determined | None |
| Endcol - d paediatric cough syrup EACH 5 ml CONTAINS DEXTROMETHORPHAN HYDROBROMIDE 4,0 mg PSEUDOEPHEDRINE HYDROCHLORIDE 12,0 mg TRIPROLIDINE HYDROCHLORIDE 0,6 mg | -Syrup | Z0121Z/10.1/121 | Cancelled | Not determined | None |
| Endcol - d cough linctus EACH 5 ml LIQUID CONTAINS DEXTROMETHORPHAN HYDROBROMIDE 15,00 mg PSEUDOEPHEDRINE HYDROCHLORIDE 30,00 mg TRIPROLIDINE HYDROCHLORIDE 1,25 mg | -Linctus | Z0122Z/10.1/122 | Cancelled | Not determined | None |
Regulatory status
Where S2 sits on the scale
A pharmacist can sell it directly, without a prescription.
Schedule 2 medicines sit behind the pharmacy counter. A pharmacist can decide to sell one of these directly, using their own professional judgement, without a doctor's prescription. It can also be dispensed against a prescription like the higher tiers, in which case the usual repeat limits apply. A child under 12 may only be sold a Schedule 2 substance on a prescription, or on a written order that names the purpose and carries a signature the seller recognises. Even though it cannot be advertised to the public in the ordinary sense, its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S2, read from the product's PI-PIL leaflet.
The Consolidated Schedules list this ingredient up to S6; the leaflet's S2 applies to this product.
Who may supply: Only a pharmacist, pharmacist intern or supervised pharmacist's assistant may sell it without a prescription. It may otherwise be dispensed by a pharmacist against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Dextromethorphan, pseudoephedrine hydrochloride, triprolidine hydrochloride
S6: Pseudoephedrine
- except contained in products registered in terms of the Act, and not intended for export, being oral preparations and mixtures containing not more than 60 milligrams or controlled-release oral preparations and mixtures containing not more than 120 milligrams of pseudoephedrine per dose, and not more than 240 milligrams per day, when in combination with another pharmacologically active substance and intended for the symptomatic relief of colds and flu, subject to a maximum pack size of 720 milligrams and limited to one pack per customer. (S2)
Consolidated Schedules 06 July 2026, lines 10412 to 10417
S2: Dextromethorphan
Consolidated Schedules 06 July 2026, line 1801
S2: Pseudoephedrine
- contained in products registered in terms of the Act, and not intended for export,
- Immediate-release oral preparations and mixtures containing not more than 60 milligrams of pseudoephedrine per dose or controlled-release oral preparations and mixtures containing not more than 120 milligrams of pseudoephedrine per dose, and not more than 240 milligrams per day, when in combination with another pharmacologically active substance and intended for the symptomatic relief of colds and flu, subject to a maximum pack size of 720 milligrams and limited to one pack per customer. (S6)
Consolidated Schedules 06 July 2026, lines 2600 to 2607
S2: Triprolidine
Consolidated Schedules 06 July 2026, line 2745
Pharmacological class: Antitussives and expectorants. (class 10.1)
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
Schedule Verification
Coryx cough and cold, Cipla Medpro (Pty) Ltd is scheduled S2 in its official SAHPRA documents, read with 90% confidence.
These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.