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Fentanyl-analogues

Group of substances

Schedule 7, conditions apply

No structure available

Fentanyl-analogues is a group of substances, so there is no single molecule to show.

Background

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Listing

Schedules
Schedule 7, conditions apply
Exceptions reach
Schedule 6
Source
Consolidated Schedules 06 July 2026

Registered medicines

The ingredient index links no registered medicine to Fentanyl-analogues (register of 13 September 2026).

Counted through the register's ingredient index, which does not reach every record.

Regulatory status

Where S7 sits on the scale

Prohibited outside a government permit.

Schedule 7 substances cannot be bought, sold, possessed or used at all, not even on a doctor's prescription, unless a special permit has been issued by the Director-General. Nothing in the Act allows an ordinary prescription for these substances; only a Director-General permit does.

Schedule S7, as the Consolidated Schedules list it.

Who may supply: Nobody, except under a permit issued by the Director-General. The Director-General may also authorise a medical practitioner, analyst, researcher or veterinarian to acquire or use it, on prescribed conditions, for the treatment or prevention of a medical condition in a particular patient, or for education, analysis or research. An ordinary prescription does not apply.

Consolidated Schedules listings for Fentanyl-analogues

  • S7: Fentanyl-analogues (unless listed in another Schedule) including

    • (i) acetyl-alpha-methylfentanyl; (ii) alpha-methylfentanyl; (iii) alpha-methylfentanyl-acetanilide; (iv) alpha-methylthiofentanyl; (v) benzyl-fentanyl; (vi) beta-hydroxyfentanyl; (vii) beta-hydroxy-3-methylfentanyl; (viii) 3-methylfentanyl and its two isomeric forms: cis-N-(3-methyl-1-(2-phenethyl)-4-piperidyl) propionanilide; and trans-N-(3-methyl-1-(2-phenethyl)-4-piperidyl) propionanilide; (ix) 3-methylthiofentanyl; (x) para-fluorofentanyl; and (xi) thiofentanyl. (S6) (xii) 4-anilino-N-phenethylpiperidine (ANPP); (xiii) N-phenethyl-4-piperidone (NPP). (xiv) Acryloylfentanyl (acrylfentanyl). (xv) 4-fluoroisobutyrfentanyl (4-FIBF, pFIBF). (xvi) Furanylfentanyl (xvii) Tetrahydrofuranylfentanyl (THF-F). (xviii) Cyclopropylfentanyl. (N-Phenyl-N-[ l-(2-phenylethyl)piperidin-4-ylJcyclopropanecarboxamide) (xix) Methoxyacetyl fentanyl. (2-methoxy-N-phenyl-N-[ 1-(2-phenylethyl)piperidin-4-yl]acetamide) (xx) Ortho-fluorofentanyl. (N-(2-fluorophenyl)-N-[ 1-(2-phenylethyl)piperidin-4-yl ]propanamide) (xxi) Parafluorobutyrlfentanyl (N-( 4-fluorophenyl)-N-[ 1-(2-phenylethyl)piperidin-4-yl]butanamide) (xxii) Crotonylfentanyl. (xxiii) Valerylfentanyl.

    Consolidated Schedules 06 July 2026, lines 10676 to 10725

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

Research articles

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