Valaciclovir

Sold as Zelitrex, Valatrex, Varizost, Zelivire, Ran-valaciclovir, Anviro, Vavirex, Aspen valaciclovir, Hevitrex, Vorior, Voliret, Valzost, Shilova, Valaciclovir viatris, Actiprez, Valaciclovir unicorn, Jubitrex, Zelinova, Herpiva

C₁₃H₂₀N₆O₄324.34 g/mol

2-[(2-Amino-6-oxo-1H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate

Drag to rotate. Structure from PubChem CID 135398742.

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Registration

Applicants: 16
Registrations: 30
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Acino Pharma (Pty) LtdCancelled	Zelitrex	250, 500	290442, 320465	S4	None
Sandoz South Africa (Pty) Ltd1 of 2 cancelled	Valatrex	250, 500	420340, 420341	S4	None
Trinity Pharma (Pty) Ltd	Varizost, Ran-valaciclovir	250, 500	420342, 420343, 420477	S4	None
Ranbaxy Pharmaceutical (Pty) LtdCertificate held by Ranbaxy Pharmaceuticals (Pty) Ltd	Zelivire	500 mg	420476	S4	PI PIL
Zydus Healthcare (Pty) Ltd	Anviro	500	420820	S4	None
Pharmacare limited û woodmead	Vavirex, Aspen valaciclovir	250 mg, 500 mg	430388, 430748, 430749	S4	None
Bliss Pharmaceuticals (Pty) Ltd	Hevitrex	Not stated	440015	S4	None
Hetero Drugs South Africa (Pty) Ltd	Vorior	Not stated	440016	S4	None
Aurogen South Africa (Pty) Ltd	Voliret, Shilova	1 g, 500 mg	450586, 450587, 450590, 450591	S4	None
Novagen Pharma (Pty) LtdCancelled	Valzost	1 g, 500 mg	450588, 450589	S4	None
Viatris South Africa (Pty) Ltd	Valaciclovir viatris	250 mg, 500 mg	450604, 450605	S4	None
Actavis Pharma (Pty) Ltd	Actiprez	1000	450723	S4	None
Unicorn Pharmaceuticals (Pty) Ltd	Valaciclovir unicorn	500 mg / 1000 mg	490443, 490444	S4	PI PIL
Jubilant Pharma SA (Pty) Ltd	Jubitrex	500, 500 mg and 1 000 mg	490546, 490547	S4	PI PIL
Unimed Healthcare (Pty) Ltd	Zelinova	Not stated	501113	S4	None
Innovata pharmaceuticals	Herpiva	1 000, 500	550734, 550735	S4	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Zelitrex 500 EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO 500 mg VALACICLOVIR	500	29044229/20.2.8/0442	Cancelled	S4	None
Zelitrex 250 EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO 250,0 mg VALACICLOVIR	250	32046532/20.2.8/0465	Cancelled	S4	None
Valatrex 250 EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 250,0 mg	250	42034042/20.2.5/0340	Cancelled	S4	None
Valatrex 500 EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 500,0 mg	500	42034142/20.2.5/0341	Registered	S4	None
Varizost 250 EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 250,0 mg	250	42034242/20.2.8/0342	Registered	S4	None
Varizost 500 EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 500,0 mg	500	42034342/20.2.8/0343	Registered	S4	None
Zelivire 500 EACH TABLET CONTAINS: VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 500,0 mg	500 mgTablet.	42047642/20.2.8/0476Approved 14 August 2025	Registered	S4	PI PIL
Ran-valaciclovir 500 EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 500,0 mg	500	42047742/20.2.8/0477	Registered	S4	None
Anviro 500 tablets EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 500,0 mg	500Tablets	42082042/20.2.8/0820	Registered	S4	None
Vavirex-500 EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 500,0 mg	500	43038843/20.2.8/0388	Registered	S4	None
Aspen valaciclovir 250 MG EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 250,0 mg	250 mg	43074843/20.2.8/0748	Registered	S4	None
Aspen valaciclovir 500 MG EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 500,0 mg	500 mg	43074943/20.2.8/0749	Registered	S4	None
Hevitrex EACH TABLET CONTAINS VALACICLOVIR 500,0 mg	Not listed	44001544/20.2.8/0015	Registered	S4	None
Vorior EACH TABLET CONTAINS VALACICLOVIR 500,0 mg	Not listed	44001644/20.2.8/0016	Registered	S4	None
Voliret 500 MG tablets EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 500,0 mg	500 mgTablets	45058645/20.2.8/0586	Registered	S4	None
Voliret 1 g tablets EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 1,0 g	1 gTablets	45058745/20.2.8/0587	Registered	S4	None
Valzost 500 MG EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 500,0 mg	500 mg	45058845/20.2.8/0588	Cancelled	S4	None
Valzost 1 g EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 1,0 g	1 g	45058945/20.2.8/0589	Cancelled	S4	None
Shilova 500 MG tablets EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 500,0 mg	500 mgTablets	45059045/20.2.8/0590	Registered	S4	None
Shilova 1 g tablets EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 1,0 g	1 gTablets	45059145/20.2.8/0591	Registered	S4	None
Valaciclovir 250 MG viatris EACH TABLET CONTAINS :VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 250,0 mg	250 mg	45060445/20.2.8/0604	Registered	S4	None
Valaciclovir 500 MG viatris EACH TABLET CONTAINS :VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 500,0 mg	500 mg	45060545/20.2.8/0605	Registered	S4	None
Actiprez 1000 EACH TABLET CONTAINS VALACICLOVIR HYDROCHLORIDE EQUIVALENT TO VALACICLOVIR 1 000,0 mg	1000	45072345/20.2.8/0723	Registered	S4	None
Valaciclovir 500 unicorn	500 mg / 1000 mgFilm coated tablet	49044349/20.2.8/0443Approved 11 August 2021	Registered	S4	PI PIL
Valaciclovir 1000 unicorn	500 mg / 1000 mgFilm coated tablet	49044449/20.2.8/0444Approved 11 August 2021	Registered	S4	PI PIL
Jubitrex 500	500Film coated tablet.	49054649/20.2.8/0546Approved 12 May 2025	Registered	S4	PI PIL
Jubitrex 1 000	500 mg and 1 000 mgFilm coated tablet.	49054749/20.2.8/0547Approved 12 May 2025	Registered	S4	PI PIL
Zelinova Each Tablet contains: Valaciclovir Hydrochloride equivalent to Valaciclovir 500 mg	Not listed	50111350/20.2.8/1113	Registered	S4	None
Herpiva 500 EACH TABLET CONTAINS VALACICLOVIR 500,0 mg	500	55073455/20.2.8/0734	Registered	S4	None
Herpiva 1 000 EACH TABLET CONTAINS VALACICLOVIR 1 000,0 mg	1 000	55073555/20.2.8/0735	Registered	S4	None

Regulatory status

Where S4 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only medicine.

Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S4, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Valaciclovir hydrochloride equivalent to valaciclovir

S4: Valaciclovir
Consolidated Schedules 06 July 2026, line 8340

Pharmacological class: Antiviral agents. (class 20.2.8)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

Zelivire 500, Ranbaxy Pharmaceutical (Pty) Ltd is scheduled S4 in its official SAHPRA documents, read with 90% confidence.

Professional information (PI)For healthcare professionalsZelivire 500, Ranbaxy Pharmaceutical (Pty) Ltd Patient information leaflet (PIL)For patients and carersZelivire 500, Ranbaxy Pharmaceutical (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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