Sacubitril, valsartan
Sold as Arnizyd, Valsartan sacubitril zydus, Sacubitril valsartan cipla, Lavacutran, Sacuvan, Zavelqo, Vypora registration, Vypora, Trevylna
Combination product
This product contains more than one active ingredient, so it has no single molecular structure.
Background
Registration
- Applicants
- 4
- Registrations
- 23
- Schedule source
- Consolidated Schedules 06 July 2026
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Zydus Healthcare (Pty) Ltd | Arnizyd, Valsartan sacubitril zydus | 26/24, 51/49, 103/97 | 550497, 550498, 550499, 550500.497, 550501.498, 550502.499 | S3 | None |
| Cipla Medpro (Pty) Ltd | Sacubitril valsartan cipla | 24/26 mg, 49/51 mg, 97/103 mg | 560349, 560350, 560351 | S3 | None |
| Hetero Drugs South Africa (Pty) Ltd | Lavacutran, Sacuvan | 24/26, 24 mg/ 26 mg, 49/51, 49 mg/51 mg, 97 mg/103 mg | 561113, 561114, 561116.1113, 561117.1114, 561118.1115 | S3 | None |
| Viatris South Africa (Pty) Ltd | Zavelqo, Vypora registration, Vypora, Trevylna | 24 mg/26 mg, 24 mg/26 mg 2, 49 mg/51 mg, 97 mg/103 mg | 590542, 590543, 590544, 590545.542, 590546.543, 590547.544, 590548.542, 590549.543, 590550.544 | S3 | None |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Arnizyd 26/24 Each Tablet contains: Sacubitril 24,0 mg; Valsartan 26,0 mg | 26/24 | 55049755/7.6/0497 | Registered | S3 | None |
| Arnizyd 51/49 Each Tablet contains: Sacubitril 49,0 mg; Valsartan 51,0 mg | 51/49 | 55049855/7.6/0498 | Registered | S3 | None |
| Arnizyd 103/97 Each Tablet contains: Sacubitril 97,0 mg; Valsartan 103,0 mg | 103/97 | 55049955/7.6/0499 | Registered | S3 | None |
| Valsartan sacubitril 26/24 zydus Each Tablet contains: Sacubitril 24,0 mg; Valsartan 26,0 mg | 26/24 | 550500.49755/7.6/0500.407 | Registered | S3 | None |
| Valsartan sacubitril 51/49 zydus Each Tablet contains: Sacubitril 49,0 mg; Valsartan 51,0 mg | 51/49 | 550501.49855/7.6/501.498 | Registered | S3 | None |
| Valsartan sacubitril 103/97 zydus Each Tablet contains: Sacubitril 97,0 mg; Valsartan 103,0 mg | 103/97 | 550502.49955/7.6/0502.499 | Registered | S3 | None |
| Sacubitril valsartan 24/26 MG cipla EACH TABLET CONTAINS SACUBITRIL 24,3 mg VALSARTAN 25,7 mg | 24/26 mg | 56034956/7.6/0349 | Registered | S3 | None |
| Sacubitril valsartan 49/51 MG cipla EACH TABLET CONTAINS SACUBITRIL 48,6 mg VALSARTAN 51,4 mg | 49/51 mg | 56035056/7.6/0350 | Registered | S3 | None |
| Sacubitril valsartan 97/103 MG cipla EACH TABLET CONTAINS SACUBITRIL 97,2 mg VALSARTAN 102,8 mg | 97/103 mg | 56035156/7.6/0351 | Registered | S3 | None |
| Lavacutran 24/26 Each Tablet contains: Sacubitril 24,0 mg; Valsartan 26,0 mg | 24/26 | 56111356/7.6/1113 | Registered | S3 | None |
| Lavacutran 49/51 Each Tablet contains: Sacubitril 49,0 mg; Valsartan 51,0 mg | 49/51 | 56111456/7.6/1114 | Registered | S3 | None |
| Sacuvan 24 mg/ 26 MG Each Tablet contains: Sacubitril 24,0 mg; Valsartan 26,0 mg | 24 mg/ 26 mg | 561116.111356/7.6/1116.1113 | Registered | S3 | None |
| Sacuvan 49 mg/51 MG Each Tablet contains: Sacubitril 49,0 mg; Valsartan 51,0 mg | 49 mg/51 mg | 561117.111456/7.6/1117.1114 | Registered | S3 | None |
| Sacuvan 97 mg/103 MG Each Tablet contains: Sacubitril 97,0 mg; Valsartan 103,0 mg | 97 mg/103 mg | 561118.111556/7.6/1118.1115 | Registered | S3 | None |
| Zavelqo 24 mg/26 MG EACH TABLET CONTAINS: SACUBITRIL 24,0 mg VALSARTAN 26,0 mg | 24 mg/26 mg | 59054259/7.6/0542 | Registered | S3 | None |
| Zavelqo 49 mg/51 MG EACH TABLET CONTAINS: SACUBITRIL 49,0 mg VALSARTAN 51,0 mg | 49 mg/51 mg | 59054359/7.6/0543 | Registered | S3 | None |
| Zavelqo 97 mg/103 MG EACH TABLET CONTAINS: SACUBITRIL 97,0 mg VALSARTAN 103,0 mg | 97 mg/103 mg | 59054459/7.6/0544 | Registered | S3 | None |
| Vypora 24 mg/26 MG 2. Registration EACH TABLET CONTAINS: SACUBITRIL 24,0 mg VALSARTAN 26,0 mg | 24 mg/26 mg 2. | 590545.54259/7.6/0545.542 | Registered | S3 | None |
| Vypora 49 mg/51 MG EACH TABLET CONTAINS: SACUBITRIL 49,0 mg VALSARTAN 51,0 mg | 49 mg/51 mg | 590546.54359/7.6/0546.543 | Registered | S3 | None |
| Vypora 97 mg/103 MG EACH TABLET CONTAINS: SACUBITRIL 97,0 mg VALSARTAN 103,0 mg | 97 mg/103 mg | 590547.54459/7.6/0547.544 | Registered | S3 | None |
| Trevylna 24 mg/26 MG EACH TABLET CONTAINS: SACUBITRIL 24,0 mg VALSARTAN 26,0 mg | 24 mg/26 mg | 590548.54259/7.6/0548.542 | Registered | S3 | None |
| Trevylna 49 mg/51 MG EACH TABLET CONTAINS: SACUBITRIL 49,0 mg VALSARTAN 51,0 mg | 49 mg/51 mg | 590549.54359/7.6/0549.543 | Registered | S3 | None |
| Trevylna 97 mg/103 MG EACH TABLET CONTAINS: SACUBITRIL 97,0 mg VALSARTAN 103,0 mg | 97 mg/103 mg | 590550.54459/7.6/0550.544 | Registered | S3 | None |
Regulatory status
Where S3 sits on the scale
Needs a doctor's prescription, dispensed by a pharmacist.
Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S3, matched to the Consolidated Schedules by ingredient, confidence medium.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Sacubitril, valsartan
S3: Sacubitril
Consolidated Schedules 06 July 2026, line 4236
S3: Valsartan
Consolidated Schedules 06 July 2026, line 4376
Pharmacological class: Others. (class 7.6)
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
SAHPRA has not published a professional information or patient information leaflet for this product.