Piperacillin, tazobactam

Sold as Tazobax, Zopercin, Tazlin, Curitaz, Litha piperacillin co, Caplin, Piperacillin and tazobactam propan, Razobin, Nildin, Pirabax, Accord-piperacillin tazobactam, Cinotaz, Piperacillin/tazobactam fresenius, Zobact iv, Tapranem, Tazopip, Tiperabex

C₁₀H₁₂N₄O₅S300.29 g/mol

(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Drag to rotate. Structure from PubChem CID 123630.

Loading Wikipedia summary

Registration

Applicants: 14
Registrations: 28
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Acino Pharma (Pty) Ltd3 of 4 cancelled	Tazobax, Litha piperacillin co	2, 3, 4 g/ 0,5 g, 4	370454, 420251, 420252, 420253	Not determined	PI PIL
Orchid Pharmaceuticals SA (Pty) LtdCancelled	Zopercin	Not stated	410829	S4	None
Oethmaan Biosims (Pty) Ltd	Tazlin	4,5mg	420003	S4	PI PIL
Sandoz South Africa (Pty) LtdCancelled	Curitaz	4,5	420004	Not determined	None
Viatris South Africa (Pty) Ltd	Caplin	2 g/250 mg, 4 g/500 mg	420694, 420695	Not determined	None
Adcock ingram limitedCancelled	Piperacillin and tazobactam propan	4 g/0,5 g	430391	S4	None
Aurogen South Africa (Pty) Ltd	Razobin, Nildin	2 mg/3 mg/4 mg, 2 g, 3 g, 4 g	440080, 440081, 440082, 440083, 440084, 440085	S4	PI PIL
Accord Healthcare (Pty) Ltd	Pirabax, Accord-piperacillin tazobactam	2/0,25, 4/0,5, + 2/0,25, + 4/0,5	440273, 440274, 440275, 440276	Not determined	None
Biotech Laboratories (Pty) Ltd	Cinotaz	2, 4	450399, 450400	S4	PI PIL
Fresenius Kabi South Africa (Pty) Ltd	Piperacillin/tazobactam fresenius	2 g/0,25 g, 4 g/0,5 g	451172, 451173	Not determined	None
Austell Pharmaceuticals (Pty) LtdCancelled	Zobact iv	4,5 g	500742	Not determined	None
Ando Pharma (Pty) Ltd	Tapranem	Not stated	56/20.1.1/0247	Not determined	None
Encha Health (Pty) Ltd	Tazopip	Not stated	570266	Not determined	None
Abex Pharmaceutica (Pty) LtdCancelled	Tiperabex	4 g/0,5 g	570421	Not determined	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Tazobax EACH SINGLE DOSE VIAL CONTAINS :PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g, TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 500,0 mg	4 g/ 0,5 gPowder for solution for infusion	37045437/20.1.1/0454Approved 22 May 2025	Registered	Not determined	PI PIL
Zopercin EACH VIAL CONTAINS PIPERACILLIN 4,0 g TAZOBACTAM 0,5 g	Not listed	410829410/20.1.1/0829	Cancelled	S4	None
Tazlin 4,5 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 500,0 mg	4,5mgPowder for solution for injection.	42000342/20.1.1/0003Approved 6 March 2025	Registered	S4	PI PIL
Curitaz 4,5 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 500,0 mg	4,5	42000442/20.1.1/0004	Cancelled	Not determined	None
Litha piperacillin co 2 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 2,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,250 g	2	42025142/20.1.1/0251	Cancelled	Not determined	None
Litha piperacillin co 3 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 3,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,375 g	3	42025242/20.1.1/0252	Cancelled	Not determined	None
Litha piperacillin co 4 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,5 g	4	42025342/20.1.1/0253	Cancelled	Not determined	None
Caplin 2 g/250 MG EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 2,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 250,0 mg	2 g/250 mg	42069442/20.1.1/0694	Registered	Not determined	None
Caplin 4 g/500 MG EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 500,0 mg	4 g/500 mg	42069542/20.1.1/0695	Registered	Not determined	None
Piperacillin and tazobactam 4 g/0,5 g propan EACH VIAL CONTAINS PIPERACILLIN 4,0 g TAZOBACTAM 500,0 mg	4 g/0,5 g	43039143/20.1.1/0391	Cancelled	S4	None
Razobin-2 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 2,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,25 g	2 mg/3 mg/4 mgLyophilised powder for solution for injection/infusion	44008044/20.1.1/0080Approved 29 January 2024	Registered	S4	PI PIL
Razobin-3 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 3,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,375 g	2 mg/3 mg/4 mgLyophilised powder for solution for injection/infusion	44008144/20.1.1/0081Approved 29 January 2024	Registered	S4	PI PIL
Razobin-4 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,5 g	2 mg/3 mg/4 mgLyophilised powder for solution for injection/infusion	44008244/20.1.1/0082Approved 29 January 2024	Registered	S4	PI PIL
Nildin 2 g injection EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 2,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,25 g	2 gInjection	44008344/20.1.1/0083	Registered	Not determined	None
Nildin 3 g injection EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 3,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,375 g	3 gInjection	44008444/20.1.1/0084	Registered	Not determined	None
Nildin 4 g EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,5 g	4 g	44008544/20.1.1/0085	Registered	Not determined	None
Pirabax 2/0,25 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 2 000,0 mg TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 250,0 mg	2/0,25	44027344/20.1.1/0273	Registered	Not determined	None
Pirabax 4/0,5 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4 000,0 mg TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 500,0 mg	4/0,5	44027444/20.1.1/0274	Registered	Not determined	None
Accord-piperacillin + tazobactam 2/0,25 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 2 000,0 mg TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 250,0 mg	+ 2/0,25	44027544/20.1.1/0275	Registered	Not determined	None
Accord-piperacillin + tazobactam 4/0,5 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4 000,0 mg TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 500,0 mg	+ 4/0,5	44027644/20.1.1/0276	Registered	Not determined	None
Cinotaz 2 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 2,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 250,0 mg	2Powder for solution for infusion	45039945/20.1.1/0399Approved 4 February 2025	Registered	S4	PI PIL
Cinotaz 4 EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 500,0 mg	4Powder for solution for infusion	45040045/20.1.1/0400Approved 4 February 2025	Registered	S4	PI PIL
Piperacillin/tazobactam 2 g/0,25 g fresenius EACH VIAL CONTAINS : PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 2,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,25 g	2 g/0,25 g	45117245/20.1.1/1172	Registered	Not determined	None
Piperacillin/tazobactam 4 g/0,5 g fresenius EACH VIAL CONTAINS : PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,5 g	4 g/0,5 g	45117345/20.1.1/1173	Registered	Not determined	None
Zobact iv 4,5 g EACH VIAL CONTAINS: PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,5 g	4,5 g	50074250/20.1.1/0742	Cancelled	Not determined	None
Tapranem EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,5 g	Not listed	56/20.1.1/0247	Registered	Not determined	None
Tazopip EACH VIAL CONTAINS PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,5 g	Not listed	57026657/20.1.1/0266	Registered	Not determined	None
Tiperabex 4 g/0,5 g EACH VIAL CONTAINS :PIPERACILLIN SODIUM EQUIVALENT TO PIPERACILLIN 4,0 g, TAZOBACTAM SODIUM EQUIVALENT TO TAZOBACTAM 0,5 g	4 g/0,5 g	57042157/20.1.1/0421	Cancelled	Not determined	None

Regulatory status

Where S4 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only medicine.

Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S4, matched to the Consolidated Schedules by ingredient, confidence medium.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Piperacillin, tazobactam

S4: Piperacillin
- anhydrous.
Consolidated Schedules 06 July 2026, line 7570
S4: Tazobactam
Consolidated Schedules 06 July 2026, line 8106

Pharmacological class: Broad and medium spectrum antibiotics. (class 20.1.1)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsTazobax, Acino Pharma (Pty) Ltd Patient information leaflet (PIL)For patients and carersTazobax, Acino Pharma (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

Loading PubMed articles

Background