Naloxone, oxycodone
Sold as Targinact prolonged release, Xonocod xr, Codep xr
Combination product
This product contains more than one active ingredient, so it has no single molecular structure.
Background
Registration
- Applicants
- 2
- Registrations
- 14
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Mundipharma (Pty) Ltd | Targinact prolonged release | 5 mg/2,5 mg, 10 mg/5 mg, 20 mg/10 mg, 40 mg/20 mg | 460645, 460646, 460647, 460648 | Not determined | None |
| Austell Pharmaceuticals (Pty) Ltd | Xonocod xr, Codep xr | 5/2,5 mg, 10/5 mg, 20/10 mg, 30/15 mg, 40/20 mg | 530745, 530746, 530747, 530748, 530749, 530750.745, 530751.746, 530752.747, 530753.748, 530754.749 | Not determined | None |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Targinact 5 mg/2,5 MG prolonged release tablet EACH TABLET CONTAINS NALOXONE HYDROCHLORIDE (DIHYDRATE) 2,5 mg OXYCODONE HYDROCHLORIDE 5,0 mg | 5 mg/2,5 mgTablet | 46064546/2.9/0645 | Registered | Not determined | None |
| Targinact 10 mg/5 MG prolonged release tablet EACH TABLET CONTAINS NALOXONE HYDROCHLORIDE (DIHYDRATE) 5,0 mg OXYCODONE HYDROCHLORIDE 10,0 mg | 10 mg/5 mgTablet | 46064646/2.9/0646 | Registered | Not determined | None |
| Targinact 20 mg/10 MG prolonged release tablet EACH TABLET CONTAINS NALOXONE HYDROCHLORIDE (DIHYDRATE) 10,0 mg OXYCODONE HYDROCHLORIDE 20,0 mg | 20 mg/10 mgTablet | 46064746/2.9/0647 | Registered | Not determined | None |
| Targinact 40 mg/20 MG prolonged release tablet EACH TABLET CONTAINS NALOXONE HYDROCHLORIDE (DIHYDRATE) 20,0 mg OXYCODONE HYDROCHLORIDE 40,0 mg | 40 mg/20 mgTablet | 46064846/2.9/0648 | Registered | Not determined | None |
| Xonocod xr 5/2,5 MG EACH TABLET CONTAINS OXYCODONE HYDROCHLORIDE EQUIVALENT TO OXYCODONE 5,0 mg NALOXONE HYDROCHLORIDE DIHYDRATE EQUIVALENT TO NALOXONE 2,5 mg | 5/2,5 mg | 53074553/2.9/0745 | Registrered | Not determined | None |
| Xonocod xr 10/5 MG EACH TABLET CONTAINS OXYCODONE HYDROCHLORIDE EQUIVALENT TO OXYCODONE 10,0 mg NALOXONE HYDROCHLORIDE DIHYDRATE EQUIVALENT TO NALOXONE 5,0 mg | 10/5 mg | 53074653/2.9/0746 | Registrered | Not determined | None |
| Xonocod xr 20/10 MG EACH TABLET CONTAINS OXYCODONE HYDROCHLORIDE EQUIVALENT TO OXYCODONE 20,0 mg NALOXONE HYDROCHLORIDE DIHYDRATE EQUIVALENT TO NALOXONE 10,0 mg | 20/10 mg | 53074753/2.9/0747 | Registrered | Not determined | None |
| Xonocod xr 30/15 MG EACH TABLET CONTAINS OXYCODONE HYDROCHLORIDE EQUIVALENT TO OXYCODONE 30,0 mg NALOXONE HYDROCHLORIDE DIHYDRATE EQUIVALENT TO NALOXONE 15,0 mg | 30/15 mg | 53074853/2.9/0748 | Registrered | Not determined | None |
| Xonocod xr 40/20 MG EACH TABLET CONTAINS OXYCODONE HYDROCHLORIDE EQUIVALENT TO OXYCODONE 40,0 mg NALOXONE HYDROCHLORIDE DIHYDRATE EQUIVALENT TO NALOXONE 20,0 mg | 40/20 mg | 53074953/2.9/0749 | Registrered | Not determined | None |
| Codep xr 5/2,5 MG EACH TABLET CONTAINS OXYCODONE HYDROCHLORIDE EQUIVALENT TO OXYCODONE 5,0 mg NALOXONE HYDROCHLORIDE DIHYDRATE EQUIVALENT TO NALOXONE 2,5 mg | 5/2,5 mg | 530750.74553/2.9/0750.745 | Registrered | Not determined | None |
| Codep xr 10/5 MG EACH TABLET CONTAINS OXYCODONE HYDROCHLORIDE EQUIVALENT TO OXYCODONE 10,0 mg NALOXONE HYDROCHLORIDE DIHYDRATE EQUIVALENT TO NALOXONE 5,0 mg | 10/5 mg | 530751.74653/2.9/0751.746 | Registrered | Not determined | None |
| Codep xr 20/10 MG EACH TABLET CONTAINS OXYCODONE HYDROCHLORIDE EQUIVALENT TO OXYCODONE 20,0 mg NALOXONE HYDROCHLORIDE DIHYDRATE EQUIVALENT TO NALOXONE 10,0 mg | 20/10 mg | 530752.74753/2.9/0752.747 | Registrered | Not determined | None |
| Codep xr 30/15 MG EACH TABLET CONTAINS OXYCODONE HYDROCHLORIDE EQUIVALENT TO OXYCODONE 30,0 mg NALOXONE HYDROCHLORIDE DIHYDRATE EQUIVALENT TO NALOXONE 15,0 mg | 30/15 mg | 530753.74853/2.9/0753.748 | Registrered | Not determined | None |
| Codep xr 40/20 MG EACH TABLET CONTAINS OXYCODONE HYDROCHLORIDE EQUIVALENT TO OXYCODONE 40,0 mg NALOXONE HYDROCHLORIDE DIHYDRATE EQUIVALENT TO NALOXONE 20,0 mg | 40/20 mg | 530754.74953/2.9/0754.749 | Registrered | Not determined | None |
Regulatory status
This product is still scheduled by law even when this site could not determine which tier it falls under. The label carries the S number in a square border; ask a pharmacist if you need to know its schedule.
Listings for this ingredient that could not be applied to this product
S6: Oxycodone
Consolidated Schedules 06 July 2026, line 10363
S4: Naloxone
Consolidated Schedules 06 July 2026, line 7206
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
SAHPRA has not published a professional information or patient information leaflet for this product.