Methylprednisolone aceponate

Sold as Advantan scalp, Advantan milk, Macepatan, Adexityl, Vantiglen, Metiderm, Vantaderm, Macepatan fatty, Advantan, Advantan fatty

S4Read from the PI-PIL document and verified

C₂₇H₃₆O₇472.60 g/mol

[(6S,8S,9S,10R,11S,13S,14S,17R)-17-(2-Acetyloxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate

Drag to rotate. Structure from PubChem CID 63019.

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Registration

Applicants: 4
Registrations: 16
Schedule source: SAHPRA documentation

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Adcock ingram limitedCertificate held by Bayer (Pty) Ltd1 of 5 cancelled	Advantan scalp, Advantan milk, Advantan, Advantan fatty	solution, 1 mg / g, 1mg, ointment	320361, 320362, X0384, X0385, X0386	S4	PI PIL
Pharmacare limited û woodmeadCertificate held by Pharmacare limited, Pharmacare Ltd	Macepatan, Macepatan fatty	ointment, 1 mg, 10 mg/200 mg/350 mg	510330, 560423, 590670	S4	PI PIL
Glenmark Pharmaceuticals South Africa (Pty) Ltd	Adexityl, Vantiglen	emulsion, cream	540493, 540494, 540495, 540496.495	Not determined	None
Abex Pharmaceutica (Pty) Ltd	Metiderm, Vantaderm	1 mg, ointment	580151, 580152.151, 590160, 590161.160	S4	PI PIL

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Advantan scalp solution EACH 1,0 ml SOLUTION CONTAINS: METHYLPREDNISOLONE ACEPONATE 1,0 mg	Solution	32036132/13.4.1/0361	Cancelled	Not determined	None
Advantan milk EACH 100,0 g EMULSION CONTAINS METHYLPREDNISOLONE ACEPONATE 100,0 mg	1 mg / gEmulsion.	32036232/13.4.1/0362Approved 8 May 2023	Registered	Not determined	PI PIL
Macepatan ointment EACH 1,0 g OF OINTMENT CONTAINS METHYLPREDNISOLONE ACEPONATE 1,0 mg	Ointment	51033051/13.4.1/0330	Registered	Not determined	None
Adexityl emulsion EACH 1,0 g EMULSION CONTAINS METHYLPREDNISOLONE ACEPONATE 1,0 mg	Emulsion	54049354/13.4.1/0493	Registered	Not determined	None
Vantiglen emulsion EACH 1,0 g EMULSION CONTAINS METHYLPREDNISOLONE ACEPONATE 1,0 mg	Emulsion	54049454/13.4.1/0494.493	Registered	Not determined	None
Adexityl cream EACH 1,0 g CREAM CONTAINS METHYLPREDNISOLONE ACEPONATE 1,0 mg	Cream	54049554/13.4.1/0495	Registered	Not determined	None
Vantiglen cream EACH 1,0 g CREAM CONTAINS METHYLPREDNISOLONE ACEPONATE 1,0 mg	Cream	540496.49554/13.4.1/0496.495	Registered	Not determined	None
Macepatan cream EACH 1,0 g CREAM CONTAINS METHYLPREDNISOLONE ACEPONATE 0,1% m/m	10 mg/200 mg/350 mgCream.	56042356/13.4.1/0423Approved 23 July 2024	Registered	S4	PI PIL
Metiderm cream EACH 1,0 g CREAM CONTAINS: METHYLPREDNISOLONE ACEPONATE 1,0 mg	1 mgCream	58015158/13.4.1/0151Approved 25 November 2025	Registered	S4	PI PIL
Vantaderm cream EACH 1,0 g CREAM CONTAINS: METHYLPREDNISOLONE ACEPONATE 1,0 mg	1 mgCream	580152.15158/13.4.1/0152.151Approved 25 November 2025	Registered	S4	PI PIL
Metiderm ointment EACH 1,0 g OF OINTMENT CONTAINS: METHYLPREDNISOLONE ACEPONATE 1,0 mg	Ointment	59016059/13.4.1/0160	Registered	Not determined	None
Vantaderm ointment EACH 1,0 g OF OINTMENT CONTAINS: METHYLPREDNISOLONE ACEPONATE 1,0 mg	Ointment	590161.16059/13.4.1/0161.160	Registered	Not determined	None
Macepatan fatty ointment EACH 1,0 g OF OINTMENT CONTAINS: METHYLPREDNISOLONE ACEPONATE 1,0 mg	1 mgFatty ointment	59067059/13.4.1/0670Approved 30 June 2026	Registered	S4	PI PIL
Advantan cream EACH 1 g CREAM CONTAINS METHYLPREDNISOLONE ACEPONATE 1 mg	1mgCream. Ointment. Fatty ointment	X0384X/13.4.1/384Approved 8 May 1992	Registered	S4	PI
Advantan ointment EACH 1 g OINTMENT CONTAINS METHYLPREDNISOLONE ACEPONATE 1 mg	Ointment	X0385X/13.4.1/385	Registered	Not determined	None
Advantan fatty ointment EACH 1 g OINTMENT CONTAINS METHYLPREDNISOLONE ACEPONATE 1 mg	Ointment	X0386X/13.4.1/386	Registered	Not determined	None

Regulatory status

Where S4 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only medicine.

Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S4, read from the product's PI-PIL leaflet.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsAdvantan milk, Adcock ingram limited Patient information leaflet (PIL)For patients and carersAdvantan milk, Adcock ingram limited

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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