Levofloxacin

Sold as Tavanic, Tavanic I.V., Tavaloxx, Cipla levofloxacin, Cipla-levofloxacin, Austell levofloxacin, Ausvanic, Levostel, Levofloxacin specpharm iv, SPEC levofloxacin iv, Aspen levofloxacin, Litha levofloxacin, Lintrip, Acaquin, Levonic iv, Levofloxacin biotech, Spec-levofloxacin, Levotav iv, Levotav I.V., Mylan levofloxacin, Levofloxacin winthrop, Propan levofloxacin iv, Restan levofloxacin iv, Covan levofloxacin iv, Zybact, Arylevo, Levofloxacin trinity, Levofloxacin ( ) fresenius, Avrokel, Datex, Levofloxacin unicorn, Levojub, Levantrin, Levofloxacin ipharma, Levofloxacin iv cipla, Tavaloxx iv, Sandoz levofloxacin

C₁₈H₂₀FN₃O₄361.40 g/mol

(2S)-7-Fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid

Drag to rotate. Structure from PubChem CID 149096.

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Registration

Applicants: 22
Registrations: 68
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Ranbaxy (SA) (Pty) LtdCancelled	Tavanic, Tavanic I.V.	250, 500, 750	320123, 320124, 320125, 340002, 430947, 430948	S4	None
Cipla Medpro (Pty) Ltd6 of 8 cancelled	Tavaloxx, Cipla levofloxacin, Cipla-levofloxacin, Levofloxacin iv cipla, Tavaloxx iv	250mg / 500mg / 750mg, 250, 500, 750	410007, 410008, 410009, 410010, 410011, 410012, 500320, 500322	S4	PI PIL
Austell Pharmaceuticals (Pty) LtdCertificate held by Austell Laboratories (Pty) Ltd.	Austell levofloxacin, Ausvanic	250/500 mg, 250, 500	411018, 411019, 411020, 411021	S4	PI PIL
Dezzo Trading 392 (Pty) Ltd	Levostel	250, 500	411022, 411023	S4	None
Specpharm (Pty) Ltd	Levofloxacin specpharm iv, SPEC levofloxacin iv, Spec-levofloxacin	250, 500	420427, 420428, 420439, 420440, 430425, 430426	S4	None
Acino Pharma (Pty) LtdCancelled	Aspen levofloxacin, Litha levofloxacin	5 mg/ml, 250 mg, 500 mg	420509, 420510, 421002	S4	None
Dr Reddyæs Laboratories (Pty) Ltd	Lintrip	250, 500	420632, 420633	S4	None
Ascendis Pharma (Pty) Ltd	Acaquin	250, 500	420859, 420860	S4	None
Population services international(incorporated in united states of america) external non-profit company	Levonic iv	500	420998	S4	None
Biotech Laboratories (Pty) Ltd	Levofloxacin biotech	250 / 500 mg	430231, 430232	S4	PI PIL
Adcock Ingram Critical Care (Pty) Ltd6 of 8 cancelled	Levotav iv, Levotav I.V., Propan levofloxacin iv, Restan levofloxacin iv, Covan levofloxacin iv	250, 500	430783, 430784, 440220, 440221, 440222, 440223, 440224, 440225	S4	None
Viatris South Africa (Pty) Ltd	Mylan levofloxacin	250 mg, 500 mg	430841, 430842	S4	None
Sanofi-aventis South Africa (Pty) LtdCancelled	Levofloxacin winthrop	750	431058	S4	None
Zydus Healthcare (Pty) Ltd	Zybact, Arylevo	250 mg, 500 mg	440249, 440250, 440251, 440252	S4	None
Trinity Pharma (Pty) LtdCertificate held by Trinity Pharma (Pty) Ltd.	Levofloxacin trinity	250 mg / 500 mg	440421, 440422	S4	PI PIL
Fresenius Kabi South Africa (Pty) Ltd	Levofloxacin ( ) fresenius	5 mg/ml	450139	S4	PI PIL
Macleods Pharmaceuticals SA (Pty) Ltd	Avrokel	250, 500	450684, 450685	S4	None
Aurogen South Africa (Pty) LtdCancelled	Datex	250 mg, 500 mg	460859, 460860	S4	None
Unicorn Pharmaceuticals (Pty) Ltd	Levofloxacin unicorn	250, 500	460944, 460945	S4	PI PIL
Jubilant Pharma SA (Pty) Ltd	Levojub, Levantrin	250 mg, 500 mg	460977, 460978, 480151, 480152	S4	None
Ipharma (Pty) LtdCancelled	Levofloxacin ipharma	250, 500	490903, 490904	S4	None
Sandoz South Africa (Pty) Ltd	Sandoz levofloxacin	250, 500	A400525, A400526	S4	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Tavanic 250 EACH TABLET CONTAINS LEVOFLOXACIN 250,0 mg	250	32012332/20.1.1/0123	Cancelled	S4	None
Tavanic 500 EACH TABLET CONTAINS LEVOFLOXACIN 500,0 mg	500	32012432/20.1.1/0124	Cancelled	S4	None
Tavanic I.V. 500 EACH 100 ml INFUSION SOLUTION CONTAINS LEVOFLOXACIN 500,0 mg	500	32012532/20.1.1/0125	Cancelled	S4	None
Tavanic I.V. 250 EACH 50,0 ml SOLUTION CONTAINS LEVOFLOXACIN 250,0 mg	250	34000234/20.1.1/0002	Cancelled	S4	None
Tavaloxx 250 EACH TABLET CONTAINS:LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 250,0 mg	250mg / 500mg / 750mgTablets	41000741/20.1.1/0007Approved 16 August 2020	Cancelled	S4	PI PIL
Tavaloxx 500 EACH TABLET CONTAINS:LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 500,0 mg	250mg / 500mg / 750mgTablets	41000841/20.1.1/0008Approved 16 August 2020	Registered	S4	PI PIL
Tavaloxx 750 EACH TABLET CONTAINS:LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 750,0 mg	250mg / 500mg / 750mgTablets	41000941/20.1.1/0009Approved 16 August 2020	Registered	S4	PI PIL
Cipla levofloxacin 250 EACH TABLET CONTAINS:LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 250,0 mg	250	41001041/20.1.1/0010	Cancelled	S4	None
Cipla levofloxacin 500 EACH TABLET CONTAINS:LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 500,0 mg	500	41001141/20.1.1/0011	Cancelled	S4	None
Cipla-levofloxacin 750 EACH TABLET CONTAINS:LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 750,0 mg	750	41001241/20.1.1/0012	Cancelled	S4	None
Austell levofloxacin 250 MG EACH TABLET CONTAINS:LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 250,0 mg	250/500 mgFilm-coated tablets.	41101841/20.1.1/1018Approved 8 July 2020	Registered	S4	PI PIL
Austell levofloxacin 500 MG EACH TABLET CONTAINS LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 500,0 mg	250/500 mgFilm-coated tablets.	41101941/20.1.1/1019Approved 8 July 2020	Registered	S4	PI PIL
Ausvanic 250 EACH TABLET CONTAINS:LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 250,0 mg	250	41102041/20.1.1/1020	Registered	S4	None
Ausvanic 500 EACH TABLET CONTAINS:LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 500,0 mg	500	41102141/20.1.1/1021	Registered	S4	None
Levostel-250 EACH TABLET CONTAINS LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 250,0 mg	250	41102241/20.1.1/1022	Registered	S4	None
Levostel - 500 EACH TABLET CONTAINS LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 500,0 mg	- 500	41102341/20.1.1/1023	Registered	S4	None
Levofloxacin specpharm 250 iv EACH 50,0 ml SOLUTION CONTAINS LEVOFLOXACIN 250,0 mg	250	42042742/20.1.1/0427	Registered	S4	None
SPEC levofloxacin 500 iv EACH 50,0 ml SOLUTION CONTAINS LEVOFLOXACIN 500,0 mg	500	42042842/20.1.1/0428	Registered	S4	None
Levofloxacin specpharm 500 iv EACH 50,0 ml SOLUTION CONTAINS LEVOFLOXACIN 500,0 mg	500	42043942/20.1.1/0439	Registered	S4	None
SPEC levofloxacin 250 iv EACH 50,0 ml SOLUTION CONTAINS LEVOFLOXACIN 250,0 mg	250	42044042/20.1.1/0440	Registered	S4	None
Aspen levofloxacin 250 MG EACH TABLET CONTAINS LEVOFLOXACIN 250,0 mg	250 mg	42050942/20.1.1/0509	Cancelled	S4	None
Litha levofloxacin 500 MG EACH TABLET CONTAINS LEVOFLOXACIN 500,0 mg	500 mg	42051042/20.1.1/0510	Cancelled	S4	None
Lintrip 250 EACH TABLET CONTAINS LEVOFLOXACIN 250,0 mg	250	42063242/20.1.1/0632	Registered	S4	None
Lintrip 500 EACH TABLET CONTAINS LEVOFLOXACIN 500,0 mg	500	42063342/20.1.1/0633	Registered	S4	None
Acaquin 250 EACH TABLET CONTAINS LEVOFLOXACIN 250,0 mg	250	42085942/20.1.1/0859	Registered	S4	None
Acaquin 500 EACH TABLET CONTAINS:LEVOFLOXACIN 500,0 mg	500	42086042/20.1.1/0860	Registered	S4	None
Levonic iv 500 EACH 100,0 ml SOLUTION CONTAINS LEVOFLOXACIN 500,0 mg	500	42099842/20.1.1/0998	Registered	S4	None
Aspen levofloxacin 5 mg/ml EACH 1,0 ml SOLUTION CONTAINS LEVOFLOXACIN 5,0 mg	5 mg/ml	42100242/20.1.1/1002	Cancelled	S4	None
Levofloxacin 250 biotech EACH 50,0 ml VIAL CONTAINS:LEVOFLOXACIN 250,0 mg	250 / 500 mgSolution for infusion	43023143/20.1.1/0231Approved 6 March 2023	Registered	S4	PI PIL
Levofloxacin 500 biotech EACH 100,0 ml VIAL CONTAINS:LEVOFLOXACIN 500,0 mg	250 / 500 mgSolution for infusion	43023243/20.1.1/0232Approved 6 March 2023	Registered	S4	PI PIL
Spec-levofloxacin 250 EACH TABLET CONTAINS LEVOFLOXACIN 250,0 mg	250	43042543/20.1.1/0425	Registered	S4	None
Spec-levofloxacin 500 EACH TABLET CONTAINS LEVOFLOXACIN 500,0 mg	500	43042643/20.1.1/0426	Registered	S4	None
Levotav iv 250 EACH 50,0 ml SOLUTION CONTAINS LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 250,0 mg	250	43078343/20.1.1/0783	Registered	S4	None
Levotav I.V. 500 EACH 100,0 ml SOLUTION CONTAINS LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 500,0 mg	500	43078443/20.1.1/0784	Registered	S4	None
Mylan levofloxacin 250 MG EACH TABLET CONTAINS LEVOFLOXACIN 250,0 mg	250 mg	43084143/20.1.1/0841	Registered	S4	None
Mylan levofloxacin 500 MG EACH TABLET CONTAINS LEVOFLOXACIN 500,0 mg	500 mg	43084243/20.1.1/0842	Registered	S4	None
Tavanic 750 EACH TABLET CONTAINS LEVOFLOXACIN 750,0 mg	750	43094743/20.1.1/0947	Cancelled	S4	None
Tavanic I.V. 750 EACH VIAL CONTAINS LEVOFLOXACIN 750,0 mg	750	43094843/20.1.1/0948	Cancelled	S4	None
Levofloxacin winthrop 750 EACH TABLET CONTAINS LEVOFLOXACIN 750,0 mg	750	43105843/20.1.1/1058	Cancelled	S4	None
Propan levofloxacin iv 250 EACH 50,0 ml SOLUTION CONTAINS LEVOFLOXACIN 250,0 mg	250	44022044/20.1.1/0220	Cancelled	S4	None
Propan levofloxacin iv 500 EACH 100,0 ml SOLUTION CONTAINS LEVOFLOXACIN 500,0 mg	500	44022144/20.1.1/0221	Cancelled	S4	None
Restan levofloxacin iv 250 EACH 50,0 ml SOLUTION CONTAINS LEVOFLOXACIN 250,0 mg	250	44022244/20.1.1/0222	Cancelled	S4	None
Restan levofloxacin iv 500 EACH 100,0 ml SOLUTION CONTAINS LEVOFLOXACIN 500,0 mg	500	44022344/20.1.1/0223	Cancelled	S4	None
Covan levofloxacin iv 250 EACH 50,0 ml SOLUTION CONTAINS LEVOFLOXACIN 250,0 mg	250	44022444/20.1.1/0224	Cancelled	S4	None
Covan levofloxacin iv 500 EACH 50,0 ml SOLUTION CONTAINS LEVOFLOXACIN 500,0 mg	500	44022544/20.1.1/0225	Cancelled	S4	None
Zybact 250 MG EACH TABLET CONTAINS LEVOFLOXACIN 250,0 mg	250 mg	44024944/20.1.1/0249	Registered	S4	None
Zybact 500 MG EACH TABLET CONTAINS LEVOFLOXACIN 500,0 mg	500 mg	44025044/20.1.1/0250	Registered	S4	None
Arylevo 250 EACH TABLET CONTAINS LEVOFLOXACIN 250,0 mg	250	44025144/20.1.1/0251	Registered	S4	None
Arylevo 500 EACH TABLET CONTAINS LEVOFLOXACIN 500,0 mg	500	44025244/20.1.1/0252	Registered	S4	None
Levofloxacin trinity 250 EACH TABLET CONTAINS LEVOFLOXACIN 250,0 mg	250 mg / 500 mgFilm coated tablets	44042144/20.1.1/0421Approved 9 November 2022	Registered	S4	PI PIL
Levofloxacin trinity 500 EACH TABLET CONTAINS LEVOFLOXACIN 500,0 mg	250 mg / 500 mgFilm coated tablets	44042244/20.1.1/0422Approved 9 November 2022	Registered	S4	PI PIL
Levofloxacin 5 mg/ml (100 ml) fresenius	5 mg/mlSolution for infusion.	45013945/20.1.1/0139Approved 13 January 2026	Registered	S4	PI PIL
Avrokel 250 EACH TABLET CONTAINS :LEVOFLOXACIN 250,0 mg	250	45068445/20.1.1/0684	Registered	S4	None
Avrokel 500 EACH TABLET CONTAINS LEVOFLOXACIN 500,0 mg	500	45068545/20.1.1/0685	Registered	S4	None
Datex 250 MG EACH TABLET CONTAINS: LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 250,0 mg	250 mg	46085946/20.1.1/0859	Cancelled	S4	None
Datex 500 MG EACH TABLET CONTAINS: LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 500,0 mg	500 mg	46086046/20.1.1/0860	Cancelled	S4	None
Levofloxacin unicorn 250	250Film coated tablet	46094446/20.1.1/0944Approved 2 March 2021	Registered	S4	PI PIL
Levofloxacin unicorn 500	500Film coated tablet	46094546/20.1.1/0945Approved 2 March 2021	Registered	S4	PI PIL
Levojub 250 EACH TABLET CONTAINS LEVOFLOXACIN 250,0 mg	250	46097746/20.1.1/0977	Registered	S4	None
Levojub 500 EACH TABLET CONTAINS LEVOFLOXACIN 500,0 mg	500	46097846/20.1.1/0978	Registered	S4	None
Levantrin 250 MG Each Tablet contains: Levofloxacin Hemihydrate equivalent to Levofloxacin 250,0 mg	250 mg	48015148/20.1.1/0151	Registered	S4	None
Levantrin 500 MG Each Tablet contains: Levofloxacin Hemihydrate equivalent to Levofloxacin 500,0 mg	500 mg	48015248/20.1.1/0152	Registered	S4	None
Levofloxacin 250 ipharma EACH TABLET CONTAINS: LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 250,0 mg	250	49090349/20.1.1/0903	Cancelled	S4	None
Levofloxacin 500 ipharma EACH TABLET CONTAINS: LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 500,0 mg	500	49090449/20.1.1/0904	Cancelled	S4	None
Levofloxacin iv 500 cipla EACH 100 mL VIAL CONTAINS: LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 500,0 mg	500	50032050/20.1.1/0320	Cancelled	S4	None
Tavaloxx iv 500 EACH 100 mL VIAL CONTAINS: LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 500,0 mg	500	50032250/20.1.1/0322	Cancelled	S4	None
Sandoz levofloxacin 250 EACH TABLET CONTAINS LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 250,0 mg	250	A400525A40/20.1.1/0525	Registered	S4	None
Sandoz levofloxacin 500 EACH TABLET CONTAINS LEVOFLOXACIN HEMIHYDRATE EQUIVALENT TO LEVOFLOXACIN 500,0 mg	500	A400526A40/20.1.1/0526	Registered	S4	None

Regulatory status

Where S4 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only medicine.

Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S4, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Levofloxacin

S4: Levofloxacin
Consolidated Schedules 06 July 2026, line 6909

Pharmacological class: Broad and medium spectrum antibiotics. (class 20.1.1)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

Tavaloxx 250, Cipla Medpro (Pty) Ltd is scheduled S4 in its official SAHPRA documents, read with 90% confidence.

Professional information (PI)For healthcare professionalsTavaloxx 250, Cipla Medpro (Pty) Ltd Patient information leaflet (PIL)For patients and carersTavaloxx 250, Cipla Medpro (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

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