Isoniazid, rifampicin
Sold as Rimactazid pead, Rimactazid, Montonex, Rimactazid paed, Rifizid, Afaris fc, Afaris paed odt, Afaris paed, Ripyso paed, Orizit paed, R-cin plus, Akurit kid odt, Duopic, Duopic paed, Rifinah, Rifinah fc
Combination product
This product contains more than one active ingredient, so it has no single molecular structure.
Background
Registration
- Applicants
- 8
- Registrations
- 19
- Schedule source
- Consolidated Schedules 06 July 2026
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Sandoz South Africa (Pty) LtdCertificate held by Sandoz | Rimactazid pead, Rimactazid, Rimactazid paed | 60/60, 60/30, 150/75 | 320548, 350280, 370026 | S4 | PIPIL |
| Innovata pharmaceuticals | Montonex | 150, 300 | 360496, 360497 | S4 | None |
| Dezzo Trading 392 (Pty) Ltd | Rifizid | 150/75 | 410079 | S4 | None |
| Macleods Pharmaceuticals SA (Pty) Ltd1 of 6 cancelled | Afaris fc, Afaris paed odt, Afaris paed, Ripyso paed, Orizit paed | 60/60, 75/50, 150/75, 300/150 | 480748, 480749, 480751, 510852, 510853.852, 510854.852 | S4 | PIPIL |
| Pharma Dynamics (Pty) LtdCertificate held by Pharma Dynamics (Pty) Ltd. | R-cin plus, Akurit kid odt | 75/50, 150 mg and 75 mg | 540315, 540648 | S4 | PIPIL |
| Adcock ingram limited | Duopic, Duopic paed | 75 & 50 mg, 150/75 | 550304, 570420 | S4 | PIPIL |
| Sanofi-aventis South Africa (Pty) LtdCancelled | Rifinah, Rifinah fc | 150/75, 300 | A400534, A400535 | S4 | None |
| Medicine Developers International (Pty) LtdCancelled | Rifizid | 300/150 | A400543 | S4 | None |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Rimactazid pead 60/60 EACH TABLET CONTAINS ISONIAZID 60,0 mg, RIFAMPICIN 60,0 mg | 60/60 | 32054832/20.2.3/0548 | Registered | S4 | None |
| Rimactazid 150/75 EACH TABLET CONTAINS ISONIAZID 75,0 mg RIFAMPICIN 150,0 mg | 150/75Tablet | 35028035/20.2.3/0280Approved 5 August 2002 | Registered | S4 | PI |
| Montonex-150 tablets EACH TABLET CONTAINS ISONIAZID 100,0 mg RIFAMPICIN 150,0 mg | 150Tablets | 36049636/20.2.3/0496 | Registered | S4 | None |
| Montonex-300 tablets EACH TABLET CONTAINS ISONIAZID 150,0 mg RIFAMPICIN 300,0 mg | 300Tablets | 36049736/20.2.3/0497 | Registered | S4 | None |
| Rimactazid paed 60/30 EACH TABLET CONTAINS ISONIAZID 30,0 mg RIFAMPICIN 60,0 mg | 60/30Tablet | 37002637/20.2.3/0026Approved 6 September 2018 | Registered | S4 | PIPIL |
| Rifizid 150/75 EACH TABLET CONTAINS ISONIAZID 75,0 mg RIFAMPICIN 150,0 mg | 150/75 | 41007941/20.2.3/0079 | Registered | S4 | None |
| Afaris fc 150/75 EACH TABLET CONTAINS ISONIAZID 75,0 mgRIFAMPICIN 150,0 mg | 150/75 | 48074848/20.2.3/0748 | Registered | S4 | None |
| Afaris fc 300/150 EACH TABLET CONTAINS: ISONIAZID 150,0 mg, RIFAMPICIN 300,0 mg | 300/150 | 48074948/20.2.3/0749 | Registered | S4 | None |
| Afaris paed odt 60/60 EACH TABLET CONTAINS :ISONIAZID 60,0 mg, RIFAMPICIN 60,0 mg | 60/60 | 48075148/20.2.3/0751 | Registered | S4 | None |
| Afaris paed 75/50 EACH TABLET CONTAINS: ISONIAZID 50,0 mg; RIFAMPICIN 75,0 mg | 75/50Dispersible tablet | 51085251/20.2.3/0852Approved 26 July 2024 | Registered | S4 | PIPIL |
| Ripyso paed 75/50 EACH TABLET CONTAINS: ISONIAZID 50,0 mg; RIFAMPICIN 75,0 mg | 75/50Dispersible tablet | 510853.85251/20.2.3/0853.852Approved 26 July 2024 | Registered | S4 | PIPIL |
| Orizit paed 75/50 EACH TABLET CONTAINS ISONIAZID 50,0 mgRIFAMPICIN 75,0 mg | 75/50 | 510854.85251/20.2.3/0854.852 | Cancelled | S4 | None |
| R-cin plus EACH TABLET CONTAINS :ISONIAZID 75,0 mg, RIFAMPICIN 150,0 mg | 150 mg and 75 mgCoated tablet. | 54031554/20.2.3/0315Approved 14 March 2023 | Registered | S4 | PIPIL |
| Akurit kid 75/50 odt EACH TABLET CONTAINS ISONIAZID 50,0 mgRIFAMPICIN 75,0 mg | 75/50Tablet | 54064854/20.2.3/0648Approved 14 December 2021 | Registered | S4 | PIPIL |
| Duopic 150/75 | 150/75Tablet | 55030455/20.2.3/0304Approved 31 May 2022 | Registered | S4 | PIPIL |
| Duopic paed Each Tablet contains: Rifampicin 75,0 mg; Isoniazid 50,0 mg | 75 & 50 mgTablets | 57042057/20.2.3/0430Approved 18 November 2025 | Registered | S4 | PIPIL |
| Rifinah 150/75 EACH TABLET CONTAINS ISONIAZID 75,0 mg RIFAMPICIN 150,0 mg | 150/75 | A400534A40/20.2.3/0534 | Cancelled | S4 | None |
| Rifinah 300 fc EACH TABLET CONTAINS ISONIAZID 150,0 mg RIFAMPICIN 300,0 mg | 300 | A400535A40/20.2.3/0535 | Cancelled | S4 | None |
| Rifizid 300/150 EACH TABLET CONTAINS ISONIAZID 150,0 mg RIFAMPICIN 300,0 mg | 300/150 | A400543A40/20.2.3/0543 | Cancelled | S4 | None |
Regulatory status
Where S4 sits on the scale
Prescription-only medicine.
Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S4, matched to the Consolidated Schedules by ingredient, confidence medium.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Isoniazid, rifampicin
S4: Isoniazid
Consolidated Schedules 06 July 2026, line 6819
S4: Rifampicin
Consolidated Schedules 06 July 2026, line 7802
Pharmacological class: Tuberculostatics. (class 20.2.3)
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
Schedule Verification
Rimactazid 150/75, Sandoz South Africa (Pty) Ltd is scheduled S4 in its official SAHPRA documents, read with 90% confidence.
These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.