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Estradiol (Evorel)

Estradiol

Adcock ingram limited

S4Read from the PI-PIL document and verified

Registration

Applicant
Adcock ingram limited
Certificate holder
Adcock ingram limited
Registrations
4
Schedule source
SAHPRA documentation

Variants

ProductStrength and formRegistrationStatusScheduleLeaflets
Evorel 25

EACH PATCH CONTAINS ESTRADIOL 1,6 mg

1,6 mg/ 3,2 mg/ 4,8 mg/ 6,4 mgTransdermal patch.30020730/21.8.1/0207Approved 17 December 2021RegisteredS4PIPIL
Evorel 75

EACH PATCH CONTAINS ESTRADIOL 4,8 mg

1,6 mg/ 3,2 mg/ 4,8 mg/ 6,4 mgTransdermal patch.30020830/21.8.1/0208Approved 17 December 2021RegisteredS4PIPIL
Evorel 100

EACH PATCH CONTAINS ESTRADIOL 6,4 mg

1,6 mg/ 3,2 mg/ 4,8 mg/ 6,4 mgTransdermal patch.30020930/21.8.1/0209Approved 17 December 2021RegisteredS4PIPIL
Evorel 50

EACH PATCH CONTAINS ESTRADIOL 3,2 mg

1,6 mg/ 3,2 mg/ 4,8 mg/ 6,4 mgTransdermal patch.Z0339Z/21.8.1/339Approved 17 December 2021RegisteredS4PIPIL

Regulatory status

Where S4 sits on the scale

Prescription-only medicine.

Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S4, read from the product's PI-PIL leaflet.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Estradiol

  • S4: Estradiol

    • when intended for hormone replacement therapy;
    • except when intended for human vaginal use; (S2)
    • except when intended for oral contraception. (S3)

    Consolidated Schedules 06 July 2026, lines 6246 to 6251

  • S3: Estradiol

    • when intended for oral contraception;
    • except when intended for human vaginal use; (S2)
    • except when intended for hormone replacement therapy. (S4)

    Consolidated Schedules 06 July 2026, lines 3514 to 3524

  • S2: Estradiol

    • when intended for human vaginal use;
    • except when intended for oral contraception; (S3)
    • except when intended for hormone replacement therapy. (S4)

    Consolidated Schedules 06 July 2026, lines 1927 to 1933

Pharmacological class: Oestrogens. (class 21.8.1)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

C18H24O2272.40 g/mol

(8R,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

Drag to rotate. Structure from PubChem CID 5757.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

This medication's schedule (S4) has been verified from official SAHPRA documents with 90% confidence.

Professional information (PI)For healthcare professionalsPatient information leaflet (PIL)For patients and carers

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Background

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Research articles

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