Enalapril, hydrochlorothiazide

Sold as Enap-co, Pharmapress co, Renipral-co, Acenten, Renlin, Enalapril hctz austell, Enpresil co, Enalapril co biotech, Enaside, Co-renitec

S3Read from the PI-PIL document and verified

Combination product

This product contains more than one active ingredient, so it has no single molecular structure.

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Registration

Applicants: 6
Registrations: 10
Schedule source: SAHPRA documentation

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Pharma Dynamics (Pty) Ltd	Enap-co	20,0/12,5 mg	340088	S3	PI PIL
Pharmacare limited û woodmeadCertificate held by Pharmacare limited1 of 2 cancelled	Pharmapress co, Renipral-co	20.0mg/12.5 mg	340190, 350317	S3	PI PIL
Austell Pharmaceuticals (Pty) LtdCertificate held by Austell Pharmaceuticals (Pty) Ltd,	Acenten, Renlin, Enalapril hctz austell	20/12,5	491087, 491088, 491089	S3	PI PIL
Unicorn Pharmaceuticals (Pty) Ltd	Enpresil co	20 mg, 12,5 mg	550413	S3	PI PIL
Biotech Laboratories (Pty) Ltd	Enalapril co biotech, Enaside	20/12,5	560184, 560185.184	S3	PI PIL
Organon South Africa (Pty) LtdCancelled	Co-renitec	20/12,5	V0119	S3	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Enap-co EACH TABLET CONTAINS ENALAPRIL MALEATE 20,0 mg HYDROCHLOROTHIAZIDE 12,5 mg	20,0/12,5 mgTablets.	34008834/7.1.3/0088Approved 11 October 2024	Registered	S3	PI PIL
Pharmapress co EACH TABLET CONTAINS ENALAPRIL MALEATE 20,0 mg HYDROCHLOROTHIAZIDE 12,5 mg	20.0mg/12.5 mgTablet	34019034/7.1.3/0190Approved 3 June 2025	Registered	S3	PI PIL
Renipral-co EACH TABLET CONTAINS ENALAPRIL MALEATE 20,0 mg HYDROCHLOROTHIAZIDE 12,50 mg	Not listed	35031735/7.1.3/0317	Cancelled	S3	None
Acenten 20/12,5 Each tablet contains ENALAPRIL MALEATE 20,0 mg and HYDROCHLOROTHIAZIDE 12,5 mg	20/12,5Tablets	49108749/7.1.3/1087Approved 23 December 2022	Registered	S3	PI PIL
Renlin 20/12,5 Each tablet contains ENALAPRIL MALEATE 20,0 mg and HYDROCHLOROTHIAZIDE 12,5 mg	20/12,5Tablets	49108849/7.1.3/1088Approved 23 December 2022	Registered	S3	PI PIL
Enalapril hctz 20/12,5 austell Each tablet contains ENALAPRIL MALEATE 20,0 mg and HYDROCHLOROTHIAZIDE 12,5 mg	20/12,5Tablets	49108949/7.1.3/1089Approved 23 December 2022	Registered	S3	PI PIL
Enpresil co EACH TABLET CONTAINS ENALAPRIL MALEATE 20,0 mg HYDROCHLOROTHIAZIDE 12,5 mg	20 mg, 12,5 mgTablet	55041355/7.1.3/0413Approved 23 May 2023	Registered	S3	PI PIL
Enalapril co 20/12,5 biotech EACH TABLET CONTAINS ENALAPRIL MALEATE 20,0 mg HYDROCHLOROTHIAZIDE 12,5 mg	20/12,5Tablets	56018456/7.1.3/0184Approved 10 October 2023	Registered	S3	PI PIL
Enaside 20/12,5 EACH TABLET CONTAINS ENALAPRIL MALEATE 20,0 mg HYDROCHLOROTHIAZIDE 12,5 mg	20/12,5Tablets	560185.18456/7.1.3/0185.184Approved 10 October 2023	Registered	S3	PI PIL
Co-renitec 20/12,5 EACH TABLET CONTAINS ENALAPRIL MALEATE 20 MG HYDROCHLOROTHIAZIDE 12,5 MG	20/12,5	V0119V/7.1.3/119	Cancelled	S3	None

Regulatory status

Where S3 sits on the scale

S0S1S2S3S4S5S6S7S8

Needs a doctor's prescription, dispensed by a pharmacist.

Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S3, read from the product's PI-PIL leaflet.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Enalapril maleate, hydrochlorothiazide

S3: Enalapril
Consolidated Schedules 06 July 2026, line 3498
S3: Hydrochlorothiazide
Consolidated Schedules 06 July 2026, line 3721

Pharmacological class: Other hypotensives. (class 7.1.3)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

Enap-co, Pharma Dynamics (Pty) Ltd is scheduled S3 in its official SAHPRA documents, read with 90% confidence.

Professional information (PI)For healthcare professionalsEnap-co, Pharma Dynamics (Pty) Ltd Patient information leaflet (PIL)For patients and carersEnap-co, Pharma Dynamics (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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