Emtricitabine, tenofovir alafenamide

Sold as Descovy, Priprema, Tafbin, Etavir, Makovy, Emtritaf, Duemtrino, Bintaf, Tridolence, Aurotem

S4Read from the PI-PIL document and verified

C₂₁H₂₉N₆O₅P476.50 g/mol

Propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate

Drag to rotate. Structure from PubChem CID 9574768.

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Registration

Applicants: 7
Registrations: 11
Schedule source: SAHPRA documentation

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Gilead Sciences South Africa (Pty) Ltd	Descovy	200/10, 200/25	510506, 510507	Not determined	PI PIL
Cipla Medpro Manufacturing (Pty) LtdCertificate held by Cipla Medpro (Pty) Ltd	Priprema, Tafbin	25mg, 200mg	550079, 550080.079	S4	PI PIL
Pharma Dynamics (Pty) Ltd	Etavir	Not stated	570427	Not determined	None
Macleods Pharmaceuticals SA (Pty) Ltd	Makovy, Emtritaf	200 /25 mg	580026, 580027.026	S4	PI PIL
Austell Pharmaceuticals (Pty) Ltd	Duemtrino	Not stated	580134	Not determined	None
Aurogen South Africa (Pty) Ltd	Bintaf, Tridolence	Not stated	580209, 580210.209	Not determined	None
Aurobindo Pharma (Pty) Ltd	Aurotem	200 mg & 25 mg	580221	S4	PI PIL

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Descovy 200/10 EACH TABLET CONTAINS EMTRICITABINE 200,0 mg TENOFOVIR ALAFENAMIDE FUMARATE EQUIVALENT TO TENOFOVIR ALAFENAMIDE 10,0 mg	200/10Film coated tablet	51050651/20.2.8/0506Approved 3 November 2020	Registered	Not determined	PI PIL
Descovy 200/25 EACH TABLET CONTAINS EMTRICITABINE 200,0 mg TENOFOVIR ALAFENAMIDE FUMARATE EQUIVALENT TO TENOFOVIR ALAFENAMIDE 25,0 mg	200/25Film coated tablet	51050751/20.2.8/507Approved 3 November 2020	Registered	Not determined	PI PIL
Priprema EACH TABLET CONTAINS EMTRICITABINE 200,0 mg TENOFOVIR ALAFENAMIDE 25,0 mg	25mg. 200mgTablet	55007955/20.2.8/0079Approved 25 May 2022	Registered	S4	PI PIL
Tafbin EACH TABLET CONTAINS EMTRICITABINE 200,0 mg TENOFOVIR ALAFENAMIDE 25,0 mg	25mg. 200mgTablet	550080.07955/20.2.8/0080.079Approved 25 May 2022	Registered	S4	PI PIL
Etavir EACH TABLET CONTAINS EMTRICITABINE 200,0 mg TENOFOVIR ALAFENAMIDE FUMARATE EQUIVALENT TO TENOFOVIR ALAFENAMIDE 25,0 mg	Not listed	57042757/20.2.8/0427	Registered	Not determined	None
Makovy 200/25 Each Tablet contains: Emtricitabine 200,0 mg, Tenofovir Alafenamide fumarate equivalent to Tenofovir Alafenamide 25,0 mg	200 /25 mgFilm-coated tablets	58002658/20.2.8/0026Approved 8 July 2025	Registered	S4	PI PIL
Emtritaf 200/25 Each Tablet contains: Emtricitabine 200,0 mg, Tenofovir Alafenamide fumarate equivalent to Tenofovir Alafenamide 25,0 mg	200 /25 mgFilm-coated tablets	580027.02658/20.2.8/0027.026Approved 8 July 2025	Registered	S4	PI PIL
Duemtrino EACH TABLET CONTAINS EMTRICITABINE 200,0 mg TENOFOVIR ALAFENAMIDE FUMARATE EQUIVALENT TO TENOFOVIR ALAFENAMIDE 25,0 mg	Not listed	58013458/20.2.8/0134	Registered	Not determined	None
Bintaf EACH TABLET CONTAINS: EMTRICITABINE 200,0 mg TENOFOVIR ALAFENAMIDE FUMARATE EQUIVALENT TO TENOFOVIR ALAFENAMIDE 25,0 mg	Not listed	58020958/20.2.8/0209	Registered	Not determined	None
Tridolence EACH TABLET CONTAINS: EMTRICITABINE 200,0 mg TENOFOVIR ALAFENAMIDE FUMARATE EQUIVALENT TO TENOFOVIR ALAFENAMIDE 25,0 mg	Not listed	580210.20958/20.2.8/0210.209	Registered	Not determined	None
Aurotem EACH TABLET CONTAINS: EMTRICITABINE 200,0 mg TENOFOVIR ALAFENAMIDE FUMARATE EQUIVALENT TO TENOFOVIR ALAFENAMIDE 25,0 mg	200 mg & 25 mgFilm coated tablets	58022158/20.2.8/0221Approved 3 February 2026	Registered	S4	PI PIL

Regulatory status

Where S4 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only medicine.

Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S4, read from the product's PI-PIL leaflet.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Emtricitabine, tenofovir alafenamide

S4: Emtricitabine
Consolidated Schedules 06 July 2026, line 6178
S4: Tenofovir
Consolidated Schedules 06 July 2026, line 8130

Pharmacological class: Antiviral agents. (class 20.2.8)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsDescovy 200/10, Gilead Sciences South Africa (Pty) Ltd Patient information leaflet (PIL)For patients and carersDescovy 200/10, Gilead Sciences South Africa (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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