Efavirenz

Sold as Medpro efavirenz, Cipla efavirenz, Zenvir, Erige, Adco efavirenz, Aspen efavirenz, Avirez, Adco-efavirenz, Hevaz, Arrow efavirenz, Stabinez, Apafar, Zenfar, Efrin, Macleods efavirenz, Efavirenz specpharm, Efamat, Efavirenz winthrop, Efavirenz SPEC, Efavirenz austell, Sonke efavirenz

C₁₄H₉ClF₃NO₂315.67 g/mol

(4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one

Drag to rotate. Structure from PubChem CID 64139.

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Registration

Applicants: 15
Registrations: 33
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Cipla Medpro (Pty) LtdCancelled	Medpro efavirenz	600	410097	S4	None
Cipla Medpro Manufacturing (Pty) Ltd	Cipla efavirenz	600	410106	S4	None
Aurobindo Pharma (Pty) LtdCancelled	Zenvir	50 mg, 100 mg, 200 mg, 600 mg	410538, 410539, 410540, 420473	S4	None
Novagen Pharma (Pty) Ltd3 of 4 cancelled	Erige	50 mg, 100 mg, 200 mg, 600 mg	410541, 410542, 410543, A400513	S4	None
Adcock ingram limited1 of 4 cancelled	Adco efavirenz, Adco-efavirenz	50 mg, 100 mg, 200 mg, 600 mg	410929, 420979, 420980, 420981	S4	None
Pharmacare limited û woodmead	Aspen efavirenz, Avirez	200 mg, 600 mg	420026, 420111, 440385	S4	None
Hetero Drugs South Africa (Pty) Ltd	Hevaz	600	430363	S4	None
Teva Pharmaceuticals (Pty) LtdCancelled	Arrow efavirenz	Not stated	430581	S4	None
Aurogen South Africa (Pty) Ltd1 of 2 cancelled	Stabinez, Apafar	600 mg	440288, 440291	S4	None
Macleods Pharmaceuticals SA (Pty) Ltd	Zenfar, Macleods efavirenz	600 mg	450084, 450537	S4	None
Viatris Healthcare (Pty) Ltd	Efrin, Efamat	50 mg, 100 mg, 200 mg, 600 mg	450169, 460020, 460021, 460022	S4	PI PIL
Specpharm (Pty) LtdCancelled	Efavirenz specpharm, Efavirenz SPEC	600	460018, 460511	S4	None
Zentiva South Africa (Pty) Ltd	Efavirenz winthrop	Not stated	460039	S4	None
Austell Pharmaceuticals (Pty) LtdCancelled	Efavirenz austell	600	470607	S4	None
Sonke Pharmaceuticals (Pty) Ltd	Sonke efavirenz	200, 600	A400507, A400508	S4	PI PIL

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Medpro efavirenz 600 EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600	41009741/20.2.8/0097	Cancelled	S4	None
Cipla efavirenz 600 EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600	41010641/20.2.8/0106	Registered	S4	None
Zenvir capsules 50 MG EACH CAPSULE CONTAINS EFAVIRENZ 50,0 mg	50 mgCapsules	41053841/20.2.8/0538	Cancelled	S4	None
Zenvir capsules 100 MG EACH CAPSULE CONTAINS EFAVIRENZ 100,0 mg	100 mgCapsules	41053941/20.2.8/0539	Cancelled	S4	None
Zenvir capsules 200 MG EACH CAPSULE CONTAINS EFAVIRENZ 200,0 mg	200 mgCapsules	41054041/20.2.8/0540	Cancelled	S4	None
Erige 50 MG capsules EACH CAPSULE CONTAINS: EFAVIRENZ 50,0 mg	50 mgCapsules	41054141/20.2.8/0541	Registered	S4	None
Erige 100 MG capsules EACH CAPSULE CONTAINS EFAVIRENZ 100,0 mg	100 mgCapsules	41054241/20.2.8/0542	Cancelled	S4	None
Erige 200 MG capsules EACH CAPSULE CONTAINS EFAVIRENZ 200,0 mg	200 mgCapsules	41054341/20.2.8/0543	Cancelled	S4	None
Adco efavirenz 600 MG EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600 mg	41092941/20.2.8/0929	Registered	S4	None
Aspen efavirenz 600 MG EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600 mg	42002642/20.2.8/0026	Registered	S4	None
Avirez EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	Not listed	42011142/20.2.8/0111	Registered	S4	None
Zenvir tablets 600 MG EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600 mgTablets	42047342/20.2.8/0473	Cancelled	S4	None
Adco-efavirenz 50 MG EACH CAPSULE CONTAINS EFAVIRENZ 50,0 mg	50 mg	42097942/20.2.8/0979	Registered	S4	None
Adco-efavirenz 100 MG EACH CAPSULE CONTAINS EFAVIRENZ 100,0 mg	100 mg	42098042/20.2.8/0980	Cancelled	S4	None
Adco-efavirenz 200 MG EACH CAPSULE CONTAINS: EFAVIRENZ 200,0 mg	200 mg	42098142/20.2.8/0981	Registered	S4	None
Hevaz 600 EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600	43036343/20.2.8/0363	Registered	S4	None
Arrow efavirenz EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	Not listed	43058143/20.2.8/0581	Cancelled	S4	None
Stabinez 600 MG tablets EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600 mgTablets	44028844/20.2.8/0288	Registered	S4	None
Apafar 600 MG tablets EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600 mgTablets	44029144/20.2.8/0291	Cancelled	S4	None
Aspen efavirenz 200 MG EACH TABLET CONTAINS EFAVIRENZ 200,0 mg	200 mg	44038544/20.2.8/0385	Registered	S4	None
Zenfar 600 MG EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600 mg	45008445/20.2.8/0084	Registered	S4	None
Efrin EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600 mgFilm-coated tablets,	45016945/20.2.8/0169Approved 14 April 2023	Registered	S4	PI PIL
Macleods efavirenz 600 MG EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600 mg	45053745/20.2.8/0537	Registered	S4	None
Efavirenz specpharm 600 EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600	46001846/20.2.8/0018	Cancelled	S4	None
Efamat 50 MG EACH TABLET CONTAINS EFAVIRENZ 50,0 mg	50 mg	46002046/20.2.8/0020	Registered	S4	None
Efamat 100 MG EACH TABLET CONTAINS EFAVIRENZ 100,0 mg	100 mg	46002146/20.2.8/0021	Registered	S4	None
Efamat 200 MG EACH TABLET CONTAINS EFAVIRENZ 200,0 mg	200 mg	46002246/20.2.8/0022	Registered	S4	None
Efavirenz winthrop EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	Not listed	46003946/20.2.8/0039	Registered	S4	None
Efavirenz SPEC 600 EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600	46051146/20.2.8/0511	Cancelled	S4	None
Efavirenz austell 600 EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600	47060747/20.2.8/0607	Cancelled	S4	None
Sonke efavirenz 200 EACH CAPSULE CONTAINS EFAVIRENZ 200,0 mg	200Capsule	A400507A40/20.2.8/0507Approved 30 September 2022	Registered	S4	PI PIL
Sonke efavirenz 600 EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600Capsule	A400508A40/20.2.8/0508Approved 30 September 2022	Registered	S4	PI PIL
Erige 600 MG tablets EACH TABLET CONTAINS EFAVIRENZ 600,0 mg	600 mgTablets	A400513A40/20.2.8/0513	Cancelled	S4	None

Regulatory status

Where S4 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only medicine.

Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S4, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Efavirenz

S4: Efavirenz
Consolidated Schedules 06 July 2026, line 6159

Pharmacological class: Antiviral agents. (class 20.2.8)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

Efrin, Viatris Healthcare (Pty) Ltd is scheduled S4 in its official SAHPRA documents, read with 90% confidence.

Professional information (PI)For healthcare professionalsEfrin, Viatris Healthcare (Pty) Ltd Patient information leaflet (PIL)For patients and carersEfrin, Viatris Healthcare (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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