Ciprofloxacin

Sold as Ciprobay, Ciprofloxacin pharma q, Cifran, Biocip, Simayla ciprofloxacin, Cifloc, Cilofloc, Dynafloc, Orpic, Ciloxan eye, Cipro unimed, Ciploxx, Ciprogen, Ciprofloxacin actor, Ciprobay xr, Ciploxx iv, Ciploxx-iv, Ciprofloxacin austell, Ciprol, Ciprofloxacin iv cospharm, SPEC ciprofloxacin, Merck-ciprofloxcin iv, Gulf ciprofloxacin, Loxip, Mylan ciprofloxacin, Adco ciprofloxacin, Ciprofloxacin unicorn, Profloxin, Foxin, Flopro, Coliprid, Ciprofloxacin ( ) fresenius, Ciprofloxacin dezzo iv, Profloxin iv, Floqin iv, Apex ciprofloxacin, Ciprodac, Ciprochem, Camox-ciprofloxacin, Ciprofloxacin-safeline, Ceprolen eye, Zoxan eye, Ciprocina, Bio-ciprofloxacin, Biofloxx, *Ciprofloxacin iv cospharm, Orpic iv, Ciprogen iv, Ciprobay iv

C₁₇H₁₈FN₃O₃331.34 g/mol

1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid

Drag to rotate. Structure from PubChem CID 2764.

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Registration

Applicants: 30
Registrations: 98
Schedule source: Consolidated Schedules 06 July 2026

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Bayer (Pty) Ltd û IsandoCertificate held by Bayer (Pty) Ltd4 of 7 cancelled	Ciprobay, Ciprobay xr, Ciprobay iv	5 %, 100 mg, 200 mg, 250, 400 mg, 500, 750, 1000	310111, 370250, 380024, U0126, U0127, U0128, Y0311	S4	PI PIL
Pharma-q Holdings (Pty) Ltd	Ciprofloxacin pharma q	250, 500	320118, 320119	S4	None
Ranbaxy Pharmaceutical (Pty) Ltd2 of 4 cancelled	Cifran, Biocip	250, 500	330365, 330366, 330368, 330369	S4	None
Ranbaxy (SA) (Pty) Ltd	Simayla ciprofloxacin	250 mg, 500 mg	330371, 330372	S4	None
Dr Reddyæs Laboratories (Pty) LtdCertificate held by Dr. Reddy’s Laboratories (Pty) Ltd.	Cifloc	250, 500, 750	340308, 340309, 340310	S4	PI
Be-tabs Pharmaceuticals (Pty) LtdCancelled	Cilofloc	250, 500, 750	340312, 340313, 340314	S4	None
Pharma Dynamics (Pty) Ltd	Dynafloc	500 mg	340405	S4	PI PIL
Acino Pharma (Pty) LtdCancelled	Orpic, Orpic iv	2 mg/ml, 250 mg, 500 mg, 750 mg	350101, 350102, 350103, A400454	S4	None
Novartis South Africa (Pty) Ltd	Ciloxan eye	3 mg/ml, drops	350410, Z0202	S4	PI PIL
Unimed Healthcare (Pty) Ltd	Cipro unimed, Ciprol, Flopro, Ciprodac	250 mg, 500 mg, 750 mg	360170, 360171, 360172, 370573, 370574, 370575, 450198, 450199, 450200, A380715	S4	PI PIL
Cipla Medpro (Pty) Ltd3 of 7 cancelled	Ciploxx, Ciprofloxacin actor, Ciploxx iv, Ciploxx-iv	100, 200, 250mg / 500mg, 250, 500	360376, 360377, 360378, 370079, 370080, 370294, 370295	S4	PI PIL
Trinity Pharma (Pty) Ltd	Ciprogen	250 mg, 500 mg, 750 mg	360427, 360428, 360429	S4	None
Austell Pharmaceuticals (Pty) LtdCertificate held by Austell Laboratories (Pty) Ltd2 of 6 cancelled	Ciprofloxacin austell, Floqin iv, Ciprochem	2 mg/mL, 250 MG, 500 MG, 750 MG	370354, 380011, 380012, 501035, A390044, A390045	S4	PI PIL
Cospharm Investments (Pty) Ltd	Ciprofloxacin iv cospharm, *Ciprofloxacin iv cospharm	200, 400	370655, A400390	S4	None
Specpharm (Pty) Ltd	SPEC ciprofloxacin	Not stated	380191	S4	None
Viatris South Africa (Pty) Ltd	Merck-ciprofloxcin iv, Ciprogen iv	Not stated	410390, A400618	S4	None
Gulf Drug Company (Pty) Ltd1 of 3 cancelled	Gulf ciprofloxacin, Foxin	250, 500	410974, 410975, 450034	S4	None
Aurogen South Africa (Pty) Ltd1 of 5 cancelled	Loxip, Coliprid	250 mg, 500 mg, 750 mg	411052, 411053, 450201, 450202, 450203	S4	None
Viatris Healthcare (Pty) Ltd	Mylan ciprofloxacin	200 mg/100 ml, 400 mg/200 ml	430955, 430956	S4	None
Adcock ingram limitedCancelled	Adco ciprofloxacin	2 mg/ml	431025	S4	None
Ascendis Pharma (Pty) Ltd	Ciprofloxacin unicorn, Profloxin iv, Ciprocina	250, 500, 750	440538, 440539, 440540, 471286, A400114	S4	None
Dezzo Trading 392 (Pty) Ltd	Profloxin, Ciprofloxacin dezzo iv	250, 500, 750	440541, 440542, 440543, 471285	S4	None
Fresenius Kabi South Africa (Pty) Ltd	Ciprofloxacin ( ) fresenius	2 mg/mL, 2 mg/mL, 2 mg/mL, 2 mg/ml 100 ml, 2 mg/ml 200 ml	450797, 450798, 450799	S4	PI PIL
Camox Pharmaceuticals (Pty) LtdCancelled	Apex ciprofloxacin, Camox-ciprofloxacin	250 mg, 500 mg, 750 mg	A380448, A380449, A380450, A390046	S4	None
Safeline Pharmaceuticals (Pty) LtdCancelled	Ciprofloxacin-safeline	100, 200, 400	A390334, A390335, A390336	S4	None
Adcock Ingram Critical Care (Pty) Ltd	Adco ciprofloxacin	2 mg/ML	A390646	S4	None
Epiglo Pharmaceuticals (Pty) Ltd	Ceprolen eye	drops	A400048	S4	None
FDC SA (Pty) Ltd	Zoxan eye	0.3% w/v	A400091	S4	PI PIL
Biotech Laboratories (Pty) Ltd	Bio-ciprofloxacin	250, 500, 750	A400368, A400369, A400370	S4	None
Arya Pharma (Pty) Ltd	Biofloxx	250, 500, 750	A400371, A400372, A400373	S4	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Ciprobay suspension 5 % EACH 50 ml SUSPENSION CONTAINS CIPROFLOXACIN 2,5 g	5 %Suspension	31011131/20.1.1/0111	Registered	S4	None
Ciprofloxacin 250 pharma q EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250	32011832/20.1.1/0118	Registered	S4	None
Ciprofloxacin 500 pharma q EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500	32011932/20.1.1/0119	Registered	S4	None
Cifran 250 tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250Tablets	33036533/20.1.1/0365	Registered	S4	None
Cifran 500 tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500Tablets	33036633/20.1.1/0366	Registered	S4	None
Biocip 250 tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250Tablets	33036833/20.1.1/0368	Cancelled	S4	None
Biocip 500 tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500Tablets	33036933/20.1.1/0369	Cancelled	S4	None
Simayla ciprofloxacin 250 MG EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250 mg	33037133/20.1.1/0371	Registered	S4	None
Simayla ciprofloxacin 500 MG EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500 mg	33037233/20.1.1/0372	Registered	S4	None
Cifloc 250 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250Film-coated tablets	34030834/20.1.1/0308Approved 26 July 2020	Registered	S4	PI
Cifloc 500 EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500Film-coated tablets	34030934/20.1.1/0309Approved 26 July 2020	Registered	S4	PI
Cifloc 750 EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750Film-coated tablets	34031034/20.1.1/0310Approved 26 July 2020	Registered	S4	PI
Cilofloc 250 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250	34031234/20.1.1/0312	Cancelled	S4	None
Cilofloc 500 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500	34031334/20.1.1/0313	Cancelled	S4	None
Cilofloc 750 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750	34031434/20.1.1/0314	Cancelled	S4	None
Dynafloc 500 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500 mgTablets.	34040534/20.1.1/0405Approved 19 September 2025	Registered	S4	PI PIL
Orpic 250 MG tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250 mgTablets	35010135/20.1.1/0101	Cancelled	S4	None
Orpic 500 MG tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500 mgTablets	35010235/20.1.1/0102	Cancelled	S4	None
Orpic 750 MG tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750 mgTablets	35010335/20.1.1/0103	Cancelled	S4	None
Ciloxan eye ointment EACH 1,0 g OINTMENT CONTAINS CIPROFLOXACIN HYDROCHLORIDE E EQUIVALENT TO CIPROFLOXACIN 3,0 mg	3 mg/mlEye drops: colourless, clear solution	35041035/15.1/0410Approved 30 November 2021	Registered	S4	PI PIL
Cipro 250 unimed EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250Film-coated tablets	36017036/20.1.1/0170Approved 28 May 2024	Registered	S4	PI PIL
Cipro 500 unimed EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500Film-coated tablets	36017136/20.1.1/0171Approved 28 May 2024	Registered	S4	PI PIL
Cipro 750 unimed EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750Film-coated tablets	36017236/20.1.1/0172Approved 28 May 2024	Registered	S4	PI PIL
Ciploxx 250 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250mg / 500mgTablets	36037636/20.1.1/0376Approved 21 November 2025	Registered	S4	PI PIL
Ciploxx 500 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	250mg / 500mgTablets	36037736/20.1.1/0377Approved 21 November 2025	Registered	S4	PI PIL
Ciploxx 750 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	250mg / 500mgTablets	36037836/20.1.1/0378Approved 21 November 2025	Cancelled	S4	PI PIL
Ciprogen 750 MG EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750 mg	36042736/20.1.1/0427	Registered	S4	None
Ciprogen 250 MG EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250 mg	36042836/20.1.1/0428	Registered	S4	None
Ciprogen 500 MG EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500 mg	36042936/20.1.1/0429	Registered	S4	None
Ciprofloxacin actor 250 EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TOIPROFLOXACIN 250,0 mg	250	37007937/20.1.1/0079	Registered	S4	None
Ciprofloxacin actor 500 EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500	37008037/20.1.1/0080	Registered	S4	None
Ciprobay xr 500 EACH TABLET CONTAINS CIPROFLOXACIN 500,0 mg	500	37025037/20.1.1/0250	Cancelled	S4	None
Ciploxx iv 100 EACH 10,0 ml AMPOULE CONTAINS CIPROFLOXACIN 100,0 mg	100	37029437/20.1.1/0294	Cancelled	S4	None
Ciploxx-iv 200 EACH VIAL CONTAINS CIPROFLOXACIN 200,0 mg	200	37029537/20.1.1/0295	Cancelled	S4	None
Ciprofloxacin 750 MG austell EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750 MG	37035437/20.1.1/0354	Registered	S4	None
Ciprol 250 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250	37057337/20.1.1/0573	Registered	S4	None
Ciprol 500 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500	37057437/20.1.1/0574	Registered	S4	None
Ciprol 750 EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750	37057537/20.1.1/0575	Registered	S4	None
Ciprofloxacin 200 iv cospharm EACH 1,0 ml SOLUTION CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 2,0 mg	200	37065537/20.1.1/0655	Registered	S4	None
Ciprofloxacin 250 MG austell EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250 MG	38001138/20.1.1/0011	Registered	S4	None
Ciprofloxacin 500 MG austell EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500 MG	38001238/20.1.1/0012	Registered	S4	None
Ciprobay xr 1000 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 1000,0 mg	1000	38002438/20.1.1/0024	Cancelled	S4	None
SPEC ciprofloxacin EACH 1,0 ml SOLUTION CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 2,0 mg	Not listed	38019138/20.1.1/0191	Registered	S4	None
Merck-ciprofloxcin iv EACH 100,0 ml SOLUTION CONTAINS CIPROFLOXACIN 200,0 mg	Not listed	41039041/20.1.1/0390	Registered	S4	None
Gulf ciprofloxacin 250 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250	41097441/20.1.1/0974	Registered	S4	None
Gulf ciprofloxacin 500 EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500	41097541/20.1.1/0975	Registered	S4	None
Loxip 250 MG EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250 mg	41105241/20.1.1/1052	Registered	S4	None
Loxip 500 MG EACH TABLET CONTAINS;CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500 mg	41105341/20.1.1/1053	Registered	S4	None
Mylan ciprofloxacin 200 mg/100 ML EACH 1,0 ml SOLUTION CONTAINS CIPROFLOXACIN 2,0 mg	200 mg/100 ml	43095543/20.1.1/0955	Registered	S4	None
Mylan ciprofloxacin 400 mg/200 ML EACH 1,0 ml SOLUTION CONTAINS CIPROFLOXACIN 2,0 mg	400 mg/200 ml	43095643/20.1.1/0956	Registered	S4	None
Adco ciprofloxacin 2 mg/ml infusion EACH 1,0 ml SOLUTION CONTAINS CIPROFLOXACIN 2,0 mg	2 mg/mlInfusion	43102543/20.1.1/1025	Cancelled	S4	None
Ciprofloxacin unicorn 250 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250	44053844/20.1.1/0538	Registered	S4	None
Ciprofloxacin unicorn 500 EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500	44053944/20.1.1/0539	Registered	S4	None
Ciprofloxacin unicorn 750 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750	44054044/20.1.1/0540	Registered	S4	None
Profloxin 250 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250	44054144/20.1.1/0541	Registered	S4	None
Profloxin 500 EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500	44054244/20.1.1/0542	Registered	S4	None
Profloxin 750 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750	44054344/20.1.1/0543	Registered	S4	None
Foxin EACH 1,0 ml EYE DROPS CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 3,0 mg	Not listed	45003445/15.1/0034	Cancelled	S4	None
Flopro 250 MG tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250 mgTablets	45019845/20.1.1/0198	Registered	S4	None
Flopro 500 MG tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500 mgTablets	45019945/20.1.1/0199	Registered	S4	None
Flopro 750 MG tablets EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750 mgTablets	45020045/20.1.1/0200	Registered	S4	None
Coliprid 250 MG tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250 mgTablets	45020145/20.1.1/0201	Registered	S4	None
Coliprid 500 MG tablets EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500 mgTablets	45020245/20.1.1/0202	Registered	S4	None
Coliprid 750 MG tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750 mgTablets	45020345/20.1.1/0203	Cancelled	S4	None
Ciprofloxacin 2 mg/ml (50 ml) fresenius EACH 50,0 ml CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 100,0 mg	2 mg/mL, 2 mg/mL, 2 mg/mLSolution for infusion.	45079745/20.1.1/0797Approved 11 October 2023	Registered	S4	PI PIL
Ciprofloxacin 2 mg/ml (100 ml) fresenius EACH 100,0 ml CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 200,0 mg	2 mg/ml 100 ml	45079845/20.1.1/0798	Registered	S4	None
Ciprofloxacin 2 mg/ml (200 ml) fresenius EACH 250,0 ml CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	2 mg/ml 200 ml	45079945/20.1.1/0799	Registered	S4	None
Ciprofloxacin dezzo iv EACH 1,0 ml SOLUTION CONTAINS : CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 2,0 mg	Not listed	47128547/20.1.1/1285	Registered	S4	None
Profloxin iv EACH 1,0 ml SOLUTION CONTAINS : CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 2,0 mg	Not listed	47128647/20.1.1/1286	Registered	S4	None
Floqin iv 2 mg/ml EACH 1,0 ml SOLUTION CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 2,0 mg	2 mg/mLSolution for infusion	50103550/20.1.1/1035Approved 4 August 2020	Registered	S4	PI PIL
Apex ciprofloxacin 250 MG tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250 mgTablets	A380448A38/20.1.1/0448	Cancelled	S4	None
Apex ciprofloxacin 500 MG tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500 mgTablets	A380449A38/20.1.1/0449	Cancelled	S4	None
Apex ciprofloxacin 750 MG tablets EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750 mgTablets	A380450A38/20.1.1/0450	Cancelled	S4	None
Ciprodac 500 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500	A380715A38/20.1.1/0715	Registered	S4	None
Ciprochem 250 MG EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250 mg	A390044A39/20.1.1/0044	Cancelled	S4	None
Ciprochem 500 MG EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500 mg	A390045A39/20.1.1/0045	Cancelled	S4	None
Camox-ciprofloxacin 750 MG EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750 mg	A390046A39/20.1.1/0046	Cancelled	S4	None
Ciprofloxacin-safeline 100 EACH 50,0 ml SOLUTION CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 100,0 mg	100	A390334A39/20.1.1/0334	Cancelled	S4	None
Ciprofloxacin-safeline 200 EACH 100,0 ml SOLUTION CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 200,0 mg	200	A390335A39/20.1.1/0335	Cancelled	S4	None
Ciprofloxacin-safeline 400 EACH 200,0 ml SOLUTION CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 400,0 mg	400	A390336A39/20.1.1/0336	Cancelled	S4	None
Adco ciprofloxacin 2 mg/ml EACH 1,0 ml SOLUTION CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 2,0 mg	2 mg/ML	A390646A39/20.1.1/0646	Registered	S4	None
Ceprolen eye drops EACH 1,00 ml SOLUTION CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 0,30 g	Drops	A400048A40/15.1/0048	Registered	S4	None
Zoxan eye drops EACH 1,0 ml SOLUTION CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 3,0 mg	0.3% w/vEye drops:	A400091A40/15.1/0091Approved 14 June 2023	Registered	S4	PI PIL
Ciprocina EACH 1,0 ml SOLUTION CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 2,0 mg	Not listed	A400114A40/20.1.1/0114	Registered	S4	None
Bio-ciprofloxacin 250 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250	A400368A40/20.1.1/0368	Registered	S4	None
Bio-ciprofloxacin 500 EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500	A400369A40/20.1.1/0369	Registered	S4	None
Bio-ciprofloxacin 750 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750	A400370A40/20.1.1/0370	Registered	S4	None
Biofloxx 250 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250	A400371A40/20.1.1/0371	Registered	S4	None
Biofloxx 500 EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500	A400372A40/20.1.1/0372	Registered	S4	None
Biofloxx 750 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750	A400373A40/20.1.1/0373	Registered	S4	None
*Ciprofloxacin 400 iv cospharm EACH 1,0 ml SOLUTION CONTAINS: CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 2,0 mg	400	A400390A40/20.1.1/0390	Registered	S4	None
Orpic 2 mg/ml iv EACH 1,0 ml SOLUTION CONTAINS CIPROFLOXACIN LACTATE EQUIVALENT TO CIPROFLOXACIN 2,0 mg	2 mg/ml	A400454A40/20.1.1/0454	Cancelled	S4	None
Ciprogen iv EACH 100,0 ml SOLUTION CONTAINS CIPROFLOXACIN 200,0 mg	Not listed	A400618A40/20.1.1/0618	Registered	S4	None
Ciprobay 250 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE MONOHYDRATE EQUIVALENT TO CIPROFLOXACIN 250,0 mg	250	U0126U/20.1.1/126	Cancelled	S4	None
Ciprobay 500 EACH TABLET CONTAINS:CIPROFLOXACIN HYDROCHLORIDE MONOHYDRATE EQUIVALENT TO CIPROFLOXACIN 500,0 mg	500	U0127U/20.1.1/127	Registered	S4	None
Ciprobay 750 EACH TABLET CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO CIPROFLOXACIN 750,0 mg	750	U0128U/20.1.1/128	Cancelled	S4	None
Ciprobay iv EACH 50 ml INFUSION SOLUTION CONTAINS CIPROFLOXACIN 100 mg	100 mg. 200 mg. 400 mgSolution for infusion	Y0311Y/20.1.1/311Approved 14 January 2025	Registered	S4	PI PIL
Ciloxan eye drops EACH 1 ml SOLUTION CONTAINS CIPROFLOXACIN HYDROCHLORIDE EQUIVALENT TO 3 g CIPROFLOXACIN	Drops	Z0202Z/15.1/202	Registered	S4	None

Regulatory status

Where S4 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only medicine.

Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S4, matched to the Consolidated Schedules by ingredient, confidence high.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Ciprofloxacin

S4: Ciprofloxacin
Consolidated Schedules 06 July 2026, line 5815

Pharmacological class: Broad and medium spectrum antibiotics. (class 20.1.1)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Professional information (PI)For healthcare professionalsCifloc 250, Dr Reddyæs Laboratories (Pty) Ltd Patient information leaflet (PIL)For patients and carersDynafloc 500, Pharma Dynamics (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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