Cefotaxime

Sold as Klafotaxim, *Litha cefotaxime, Aspen-cefotaxime, *Litha-cefotaxime, Totam, Taxokef, Sab-cefotaxime, Clofotax, Cipla-cefotaxime, Adco cefotaxime, Oritaxim, Austell-cefotaxime, Austell cefotaxime, Cefotaxime fresenius, Gulf cefotaxime, Sandoz cefotaxime, Cefotaxime oethmaan, Clatax, AURO cefotaxime, Res-cefotax, Cefotaxime-combinopharm

S4Read from the PI-PIL document and verified

C₁₆H₁₇N₅O₇S₂455.50 g/mol

(6R,7R)-3-(Acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Drag to rotate. Structure from PubChem CID 5742673.

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Registration

Applicants: 16
Registrations: 43
Schedule source: SAHPRA documentation

Applicants and registrations

Applicant	Brands	Dosages	Registrations	Schedule	Leaflets
Ranbaxy (SA) (Pty) LtdCertificate held by Ranbaxy Pharmaceuticals (Pty) Ltd	Klafotaxim	500, 1000	310328, 310329	S4	PI PIL
Litha pharmaCancelled	Litha cefotaxime, Litha-cefotaxime	0,5 g, 1 g, 2 g	340047, 340048, 340050	S4	None
Pharmacare limited û woodmeadCancelled	Aspen-cefotaxime, Clofotax	1,0 g, 2 g, 2,0 g	340049, 340304, 340305, 340306	S4	None
Cipla Medpro (Pty) LtdCancelled	Totam, Cipla-cefotaxime	500, 1000, 2000	340216, 340217, 340218, 360031, 360032, 360033	S4	None
Dezzo Trading 392 (Pty) Ltd	Taxokef	1g, 500	340257, 340258	S4	None
Innovata pharmaceuticals	Sab-cefotaxime	1 g, 500	340259, 340260	S4	PI PIL
Adcock Ingram Critical Care (Pty) LtdCancelled	Adco cefotaxime	1 g, 2 g, 500 mg	360322, 360323, 360324	S4	None
Pharma-q Holdings (Pty) LtdCertificate held by Pharma-q (Pty) Ltd	Oritaxim	500, 1000	360482, 360483	S4	PI PIL
Austell Pharmaceuticals (Pty) Ltd	Austell-cefotaxime, Austell cefotaxime	0,5 g, 1,0 g	370364, 370365	S4	None
Fresenius Kabi South Africa (Pty) LtdCancelled	Cefotaxime fresenius	0,5 g, 1,0 g	370576, 370577	S4	None
Fresenius Kabi Manufacturing SA (Pty) LtdCancelled	Cefotaxime fresenius	2,0 g	370578	S4	None
Gulf Drug Company (Pty) LtdCertificate held by Gulf Drug Company (Pty) Ltd.	Gulf cefotaxime	1 g, 2 g	410528, 420641	S4	PI PIL
Oethmaan Biosims (Pty) Ltd	Sandoz cefotaxime, Cefotaxime oethmaan, Clatax	0,5 g, 1,0 g	411063, 411064, 411065, 411066	S4	None
Aurogen South Africa (Pty) Ltd1 of 4 cancelled	AURO cefotaxime	250 mg, 500 mg, 1000 mg, 2000 mg	420601, 420602, 420603, 420604	S4	None
Resmed healthcare	Res-cefotax	500, 1000	A380580, A380581	S4	None
Pharmaplan (Pty) Ltd	Cefotaxime-combinopharm	1 G, 500 mg	A380606, A380607	S4	None

Variants

Product	Strength and form	Registration	Status	Schedule	Leaflets
Klafotaxim 500 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500 mg	500Injection	31032831/20.1.1/0328Approved 11 November 2022	Registered	S4	PI PIL
Klafotaxim 1000 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1000 mg	1000Injection	31032931/20.1.1/0329Approved 11 November 2022	Registered	S4	PI PIL
*Litha cefotaxime 0,5 g injection EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500,0 mg	0,5 gInjection	34004734/20.1.1/0047	Cancelled	S4	None
*Litha cefotaxime 1 g injection EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1,0 g	1 gInjection	34004834/20.1.1/0048	Cancelled	S4	None
Aspen-cefotaxime 2 g injection EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 2,0 g	2 gInjection	34004934/20.1.1/0049	Cancelled	S4	None
*Litha-cefotaxime 2 g infusion EACH 50,0 ml BOTTLE CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 2,0 g	2 gInfusion	34005034/20.1.1/0050	Cancelled	S4	None
Totam-500 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500,0 mg	500	34021634/20.1.1/0216	Cancelled	S4	None
Totam-1000 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1000,0 mg	1000	34021734/20.1.1/0217	Cancelled	S4	None
Totam-2000 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 2000,0 mg	Not listed	34021834/20.1.1/0218	Cancelled	S4	None
Taxokef 500 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500,0 mg	500	34025734/20.1.1/0257	Registered	S4	None
Taxokef 1g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1,0 g	1g	34025834/20.1.1/0258	Registered	S4	None
Sab-cefotaxime 500 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500,0 mg	500Injection	34025934/20.1.1/0259Approved 18 December 2025	Registered	S4	PI PIL
Sab-cefotaxime 1 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1,0 g	1 g	34026034/20.1.1/0260	Registered	S4	None
Clofotax 1,0 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1,0 g	1,0 g	34030434/20.1.1/0304	Cancelled	S4	None
Clofotax 2,0 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 2,0 g	2,0 g	34030534/20.1.1/0305	Cancelled	S4	None
Clofotax 2,0 g infusion EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 2,0 g	2,0 gInfusion	34030634/20.1.1/0306	Cancelled	S4	None
Cipla-cefotaxime 500 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500,0 mg	500	36003136/20.1.1/0031	Cancelled	S4	None
Cipla-cefotaxime 1000 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1000,0 mg	1000	36003236/20.1.1/0032	Cancelled	S4	None
Cipla-cefotaxime 2000 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 2000,0 mg	2000	36003336/20.1.1/0033	Cancelled	S4	None
Adco cefotaxime 500 MG EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500,0 mg	500 mg	36032236/20.1.1/0322	Cancelled	S4	None
Adco cefotaxime 1 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1000,0 mg	1 g	36032336/20.1.1/0323	Cancelled	S4	None
Adco cefotaxime 2 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 2000,0 mg	2 g	36032436/20.1.1/0324	Cancelled	S4	None
Oritaxim 500 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500,0 mg	500Sterile powder for injection	36048236/20.1.1/0482Approved 8 August 2025	Registered	S4	PI PIL
Oritaxim 1000 EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1000,0 mg	1000Sterile powder for injection	36048336/20.1.1/0483Approved 8 August 2025	Registered	S4	PI PIL
Austell-cefotaxime 0,5 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 0,5 g	0,5 g	37036437/20.1.1/0364	Registered	S4	None
Austell cefotaxime 1,0 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1,0 g	1,0 g	37036537/20.1.1/0365	Registered	S4	None
Cefotaxime fresenius 0,5 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500,0 mg	0,5 g	37057637/20.1.1/0576	Cancelled	S4	None
Cefotaxime fresenius 1,0 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1000,0 mg	1,0 g	37057737/20.1.1/0577	Cancelled	S4	None
Cefotaxime fresenius 2,0 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 2000,0 mg	2,0 g	37057837/20.1.1/0578	Cancelled	S4	None
Gulf cefotaxime 1 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1,0 g	1 gSterile powder for injection	41052841/20.1.1/0528Approved 30 September 2011	Registered	S4	PI PIL
Sandoz cefotaxime 0,5 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 0,5 g	0,5 g	41106341/20.1.1/1063	Registered	S4	None
Cefotaxime 1,0 g oethmaan EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1,0 g	1,0 g	41106441/20.1.1/1064	Registered	S4	None
Clatax 0,5 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 0,5 g	0,5 g	41106541/20.1.1/1065	Registered	S4	None
Clatax 1,0 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1,0 g	1,0 g	41106641/20.1.1/1066	Registered	S4	None
AURO cefotaxime 250 MG EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 250,0 mg	250 mg	42060142/20.1.1/0601	Cancelled	S4	None
AURO cefotaxime 500 MG EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500,0 mg	500 mg	42060242/20.1.1/0602	Registered	S4	None
AURO cefotaxime 1000 MG EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1000,0 mg	1000 mg	42060342/20.1.1/0603	Registered	S4	None
AURO cefotaxime 2000 MG EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 2000,0 mg	2000 mg	42060442/20.1.1/0604	Registered	S4	None
Gulf cefotaxime 2 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 2,0 g	2 g	42064142/20.1.1/0641	Registered	S4	None
Res-cefotax 500 injection EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500,0 mg	500Injection	A380580A38/20.1.1/0580	Registered	S4	None
Res-cefotax 1000 injection EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 100,0 mg	1000Injection	A380581A38/20.1.1/0581	Registered	S4	None
Cefotaxime-combinopharm 1 g EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 1,0 g	1 G	A380606A38/20.1.1/0606	Registered	S4	None
Cefotaxime-combinopharm 500 MG EACH VIAL CONTAINS CEFOTAXIME SODIUM EQUIVALENT TO CEFOTAXIME 500,0 mg	500 mg	A380607A38/20.1.1/0607	Registered	S4	None

Regulatory status

Where S4 sits on the scale

S0S1S2S3S4S5S6S7S8

Prescription-only medicine.

Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.

Schedule S4, read from the product's PI-PIL leaflet.

Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.

Consolidated Schedules listings for Cefotaxime sodium equivalent to cefotaxime

S4: Cefotaxime
Consolidated Schedules 06 July 2026, line 5717

Pharmacological class: Broad and medium spectrum antibiotics. (class 20.1.1)

This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.

SAHPRA documents

Schedule verified from official documents

Schedule Verification

Klafotaxim 500, Ranbaxy (SA) (Pty) Ltd is scheduled S4 in its official SAHPRA documents, read with 90% confidence.

Professional information (PI)For healthcare professionalsKlafotaxim 500, Ranbaxy (SA) (Pty) Ltd Patient information leaflet (PIL)For patients and carersKlafotaxim 500, Ranbaxy (SA) (Pty) Ltd

These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.

Research articles

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