Bisoprolol, hydrochlorothiazide
Sold as Ziak, Ziabeta, Bisozyd co, Zirinak, Ran bisoprolol co, Bilocor co, Bisbeta co, Dyzozip
Combination product
This product contains more than one active ingredient, so it has no single molecular structure.
Background
Registration
- Applicants
- 5
- Registrations
- 22
- Schedule source
- Consolidated Schedules 06 July 2026
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Merck (Pty) Ltd | Ziak, Ziabeta | 2,5/6,25 mg, 5 mg/6,25 mg, 5/6,25 mg, 10 mg/6,25 mg, 10/6,25 mg | 310455, 310456, 310457, 370564, 370610, 370611 | S3 | None |
| Zydus Healthcare (Pty) Ltd | Bisozyd co | 2,5/6,25 mg, 5/6,25 mg, 10/6,25 mg | 430059, 430060, 430061 | S3 | None |
| Ranbaxy (SA) (Pty) Ltd3 of 4 cancelled | Zirinak, Ran bisoprolol co | 2,5/6,25, 5/6,25, 10, 10/6,25 | 440562, 440563, 440564, 440565 | S3 | None |
| Pharma Dynamics (Pty) Ltd | Bilocor co | 2,5/6,25, 5/6,25, 10/6,25 | 441010, 441011, 441012 | S3 | PIPIL |
| Aurogen South Africa (Pty) Ltd | Bisbeta co, Dyzozip | 2,5/6,25 mg, 5/6,25 mg, 10/6,25 mg | 590646, 590647, 590648, 590649.646, 590650.647, 590651.648 | S3 | None |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Ziak 2,5/6,25 MG EACH TABLET CONTAINS BISOPROLOL FUMARATE 2,5 mg HYDROCHLOROTHIAZIDE 6,25 mg | 2,5/6,25 mg | 31045531/7.1.3/0455 | Registered | S3 | None |
| Ziak 5 mg/6,25 MG EACH TABLET CONTAINS BISOPROLOL FUMARATE 5,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 5 mg/6,25 mg | 31045631/7.1.3/0456 | Registered | S3 | None |
| Ziak 10 mg/6,25 MG EACH TABLET CONTAINS BISOPROLOL FUMARATE 10,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 10 mg/6,25 mg | 31045731/7.1.3/0457 | Registered | S3 | None |
| Ziabeta 2,5/6,25 MG EACH TABLET CONTAINS BISOPROLOL FUMARATE 2,5 mg HYDROCHLOROTHIAZIDE 6,25 mg | 2,5/6,25 mg | 37056437/7.1.3/0564 | Registered | S3 | None |
| Ziabeta 5/6,25 MG EACH TABLET CONTAINS BISOPROLOL FUMARATE 5,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 5/6,25 mg | 37061037/7.1.3/0610 | Registered | S3 | None |
| Ziabeta 10/6,25 MG EACH TABLET CONTAINS BISOPROLOL FUMARATE 10,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 10/6,25 mg | 37061137/7.1.3/0611 | Registered | S3 | None |
| Bisozyd co 2,5/6,25 MG EACH TABLET CONTAINS BISOPROLOL FUMARATE 2,5 mg HYDROCHLOROTHIAZIDE 6,25 mg | 2,5/6,25 mg | 43005943/7.1.3/0059 | Registered | S3 | None |
| Bisozyd co 5/6,25 MG EACH TABLET CONTAINS BISOPROLOL FUMARATE 5,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 5/6,25 mg | 43006043/7.1.3/0060 | Registered | S3 | None |
| Bisozyd co 10/6,25 MG EACH TABLET CONTAINS BISOPROLOL FUMARATE 10,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 10/6,25 mg | 43006143/7.1.3/0061 | Registered | S3 | None |
| Zirinak 10 EACH TABLET CONTAINS BISOPROLOL FUMARATE 10,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 10 | 44056244/7.1.3/0562 | Cancelled | S3 | None |
| Ran bisoprolol co 2,5/6,25 EACH TABLET CONTAINS BISOPROLOL FUMARATE 2,5 mg HYDROCHLOROTHIAZIDE 6,25 mg | 2,5/6,25 | 44056344/7.1.3/0563 | Registered | S3 | None |
| Ran bisoprolol co 5/6,25 EACH TABLET CONTAINS BISOPROLOL FUMARATE 5,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 5/6,25 | 44056444/7.1.3/0564 | Cancelled | S3 | None |
| Ran bisoprolol co 10/6,25 EACH TABLET CONTAINS BISOPROLOL FUMARATE 10,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 10/6,25 | 44056544/7.1.3/0565 | Cancelled | S3 | None |
| Bilocor co 2,5/6,25 EACH TABLET CONTAINS BISOPROLOL FUMARATE 2,5 mg HYDROCHLOROTHIAZIDE 6,25 mg | 2,5/6,25Film coted tablet. | 44101044/7.1.3/1010Approved 10 January 2025 | Registered | S3 | PIPIL |
| Bilocor co 5/6,25 EACH TABLET CONTAINS BISOPROLOL FUMARATE 5,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 5/6,25Film coted tablet. | 44101144/7.1.3/1011Approved 10 January 2025 | Registered | S3 | PIPIL |
| Bilocor co 10/6,25 EACH TABLET CONTAINS BISOPROLOL FUMARATE 10,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 10/6,25Film coted tablet. | 44101244/7.1.3/1012Approved 10 January 2025 | Registered | S3 | PIPIL |
| Bisbeta co 2,5/6,25 MG EACH TABLET CONTAINS: BISOPROLOL FUMARATE 2,5 mg HYDROCHLOROTHIAZIDE 6,25 mg | 2,5/6,25 mg | 59064659/7.1.3/0646 | Registered | S3 | None |
| Bisbeta co 5/6,25 MG EACH TABLET CONTAINS: BISOPROLOL FUMARATE 5,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 5/6,25 mg | 59064759/7.1.3/0647 | Registered | S3 | None |
| Bisbeta co 10/6,25 MG EACH TABLET CONTAINS: BISOPROLOL FUMARATE 10,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 10/6,25 mg | 59064859/7.1.3/0648 | Registered | S3 | None |
| Dyzozip 2,5/6,25 MG EACH TABLET CONTAINS: BISOPROLOL FUMARATE 2,5 mg HYDROCHLOROTHIAZIDE 6,25 mg | 2,5/6,25 mg | 590649.64659/7.1.3/0649.646 | Registered | S3 | None |
| Dyzozip 5/6,25 MG EACH TABLET CONTAINS: BISOPROLOL FUMARATE 5,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 5/6,25 mg | 590650.64759/7.1.3/0650.647 | Registered | S3 | None |
| Dyzozip 10/6,25 MG EACH TABLET CONTAINS: BISOPROLOL FUMARATE 10,0 mg HYDROCHLOROTHIAZIDE 6,25 mg | 10/6,25 mg | 590651.64859/7.1.3/0651.648 | Registered | S3 | None |
Regulatory status
Where S3 sits on the scale
Needs a doctor's prescription, dispensed by a pharmacist.
Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S3, matched to the Consolidated Schedules by ingredient, confidence medium.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Bisoprolol fumarate, hydrochlorothiazide
S3: Bisoprolol
Consolidated Schedules 06 July 2026, line 3221
S3: Hydrochlorothiazide
Consolidated Schedules 06 July 2026, line 3721
Pharmacological class: Other hypotensives. (class 7.1.3)
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
Schedule Verification
Bilocor co 2,5/6,25, Pharma Dynamics (Pty) Ltd is scheduled S3 in its official SAHPRA documents, read with 90% confidence.
These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.