Aspirin, caffeine, paracetamol
Sold as Compral pain, Aspimol, Excedrin, Compral extra strength, Triparc blackcurrant, Triparc orange, Triparc, Triparc lemon, Exipyn plain, Exipyn blackcurrant, Exipyn orange, Exipyn lemon, Panado extra, Neurosan, Kurra headache, Grand-pa headache, Lennon headache, Propain s, Adco-dol pain relief
Combination product
This product contains more than one active ingredient, so it has no single molecular structure.
Background
Registration
- Applicants
- 6
- Registrations
- 22
- Schedule source
- SAHPRA documentation
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Adcock ingram limited2 of 7 cancelled | Compral pain, Aspimol, Compral extra strength, Panado extra, Propain s, Adco-dol pain relief | 324 mg, powders, tablets, 500 mg | 360009, 360010, 430101, 600373, B1147, M0503, R0238 | S0 | PIPIL |
| Haleon South Africa (Pty) Ltd | Excedrin, Grand-pa headache | powders, tablets | 360183, B1113, P0022 | Not determined | None |
| Pharmacare limited û woodmead1 of 9 cancelled | Triparc blackcurrant, Triparc orange, Triparc, Triparc lemon, Exipyn plain, Exipyn blackcurrant, Exipyn orange, Exipyn lemon, Lennon headache | powders | 460137, 460138, 460139, 460140, 470127, 470128, 470129, 470130, J0072 | Not determined | None |
| The Premier Pharmaceutical Co Ltd | Neurosan | Not stated | B0575 | Not determined | None |
| Glaxosmithkline Consumer Healthcare SA (Pty) LtdCancelled | Excedrin | powders | B0612 | Not determined | None |
| Shanur Healthcare (Pty) Ltd | Kurra headache | powders | B0961 | Not determined | None |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Compral pain powders EACH SACHET CONTAINS ASPIRIN 453,60 mg CAFFEINE 64,80 mg PARACETAMOL 324,00 mg | 324 mgPowders | 36000936/2.8/0009Approved 13 November 2025 | Registered | S0 | PIPIL |
| Aspimol powders EACH SACHET CONTAINS ASPIRIN 453,60 mg CAFFEINE 64,80 mg PARACETAMOL 324,00 mg | Powders | 36001036/2.8/0010 | Cancelled | Not determined | None |
| Excedrin EACH TABLET CONTAINS: ASPIRIN 250,0 mg, CAFFEINE 65,0 mg, PARACETAMOL 250,0 mg | Not listed | 36018336/2.7/0183 | Registered | Not determined | None |
| Compral extra strength EACH TABLET CONTAINS ASPIRIN 800,0 mg CAFFEINE 60,0 mg PARACETAMOL 200,0 mg | Not listed | 43010143/2.8/0101 | Registered | Not determined | None |
| Triparc blackcurrant EACH SACHET CONTAINS ASPIRIN 453,6 mg CAFFEINE 64,80 mg PARACETAMOL 324,0 mg | Not listed | 46013746/2.8/0137 | Registered | Not determined | None |
| Triparc orange EACH SACHET CONTAINS ASPIRIN 453,6 mg CAFFEINE 64,80 mg PARACETAMOL 324,0 mg | Not listed | 46013846/2.8/0138 | Registered | Not determined | None |
| Triparc EACH SACHET CONTAINS ASPIRIN 453,6 mg CAFFEINE 64,80 mg PARACETAMOL 324,0 mg | Not listed | 46013946/2.8/0139 | Registered | Not determined | None |
| Triparc lemon EACH SACHET CONTAINS ASPIRIN 453,6 mg CAFFEINE 64,80 mg PARACETAMOL 324,0 mg | Not listed | 46014046/2.8/0140 | Registered | Not determined | None |
| Exipyn plain Each Sachet contains: Aspirin 453,6 mg, Paracetamol 324,0 mg, Caffeine 64,8 mg | Not listed | 47012747/2.8/0127 | Registered | Not determined | None |
| Exipyn blackcurrant Each Sachet contains: Aspirin 453,6 mg, Paracetamol 324,0 mg, Caffeine 64,8 mg | Not listed | 47012847/2.8/0128 | Registered | Not determined | None |
| Exipyn orange Each Sachet contains: Aspirin 453,6 mg, Paracetamol 324,0 mg, Caffeine 64,8 mg | Not listed | 47012947/2.8/0129 | Registered | Not determined | None |
| Exipyn lemon Each Sachet contains: Aspirin 453,6 mg, Paracetamol 324,0 mg, Caffeine 64,8 mg | Not listed | 47013047/2.8/0130 | Registered | Not determined | None |
| Panado extra powders Each Sachet contains: Aspirin 453,6 mg, Paracetamol 324,0 mg, Caffeine 64,8 mg | Powders | 60037360/2.8/0373 | Registered | Not determined | None |
| Neurosan 720 MG ASPIRIN 415 MG CAFFEINE 65 MG PARACETAMOL 225 MG | Not listed | B0575B/2.8/575 | Registered | Not determined | None |
| Excedrin powders POWDER ASPIRIN A 553 MG CAFFEINE A 8 MG CAFFEINE CITRATE A 33 MG PARACETAMOL A 276 MG | Powders | B0612 | Cancelled | Not determined | None |
| Kurra headache powders EACH 1 g POWDER CONTAINS ASPIRIN 800 mg CAFFEINE 50 mg PARACETAMOL 150 mg | Powders | B0961B/2.8/961 | Registered | Not determined | None |
| Grand-pa headache powders EACH POWDER CONTAINS: ASPIRIN 453,6 mg, CAFFEINE 64,8 mg, PARACETAMOL 324 mg | Powders | B1113B/2.9/1113 | Registered | Not determined | None |
| Compral pain tablets TABLET ASPIRIN 400 MG CAFFEINE 30 MG PARACETAMOL 100 MG | Tablets | B1147B/2.8/1147 | Registered | Not determined | None |
| Lennon headache powders EACH POWDER CONTAINS ASPIRIN 450 MG CAFFEINE 50 MG PARACETAMOL 300 MG | Powders | J0072J/2.8/72 | Cancelled | Not determined | None |
| Propain s EACH TABLET CONTAINS ASPIRIN 250,0 mg CAFFEINE 50,0 mg PARACETAMOL 250,0 mg | Not listed | M0503M/2.9/503 | Cancelled | Not determined | None |
| Grand-pa headache tablets EACH TABLET CONTAINS: ASPIRIN 226,8 mg, CAFFEINE 32,4 mg, PARACETAMOL 162,0 mg | Tablets | P0022P/2.9/22 | Registered | Not determined | None |
| Adco-dol pain relief powders EACH POWDER CONTAINS ASPIRIN 500 mg CAFFEINE 32,5 mg PARACETAMOL 325 mg | 500 mgPowder | R0238R/2.9/238Approved 30 November 2021 | Registered | Not determined | PIPIL |
Regulatory status
Where S0 sits on the scale
Sold anywhere, no pharmacist needed.
This is the least restricted tier of medicine. You can buy it in an ordinary shop such as a supermarket or petrol station, and no pharmacist needs to be involved in the sale. It may also be advertised to the public, subject to the general advertising rules that apply to all medicines; the label must still carry the schedule mark like every other tier.
Schedule S0, read from the product's PI-PIL leaflet.
The Consolidated Schedules list this ingredient up to S3; the leaflet's S0 applies to this product.
Who may supply: Anyone. It may be sold in an ordinary shop, not only in a pharmacy.
Consolidated Schedules listings for Aspirin, caffeine, paracetamol
S3: Caffeine
- when intended for injection.
Consolidated Schedules 06 July 2026, line 3256
S3: Paracetamol
- when intended for injection.
Consolidated Schedules 06 July 2026, line 4093
S2: Aspirin
- the treatment of children or adolescents; and
- the prophylaxis of cardiovascular disease in adults (S0)
Consolidated Schedules 06 July 2026, lines 1616 to 1620
S2: Paracetamol
- when contained in rectal suppositories, or
- when contained in modified release formulations. (S0, S1, S3)
Consolidated Schedules 06 July 2026, lines 2496 to 2500
S1: Paracetamol
- immediate release tablets or capsules each containing 500 milligrams or less of paracetamol, or in individually wrapped powders or in sachets containing 1 000 milligrams or less of paracetamol, subject to - (i) a maximum of 12,5 grams of paracetamol per primary pack, and (ii) in the case of tablets or capsules, presented in blister strip packaging or in containers with child-resistant closures; and (iii) labelled with the following boxed warning, placed prominently on at least the main panel of the immediate container label and outer label (carton): “CONTAINS PARACETAMOL - READ THE PACKAGE INSERT”; (S0)
- in liquid or syrup dosage form containing 120 milligrams or less of paracetamol per 5 millilitres or in paediatric drops containing 120 milligrams or less of paracetamol per 1,2 millilitres, subject to - (i) a maximum of 100 millilitres per primary pack in the case of the liquid or syrup dosage form containing 120 milligrams or less of paracetamol per 5 millilitres; (ii) a maximum of 20 millilitres per primary pack in the case of the paediatric drops; (iii) labelled with the following boxed warning, placed prominently on at least the main panel of the immediate container label and outer label (carton): “CONTAINS PARACETAMOL - READ THE PACKAGE INSERT”; (S0)
- when contained in rectal suppositories. (S2)
- when contained in modified release formulations. (S2)
- when intended for injection. (S3)
Consolidated Schedules 06 July 2026, lines 958 to 997
Pharmacological class: Analgesic combinations. (class 2.8)
14 of 67 approved products with this ingredient carry S5 on their leaflet.
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
Schedule Verification
Compral pain powders, Adcock ingram limited is scheduled S0 in its official SAHPRA documents, read with 90% confidence.
These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.